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Volumn 12, Issue 8, 2012, Pages 527-539

Kinesins and cancer

Author keywords

[No Author keywords available]

Indexed keywords

4SC 205; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; ARQ 621; ARRY 520; AURORA A KINASE; AURORA B KINASE; AZD 4877; CENTROMERE PROTEIN E; CYCLIN DEPENDENT KINASE; DOCETAXEL; EG5 PROTEIN; EMD 534085; GSK 923295; ISPINESIB; KINESIN; LITRONESIB; MITOTIC KINESIN LIKE 1; MK 0731; NERVE CELL ADHESION MOLECULE; NUCLEAR PROTEIN; PACLITAXEL; PHOSPHOPROTEIN; POLO LIKE KINASE; POLO LIKE KINASE 1; SB 743921; TUBULIN; UNCLASSIFIED DRUG;

EID: 84864333830     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3310     Document Type: Review
Times cited : (429)

References (212)
  • 1
    • 1942438028 scopus 로고    scopus 로고
    • Microtubules as a target for anticancer drugs
    • Jordan, M. A. & Wilson, L. Microtubules as a target for anticancer drugs. Nature Rev. Cancer 4, 253-265 (2004). (Pubitemid 38525281)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.4 , pp. 253-265
    • Jordan, M.A.1    Wilson, L.2
  • 2
    • 0345688612 scopus 로고    scopus 로고
    • Mechanisms of Taxol resistance related to microtubules
    • DOI 10.1038/sj.onc.1206934, Drug Resistance
    • Orr, G. A., Verdier-Pinard, P., McDaid, H. & Horwitz, S. B. Mechanisms of Taxol resistance related to microtubules. Oncogene 22, 7280-7295 (2003). (Pubitemid 37487160)
    • (2003) Oncogene , vol.22 , Issue.REV. ISS. 6 , pp. 7280-7295
    • Orr, G.A.1    Verdier-Pinard, P.2    McDaid, H.3    Horwitz, S.B.4
  • 3
    • 77649191871 scopus 로고    scopus 로고
    • Microtubules and resistance to tubulin-binding agents
    • Kavallaris, M. Microtubules and resistance to tubulin-binding agents. Nature Rev. Cancer 10, 194-204 (2010).
    • (2010) Nature Rev. Cancer , vol.10 , pp. 194-204
    • Kavallaris, M.1
  • 4
    • 0035433029 scopus 로고    scopus 로고
    • Past and future of the mitotic spindle as an oncology target
    • DOI 10.1016/S1471-4892(01)00064-9, PII S1471489201000649
    • Wood, K. W., Cornwell, W. D. & Jackson, J. R. Past and future of the mitotic spindle as an oncology target. Curr. Opin. Pharmacol. 1, 370-377 (2001). (Pubitemid 33585986)
    • (2001) Current Opinion in Pharmacology , vol.1 , Issue.4 , pp. 370-377
    • Wood, K.W.1    Cornwell, W.D.2    Jackson, J.R.3
  • 5
    • 24344465919 scopus 로고    scopus 로고
    • Analysis of the kinesin superfamily: Insights into structure and function
    • DOI 10.1016/j.tcb.2005.07.006, PII S0962892405001820
    • Miki, H., Okada, Y. & Hirokawa, N. Analysis of the kinesin superfamily: insights into structure and function. Trends Cell Biol. 15, 467-476 (2005). (Pubitemid 41253466)
    • (2005) Trends in Cell Biology , vol.15 , Issue.9 , pp. 467-476
    • Miki, H.1    Okada, Y.2    Hirokawa, N.3
  • 6
    • 78449269612 scopus 로고    scopus 로고
    • Molecular motors in neurons: Transport mechanisms and roles in brain function, development, and disease
    • Hirokawa, N., Niwa, S. & Tanaka, Y. Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. Neuron 68, 610-638 (2010).
    • (2010) Neuron , vol.68 , pp. 610-638
    • Hirokawa, N.1    Niwa, S.2    Tanaka, Y.3
  • 8
    • 77949540170 scopus 로고    scopus 로고
    • How kinesin motor proteins drive mitotic spindle function: Lessons from molecular assays
    • Wordeman, L. How kinesin motor proteins drive mitotic spindle function: lessons from molecular assays. Semin. Cell Dev. Biol. 21, 260-268 (2010).
    • (2010) Semin. Cell Dev. Biol. , vol.21 , pp. 260-268
    • Wordeman, L.1
  • 9
    • 70349437416 scopus 로고    scopus 로고
    • Kinesin superfamily motor proteins and intracellular transport
    • Hirokawa, N., Noda, Y., Tanaka, Y. & Niwa, S. Kinesin superfamily motor proteins and intracellular transport. Nature Rev. Mol. Cell Biol. 10, 682-696 (2009).
    • (2009) Nature Rev. Mol. Cell Biol. , vol.10 , pp. 682-696
    • Hirokawa, N.1    Noda, Y.2    Tanaka, Y.3    Niwa, S.4
  • 10
    • 0029417238 scopus 로고
    • Phosphorylation by p34cdc2 regulates spindle association of human eg5, a kinesin-related motor essential for bipolar spindle formation in vivo
    • Blangy, A. et al. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. Cell 83, 1159-1169 (1995).
    • (1995) Cell , vol.83 , pp. 1159-1169
    • Blangy, A.1
  • 11
    • 0033615357 scopus 로고    scopus 로고
    • Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen
    • Mayer, T. U. et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science 286, 971-974 (1999).
    • (1999) Science , vol.286 , pp. 971-974
    • Mayer, T.U.1
  • 12
    • 84863439290 scopus 로고    scopus 로고
    • Phase i/ii multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of azd4877 in patients with refractory acute myeloid leukemia
    • Kantarjian, H. M. et al. Phase I/II multicenter study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of AZD4877 in patients with refractory acute myeloid leukemia. Invest. New Drugs 30, 1107-111115 (2011).
    • (2011) Invest. New Drugs , vol.30 , pp. 1107-111115
    • Kantarjian, H.M.1
  • 13
    • 84856745726 scopus 로고    scopus 로고
    • A Phase i study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors
    • Infante, J. R. et al. A Phase I study to assess the safety, tolerability, and pharmacokinetics of AZD4877, an intravenous Eg5 inhibitor in patients with advanced solid tumors. Cancer Chemother. Pharmacol. 69, 165-172 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.69 , pp. 165-172
    • Infante, J.R.1
  • 14
    • 74549223522 scopus 로고    scopus 로고
    • Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer
    • Purcell, J. W. et al. Activity of the kinesin spindle protein inhibitor ispinesib (SB-715992) in models of breast cancer. Clin. Cancer Res. 16, 566-576 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 566-576
    • Purcell, J.W.1
  • 15
    • 79955627902 scopus 로고    scopus 로고
    • A phase i study of ispinesib, A kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of A 28-day cycle in patients with solid tumors
    • Burris, H. A. et al. A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors. Invest. New Drugs 29, 467-472 (2011).
    • (2011) Invest. New Drugs , vol.29 , pp. 467-472
    • Burris, H.A.1
  • 16
    • 42549084401 scopus 로고    scopus 로고
    • A phase II and pharmacokinetic study of sb-715992, in patients with metastatic hepato-cellular carcinoma: A study of the national cancer institute of canada clinical trials group (NCIC CTG IND.168)
    • Knox, J. J. et al. A phase II and pharmacokinetic study of SB-715992, in patients with metastatic hepato-cellular carcinoma: a study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG IND.168). Invest. New Drugs 26, 265-272 (2008).
    • (2008) Invest. New Drugs , vol.26 , pp. 265-272
    • Knox, J.J.1
  • 18
    • 84864329202 scopus 로고    scopus 로고
    • A phase i trial of mk-0731, A kinesin spindle protein (KSP) inhibitor, in patients with solid tumors
    • Holen, K. et al. A phase I trial of MK-0731, a Kinesin Spindle Protein (KSP) inhibitor, in patients with solid tumors. Invest. New Drugs 30,1088-1095 (2012).
    • (2012) Invest. New Drugs , vol.30 , pp. 1088-1095
    • Holen, K.1
  • 19
    • 79953770295 scopus 로고    scopus 로고
    • A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose
    • Holen, K. D. et al. A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose. Cancer Chemother. Pharmacol. 67, 447-454 (2011).
    • (2011) Cancer Chemother. Pharmacol. , vol.67 , pp. 447-454
    • Holen, K.D.1
  • 21
    • 58149190803 scopus 로고    scopus 로고
    • Southwest oncology group phase II study of ispinesib in androgen-independent prostate cancer previously treated with taxanes
    • Beer, T. M. et al. Southwest Oncology Group phase II study of ispinesib in androgen-independent prostate cancer previously treated with taxanes. Clin. Genitourin. Cancer 6, 103-109 (2008).
    • (2008) Clin. Genitourin. Cancer , vol.6 , pp. 103-109
    • Beer, T.M.1
  • 22
    • 42549088324 scopus 로고    scopus 로고
    • Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Tang, P. A. et al. Phase II study of ispinesib in recurrent or metastatic squamous cell carcinoma of the head and neck. Invest. New Drugs 26, 257-264 (2008).
    • (2008) Invest. New Drugs , vol.26 , pp. 257-264
    • Tang, P.A.1
  • 23
    • 78049278014 scopus 로고    scopus 로고
    • A pediatric phase i trial and pharmacokinetic study of ispinesib: A children's oncology group phase i consortium study
    • Souid, A. K. et al. A pediatric phase I trial and pharmacokinetic study of ispinesib: a Children's Oncology Group phase I consortium study. Pediatr. Blood Cancer 55, 1323-1328 (2010).
