Brain-immune communication pathways

Brain, Behavior, and Immunity

Volumn 21, Issue 6, 2007, Pages 727-735

  Quan, Ning ^a   Banks, William A ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Afferent nerves; Blood brain barrier; Circumventricular organ; CNS; Immune system; Neuroimmune; Vagus

Indexed keywords

CXCL9 CHEMOKINE; CYTOKINE; ENDOTHELIN 1; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR; RANTES; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR;

AUTONOMIC NERVOUS SYSTEM; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CYTOKINE RELEASE; GLIA CELL; HUMAN; IMMUNE SYSTEM; IMMUNOREACTIVITY; INTERPERSONAL COMMUNICATION; NERVE STIMULATION; NERVE TRACT; NEUROENDOCRINE SYSTEM; NEUROIMMUNOLOGY; NEUROTRANSMISSION; PATHOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TRANSPORT KINETICS;

ANIMALS; BLOOD-BRAIN BARRIER; CELL COMMUNICATION; CENTRAL NERVOUS SYSTEM; CEREBRAL VENTRICLES; CYTOKINES; HISTORY, 20TH CENTURY; HISTORY, 21ST CENTURY; HUMANS; NEURAL PATHWAYS; NEUROIMMUNOMODULATION; PSYCHONEUROIMMUNOLOGY;

EID: 34347268434     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2007.05.005     Document Type: Review

References (54)

