Interleukin-6 and neural stem cells: More than gliogenesis

Molecular Biology of the Cell

Volumn 20, Issue 1, 2009, Pages 188-199

  Islam, Omedul ^a   Gong, Xiandi ^a   Rose John, Stefan ^b   Heese, Klaus ^a  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMIC ACID; HYBRID PROTEIN; INTERLEUKIN 6 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; RECOMBINANT INTERLEUKIN 6; STAT3 PROTEIN; AMPA RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NESTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL SHAPE; CYTOLOGY; FEMALE; GENETICS; HUMAN; METABOLISM; NERVE CELL; PATCH CLAMP; PHYSIOLOGY; PREGNANCY; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALS; ASTROCYTES; CELL DIFFERENTIATION; CELL SHAPE; CELLS, CULTURED; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; FEMALE; HUMANS; INTERLEUKIN-6; INTERMEDIATE FILAMENT PROTEINS; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE TISSUE PROTEINS; NEUROGENESIS; NEURONS; PATCH-CLAMP TECHNIQUES; PREGNANCY; RECEPTORS, AMPA; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STEM CELLS;

EID: 61849112508     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E08-05-0463     Document Type: Article

References (73)

1. Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970.
2. Ayyadhury, S., and Heese, K. (2007). Neurotrophins-more than neurotrophic. Curr. Immunol. Rev. 3, 189-215.
3. Badache, A., and Hynes, N. E. (2001). Interleukin 6 inhibits proliferation and, in cooperation with an epidermal growth factor receptor autocrine loop, increases migration of T47D breast cancer cells. Cancer Res. 61, 383-391.
4. Balschun, D., Wetzel, W., Del Rey, A., Pitossi, F., Schneider, H., Zuschratter, W., and Besedovsky, H. O. (2004). Interleukin-6, a cytokine to forget. FASEB J. 18, 1788-1790.
5. Blaskovich, M. A., Sun, J., Cantor, A., Turkson, J., Jove, R., and Sebti, S. M. (2003). Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signalling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63, 1270-1279.
6. Bonni, A., Sun, Y., Nadal-Vicens, M., Bhatt, A., Frank, D. A., Rozovsky, I., Stahl, N., Yancopoulos, G. D., and Greenberg, M. E. (1997). Regulation of gliogenesis in the central nervous system by the JAK-STAT signalling pathway. Science 278, 477-483.
7. Brazel, C. Y., and Rao, M. S. (2004). Aging and neuronal replacement. Ageing Res. Rev. 3, 465-483.
8. Campbell, I. L., Abraham, C. R., Masliah, F., Kemper, P., Inglis, J. D., Old-stone, M.B.A., and Mucke, L. (1993). Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6. Proc. Natl. Acad. Sci. USA 90, 10061-10065.
9. Campos, L. S. (2004). Neurospheres: insights into neural stem cell biology. J. Neurosci. Res. 78, 761-769.
10. Chalaris, A., Rabe, B., Paliga, K., Lange, H., Laskay, T., Fielding, C. A., Jones, S. A., Rose-John, S., and Scheller, J. (2007). Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signalling function of neutrophils. Blood 110, 1748-1755.
11. Chan, K. S., Sano, S., Kiguchi, K., Anders, J., Komazawa, N., Takeda, J., and DiGiovanni, J. (2004). Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J. Clin. Invest. 114, 720-728.
12. Chao, M. V. (2003). Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat. Rev. Neurosci. 4, 299-309.
13. Chiaretti, A., Antonelli, A., Mastrangelo, A., Pezzotti, P., Tortorolo, L., Tosi, F., and Genovese, O. (2008). Interleukin-6 and nerve growth factor upregulation correlates with improved outcome in children with severe traumatic brain injury. J. Neurotrauma 25, 225-234.
14. DeLeo, F. R. (2007). Attractive shedding. Blood 110, 1711-1712.
15. Dworkin, S., Heath, J. K., DeJong-Curtain, T. A., Hogan, B. M., Lieschke, G. J., Malaterre, J., Ramsay, R. G., and Mantamadiotis, T. (2007). CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish. Dev. Biol. 307, 127-141.