    • (2010) Pediatr. Blood Cancer , vol.55 , pp. 1323-1328
    • Souid, A.K.1
  • 25
    • 84878171166 scopus 로고    scopus 로고
    • A phase i trial of the kinesin spindle protein (Eg5) inhibitor azd4877 in patients with solid and lymphoid malignancies
    • 22 May (doi:10.1007/s10637-012-9821-y)
    • Gerecitano, J. F. et al. A Phase I trial of the kinesin spindle protein (Eg5) inhibitor AZD4877 in patients with solid and lymphoid malignancies. Invest. New Drugs 22 May 2012 (doi:10.1007/s10637-012-9821-y).
    • (2012) Invest. New Drugs
    • Gerecitano, J.F.1
  • 26
    • 42549153290 scopus 로고    scopus 로고
    • Phase II, Open label study of ispinesib in patients with locally advanced or metastatic breast cancer
    • San Antonio
    • Miller, K. et al. Phase II, Open label study of ispinesib in patients with locally advanced or metastatic breast cancer. 28th Ann. San Antonio Breast Cancer Symp. Abstr. 1089 (San Antonio, 2005).
    • (2005) 28th Ann. San Antonio Breast Cancer Symp. Abstr. , pp. 1089
    • Miller, K.1
  • 27
    • 79751469568 scopus 로고    scopus 로고
    • Inhibition of kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons
    • Lin, S. et al. Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons. Traffic 12, 269-286 (2011).
    • (2011) Traffic , vol.12 , pp. 269-286
    • Lin, S.1
  • 28
    • 84855431740 scopus 로고    scopus 로고
    • Inhibitors targeting mitosis: Tales of how great drugs against a promising target were brought down by a flawed rationale
    • Komlodi-Pasztor, E., Sackett, D. L. & Fojo, A. T. Inhibitors targeting mitosis: tales of how great drugs against a promising target were brought down by a flawed rationale. Clin. Cancer Res. 18, 51-63 (2012).
    • (2012) Clin. Cancer Res. , vol.18 , pp. 51-63
    • Komlodi-Pasztor, E.1    Sackett, D.L.2    Fojo, A.T.3
  • 29
    • 0034666013 scopus 로고    scopus 로고
    • The forkhead-associated domain of ki-67 antigen interacts with the novel kinesin-like protein hklp2
    • Sueishi, M., Takagi, M. & Yoneda, Y. The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2. J. Biol. Chem. 275, 28888-28892 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 28888-28892
    • Sueishi, M.1    Takagi, M.2    Yoneda, Y.3
  • 30
    • 70350575316 scopus 로고    scopus 로고
    • Kif15 cooperates with eg5 to promote bipolar spindle assembly
    • Tanenbaum, M. E. et al. Kif15 cooperates with eg5 to promote bipolar spindle assembly. Curr. Biol. 19, 1703-1711 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1703-1711
    • Tanenbaum, M.E.1
  • 31
    • 70350575315 scopus 로고    scopus 로고
    • The role of hklp2 in the stabilization and maintenance of spindle bipolarity
    • Vanneste, D., Takagi, M., Imamoto, N. & Vernos, I. The role of Hklp2 in the stabilization and maintenance of spindle bipolarity. Curr. Biol. 19, 1712-1717 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1712-1717
    • Vanneste, D.1    Takagi, M.2    Imamoto, N.3    Vernos, I.4
  • 32
    • 3142617463 scopus 로고    scopus 로고
    • Humoral immunity to human breast cancer: Antigen definition and quantitative analysis of mrna expression
    • Scanlan, M. J. et al. Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression. Cancer Immun. 1, 4 (2001).
    • (2001) Cancer Immun , vol.1 , pp. 4
    • Scanlan, M.J.1
  • 33
    • 46449136776 scopus 로고    scopus 로고
    • Identification of proteins secreted from leptin stimulated mcf-7 breast cancer cells: A dual proteomic approach
    • Perera, C. N., Spalding, H. S., Mohammed, S. I. & Camarillo, I. G. Identification of proteins secreted from leptin stimulated MCF-7 breast cancer cells: a dual proteomic approach. Exp. Biol. Med. 233, 708-720 (2008).
    • (2008) Exp. Biol. Med. , vol.233 , pp. 708-720
    • Perera, C.N.1    Spalding, H.S.2    Mohammed, S.I.3    Camarillo, I.G.4
  • 35
    • 78049514886 scopus 로고    scopus 로고
    • Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching
    • Liu, M. et al. Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching. J. Neurosci. 30, 14896-14906 (2010).
    • (2010) J. Neurosci. , vol.30 , pp. 14896-14906
    • Liu, M.1
  • 36
    • 33845318699 scopus 로고    scopus 로고
    • Phase i study of ispinesib in combination with carboplatin in patients with advanced solid tumors
    • Jones, S. F. et al. Phase I study of ispinesib in combination with carboplatin in patients with advanced solid tumors. Proc. Am. Soc. Clin. Oncol. Abstr. 24, 2027 (2006).
    • (2006) Proc. Am. Soc. Clin. Oncol. Abstr. , vol.24 , pp. 2027
    • Jones, S.F.1
  • 37
    • 34249014574 scopus 로고    scopus 로고
    • Phase i study of ispinesib (SB-715992), a kinesin spindle protein inhibitor, in combination with capecitabine in patients with advanced solid tumors
    • Rhodon, J. et al. Phase I study of ispinesib (SB-715992), a kinesin spindle protein inhibitor, in combination with capecitabine in patients with advanced solid tumors. Eur. J. Canc. Suppl. 4, 193 (2006).
    • (2006) Eur. J. Canc. Suppl. , vol.4 , pp. 193
    • Rhodon, J.1
  • 39
    • 24944452696 scopus 로고    scopus 로고
    • Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling
    • DOI 10.1083/jcb.200505040
    • Mao, Y., Desai, A. & Cleveland, D. W. Microtubule capture by CENP-E silences BubR1-dependent mitotic checkpoint signaling. J. Cell Biol. 170, 873-880 (2005). (Pubitemid 41306286)
    • (2005) Journal of Cell Biology , vol.170 , Issue.6 , pp. 873-880
    • Mao, Y.1    Desai, A.2    Cleveland, D.W.3
  • 40
    • 77954740977 scopus 로고    scopus 로고
    • Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E
    • Kim, Y., Holland, A. J., Lan, W. & Cleveland, D. W. Aurora kinases and protein phosphatase 1 mediate chromosome congression through regulation of CENP-E. Cell 142, 444-455 (2010).
    • (2010) Cell , vol.142 , pp. 444-455
    • Kim, Y.1    Holland, A.J.2    Lan, W.3    Cleveland, D.W.4
  • 41
    • 0032846338 scopus 로고    scopus 로고
    • Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC
    • DOI 10.1083/jcb.146.5.941
    • Chan, G. K., Jablonski, S. A., Sudakin, V., Hittle, J. C. & Yen, T. J. Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J. Cell Biol. 146, 941-954 (1999). (Pubitemid 29430438)
    • (1999) Journal of Cell Biology , vol.146 , Issue.5 , pp. 941-954
    • Chan, G.K.T.1    Jablonski, S.A.2    Sudakin, V.3    Hittle, J.C.4    Yen, T.J.5
  • 42
    • 77953510484 scopus 로고    scopus 로고
    • The interaction between mitotic checkpoint proteins, CENP-E and bubr1, is diminished in epothilone b-resistant a549 cells
    • Yang, C. P., Liu, L., Ikui, A. E. & Horwitz, S. B. The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells. Cell Cycle 9, 1207-1213 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 1207-1213
    • Yang, C.P.1    Liu, L.2    Ikui, A.E.3    Horwitz, S.B.4
  • 43
    • 77953548556 scopus 로고    scopus 로고
    • CENP-E checks in microtubule-drug resistance
    • Chanel-Vos, C. & Giannakakou, P. CENP-E checks in microtubule-drug resistance. Cell Cycle 9, 1456-1465 (2010).
    • (2010) Cell Cycle , vol.9 , pp. 1456-1465
    • Chanel-Vos, C.1    Giannakakou, P.2
  • 44
    • 0036744787 scopus 로고    scopus 로고
    • Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
    • Putkey, F. R. et al. Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E. Dev. Cell 3, 351-365 (2002).
    • (2002) Dev. Cell , vol.3 , pp. 351-365
    • Putkey, F.R.1
  • 45
    • 35948943082 scopus 로고    scopus 로고
    • Aneuploidy: Instigator and inhibitor of tumorigenesis
    • DOI 10.1158/0008-5472.CAN-07-2266
    • Weaver, B. A. & Cleveland, D. W. Aneuploidy: instigator and inhibitor of tumorigenesis. Cancer Res. 67, 10103-10105 (2007). (Pubitemid 350070779)
    • (2007) Cancer Research , vol.67 , Issue.21 , pp. 10103-10105
    • Weaver, B.A.A.1    Cleveland, D.W.2
  • 46
    • 33846065784 scopus 로고    scopus 로고
    • Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
    • DOI 10.1016/j.ccr.2006.12.003, PII S1535610806003680
    • Weaver, B. A., Silk, A. D., Montagna, C., Verdier-Pinard, P. & Cleveland, D. W. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11, 25-36 (2007). (Pubitemid 46070223)
    • (2007) Cancer Cell , vol.11 , Issue.1 , pp. 25-36
    • Weaver, B.A.A.1    Silk, A.D.2    Montagna, C.3    Verdier-Pinard, P.4    Cleveland, D.W.5
  • 47
    • 66649093842 scopus 로고    scopus 로고
    • Integrative analysis of cyclin protein levels identifies cyclin B1 as a classifier and predictor of outcomes in breast cancer
    • Agarwal, R. et al. Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer. Clin. Cancer Res. 15, 3654-3662 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3654-3662
    • Agarwal, R.1
  • 48
    • 76249095119 scopus 로고    scopus 로고
    • Reduced expression of cenp-e in human hepatocellular carcinoma
    • Liu, Z. et al. Reduced expression of cenp-e in human hepatocellular carcinoma. J. Exp. Clin. Cancer Res. 28, 156 (2009).