1. Ader R., and Cohen N. Behaviorally conditioned immunosuppression. Psychosom. Med. 37 (1975) 333-350
2. Ban E., Haour F., and Lenstra R. Brain interleukin 1 gene expression induced by peripheral lipopolysaccharide administration. Cytokine 4 (1992) 48-54
3. Banks W.A., Kastin A.J., and Durham D.A. Bidirectional transport of interleukin-1 alpha across the blood-brain barrier. Brain Res. Bull. 23 (1989) 433-437
4. Banks W.A., Farr S.A., La Scola M.E., and Morley J.E. Intravenous human interleukin-1α impairs memory processing in mice: dependence on blood-brain barrier transport into posterior division of the septum. J. Pharmacol. Exp. Ther. 299 (2001) 536-541
5. Banks W.A., Niehoff M.L., and Zalcman S. Permeability of the mouse blood-brain barrier to murine interleukin-2: predominance of a saturable efflux system. Brain Behav. Immun. 18 (2004) 434-442
6. Besedovsky H.O., de Rey A., Sorkin E., Da Prada M., and Keller H.H. Immunoregulation mediated by the sympathetic nervous system. Cell Immunol. 48 (1979) 346-355
7. Blalock J.E., Bost K.I., and Smith E.M. Neuroendocrine peptide hormones and their receptors in the immune system. Production, processing and action. J. Neuroimmunol. 10 (1985) 31-40
8. Blatteis C.M., Bealer S.L., Hunter W.S., Llanos Q.J., Ahokas R.A., and Mashburn Jr. T.A. Suppression of fever after lesions of the anteroventral third ventricle in guinea pigs. Brain Res. Bull. 11 (1983) 519-526
9. Bluthe R.M., Walter V., Parnet P., Laye S., Lestage J., Verrier D., Poole S., Stenning B.E., Kelley K.W., and Dantzer R. Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism. C R Acad. Sci. III 317 (1994) 499-503
10. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., and Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405 (2000) 458-462
11. Breder C.D., Dinarello C.A., and Saper C.B. Interleukin-1 immunoreactive innervation of the human hypothalamus. Science 240 (1988) 321-324
12. Cao C., Watanabe Y., Yamagata K., and Matsumura K. Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain. Am. J. Physiol. 272 (1997) R1712-R1725
13. 125 I-labelled interleukin-6 from brain into blood following intracerebroventricular injection in rats. Endocrinology 138 (1997) 4830-4836
14. Chen G., McCuskey R.S., and Reichlin S. Blood interleukin-6 and tumor necrosis factor-α elevation after intracerebroventricular injection of Escherichia coli endotoxin in the rat is determined by two opposing factors: peripheral induction by LPS transferred from brain to blood and inhibition of peripheral response by a brain-mediated mechanism. nim 8 (2000) 59-69
15. Ching S., Zhang H., Lai W., and Quan N. Peripheral injection of lipopolysaccharide prevents brain recruitment of leukocytes induced by central injection of interleukin-1. Neuroscience 137 (2006) 717-726
16. Cunningham Jr. E.T., Wada E., Carter D.B., Tracey D.E., Battey J.F., and De Souza E.B. In situ histochemical localization of type 1 interleukin-1 receptor messenger RNA in the central nervous system, pituitary, and adrenal gland of the mouse. J. Neurosci. 12 (1992) 1101-1114
17. Dantzer R., Konsman J.P., Bluthe R.M., and Kelley K.W. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent?. Auton. Neurosci. 85 (2000) 60-65
18. Ek M., Kurosawa M., Lundeberg T., and Ericsson A. Activation of vagal afferents after intravenous injection of interleukin-1 beta: role of endogenous prostaglandins. Neuroscience 18 (1998) 9471-9479
19. Ericsson A., Kovacs K.J., and Sawchenko P.E. A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons. J. Neurosci. 14 (1994) 897-913
20. Fabry Z., Fitzsimmons K.M., Herlein J.A., Moninger T.O., Dobbs M.B., and Hart M.N. Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J. Neuroimmunol. 47 (1993) 23-34
21. Felten D.L., Felten S.Y., Carlson S.L., Olschowka J.A., and Livnat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J. Immunol. 135 (1985) 755s-765s
22. French R.A., VanHoy R.W., Chizzonite R., Zachary J.F., Dantzer R., Parnet P., Bluthe R.M., and Kelley K.W. Expression and localization of p80 and p68 interleukin-1 receptor proteins in the brain of adult mice. J. Neuroimmunol. 93 (1999) 194-202
23. Gatti S., and Bartfai T. Induction of tumor necrosis factor-alpha mRNA in the brain after peripheral endotoxin treatment: comparison with interleukin-1 family and interleuin-6. Brain Res. 624 (1993) 291-294
24. Goehler L.E., Relton J.K., Dripps D., Kiechle R., Tartaglia N., Maier S.F., and Watkins L.R. Vagal paraganglia bind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Brain Res. Bull. 43 (1997) 357-364
25. Goehler L.E., Gaykema R.P., Nguyen K.T., Lee J.E., Tilders F.J., Maier S.F., and Watkins L.R. Interleukin-1 beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems?. J. Neurosci. 19 (1999) 2799-2806
26. Guerrero J.M., and Reiter R.J. A brief survey of pineal gland-immune system interrelationships. Endocr. Res. 18 (1992) 91-113