16. Fischer, M., Goldschmitt, J., Peschel, C., Kallen, K. J., Brakenhoff, J.P.J., Wollmer, A., Grotzinger, J., and Rose-John, S. (1997). A designer cytokine with activity on human hematopoietic progenitor cells. Nat. Biotech. 15, 142-145.
17. Gadient, R. A., and Otten, U. (1995). Interleukin-6 and interleukin-6 receptor mRNA expression in rat central nervous system. Ann. NY Acad. Sci. 762, 403-406.
18. Gadient, R. A., and Otten, U. (1997). Interleukin-6 (IL-6): a molecule with both beneficial and destructive potentials. Prog. Neurobiol. 521, 379-390.
19. Gage, F. H. (2000). Mammalian neural stem cells. Science 287, 1433-1438.
20. Giachino, C., De Marchis, S., Giampietro, C., Parlato, R., Perroteau, I., Schutz, G., Fasolo, A., and Peretto, P. (2005). cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb. J. Neurosci. 25, 10105-10118.
21. Gruol, D. L., and Nelson, T. E. (1997). Physiological and pathological roles of interleukin-6 in the central nervous system. Mol. Neurobiol. 15, 307-339.
22. Gu, F., Hata, R., Ma, Y. J., Tanaka, J., Mitsuda, N., Kumon, Y., Hanakawa, Y., Hashimoto, K., Nakajima, K., and Sakanaka, M. (2005). Suppression of Stat3 promotes neurogenesis in cultured neural stem cells. J. Neurosci. Res. 81, 163-171.
23. Hakkoum, D., Stoppini, L., and Muller, D. (2007). Interleukin-6 promotes sprouting and functional recovery in lesioned organotypic hippocampal slice cultures. J. Neurochem. 100, 747-757.
24. Heese, K., Yamada, T., Akatsu, H., Yamamoto, T., Kosaka, K., Nagai, Y., and Sawada, T. (2004). Characterization of the new transcription-regulator- protein p60TRP. J. Cell. Biochem. 91, 1030-1042.
25. Heinrich, P. C., Behrmann, I., Haan, S., Hermann, H. M., Muller-Newen, G., and Schaper, F. (2003). Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem. J. 374, 1-20.
26. Himi, T., Okazaki, T., and Mori, N. (1994). SCG10 mRNA localization in the hippocampus: comparison with other mRNAs encoding neuronal growth-associated proteins (nGAPs). Brain Res. 655, 177-185.
27. Huang, E. J., and Reichardt, L. F. (2003). Trk receptors: roles in neuronal signal transduction. Annu. Rev. Biochem. 72, 609-642.
28. Jones, S. A., Horiuchi, S., Topley, N., Yamamoto, N., and Fuller, G. M. (2001). The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J. 15, 43-58.
29. Jones, S. A., Richards, P. J., Scheller, J., and Rose-John, S. (2005). IL-6 trans-signalling: the in vivo consequences. J. Interferon Cytokine Res. 25, 241-253.
30. Jones, S. A., and Rose-John, S. (2002). The role of soluble receptors in cytokine biology: the agonistic properties of the sIL-6R/IL-6 complex. Biochim. Bio-phys. Acta 1592, 251-263.
31. Josselyn, S. A., and Nguyen, P. V. (2005). CREB, synapses and memory disorders: past progress and future challenges. Curr. Drug Targets CNS Neurol. Disord. 4, 481-497.
32. Kahn, M. A., and De Vellis, J. (1994). Regulation of an oligodendrocyte progenitor cell line by the interleukin-6 family of cytokines. Glia 12, 87-98.
33. Kempermann, G., and Gage, F. H. (1999). New nerve cells for the adult brain. Sci. Am. 280, 48-53.
34. Kholodenko, B. N. (2007). Untangling the signalling wires. Nat. Cell Biol. 9, 247-249.
35. Kitayama, T., Yoneyama, M., Tamaki, K., and Yoneda, Y. (2004). Regulation of neuronal differentiation by N-methyl-D-aspartate receptors expressed in neural progenitor cells isolated from adult mouse hippocampus. J. Neurosci. Res. 76, 599-612.
