-
3
-
-
34249734165
-
Chromosomal chaos and cancer
-
Duesberg P. Chromosomal chaos and cancer. Sci Am 296 (2007) 52-59
-
(2007)
Sci Am
, vol.296
, pp. 52-59
-
-
Duesberg, P.1
-
4
-
-
49849083943
-
Whole chromosome instability and cancer: a complex relationship
-
Ricke R.M., van Ree J.H., and van Deursen J.M. Whole chromosome instability and cancer: a complex relationship. Trends Genet 24 (2008) 457-466
-
(2008)
Trends Genet
, vol.24
, pp. 457-466
-
-
Ricke, R.M.1
van Ree, J.H.2
van Deursen, J.M.3
-
5
-
-
0031004175
-
Genetic instability in colorectal cancers
-
Lengauer C., Kinzler K.W., and Vogelstein B. Genetic instability in colorectal cancers. Nature 386 (1997) 623-627
-
(1997)
Nature
, vol.386
, pp. 623-627
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
7
-
-
0347762556
-
From polyploidy to aneuploidy, genome instability and cancer
-
Storchova Z., and Pellman D. From polyploidy to aneuploidy, genome instability and cancer. Nat Rev Mol Cell Biol 5 (2004) 45-54
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 45-54
-
-
Storchova, Z.1
Pellman, D.2
-
8
-
-
9244263076
-
Aneuploidy and cancer
-
Rajagopalan H., and Lengauer C. Aneuploidy and cancer. Nature 432 (2004) 338-341
-
(2004)
Nature
, vol.432
, pp. 338-341
-
-
Rajagopalan, H.1
Lengauer, C.2
-
9
-
-
0036831681
-
Centrosome aberrations: cause or consequence of cancer progression?
-
Nigg E.A. Centrosome aberrations: cause or consequence of cancer progression?. Nat Rev Cancer 2 (2002) 815-825
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 815-825
-
-
Nigg, E.A.1
-
10
-
-
0032546360
-
Mutations of mitotic checkpoint genes in human cancers
-
Cahill D.P., Lengauer C., Yu J., Riggins G.J., Willson J.K., Markowitz S.D., Kinzler K.W., and Vogelstein B. Mutations of mitotic checkpoint genes in human cancers. Nature 392 (1998) 300-303
-
(1998)
Nature
, vol.392
, pp. 300-303
-
-
Cahill, D.P.1
Lengauer, C.2
Yu, J.3
Riggins, G.J.4
Willson, J.K.5
Markowitz, S.D.6
Kinzler, K.W.7
Vogelstein, B.8
-
11
-
-
34247333444
-
The spindle-assembly checkpoint in space and time
-
Musacchio A., and Salmon E.D. The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol 8 (2007) 379-393
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 379-393
-
-
Musacchio, A.1
Salmon, E.D.2
-
13
-
-
51649089303
-
Preventing aneuploidy: the contribution of mitotic checkpoint proteins
-
Suijkerbuijk S.J., and Kops G.J. Preventing aneuploidy: the contribution of mitotic checkpoint proteins. Biochim Biophys Acta 1786 (2008) 24-31
-
(2008)
Biochim Biophys Acta
, vol.1786
, pp. 24-31
-
-
Suijkerbuijk, S.J.1
Kops, G.J.2
-
14
-
-
48449098623
-
Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
-
This paper shows that commonly studied CIN cells lines do not have SAC defects. The paper also provides a comprehensive analysis cell fate after checkpoint activation by antimitotic drugs.
-
Gascoigne K.E., and Taylor S.S. Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell 14 (2008) 111-122. This paper shows that commonly studied CIN cells lines do not have SAC defects. The paper also provides a comprehensive analysis cell fate after checkpoint activation by antimitotic drugs.
-
(2008)
Cancer Cell
, vol.14
, pp. 111-122
-
-
Gascoigne, K.E.1
Taylor, S.S.2
-
15
-
-
40849096242
-
Examining the link between chromosomal instability and aneuploidy in human cells
-
This paper makes several important points. The authors show that merotely, not defects in the spindle assembly checkpoint, generates chromosome mis-segregation in 'CIN' cancer cell lines. They also show that most non-CIN cell lines cannot be induced to become stably aneuploid by increasing chromosome segregation errors.
-
Thompson S.L., and Compton D.A. Examining the link between chromosomal instability and aneuploidy in human cells. J Cell Biol 180 (2008) 665-672. This paper makes several important points. The authors show that merotely, not defects in the spindle assembly checkpoint, generates chromosome mis-segregation in 'CIN' cancer cell lines. They also show that most non-CIN cell lines cannot be induced to become stably aneuploid by increasing chromosome segregation errors.
-
(2008)
J Cell Biol
, vol.180
, pp. 665-672
-
-
Thompson, S.L.1
Compton, D.A.2
-
16
-
-
0034906435
-
Aneuploid colon cancer cells have a robust spindle checkpoint
-
Tighe A., Johnson V.L., Albertella M., and Taylor S.S. Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep 2 (2001) 609-614
-
(2001)
EMBO Rep
, vol.2
, pp. 609-614
-
-
Tighe, A.1
Johnson, V.L.2
Albertella, M.3
Taylor, S.S.4
-
17
-
-
51649121909
-
When 2 + 2 = 5: the origins and fates of aneuploid and tetraploid cells
-
King R.W. When 2 + 2 = 5: the origins and fates of aneuploid and tetraploid cells. Biochim Biophys Acta 1786 (2008) 4-14
-
(2008)
Biochim Biophys Acta
, vol.1786
, pp. 4-14
-
-
King, R.W.1
-
18
-
-
27544515607
-
The mitotic checkpoint in cancer and aging: what have mice taught us?