    • (2009) J. Exp. Clin. Cancer Res. , vol.28 , pp. 156
    • Liu, Z.1
  • 49
    • 77950525308 scopus 로고    scopus 로고
    • Antitumor activity of an allosteric inhibitor of centromere-associated protein-e
    • Wood, K. W. et al. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E. Proc. Natl Acad. Sci. USA 107, 5839-5844 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 5839-5844
    • Wood, K.W.1
  • 50
    • 59449092629 scopus 로고    scopus 로고
    • Centromere-associated protein E: A motor that puts the brakes on the mitotic checkpoint
    • Wood, K. W., Chua, P., Sutton, D. & Jackson, J. R. Centromere-associated protein E: a motor that puts the brakes on the mitotic checkpoint. Clin. Cancer Res. 14, 7588-7592 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7588-7592
    • Wood, K.W.1    Chua, P.2    Sutton, D.3    Jackson, J.R.4
  • 51
    • 84859744596 scopus 로고    scopus 로고
    • First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein e (CENP-E), in patients with refractory cancer
    • Chung, V. et al. First-time-in-human study of GSK923295, a novel antimitotic inhibitor of centromere-associated protein E (CENP-E), in patients with refractory cancer. Cancer Chemother. Pharmacol. 69, 733-741 (2012).
    • (2012) Cancer Chemother. Pharmacol. , vol.69 , pp. 733-741
    • Chung, V.1
  • 52
    • 78649879703 scopus 로고    scopus 로고
    • Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin
    • Ding, X. et al. Probing CENP-E function in chromosome dynamics using small molecule inhibitor syntelin. Cell Res. 20, 1386-1389 (2010).
    • (2010) Cell Res , vol.20 , pp. 1386-1389
    • Ding, X.1
  • 53
    • 69249209892 scopus 로고    scopus 로고
    • Defects in chromosome congression and mitotic progression in kif18a-deficient cells are partly mediated through impaired functions of CENP-E
    • Huang, Y. et al. Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. Cell Cycle 8, 2643-2649 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 2643-2649
    • Huang, Y.1
  • 54
    • 0034618565 scopus 로고    scopus 로고
    • Microtubule motors in mitosis
    • Sharp, D. J., Rogers, G. C. & Scholey, J. M. Microtubule motors in mitosis. Nature 407, 41-47 (2000).
    • (2000) Nature , vol.407 , pp. 41-47
    • Sharp, D.J.1    Rogers, G.C.2    Scholey, J.M.3
  • 56
    • 0035958945 scopus 로고    scopus 로고
    • Purification and characterization of native conventional kinesin, HSET, and CENP-E from mitotic hela cells
    • DeLuca, J. G., Newton, C. N., Himes, R. H., Jordan, M. A. & Wilson, L. Purification and characterization of native conventional kinesin, HSET, and CENP-E from mitotic hela cells. J. Biol. Chem. 276, 28014-28021 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 28014-28021
    • Deluca, J.G.1    Newton, C.N.2    Himes, R.H.3    Jordan, M.A.4    Wilson, L.5
  • 57
    • 0032702315 scopus 로고    scopus 로고
    • The kinesin-related protein, HSET, opposes the activity of eg5 and cross-links microtubules in the mammalian mitotic spindle
    • Mountain, V. et al. The kinesin-related protein, HSET, opposes the activity of Eg5 and cross-links microtubules in the mammalian mitotic spindle. J. Cell Biol. 147, 351-366 (1999).
    • (1999) J. Cell Biol. , vol.147 , pp. 351-366
    • Mountain, V.1
  • 59
    • 65249162890 scopus 로고    scopus 로고
    • Kinesin-14 family proteins hset/xctk2 control spindle length by cross-linking and sliding microtubules
    • Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E. Kinesin-14 family proteins HSET/XCTK2 control spindle length by cross-linking and sliding microtubules. Mol. Biol. Cell 20, 1348-1359 (2009).
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1348-1359
    • Cai, S.1    Weaver, L.N.2    Ems-McClung, S.C.3    Walczak, C.E.4
  • 60
    • 77953133964 scopus 로고    scopus 로고
    • Proper organization of microtubule minus ends is needed for midzone stability and cytokinesis
    • Cai, S., Weaver, L. N., Ems-McClung, S. C. & Walczak, C. E. Proper organization of microtubule minus ends is needed for midzone stability and cytokinesis. Curr. Biol. 20, 880-885 (2010).
    • (2010) Curr. Biol. , vol.20 , pp. 880-885
    • Cai, S.1    Weaver, L.N.2    Ems-McClung, S.C.3    Walczak, C.E.4
  • 61
    • 63449101161 scopus 로고    scopus 로고
    • The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain
    • Grinberg-Rashi, H. et al. The expression of three genes in primary non-small cell lung cancer is associated with metastatic spread to the brain. Clin. Cancer Res. 15, 1755-1761 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 1755-1761
    • Grinberg-Rashi, H.1
  • 62
    • 70350217423 scopus 로고    scopus 로고
    • Overexpression of kinesins mediates docetaxel resistance in breast cancer cells
    • De, S., Cipriano, R., Jackson, M. W. & Stark, G. R. Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. Cancer Res. 69, 8035-8042 (2009).
    • (2009) Cancer Res , vol.69 , pp. 8035-8042
    • De, S.1    Cipriano, R.2    Jackson, M.W.3    Stark, G.R.4
  • 63
    • 50049085789 scopus 로고    scopus 로고
    • Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
    • Kwon, M. et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 22, 2189-2203 (2008).
    • (2008) Genes Dev , vol.22 , pp. 2189-2203
    • Kwon, M.1
  • 64
    • 60949102816 scopus 로고    scopus 로고
    • A little CIN may cost a lot: Revisiting aneuploidy and cancer
    • Chandhok, N. S. & Pellman, D. A little CIN may cost a lot: revisiting aneuploidy and cancer. Curr. Opin. Genet. Dev. 19, 74-81 (2009).
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 74-81
    • Chandhok, N.S.1    Pellman, D.2
  • 65
    • 77949489741 scopus 로고    scopus 로고
    • Kinesin-13s in mitosis: Key players in the spatial and temporal organization of spindle microtubules
    • Ems-McClung, S. C. & Walczak, C. E. Kinesin-13s in mitosis: key players in the spatial and temporal organization of spindle microtubules. Semin. Cell Dev. Biol. 21, 276-282 (2010).
    • (2010) Semin. Cell Dev. Biol. , vol.21 , pp. 276-282
    • Ems-McClung, S.C.1    Walczak, C.E.2
  • 66
    • 67649838621 scopus 로고    scopus 로고
    • Plk1 and aurora A regulate the depolymerase activity and the cellular localization of kif2a
    • Jang, C. Y. et al. Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. J. Cell Sci. 122, 1334-1341 (2009).
    • (2009) J. Cell Sci. , vol.122 , pp. 1334-1341
    • Jang, C.Y.1
  • 68
    • 84862538643 scopus 로고    scopus 로고
    • Plk1 regulates the kinesin-13 protein kif2b to promote faithful chromosome segregation
    • 25 apr (doi:10.1091/mbc.E11-12-1013)
    • Hood, E. A., Kettenbach, A. N., Gerber, S. A. & Compton, D. A. Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation. Mol. Biol. Cell 25 Apr 2012 (doi:10.1091/mbc. E11-12-1013).
    • (2012) Mol. Biol. Cell
    • Hood, E.A.1    Kettenbach, A.N.2    Gerber, S.A.3    Compton, D.A.4
  • 69
    • 84992268369 scopus 로고    scopus 로고
    • Regulation of localization and activity of the microtubule depolymerase MCAK
    • Tanenbaum, M. E., Medema, R. H. & Akhmanova, A. Regulation of localization and activity of the microtubule depolymerase MCAK. Bioarchitecture 1, 80-87 (2011).
    • (2011) Bioarchitecture , vol.1 , pp. 80-87
    • Tanenbaum, M.E.1    Medema, R.H.2    Akhmanova, A.3
  • 70
    • 4143075910 scopus 로고    scopus 로고
    • The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK
    • DOI 10.1083/jcb.200404012
    • Ganem, N. J. & Compton, D. A. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J. Cell Biol. 166, 473-478 (2004). (Pubitemid 39097166)
    • (2004) Journal of Cell Biology , vol.166 , Issue.4 , pp. 473-478
    • Ganem, N.J.1    Compton, D.A.2
  • 71
    • 0043199576 scopus 로고    scopus 로고
    • Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension
    • DOI 10.1016/S0092-8674(03)00522-1
    • Homma, N. et al. Kinesin superfamily protein 2A (KIF2A) functions in suppression of collateral branch extension. Cell 114, 229-239 (2003). (Pubitemid 36936916)
    • (2003) Cell , vol.114 , Issue.2 , pp. 229-239
    • Homma, N.1    Takei, Y.2    Tanaka, Y.3    Nakata, T.4    Terada, S.5    Kikkawa, M.6    Noda, Y.7    Hirokawa, N.8
  • 72
    • 72149125306 scopus 로고    scopus 로고
    • Overexpression of kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue
    • Wang, C. Q. et al. Overexpression of Kif2a promotes the progression and metastasis of squamous cell carcinoma of the oral tongue. Oral Oncol. 46, 65-69 (2010).
