NSC 622124 inhibits human Eg5 and other kinesins via interaction with the conserved microtubule-binding site

Biochemistry

Volumn 48, Issue 8, 2009, Pages 1754-1762

  Learman, Sarah S ^a   Kim, Catherine D ^b   Stevens, Nathaniel S ^a   Kim, Sunyoung ^b   Wojcik, Edward J ^b   Walker, Richard A ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CANCER AGENTS; ATP-ASE ACTIVITIES; EUKARYOTIC CELLS; KINESIN; KINESINS; MECHANO CHEMICALS; MICROTUBULE; MICROTUBULES; MITOTIC SPINDLES; MONASTROL; MOTOR PROTEINS; NEGATIVE REGULATORS; PROTEOLYTIC DEGRADATIONS; SMALL-MOLECULE INHIBITORS;

BINDING ENERGY; PROTEINS; TARGETS;

BINDING SITES;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; HUMAN EG5 PROTEIN; KINESIN; MOLECULAR MOTOR; MONASTROL; NSC 622124; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MICROTUBULE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; DROSOPHILA; DROSOPHILA PROTEINS; HUMANS; KINESIN; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MOLYBDENUM; MOVEMENT; OXIDES; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PYRIMIDINES; THIONES;

EUKARYOTA;

EID: 64349121798     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801291q     Document Type: Article

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