36. Klouche, M., Bhakdi, S., Hemmes, M., and Rose-John, S. (1999). Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J. Immunol. 163, 4583-4589.
37. Marz, P., Cheng, J. G., Gadient, R. A., Patterson, P. H., Stoyan, T., Otten, U., and Rose-John, S. (1998). Sympathetic neurons can produce and respond to interleukin 6. Proc. Natl. Acad. Sci. USA 95, 3251-3256.
38. Marz, P., Heese, K., Dimitriades-Schmutz, B., Rose-John, S., and Otten, U. (1999). Role of interleukin-6 and soluble IL-6 receptor in region-specific induction of astrocytic differentiation and neurotrophin expression. Glia 26, 191-200.
39. Marz, P., Herget, T., Lang, E., Otten, U., and Rose-John, S. (1997). Activation of gp130 by IL-6/soluble IL-6 receptor induces neuronal differentiation. Eur. J. Neurosci. 9, 2765-2773.
40. Ming, G. L., and Song, H. (2005). Adult neurogenesis in the mammalian central nervous system. Annu. Rev. Neurosci. 28, 223-250.
41. Melchiorri, D., Cappuccio, I., Ciceroni, C., Spinsanti, P., Mosillo, P., Sarichelou, I., Sale, P., and Nicoletti, F. (2007). Metabotropic glutamate receptors in stem/progenitor cells. Neuropharmacology 53, 473-480.
42. Molne, M., Studer, L., Tabar, V., Ting, Y. T., Eiden, M. V., and McKay, R. D. (2000). Early cortical precursors do not undergo LIF-mediated astrocytic differentiation. J. Neurosci. Res. 59, 301-311.
43. Mori, N., and Morii, H. (2002). SCG10-related neuronal growth-associated proteins in neural development, plasticity, degeneration, and aging. J. Neu-rosci. Res. 70, 264-273.
44. Morii, H., Shiraishi-Yamaguchi, Y., and Mori, N. (2006). SCG10, a microtubule destabilizing factor, stimulates the neurite outgrowth by modulating micro-tubule dynamics in rat hippocampal primary cultured neurons. J. Neurobiol. 66, 1101-1114.
45. Nakanishi, M., Niidome, T., Matsuda, S., Akaike, A., Kihara, T., and Sugimoto, H. (2007). Microglia-derived interleukin-6 and leukaemia inhibitory factor promote astrocytic differentiation of neural stem/progenitor cells. Eur. J. Neurosci. 25, 649-658.
46. Ng, D. C., Lin, B. H., Lim, C. P., Huang, G., Zhang, T., Poli, V., and Cao, X. (2006). Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J. Cell Biol. 172, 245-257.
47. Ohbayashi, N., Ikeda, O., Taira, N., Yamamoto, Y., Muromoto, R., Sekine, Y., Sugiyama, K., Honjoh, T., and Matsuda, T. (2007). LIF-and IL-6-induced acetylation of STAT3 at Lys-685 through PI3K/Akt activation. Biol. Pharm. Bull. 30, 1860-1864.
48. Okano, H. (2002). Stem cell biology of the central nervous system. J. Neurosci. Res. 69, 698-707.
49. Otten, U., Marz, P., Heese, K., Hock, C., Kunz, D., and Rose-John, S. (2001) Signals regulating neurotrophin expression in glial cells. Prog. Brain Res. 132, 545-554.
50. Peltier, J., O'Neill, A., and Schaffer, D. V. (2007). PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation. Dev. Neurobiol. 67, 1348-1361.
51. Qiu, Z., Parsons, K. L., and Gruol, D. L. (1995). Interleukin-6 selectively enhances the intracellular calcium response to NMDA in developing CNS neurons. J. Neurosci. 15, 6688-6699.
52. Qiu, Z., Sweeney, D. D., Netzeband, J. G., and Gruol, D. L. (1998). Chronic interleukin-6 alters NMDA receptor-mediated membrane responses and enhances neurotoxicity in developing CNS neurons. J. Neurosci. 18, 10445-10456.