    • (2010) Oral Oncol , vol.46 , pp. 65-69
    • Wang, C.Q.1
  • 73
    • 77956221377 scopus 로고    scopus 로고
    • Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents
    • Schimizzi, G. V., Currie, J. D. & Rogers, S. L. Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. PLoS ONE 5, e11381 (2010).
    • (2010) PLoS ONE , vol.5
    • Schimizzi, G.V.1    Currie, J.D.2    Rogers, S.L.3
  • 74
    • 58149334818 scopus 로고    scopus 로고
    • Genome stability is ensured by temporal control of kinetochore- microtubule dynamics
    • Bakhoum, S. F., Thompson, S. L., Manning, A. L. & Compton, D. A. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nature Cell Biol. 11, 27-35 (2009).
    • (2009) Nature Cell Biol , vol.11 , pp. 27-35
    • Bakhoum, S.F.1    Thompson, S.L.2    Manning, A.L.3    Compton, D.A.4
  • 75
    • 0242287897 scopus 로고    scopus 로고
    • Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms
    • DOI 10.1242/jcs.00716
    • Cimini, D., Moree, B., Canman, J. C. & Salmon, E. D. Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms. J. Cell Sci. 116, 4213-4225 (2003). (Pubitemid 37337094)
    • (2003) Journal of Cell Science , vol.116 , Issue.20 , pp. 4213-4225
    • Cimini, D.1    Moree, B.2    Canman, J.C.3    Salmon, E.D.4
  • 78
    • 70450176266 scopus 로고    scopus 로고
    • Deviant kinetochore microtubule dynamics underlie chromosomal instability
    • Bakhoum, S. F., Genovese, G. & Compton, D. A. Deviant kinetochore microtubule dynamics underlie chromosomal instability. Curr. Biol. 19, 1937-1942 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1937-1942
    • Bakhoum, S.F.1    Genovese, G.2    Compton, D.A.3
  • 79
    • 0018569942 scopus 로고
    • A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate
    • Goldie, J. H. & Coldman, A. J. A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat. Rep. 63, 1727-1733 (1979). (Pubitemid 10138923)
    • (1979) Cancer Treatment Reports , vol.63 , Issue.11-12 , pp. 1727-1733
    • Goldie, J.H.1    Coldman, A.J.2
  • 80
    • 44349151502 scopus 로고    scopus 로고
    • Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer
    • DOI 10.1038/sj.bjc.6604379, PII 6604379
    • Ishikawa, K. et al. Mitotic centromere-associated kinesin is a novel marker for prognosis and lymph node metastasis in colorectal cancer. Br. J. Cancer 98, 1824-1829 (2008). (Pubitemid 351748844)
    • (2008) British Journal of Cancer , vol.98 , Issue.11 , pp. 1824-1829
    • Ishikawa, K.1    Kamohara, Y.2    Tanaka, F.3    Haraguchi, N.4    Mimori, K.5    Inoue, H.6    Mori, M.7
  • 83
    • 33845649320 scopus 로고    scopus 로고
    • Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells
    • DOI 10.1111/j.1349-7006.2006.00381.x
    • Shimo, A. et al. Elevated expression of protein regulator of cytokinesis 1, involved in the growth of breast cancer cells. Cancer Sci. 98, 174-181 (2007). (Pubitemid 44941869)
    • (2007) Cancer Science , vol.98 , Issue.2 , pp. 174-181
    • Shimo, A.1    Nishidate, T.2    Ohta, T.3    Fukuda, M.4    Nakamura, Y.5    Katagiri, T.6
  • 84
    • 79958725353 scopus 로고    scopus 로고
    • Overexpression of mitotic centromere-associated kinesin stimulates microtubule detachment and confers resistance to paclitaxel
    • Ganguly, A., Yang, H. & Cabral, F. Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel. Mol. Cancer Ther. 10, 929-937 (2011).
    • (2011) Mol. Cancer Ther. , vol.10 , pp. 929-937
    • Ganguly, A.1    Yang, H.2    Cabral, F.3
  • 85
    • 80054705000 scopus 로고    scopus 로고
    • Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance
    • Ganguly, A., Yang, H., Pedroza, M., Bhattacharya, R. & Cabral, F. Mitotic centromere-associated kinesin (MCAK) mediates paclitaxel resistance. J. Biol. Chem. 286, 36378-36384 (2011).
    • (2011) J. Biol. Chem. , vol.286 , pp. 36378-36384
    • Ganguly, A.1    Yang, H.2    Pedroza, M.3    Bhattacharya, R.4    Cabral, F.5
  • 86
    • 0033588254 scopus 로고    scopus 로고
    • AΒ-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance
    • Gonzalez-Garay, M. L., Chang, L., Blade, K., Menick, D. R. & Cabral, F. A β-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance. J. Biol. Chem. 274, 23875-23882 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 23875-23882
    • Gonzalez-Garay, M.L.1    Chang, L.2    Blade, K.3    Menick, D.R.4    Cabral, F.5
  • 87
    • 47749138578 scopus 로고    scopus 로고
    • Effects of anti-microtubule agents on microtubule organization in cells lacking the kinesin-13 MCAK
    • Hedrick, D. G., Stout, J. R. & Walczak, C. E. Effects of anti-microtubule agents on microtubule organization in cells lacking the kinesin-13 MCAK. Cell Cycle 7, 2146-2156 (2008). (Pubitemid 352031517)
    • (2008) Cell Cycle , vol.7 , Issue.14 , pp. 2146-2156
    • Hedrick, D.G.1    Stout, J.R.2    Walczak, C.E.3
  • 88
    • 18444407796 scopus 로고    scopus 로고
    • Mammalian mitotic centromere-associated kinesin (MCAK): A new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents
    • DOI 10.1111/j.1742-4658.2005.04600.x
    • Aoki, S., Ohta, K., Yamazaki, T., Sugawara, F. & Sakaguchi, K. Mammalian mitotic centromere-associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agents. FEBS J. 272, 2132-2140 (2005). (Pubitemid 40646783)
    • (2005) FEBS Journal , vol.272 , Issue.9 , pp. 2132-2140
    • Aoki, S.1    Ohta, K.2    Yamazaki, T.3    Sugawara, F.4    Sakaguchi, K.5
  • 90
    • 21744452482 scopus 로고    scopus 로고
    • Chromokinesins: Multitalented players in mitosis
    • DOI 10.1016/j.tcb.2005.05.006, PII S0962892405001315
    • Mazumdar, M. & Misteli, T. Chromokinesins: multitalented players in mitosis. Trends Cell Biol. 15, 349-355 (2005). (Pubitemid 40943523)
    • (2005) Trends in Cell Biology , vol.15 , Issue.7 , pp. 349-355
    • Mazumdar, M.1    Misteli, T.2
  • 91
    • 12244289928 scopus 로고    scopus 로고
    • Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis
    • DOI 10.1073/pnas.0408438102
    • Zhu, C. & Jiang, W. Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis. Proc. Natl Acad. Sci. USA 102, 343-348 (2005). (Pubitemid 40116769)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.2 , pp. 343-348
    • Zhu, C.1    Jiang, W.2
  • 92
    • 4444346337 scopus 로고    scopus 로고
    • Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation
    • DOI 10.1038/sj.emboj.7600347
    • Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N. & Todokoro, K. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. EMBO J. 23, 3237-3248 (2004). (Pubitemid 39209148)
    • (2004) EMBO Journal , vol.23 , Issue.16 , pp. 3237-3248
    • Kurasawa, Y.1    Earnshaw, W.C.2    Mochizuki, Y.3    Dohmae, N.4    Todokoro, K.5
  • 93
    • 4444339939 scopus 로고    scopus 로고
    • Human chromokinesin KIF4A functions in chromosome condensation and segregation
    • DOI 10.1083/jcb.200401142
    • Mazumdar, M., Sundareshan, S. & Misteli, T. Human chromokinesin KIF4A functions in chromosome condensation and segregation. J. Cell Biol. 166, 613-620 (2004). (Pubitemid 39180998)
    • (2004) Journal of Cell Biology , vol.166 , Issue.5 , pp. 613-620
    • Mazumdar, M.1    Sundareshan, S.2    Misteli, T.3
  • 97
    • 77952318977 scopus 로고    scopus 로고
    • Identifying common prognostic factors in genomic cancer studies: A novel index for censored outcomes
    • Rouam, S., Moreau, T. & Broet, P. Identifying common prognostic factors in genomic cancer studies: a novel index for censored outcomes. BMC Bioinformatics 11, 150 (2010).