27. Habif D.V., Lipton R., and Cantell K. Interferon crosses the blood-cerebrospinal fluid barrier in monkeys. Proc. Soc. Exp. Biol. Med. 149 (1975) 287-289
28. Hansen M.K., O'Connor K.A., Goehler L.E., Watkins L.R., and Maier S.F. The contribution of the vagus nerve in interleukin-1 beta-induced fever is dependent on dose. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280 (2001) R929-R934
29. Hofman F., Chen P., Incardona F., Zidovetzki R., and Hinton D.R. HIV-tat protein induces the production of interleukin-8 by human brain-derived endothelial cells. J. Neuroimmunol. 94 (1999) 28-39
30. Inoue W., Matsumura K., Yamagata K., Takemiya T., Shiraki T., and Kobayashi S. Brain-specific endothelial induction of prostaglandin E(2) synthesis enzymes and its temporal relation to fever. Neurosci. Res. 44 (2002) 51-61
31. 2 levels in several brain areas as determined by microdialysis. Am. J. Physiol. 262 (1992) E246-E251
32. Luheshi G.N., Bluthe R.M., Rushforth D., Mulcahy N., Konsman J.P., Goldbach M., and Dantzer R. Vagotomy attenuates the behavioral but not the pyrogenic effects of interlekin-1 in rats. Auton. Neurosci. 85 (2000) 127-132
33. Marvel F.A., Chen C.-C., Badr N., Gaykema R.P.A., and Goehler L.E. Reversible inactivation of the dorsal vagal complex blocks lipopolysaccharide-induced social withdrawal and c-Fos expression in central autonomic nuclei. Brain Behav. Immun. 18 (2003) 123-134
34. Medawar P. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain and to the anterior chamber of the eye. Br. J. Exp. Pathol. 29 (1948) 58-69
35. Pan W., and Kastin A.J. TNFα transport across the blood-brain barrier is abolished in receptor knockout mice. Exp. Neurol. 174 (2002) 193-200
36. Pan W., Banks W.A., Kennedy M.K., Gutierrez E.G., and Kastin A.J. Differential permeability of the BBB in acute EAE: enhanced transport of TNF-α. Am. J. Physiol. 271 (1996) E636-E642
37. Peruzzo B., Pastor F.E., Blazquez J.L., Schobitz K., Pelaez B., Amat P., and Rodriguez E.M. A second look at the barriers of the medial basal hypothalamus. Exp. Brain Res. 132 (2000) 10-26
38. Qin L., Wu X., Block M.L., Liu Y., Breese G.R., Hong J.S., Knapp D.J., and Crews F.T. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. GLIA 55 (2007) 453-462
39. Quan N., and Herkenham M. Connecting cytokines and brain: a review of current issues. Histol. Histopathol. 46 (2002) 178-192
40. Quan N., Sundar S.K., and Weiss J.M. Induction of interleukin-1 in various brain regions after peripheral and central injections of lipopolysaccharide. J. Neuroimmunol. 49 (1994) 125-134
41. Quan N., Whiteside M., Kim L., and Herkenham M. Induction of inhibitory factor κBα mRNA in the centralnervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the rat. Proc. Natl. Acad. Sci. USA 94 (1997) 10985-10990
42. Quan N., Whiteside M., and Herkenham M. Time course and localization patterns of interleukin-1β messenger RNA expression i brain and pituitary after peripheral administration of lipopolysaccharide. Neuroscience 83 (1998) 281-293
43. Reyes T.M., Fabry Z., and Coe C.L. Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli. Brain Res. 851 (1999) 215-220
44. Romanovsky A.A., Simon C.T., Szekely M., and Kulchitsky V.A. The vagus nerve in the thermoregulatory response to systemic inflammation. Am. J. Physiol. 273 (1997) R407-R413
45. Roth J., and De Souza G.E. Fever induction pathways: evidence from responses to systemic or local cytokine formation. Braz. J. Med. Biol. Res. 34 (2001) 301-314
46. Sanchez-Alavez M., Tabarean I.V., Behrens M.M., and Bartfai T. Ceramide mediates the rapid phase of febrile response to IL-1beta. Proc. Natl. Acad. Sci. USA 103 (2006) 2904-2908
47. Verma S., Nakaoke R., Dohgu S., and Banks W.A. Release of cytokines by brain endothelial cells: a polarized response to lipopolysaccharide. Brain Behav. Immun. 20 (2006) 449-455
48. Wang H., Yu M., Ochani M., Amella C.A., Tanovic M., Susarla S., Li J.H., Wang H., Yang H., Ulloa L., Al-Abed Y., Czura C.J., and Tracey K.J. Nicotinic acetycholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 421 (2003) 384-388
49. Watkins L.R., Wiertelak E.P., Goehler L.E., Mooney-Heiberger K., Martinez J., Furness L., Smith K.P., and Maier S.F. Neurocircuitry of illness-induced hyperalgesia. Brain Res. 639 (1994) 283-299
50. Watkins L.R., Maier S.F., and Goehler L.E. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci. 57 (1995) 1011-1026
51. Widner H., and Brundin P. Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis. Brain Res. 472 (1988) 287-324
52. Xiang S., Pan W., and Kastin A.J. Strategies to create a regenerating environment for the injured spinal cord. Curr. Pharmaceut. Design 11 (2005) 1267-1277
53. Yang Z.J., Rao Z.R., and Ju G. Evidence for the medullary visceral zone as a neural station of neuroimmunomodulation. Neurosci. Res. 38 (2000) 237-247
54. Zhous Y., Deneris E., and Zigmond R.E. Nicotinic acetylcholine receptor subunit proteins alpha7 and beta4 decrease in the superior cervical ganglion after axotomy. J. Neurobiol. 46 (2001) 178-192