A Tethering Mechanism Controls the Processivity and Kinetochore-Microtubule Plus-End Enrichment of the Kinesin-8 Kif18A

Molecular Cell

Volumn 43, Issue 5, 2011, Pages 764-775

  Stumpff, Jason ^b   Du, Yaqing ^a   English, Chauca A ^a   Maliga, Zoltan ^c   Wagenbach, Michael ^b   Asbury, Charles L ^b   Wordeman, Linda ^b   Ohi, Ryoma ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c MAX PLANCK INSTITUTE OF MOLECULAR CELL BIOLOGY AND GENETICS   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

KIF18A PROTEIN; KINESIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CENTROMERE; DYNAMICS; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; METAPHASE CHROMOSOME; MICROTUBULE; MUTANT; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY;

CHROMOSOME POSITIONING; HELA CELLS; HUMANS; KINESIN; KINETOCHORES; MICROTUBULES;

EID: 80052230972     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2011.07.022     Document Type: Article

References (17)

1. Bormuth V., Varga V., Howard J., Schäffer E. Protein friction limits diffusive and directed movements of kinesin motors on microtubules. Science 2009, 325:870-873.
2. Coy D.L., Hancock W.O., Wagenbach M., Howard J. Kinesin's tail domain is an inhibitory regulator of the motor domain. Nat. Cell Biol. 1999, 1:288-292.
3. Du Y., English C.A., Ohi R. The kinesin-8 Kif18A dampens microtubule plus-end dynamics. Curr. Biol. 2010, 20:374-380.
4. Gestaut D.R., Graczyk B., Cooper J., Widlund P.O., Zelter A., Wordeman L., Asbury C.L., Davis T.N. Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation. Nat. Cell Biol. 2008, 10:407-414.
5. Howell B.J., Hoffman D.B., Fang G., Murray A.W., Salmon E.D. Visualization of Mad2 dynamics at kinetochores, along spindle fibers, and at spindle poles in living cells. J. Cell Biol. 2000, 150:1233-1250.
6. Jaqaman K., King E.M., Amaro A.C., Winter J.R., Dorn J.F., Elliott H.L., McHedlishvili N., McClelland S.E., Porter I.M., Posch M., et al. Kinetochore alignment within the metaphase plate is regulated by centromere stiffness and microtubule depolymerases. J. Cell Biol. 2010, 188:665-679.
7. Mayr M.I., Hümmer S., Bormann J., Grüner T., Adio S., Woehlke G., Mayer T.U. The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression. Curr. Biol. 2007, 17:488-498.
8. Peters C., Brejc K., Belmont L., Bodey A.J., Lee Y., Yu M., Guo J., Sakowicz R., Hartman J., Moores C.A. Insight into the molecular mechanism of the multitasking kinesin-8 motor. EMBO J. 2010, 29:3437-3447.
9. Poser I., Sarov M., Hutchins J.R., Hériché J.K., Toyoda Y., Pozniakovsky A., Weigl D., Nitzsche A., Hegemann B., Bird A.W., et al. BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals. Nat. Methods 2008, 5:409-415.
10. Savoian M.S., Glover D.M. Drosophila Klp67A binds prophase kinetochores to subsequently regulate congression and spindle length. J. Cell Sci. 2010, 123:767-776.
11. Skibbens R.V., Skeen V.P., Salmon E.D. Directional instability of kinetochore motility during chromosome congression and segregation in mitotic newt lung cells: a push-pull mechanism. J. Cell Biol. 1993, 122:859-875.
12. Stumpff J., von Dassow G., Wagenbach M., Asbury C., Wordeman L. The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment. Dev. Cell 2008, 14:252-262.
13. Tischer C., Brunner D., Dogterom M. Force- and kinesin-8-dependent effects in the spatial regulation of fission yeast microtubule dynamics. Mol. Syst. Biol. 2009, 5:250.
14. Vale R.D., Funatsu T., Pierce D.W., Romberg L., Harada Y., Yanagida T. Direct observation of single kinesin molecules moving along microtubules. Nature 1996, 380:451-453.
15. Varga V., Helenius J., Tanaka K., Hyman A.A., Tanaka T.U., Howard J. Yeast kinesin-8 depolymerizes microtubules in a length-dependent manner. Nat. Cell Biol. 2006, 8:957-962.
16. Varga V., Leduc C., Bormuth V., Diez S., Howard J. Kinesin-8 motors act cooperatively to mediate length-dependent microtubule depolymerization. Cell 2009, 138:1174-1183.
17. Weinger J.S., Qiu M., Yang G., Kapoor T.M. A nonmotor microtubule binding site in kinesin-5 is required for filament crosslinking and sliding. Curr. Biol. 2011, 21:154-160.