    • (2010) BMC Bioinformatics , vol.11 , pp. 150
    • Rouam, S.1    Moreau, T.2    Broet, P.3
  • 98
    • 78751584945 scopus 로고    scopus 로고
    • Overexpression of chromokinesin kif4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo
    • Gao, J. et al. Overexpression of chromokinesin KIF4 inhibits proliferation of human gastric carcinoma cells both in vitro and in vivo. Tumour Biol. 32, 53-61 (2011).
    • (2011) Tumour Biol , vol.32 , pp. 53-61
    • Gao, J.1
  • 99
    • 0042763157 scopus 로고    scopus 로고
    • Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35
    • DOI 10.1042/BJ20030452
    • Lee, Y. M. & Kim, W. Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35. Biochem. J. 374, 497-503 (2003). (Pubitemid 37094109)
    • (2003) Biochemical Journal , vol.374 , Issue.2 , pp. 497-503
    • Lee, Y.M.1    Kim, W.2
  • 101
    • 33646019197 scopus 로고    scopus 로고
    • Kif4 motor regulates activity-dependent neuronal survival by suppressing parp-1 enzymatic activity
    • Midorikawa, R., Takei, Y. & Hirokawa, N. KIF4 motor regulates activity-dependent neuronal survival by suppressing PARP-1 enzymatic activity. Cell 125, 371-383 (2006).
    • (2006) Cell , vol.125 , pp. 371-383
    • Midorikawa, R.1    Takei, Y.2    Hirokawa, N.3
  • 102
    • 33947111858 scopus 로고    scopus 로고
    • The Human Kinesin Kif18A Is a Motile Microtubule Depolymerase Essential for Chromosome Congression
    • DOI 10.1016/j.cub.2007.02.036, PII S0960982207010135
    • Mayr, M. I. et al. The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr. Biol. 17, 488-498 (2007). (Pubitemid 46401386)
    • (2007) Current Biology , vol.17 , Issue.6 , pp. 488-498
    • Mayr, M.I.1    Hummer, S.2    Bormann, J.3    Gruner, T.4    Adio, S.5    Woehlke, G.6    Mayer, T.U.7
  • 104
    • 38849201167 scopus 로고    scopus 로고
    • The Kinesin-8 Motor Kif18A Suppresses Kinetochore Movements to Control Mitotic Chromosome Alignment
    • DOI 10.1016/j.devcel.2007.11.014, PII S1534580707004364
    • Stumpff, J., von Dassow, G., Wagenbach, M., Asbury, C. & Wordeman, L. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev. Cell 14, 252-262 (2008). (Pubitemid 351189173)
    • (2008) Developmental Cell , vol.14 , Issue.2 , pp. 252-262
    • Stumpff, J.1    Von Dassow, G.2    Wagenbach, M.3    Asbury, C.4    Wordeman, L.5
  • 105
    • 80052230972 scopus 로고    scopus 로고
    • A tethering mechanism controls the processivity and kinetochore- microtubule plus-end enrichment of the kinesin-8 kif18a
    • Stumpff, J. et al. A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A. Mol. Cell 43, 764-775 (2011).
    • (2011) Mol. Cell , vol.43 , pp. 764-775
    • Stumpff, J.1
  • 106
    • 77956276018 scopus 로고    scopus 로고
    • Kif18a is involved in human breast carcinogenesis
    • Zhang, C. et al. Kif18A is involved in human breast carcinogenesis. Carcinogenesis 31, 1676-1684 (2010).
    • (2010) Carcinogenesis , vol.31 , pp. 1676-1684
    • Zhang, C.1
  • 107
    • 80053308276 scopus 로고    scopus 로고
    • Kinesin 18a expression: Clinical relevance to colorectal cancer progression
    • Nagahara, M. et al. Kinesin 18A expression: clinical relevance to colorectal cancer progression. Int. J. Cancer 129, 2543-2552 (2011).
    • (2011) Int. J. Cancer , vol.129 , pp. 2543-2552
    • Nagahara, M.1
  • 109
    • 77956224956 scopus 로고    scopus 로고
    • Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human kif18b
    • Lee, Y. M. et al. Cell cycle-regulated expression and subcellular localization of a kinesin-8 member human KIF18B. Gene 466, 16-25 (2010).
    • (2010) Gene , vol.466 , pp. 16-25
    • Lee, Y.M.1
  • 110
    • 80052210135 scopus 로고    scopus 로고
    • Kif18b interacts with eb1 and controls astral microtubule length during mitosis
    • Stout, J. R. et al. Kif18B interacts with EB1 and controls astral microtubule length during mitosis. Mol. Biol. Cell 22, 3070-3080 (2011).
    • (2011) Mol. Biol. Cell , vol.22 , pp. 3070-3080
    • Stout, J.R.1
  • 111
    • 80052033722 scopus 로고    scopus 로고
    • A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases
    • Tanenbaum, M. E. et al. A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases. Curr. Biol. 21, 1356-1365 (2011).
    • (2011) Curr. Biol. , vol.21 , pp. 1356-1365
    • Tanenbaum, M.E.1
  • 112
    • 0038605070 scopus 로고    scopus 로고
    • The second microtubule-binding site of monomeric Kid enhances the microtubule affinity
    • DOI 10.1074/jbc.M212274200
    • Shiroguchi, K., Ohsugi, M., Edamatsu, M., Yamamoto, T. & Toyoshima, Y. Y. The second microtubule-binding site of monomeric Kid enhances the microtubule affinity. J. Biol. Chem. 278, 22460-22465 (2003). (Pubitemid 36830299)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.25 , pp. 22460-22465
    • Shiroguchi, K.1    Ohsugi, M.2    Edamatsu, M.3    Yamamoto, T.4    Toyoshima, Y.Y.5
  • 113
    • 0035904229 scopus 로고    scopus 로고
    • The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles
    • DOI 10.1083/jcb.200106093
    • Levesque, A. A. & Compton, D. A. The chromokinesin Kid is necessary for chromosome arm orientation and oscillation, but not congression, on mitotic spindles. J. Cell Biol. 154, 1135-1146 (2001). (Pubitemid 34286192)
    • (2001) Journal of Cell Biology , vol.154 , Issue.6 , pp. 1135-1146
    • Levesque, A.A.1    Compton, D.A.2
  • 116
    • 43449121008 scopus 로고    scopus 로고
    • The spindle protein CHICA mediates localization of the chromokinesin kid to the mitotic spindle
    • Santamaria, A., Nagel, S., Sillje, H. H. & Nigg, E. A. The spindle protein CHICA mediates localization of the chromokinesin Kid to the mitotic spindle. Curr. Biol. 18, 723-729 (2008).
    • (2008) Curr. Biol. , vol.18 , pp. 723-729
    • Santamaria, A.1    Nagel, S.2    Sillje, H.H.3    Nigg, E.A.4
  • 118
    • 27644541033 scopus 로고    scopus 로고
    • The chromokinesin kid is required for maintenance of proper metaphase spindle size
    • DOI 10.1091/mbc.E05-03-0244
    • Tokai-Nishizumi, N., Ohsugi, M., Suzuki, E. & Yamamoto, T. The chromokinesin Kid is required for maintenance of proper metaphase spindle size. Mol. Biol. Cell 16, 5455-5463 (2005). (Pubitemid 41566853)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.11 , pp. 5455-5463
    • Tokai-Nishizumi, N.1    Ohsugi, M.2    Suzuki, E.3    Yamamoto, T.4
  • 119
    • 12344288635 scopus 로고    scopus 로고
    • Parallel chemical genetic and genome-wide rnai screens identify cytokinesis inhibitors and targets
    • Eggert, U. S. et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2, e379 (2004).
    • (2004) PLoS Biol , vol.2
    • Eggert, U.S.1
  • 120
    • 33746356163 scopus 로고    scopus 로고
    • Animal cytokinesis: From parts list to mechanisms
    • DOI 10.1146/annurev.biochem.74.082803.133425
    • Eggert, U. S., Mitchison, T. J. & Field, C. M. Animal cytokinesis: from parts list to mechanisms. Annu. Rev. Biochem. 75, 543-566 (2006). (Pubitemid 44118043)
    • (2006) Annual Review of Biochemistry , vol.75 , pp. 543-566
    • Eggert, U.S.1    Mitchison, T.J.2    Field, C.M.3
  • 123
    • 33746328114 scopus 로고    scopus 로고
    • KIF14 mRNA expression is a predictor of grade and outcome in breast cancer
    • DOI 10.1002/ijc.21954
    • Corson, T. W. & Gallie, B. L. KIF14 mRNA expression is a predictor of grade and outcome in breast cancer. Int. J. Cancer 119, 1088-1094 (2006). (Pubitemid 44116918)
    • (2006) International Journal of Cancer , vol.119 , Issue.5 , pp. 1088-1094
    • Corson, T.W.1    Gallie, B.L.2
  • 125
    • 84857481599 scopus 로고    scopus 로고
    • Kinesin family member 14: An independent prognostic marker and potential therapeutic target for ovarian cancer
    • Theriault, B. L., Pajovic, S., Bernardini, M. Q., Shaw, P. A. & Gallie, B. L. Kinesin family member 14: an independent prognostic marker and potential therapeutic target for ovarian cancer. Int. J. Cancer 130, 1844-1854 (2011).