53. Rajan, P., and McKay, R.D.G. (1998). Multiple routes to astrocytic differentiation in the CNS. J. Neurosci. 18, 3620-3629.
54. Reynolds, B. A., and Rietze, R. L. (2005). Neural stem cells and neuro-spheres-re-evaluating the relationship. Nat. Methods 2, 333-336.
55. Rose-John, S., and Neurath, M. F. (2004). IL-6 trans-signalling: the heat is on. Immunity 20,2-4.
56. Rose-John, S., Scheller, J., Elson, G., and Jones, S. A. (2006). Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J. Leukoc. Biol. 80, 227-236.
57. Rose-John, S., Waetzig, G. H., Scheller, J., Grotzinger, J., and Seegert, D. (2007). The IL-6/sIL-6R complex as a novel target for therapeutic approaches. Expert Opin. Ther. Targets 11, 613-624.
58. Sands, W. A., and Palmer, T. M. (2008). Regulating gene transcription in response to cyclic AMP elevation. Cell Signal. 20, 460-466.
59. Satoh, T., Nakamura, S., Taga, T., Matsuda, T., Hirano, T., Kishimoto, T., and Kaziro, Y. (1988). Induction of neural differentiation in PC12 cells by B cell stimulatory factor 2/interleukin 6. Mol. Cell. Biol. 8, 3546-3549.
60. Schafer, K. H., Mestres, P., Marz, P., and Rose-John, S. (1999). The IL-6/sIL-6R fusion protein hyper-IL-6 promotes neurite outgrowth and neuron survival in cultured enteric neurons. J. Interferon Cytokine Res. 19, 527-532.
61. Scheller, J., and Rose-John, S. (2006). Interleukin-6 and its receptor: from bench to bedside. Med. Microbiol. Immunol. 195, 173-183.
62. Shimazaki, T., Shingo, T., and Weiss, S. (2001). The ciliary neurotrophic factor/leukemia inhibitory factor/gp130 receptor complex operates in the maintenance of mammalian forebrain neural stem cells. J. Neurosci. 21, 7642-653.
63. Shors, T. J. (2004). Memory traces of trace memories: neurogenesis, synapto-genesis and awareness. Trends Neurosci. 27, 250-256.
64. Sorkin, A. (2005). TRKing signals through the Golgi. Sci. STKE 267, 1-3.
65. Sterneck, E., Kaplan, D. R., and Johnson, P. F. (1996). Interleukin-6 induces expression of peripherin and cooperates with Trk receptor signalling to promote neuronal differentiation in PC12 cells. J. Neurochem. 67, 1365-1374.
66. Sugaya, K. (2005). Possible use of autologous stem cell therapies for Alzheimer's disease. Curr. Alzheimer Res. 2, 367-376.
67. Taga, T., and Fukuda, S. (2005). Role of IL-6 in the neural stem cell differentiation. Clin. Rev. Allergy Immunol. 28, 249-256.
68. Taga, T., and Kishimoto, T. (1997). Gp130 and the interleukin-6 family of cytokines. Annu. Rev. Immunol. 15, 797-819.
69. Tanne, J. H. (2005). Activating stem cells may treat Alzheimer's. Br. Med. J. 330, 622.
70. Thier, M., Marz, P., Otten, U., Weis, J., and Rose-John, S. (1999). Interleukin-6 (IL-6) and its soluble receptor support survival of sensory neurons. J. Neuro-sci. Res. 55, 411-422.
71. Wagner, J. A. (1996). Is IL-6 both a cytokine and a neurotrophic factor? J. Exp. Med. 183, 2417-2419.
72. Waltereit, R., and Weller, M. (2003). Signalling from cAMP/PKA to MAPK and synaptic plasticity. Mol. Neurobiol. 27, 99-106.
73. Yokota, T., Mishra, M., Akatsu, H., Tani, Y., Miyauchi, T., Yamamoto, T., Kosaka, K., Nagai, Y., Sawada, T., and Heese, K. (2006). Brain site-specific gene expression analysis in Alzheimer's disease patients. Eur. J. Clin. Invest. 36, 820-830.