    • (2011) Int. J. Cancer , vol.130 , pp. 1844-1854
    • Theriault, B.L.1    Pajovic, S.2    Bernardini, M.Q.3    Shaw, P.A.4    Gallie, B.L.5
  • 126
    • 23044505592 scopus 로고    scopus 로고
    • KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers
    • DOI 10.1038/sj.onc.1208641
    • Corson, T. W., Huang, A., Tsao, M. S. & Gallie, B. L. KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. Oncogene 24, 4741-4753 (2005). (Pubitemid 41076292)
    • (2005) Oncogene , vol.24 , Issue.30 , pp. 4741-4753
    • Corson, T.W.1    Huang, A.2    Tsao, M.-S.3    Gallie, B.L.4
  • 127
    • 0026781685 scopus 로고
    • A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles
    • Nislow, C., Lombillo, V. A., Kuriyama, R. & McIntosh, J. R. A plus-end-directed motor enzyme that moves antiparallel microtubules in vitro localizes to the interzone of mitotic spindles. Nature 359, 543-547 (1992).
    • (1992) Nature , vol.359 , pp. 543-547
    • Nislow, C.1    Lombillo, V.A.2    Kuriyama, R.3    McIntosh, J.R.4
  • 128
    • 0036007115 scopus 로고    scopus 로고
    • Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity
    • DOI 10.1016/S1534-5807(01)00110-1
    • Mishima, M., Kaitna, S. & Glotzer, M. Central spindle assembly and cytokinesis require a kinesin-like protein/RhoGAP complex with microtubule bundling activity. Dev. Cell 2, 41-54 (2002). (Pubitemid 34065905)
    • (2002) Developmental Cell , vol.2 , Issue.1 , pp. 41-54
    • Mishima, M.1    Kaitna, S.2    Glotzer, M.3
  • 129
    • 21844451429 scopus 로고    scopus 로고
    • Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells
    • DOI 10.1042/BJ20050097
    • Zhu, C., Bossy-Wetzel, E. & Jiang, W. Recruitment of MKLP1 to the spindle midzone/midbody by INCENP is essential for midbody formation and completion of cytokinesis in human cells. Biochem. J. 389, 373-381 (2005). (Pubitemid 41021140)
    • (2005) Biochemical Journal , vol.389 , Issue.2 , pp. 373-381
    • Zhu, C.1    Bossy-Wetzel, E.2    Jiang, W.3
  • 130
    • 0028884602 scopus 로고
    • Plk is an m-phase-specific protein kinase and interacts with a kinesin-like protein, cho1/mklp-1
    • Lee, K. S., Yuan, Y. L., Kuriyama, R. & Erikson, R. L. Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1. Mol. Cell. Biol. 15, 7143-7151 (1995).
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 7143-7151
    • Lee, K.S.1    Yuan, Y.L.2    Kuriyama, R.3    Erikson, R.L.4
  • 131
    • 4344561301 scopus 로고    scopus 로고
    • Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1
    • DOI 10.1242/jcs.01173
    • Liu, X., Zhou, T., Kuriyama, R. & Erikson, R. L. Molecular interactions of Polo-like-kinase 1 with the mitotic kinesin-like protein CHO1/MKLP-1. J. Cell Sci. 117, 3233-3246 (2004). (Pubitemid 39139909)
    • (2004) Journal of Cell Science , vol.117 , Issue.15 , pp. 3233-3246
    • Liu, X.1    Zhou, T.2    Kuriyama, R.3    Erikson, R.L.4
  • 132
    • 31944444816 scopus 로고    scopus 로고
    • Cooperation between mitotic kinesins controls the late stages of cytokinesis
    • DOI 10.1016/j.cub.2005.12.030, PII S0960982205015927
    • Neef, R., Klein, U. R., Kopajtich, R. & Barr, F. A. Cooperation between mitotic kinesins controls the late stages of cytokinesis. Curr. Biol. 16, 301-307 (2006). (Pubitemid 43190230)
    • (2006) Current Biology , vol.16 , Issue.3 , pp. 301-307
    • Neef, R.1    Klein, U.R.2    Kopajtich, R.3    Barr, F.A.4
  • 133
    • 84857051694 scopus 로고    scopus 로고
    • Downregulation of kif23 suppresses glioma proliferation
    • Takahashi, S. et al. Downregulation of KIF23 suppresses glioma proliferation. J. Neurooncol. 106, 519-529 (2012).
    • (2012) J. Neurooncol. , vol.106 , pp. 519-529
    • Takahashi, S.1
  • 134
    • 79952579536 scopus 로고    scopus 로고
    • Gene expression profiles of non-small cell lung cancer: Survival prediction and new biomarkers
    • Valk, K. et al. Gene expression profiles of non-small cell lung cancer: survival prediction and new biomarkers. Oncology 79, 283-292 (2010).
    • (2010) Oncology , vol.79 , pp. 283-292
    • Valk, K.1
  • 135
    • 80052867878 scopus 로고    scopus 로고
    • Upregulation of rac gtpase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma
    • Wang, S. M., Ooi, L. L. & Hui, K. M. Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma. Clin. Cancer Res. 17, 6040-6051 (2011).
    • (2011) Clin. Cancer Res. , vol.17 , pp. 6040-6051
    • Wang, S.M.1    Ooi, L.L.2    Hui, K.M.3
  • 138
    • 0034331310 scopus 로고    scopus 로고
    • The rab6-binding kinesin, rab6-kifl, is required for cytokinesis
    • Hill, E., Clarke, M. & Barr, F. A. The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J. 19, 5711-5719 (2000).
    • (2000) EMBO J , vol.19 , pp. 5711-5719
    • Hill, E.1    Clarke, M.2    Barr, F.A.3
  • 139
    • 0033778278 scopus 로고    scopus 로고
    • Mutations in the plk gene lead to instability of plk protein in human tumour cell lines
    • Simizu, S. & Osada, H. Mutations in the Plk gene lead to instability of Plk protein in human tumour cell lines. Nature Cell Biol. 2, 852-854 (2000).
    • (2000) Nature Cell Biol , vol.2 , pp. 852-854
    • Simizu, S.1    Osada, H.2
  • 141
    • 3342964028 scopus 로고    scopus 로고
    • Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2
    • DOI 10.1083/jcb.200403084
    • Gruneberg, U., Neef, R., Honda, R., Nigg, E. A. & Barr, F. A. Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2. J. Cell Biol. 166, 167-172 (2004). (Pubitemid 38988769)
    • (2004) Journal of Cell Biology , vol.166 , Issue.2 , pp. 167-172
    • Gruneberg, U.1    Neef, R.2    Honda, R.3    Nigg, E.A.4    Barr, F.A.5
  • 142
    • 64049090879 scopus 로고    scopus 로고
    • Cdk1 negatively regulates midzone localization of the mitotic kinesin mklp2 and the chromosomal passenger complex
    • Huemmer, S. & Mayer, T. Cdk1 negatively regulates midzone localization of the mitotic kinesin Mklp2 and the chromosomal passenger complex. Curr. Biol. 19, 607-612 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 607-612
    • Huemmer, S.1    Mayer, T.2
  • 143
    • 11244284210 scopus 로고    scopus 로고
    • Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell
    • Taniuchi, K. et al. Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell. Cancer Res. 65, 105-112 (2005). (Pubitemid 40070801)
    • (2005) Cancer Research , vol.65 , Issue.1 , pp. 105-112
    • Taniuchi, K.1    Nakagawa, H.2    Nakamura, T.3    Eguchi, H.4    Ohigashi, H.5    Ishikawa, O.6    Katagiri, T.7    Nakamura, Y.8
  • 144
    • 0035813103 scopus 로고    scopus 로고
    • Identification of a novel kinesin-related protein, krmp1, as a target for mitotic peptidyl-prolyl isomerase pin1
    • Kamimoto, T., Zama, T., Aoki, R., Muro, Y. & Hagiwara, M. Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J. Biol. Chem. 276, 37520-37528 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 37520-37528
    • Kamimoto, T.1    Zama, T.2    Aoki, R.3    Muro, Y.4    Hagiwara, M.5
  • 147
    • 79961111636 scopus 로고    scopus 로고
    • Repeated cleavage failure does not establish centrosome amplification in untransformed human cells
    • Krzywicka-Racka, A. & Sluder, G. Repeated cleavage failure does not establish centrosome amplification in untransformed human cells. J. Cell Biol. 194, 199-207 (2011).
    • (2011) J. Cell Biol. , vol.194 , pp. 199-207
    • Krzywicka-Racka, A.1    Sluder, G.2
  • 148
    • 67649467032 scopus 로고    scopus 로고
    • A mechanism linking extra centrosomes to chromosomal instability
    • Ganem, N. J., Godinho, S. A. & Pellman, D. A mechanism linking extra centrosomes to chromosomal instability. Nature 460, 278-282 (2009).
    • (2009) Nature , vol.460 , pp. 278-282
    • Ganem, N.J.1    Godinho, S.A.2    Pellman, D.3
  • 149
    • 27144507868 scopus 로고    scopus 로고
    • Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
    • DOI 10.1038/nature04217, PII N04217
    • Fujiwara, T. et al. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437, 1043-1047 (2005). (Pubitemid 41486987)
    • (2005) Nature , vol.437 , Issue.7061 , pp. 1043-1047
    • Fujiwara, T.1    Bandi, M.2    Nitta, M.3    Ivanova, E.V.4    Bronson, R.T.5    Pellman, D.6
  • 150
    • 80955181031 scopus 로고    scopus 로고
    • The hedgehog's tale: Developing strategies for targeting cancer
    • Ng, J. M. & Curran, T. The Hedgehog's tale: developing strategies for targeting cancer. Nature Rev. Cancer 11, 493-501 (2011).
    • (2011) Nature Rev. Cancer , vol.11 , pp. 493-501
    • Ng, J.M.1    Curran, T.2
  • 151
    • 77953316514 scopus 로고    scopus 로고
    • Mechanism and evolution of cytosolic Hedgehog signal transduction
    • Wilson, C. W. & Chuang, P. T. Mechanism and evolution of cytosolic Hedgehog signal transduction. Development 137, 2079-2094 (2010).
    • (2010) Development , vol.137 , pp. 2079-2094
    • Wilson, C.W.1    Chuang, P.T.2
  • 152
    • 68149178664 scopus 로고    scopus 로고
    • The mammalian cos2 homolog kif7 plays an essential role in modulating hh signal transduction during development
    • Endoh-Yamagami, S. et al. The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr. Biol. 19, 1320-1326 (2009).
    • (2009) Curr. Biol. , vol.19 , pp. 1320-1326
    • Endoh-Yamagami, S.1
  • 153
    • 69949136621 scopus 로고    scopus 로고
    • Primary cilia can both mediate and suppress hedgehog pathway-dependent tumorigenesis
    • Wong, S. Y. et al. Primary cilia can both mediate and suppress Hedgehog pathway-dependent tumorigenesis. Nature Med. 15, 1055-1061 (2009).
    • (2009) Nature Med , vol.15 , pp. 1055-1061
    • Wong, S.Y.1
  • 154
    • 69449084098 scopus 로고    scopus 로고
    • The kinesin protein kif7 is a critical regulator of gli transcription factors in mammalian hedgehog signaling
    • Cheung, H. O. et al. The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci. Signal. 2, ra29 (2009).
    • (2009) Sci. Signal. , vol.2
    • Cheung, H.O.1
  • 155
    • 80054022786 scopus 로고    scopus 로고
    • Gli proteins in development and disease
    • Hui, C. C. & Angers, S. Gli proteins in development and disease. Annu. Rev. Cell Dev. Biol. 27, 513-537 (2011).
    • (2011) Annu. Rev. Cell Dev. Biol. , vol.27 , pp. 513-537
    • Hui, C.C.1    Angers, S.2
  • 156
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo, M. & Taipale, J. Hedgehog: functions and mechanisms. Genes Dev. 22, 2454-2472 (2008).
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 157
    • 0033754604 scopus 로고    scopus 로고
    • Stirring up development with the heterotrimeric kinesin kif3
    • Hirokawa, N. Stirring up development with the heterotrimeric kinesin KIF3. Traffic 1, 29-34 (2000).
    • (2000) Traffic , vol.1 , pp. 29-34
    • Hirokawa, N.1
  • 158
    • 31644442906 scopus 로고    scopus 로고
    • Signaling from Smo to Ci/Gli: Conservation and divergence of Hedgehog pathways from Drosophila to vertebrates
    • DOI 10.1242/dev.02169
    • Huangfu, D. & Anderson, K. V. Signaling from Smo to Ci/Gli: conservation and divergence of Hedgehog pathways from Drosophila to vertebrates. Development 133, 3-14 (2006). (Pubitemid 43169315)
    • (2006) Development , vol.133 , Issue.1 , pp. 3-14
    • Huangfu, D.1    Anderson, K.V.2
  • 160
    • 34548406546 scopus 로고    scopus 로고
    • Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog- and Gli3-dependent mechanisms
    • DOI 10.1016/j.ydbio.2007.07.018, PII S0012160607011876
    • Kolpakova-Hart, E., Jinnin, M., Hou, B., Fukai, N. & Olsen, B. R. Kinesin-2 controls development and patterning of the vertebrate skeleton by Hedgehog-and Gli3-dependent mechanisms. Dev. Biol. 309, 273-284 (2007). (Pubitemid 47361112)
    • (2007) Developmental Biology , vol.309 , Issue.2 , pp. 273-284
    • Kolpakova-Hart, E.1    Jinnin, M.2    Hou, B.3    Fukai, N.4    Olsen, B.R.5
  • 161
    • 33646152550 scopus 로고    scopus 로고
    • Identification of a novel imatinib responsive kif5b-pdgfra fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia
    • Score, J. et al. Identification of a novel imatinib responsive KIF5B-PDGFRA fusion gene following screening for PDGFRA overexpression in patients with hypereosinophilia. Leukemia 20, 827-832 (2006).
    • (2006) Leukemia , vol.20 , pp. 827-832
    • Score, J.1
  • 162
    • 63949086127 scopus 로고    scopus 로고
    • Kif5b-alk, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for alk-positive lung cancer
    • Takeuchi, K. et al. KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin. Cancer Res. 15, 3143-3149 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 3143-3149
    • Takeuchi, K.1
  • 163
    • 79955973559 scopus 로고    scopus 로고
    • A novel kif5b-alk variant in nonsmall cell lung cancer
    • Wong, D. W. et al. A novel KIF5B-ALK variant in nonsmall cell lung cancer. Cancer 117, 2709-2718 (2011).
    • (2011) Cancer , vol.117 , pp. 2709-2718
    • Wong, D.W.1
  • 164
    • 78049425319 scopus 로고    scopus 로고
    • Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
    • Kwak, E. L. et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 363, 1693-1703 (2010).
    • (2010) N. Engl. J. Med. , vol.363 , pp. 1693-1703
    • Kwak, E.L.1
  • 165
    • 84856216595 scopus 로고    scopus 로고
    • Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer
    • Tan, M. H. et al. Specific kinesin expression profiles associated with taxane resistance in basal-like breast cancer. Breast Cancer Res. Treat. 131, 849-858 (2011).
    • (2011) Breast Cancer Res. Treat. , vol.131 , pp. 849-858
    • Tan, M.H.1
  • 166
    • 0029051298 scopus 로고
    • The neuron-specific kinesin superfamily protein kif1a is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors
    • Okada, Y., Yamazaki, H., Sekine-Aizawa, Y. & Hirokawa, N. The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell 81, 769-780 (1995).
    • (1995) Cell , vol.81 , pp. 769-780
    • Okada, Y.1    Yamazaki, H.2    Sekine-Aizawa, Y.3    Hirokawa, N.4
  • 167
    • 79551484520 scopus 로고    scopus 로고
    • A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma
    • Loyo, M. et al. A survey of methylated candidate tumor suppressor genes in nasopharyngeal carcinoma. Int. J. Cancer 128, 1393-1403 (2011).
    • (2011) Int. J. Cancer , vol.128 , pp. 1393-1403
    • Loyo, M.1
  • 168
    • 77954222909 scopus 로고    scopus 로고
    • Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR
    • Ostrow, K. L. et al. Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR. Clin. Cancer Res. 16, 3463-3472 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , pp. 3463-3472
    • Ostrow, K.L.1
  • 169
    • 58149241013 scopus 로고    scopus 로고
    • Exploiting gene expression profiling to identify novel minimal residual disease markers of neuroblastoma
    • Cheung, I. Y., Feng, Y., Gerald, W. & Cheung, N. K. Exploiting gene expression profiling to identify novel minimal residual disease markers of neuroblastoma. Clin. Cancer Res. 14, 7020-7027 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , pp. 7020-7027
    • Cheung, I.Y.1    Feng, Y.2    Gerald, W.3    Cheung, N.K.4
  • 170
    • 53749107898 scopus 로고    scopus 로고
    • A germline mutation of the KIF1B β gene on 1p36 in a family with neural and nonneural tumors
    • Yeh, I. T. et al. A germline mutation of the KIF1B β gene on 1p36 in a family with neural and nonneural tumors. Hum. Genet. 124, 279-285 (2008).
    • (2008) Hum. Genet. , vol.124 , pp. 279-285
    • Yeh, I.T.1
  • 171
    • 77956628160 scopus 로고    scopus 로고
    • Genome-wide association study identifies 1P36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers
    • Zhang, H. et al. Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers. Nature Genet. 42, 755-758 (2010).
    • (2010) Nature Genet , vol.42 , pp. 755-758
    • Zhang, H.1
  • 172
    • 42549100037 scopus 로고    scopus 로고
    • Therapeutic potential of mitotic kinesin inhibitors in cancer
    • DOI 10.1517/13543776.18.3.253
    • Matsuno, K., Sawada, J. S. & Asai, A. Therapeutic potential of mitotic kinesin inhibitors in cancer. Expert Opin. Ther. Patents 18, 253-274 (2008). (Pubitemid 351577860)
    • (2008) Expert Opinion on Therapeutic Patents , vol.18 , Issue.3 , pp. 253-274
    • Matsuno, K.1    Sawada, J.-I.2    Asai, A.3
  • 173
    • 84864370868 scopus 로고    scopus 로고
    • US patents 514/266.2;514/266.23; 514/309; 544/284 and 546/142
    • McDonald, A., Bergnes, G. & Morgans, D. J. US Patents 514/266.2; 514/266.23; 514/309; 544/284 and 546/142 (2004).
    • (2004)
    • McDonald, A.1    Bergnes, G.2    Morgans, D.J.3
  • 174
    • 82755185858 scopus 로고    scopus 로고
    • Elucidating the functionality of kinesins: An overview of small molecule inhibitors
    • Good, J. A., Skoufias, D. A. & Kozielski, F. Elucidating the functionality of kinesins: an overview of small molecule inhibitors. Semin. Cell Dev. Biol. 22, 935-945 (2011).
    • (2011) Semin. Cell Dev. Biol. , vol.22 , pp. 935-945
    • Good, J.A.1    Skoufias, D.A.2    Kozielski, F.3
  • 175
    • 78249232298 scopus 로고    scopus 로고
    • Relocation of aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific mklp-2 inhibitor
    • Tcherniuk, S. et al. Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor. Angew. Chem. Int. Ed Engl. 49, 8228-8231 (2010).
    • (2010) Angew. Chem. Int. Ed Engl. , vol.49 , pp. 8228-8231
    • Tcherniuk, S.1
  • 178
    • 78649906324 scopus 로고    scopus 로고
    • Chemotherapy-induced peripheral neurotoxicity
    • Cavaletti, G. & Marmiroli, P. Chemotherapy-induced peripheral neurotoxicity. Nature Rev. Neurol. 6, 657-666 (2010).
    • (2010) Nature Rev. Neurol. , vol.6 , pp. 657-666
    • Cavaletti, G.1    Marmiroli, P.2
  • 179
    • 24944505659 scopus 로고    scopus 로고
    • Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer
    • Ibrahim, N. K. et al. Multicenter phase II trial of ABI-007, an albumin-bound paclitaxel, in women with metastatic breast cancer. J. Clin. Oncol. 23, 6019-6026 (2005).
    • (2005) J. Clin. Oncol. , vol.23 , pp. 6019-6026
    • Ibrahim, N.K.1
  • 181
    • 33846523617 scopus 로고    scopus 로고
    • Targeted anti-mitotic therapies: Can we improve on tubulin agents?
    • DOI 10.1038/nrc2049, PII NRC2049
    • Jackson, J. R., Patrick, D. R., Dar, M. M. & Huang, P. S. Targeted anti-mitotic therapies: can we improve on tubulin agents? Nature Rev. Cancer 7, 107-117 (2007). (Pubitemid 46160987)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.2 , pp. 107-117
    • Jackson, J.R.1    Patrick, D.R.2    Dar, M.M.3    Huang, P.S.4
  • 182
    • 33645316142 scopus 로고    scopus 로고
    • Targeting polo-like kinase 1 for cancer therapy
    • Strebhardt, K. & Ullrich, A. Targeting polo-like kinase 1 for cancer therapy. Nature Rev. Cancer 6, 321-330 (2006).
    • (2006) Nature Rev. Cancer , vol.6 , pp. 321-330
    • Strebhardt, K.1    Ullrich, A.2
  • 183
    • 78649476052 scopus 로고    scopus 로고
    • Shared and separate functions of polo-like kinases and aurora kinases in cancer
    • Lens, S. M., Voest, E. E. & Medema, R. H. Shared and separate functions of polo-like kinases and aurora kinases in cancer. Nature Rev. Cancer 10, 825-841 (2010).
    • (2010) Nature Rev. Cancer , vol.10 , pp. 825-841
    • Lens, S.M.1    Voest, E.E.2    Medema, R.H.3
  • 184
  • 185
    • 60749109846 scopus 로고    scopus 로고
    • Cell cycle, cdks and cancer: A changing paradigm
    • Malumbres, M. & Barbacid, M. Cell cycle, CDKs and cancer: a changing paradigm. Nature Rev. Cancer 9, 153-166 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 153-166
    • Malumbres, M.1    Barbacid, M.2
  • 186
    • 72049103927 scopus 로고    scopus 로고
    • The discovery of tetrahydro-β-carbolines as inhibitors of the kinesin eg5
    • Barsanti, P. A. et al. The discovery of tetrahydro-β-carbolines as inhibitors of the kinesin Eg5. Bioorg. Med. Chem. Lett. 20, 157-160 (2010).
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 157-160
    • Barsanti, P.A.1
  • 190
    • 65949093526 scopus 로고    scopus 로고
    • K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells
    • Nakai, R. et al. K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells. Cancer Res. 69, 3901-3909 (2009).
    • (2009) Cancer Res , Issue.69 , pp. 3901-3909
    • Nakai, R.1
  • 192
    • 76749108514 scopus 로고    scopus 로고
    • The discovery and optimization of hexahydro-2H-pyrano 3,2-cquinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5
    • Schiemann, K. et al. The discovery and optimization of hexahydro-2H-pyrano3,2-cquinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5. Bioorg. Med. Chem. Lett. 20, 1491-1495 (2010).
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1491-1495
    • Schiemann, K.1
  • 193
    • 84863176814 scopus 로고    scopus 로고
    • Triphenylbutanamines: Kinesin spindle protein inhibitors with in vivo antitumor activity
    • Wang, F. et al. Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity. J. Med. Chem. 55, 1511-1525 (2012).
    • (2012) J. Med. Chem. , vol.55 , pp. 1511-1525
    • Wang, F.1
  • 198
    • 64349121798 scopus 로고    scopus 로고
    • NSC 622124 inhibits human eg5 and other kinesins via interaction with the conserved microtubule-binding site
    • Learman, S. S. et al. NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site. Biochemistry 48, 1754-1762 (2009).
    • (2009) Biochemistry , vol.48 , pp. 1754-1762
    • Learman, S.S.1
  • 199
    • 72449183762 scopus 로고    scopus 로고
    • An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex
    • Kaan, H. Y., Ulaganathan, V., Hackney, D. D. & Kozielski, F. An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex. Biochem. J. 425, 55-60 (2009).
    • (2009) Biochem. J. , vol.425 , pp. 55-60
    • Kaan, H.Y.1    Ulaganathan, V.2    Hackney, D.D.3    Kozielski, F.4
  • 201
    • 48449098623 scopus 로고    scopus 로고
    • Cancer cells display profound intra-and interline variation following prolonged exposure to antimitotic drugs
    • Gascoigne, K. E. & Taylor, S. S. Cancer cells display profound intra-and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 14, 111-122 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 111-122
    • Gascoigne, K.E.1    Taylor, S.S.2
  • 202
    • 44849127993 scopus 로고    scopus 로고
    • Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5
    • Shi, J., Orth, J. D. & Mitchison, T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 68, 3269-3276 (2008).
    • (2008) Cancer Res , vol.68 , pp. 3269-3276
    • Shi, J.1    Orth, J.D.2    Mitchison, T.3
  • 203
    • 3242771433 scopus 로고    scopus 로고
    • Crystal structure of the motor domain of the human kinetochore protein CENP-E
    • DOI 10.1016/j.jmb.2004.05.053, PII S0022283604005960
    • Garcia-Saez, I., Yen, T., Wade, R. H. & Kozielski, F. Crystal structure of the motor domain of the human kinetochore protein CENP-E. J. Mol. Biol. 340, 1107-1116 (2004). (Pubitemid 38968704)
    • (2004) Journal of Molecular Biology , vol.340 , Issue.5 , pp. 1107-1116
    • Garcia-Saez, I.1    Yen, T.2    Wade, R.H.3    Kozielski, F.4
  • 204
    • 0035816597 scopus 로고    scopus 로고
    • Crystal structure of the mitotic spindle kinesin eg5 reveals a novel conformation of the neck-linker
    • Turner, J. et al. Crystal structure of the mitotic spindle kinesin Eg5 reveals a novel conformation of the neck-linker. J. Biol. Chem. 276, 25496-25502 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 25496-25502
    • Turner, J.1
  • 205
    • 77949318844 scopus 로고    scopus 로고
    • ATP hydrolysis in eg5 kinesin involves a catalytic two-water mechanism
    • Parke, C. L., Wojcik, E. J., Kim, S. & Worthylake, D. K. ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism. J. Biol. Chem. 285, 5859-5867 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 5859-5867
    • Parke, C.L.1    Wojcik, E.J.2    Kim, S.3    Worthylake, D.K.4
  • 206
    • 77958487248 scopus 로고    scopus 로고
    • Insight into the molecular mechanism of the multitasking kinesin-8 motor
    • Peters, C. et al. Insight into the molecular mechanism of the multitasking kinesin-8 motor. EMBO J. 29, 3437-3447 (2010).
    • (2010) EMBO J , vol.29 , pp. 3437-3447
    • Peters, C.1
  • 207
    • 0035985148 scopus 로고    scopus 로고
    • Kinesin-like protein CHO1 is required for the formation of midbody matrix and the completion of cytokinesis in mammalian cells
    • DOI 10.1091/mbc.01-10-0504
    • Matuliene, J. & Kuriyama, R. Kinesin-like protein CHO1 is required for the formation of midbody matrix and the completion of cytokinesis in mammalian cells. Mol. Biol. Cell 13, 1832-1845 (2002). (Pubitemid 34651475)
    • (2002) Molecular Biology of the Cell , vol.13 , Issue.6 , pp. 1832-1845
    • Matuliene, J.1    Kuriyama, R.2
  • 211
    • 77952759760 scopus 로고    scopus 로고
    • Ectopic expression of the microtubule-dependent motor protein eg5 promotes pancreatic tumourigenesis
    • Liu, M. et al. Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis. J. Pathol. 221, 221-228 (2010).
    • (2010) J. Pathol. , vol.221 , pp. 221-228
    • Liu, M.1
  • 212
    • 78751502290 scopus 로고    scopus 로고
    • Identification of hla-a2-restricted CTL epitopes of a novel tumour-associated antigen, kif20a, overexpressed in pancreatic cancer
    • Imai, K. et al. Identification of HLA-A2-restricted CTL epitopes of a novel tumour-associated antigen, KIF20A, overexpressed in pancreatic cancer. Br. J. Cancer 104, 300-307 (2011).
    • (2011) Br. J. Cancer , vol.104 , pp. 300-307
    • Imai, K.1


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