-
Baker D.J., Chen J., and van Deursen J.M. The mitotic checkpoint in cancer and aging: what have mice taught us?. Curr Opin Cell Biol 17 (2005) 583-589
-
(2005)
Curr Opin Cell Biol
, vol.17
, pp. 583-589
-
-
Baker, D.J.1
Chen, J.2
van Deursen, J.M.3
-
19
-
-
10644258336
-
Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B
-
Hanks S., Coleman K., Reid S., Plaja A., Firth H., Fitzpatrick D., Kidd A., Mehes K., Nash R., Robin N., et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nat Genet 36 (2004) 1159-1161
-
(2004)
Nat Genet
, vol.36
, pp. 1159-1161
-
-
Hanks, S.1
Coleman, K.2
Reid, S.3
Plaja, A.4
Firth, H.5
Fitzpatrick, D.6
Kidd, A.7
Mehes, K.8
Nash, R.9
Robin, N.10
-
20
-
-
32444444090
-
Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome
-
Matsuura S., Matsumoto Y., Morishima K., Izumi H., Matsumoto H., Ito E., Tsutsui K., Kobayashi J., Tauchi H., Kajiwara Y., et al. Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. Am J Med Genet A 140 (2006) 358-367
-
(2006)
Am J Med Genet A
, vol.140
, pp. 358-367
-
-
Matsuura, S.1
Matsumoto, Y.2
Morishima, K.3
Izumi, H.4
Matsumoto, H.5
Ito, E.6
Tsutsui, K.7
Kobayashi, J.8
Tauchi, H.9
Kajiwara, Y.10
-
21
-
-
0035972237
-
Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells
-
Cimini D., Howell B., Maddox P., Khodjakov A., Degrassi F., and Salmon E.D. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J Cell Biol 153 (2001) 517-527
-
(2001)
J Cell Biol
, vol.153
, pp. 517-527
-
-
Cimini, D.1
Howell, B.2
Maddox, P.3
Khodjakov, A.4
Degrassi, F.5
Salmon, E.D.6
-
22
-
-
51649083703
-
Merotelic kinetochore orientation, aneuploidy, and cancer
-
Cimini D. Merotelic kinetochore orientation, aneuploidy, and cancer. Biochim Biophys Acta 1786 (2008) 32-40
-
(2008)
Biochim Biophys Acta
, vol.1786
, pp. 32-40
-
-
Cimini, D.1
-
23
-
-
33750612373
-
Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors
-
Cimini D., Wan X., Hirel C.B., and Salmon E.D. Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors. Curr Biol 16 (2006) 1711-1718
-
(2006)
Curr Biol
, vol.16
, pp. 1711-1718
-
-
Cimini, D.1
Wan, X.2
Hirel, C.B.3
Salmon, E.D.4
-
24
-
-
33750609316
-
Aurora B is enriched at merotelic attachment sites, where it regulates MCAK
-
Knowlton A.L., Lan W., and Stukenberg P.T. Aurora B is enriched at merotelic attachment sites, where it regulates MCAK. Curr Biol 16 (2006) 1705-1710
-
(2006)
Curr Biol
, vol.16
, pp. 1705-1710
-
-
Knowlton, A.L.1
Lan, W.2
Stukenberg, P.T.3
-
25
-
-
58149334818
-
Genome stability is ensured by temporal control of kinetochore-microtubule dynamics
-
This paper demonstrates the key role of kinetochore-microtubule dynamics on maintenance of genomic stability. Depletion of kinetochore-associated microtubule kinesins led to an increase in lagging chromosomes and subsequent segregation defects. Overexpression of these kinesins, at levels that would not activate the SAC, suppressed chromosome mis-segregation in CIN cell lines to levels comparable to stable diploid cell lines.
-
Bakhoum S.F., Thompson S.L., Manning A.L., and Compton D.A. Genome stability is ensured by temporal control of kinetochore-microtubule dynamics. Nat Cell Biol 11 (2009) 27-35. This paper demonstrates the key role of kinetochore-microtubule dynamics on maintenance of genomic stability. Depletion of kinetochore-associated microtubule kinesins led to an increase in lagging chromosomes and subsequent segregation defects. Overexpression of these kinesins, at levels that would not activate the SAC, suppressed chromosome mis-segregation in CIN cell lines to levels comparable to stable diploid cell lines.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 27-35
-
-
Bakhoum, S.F.1
Thompson, S.L.2
Manning, A.L.3
Compton, D.A.4
-
26
-
-
0037059043
-
The role of chromosomal instability in tumor initiation
-
Nowak M.A., Komarova N.L., Sengupta A., Jallepalli P.V., Shih Ie M., Vogelstein B., and Lengauer C. The role of chromosomal instability in tumor initiation. Proc Natl Acad Sci U S A 99 (2002) 16226-16231
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16226-16231
-
-
Nowak, M.A.1
Komarova, N.L.2
Sengupta, A.3
Jallepalli, P.V.4
Shih Ie, M.5
Vogelstein, B.6
Lengauer, C.7
-
27
-
-
34247200412
-
Systematic genome instability screens in yeast and their potential relevance to cancer
-
Yuen K.W., Warren C.D., Chen O., Kwok T., Hieter P., and Spencer F.A. Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci U S A 104 (2007) 3925-3930
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3925-3930
-
-
Yuen, K.W.1
Warren, C.D.2
Chen, O.3
Kwok, T.4
Hieter, P.5
Spencer, F.A.6
-
28
-
-
0037178722
-
Maintenance of genome stability in Saccharomyces cerevisiae
-
Kolodner R.D., Putnam C.D., and Myung K. Maintenance of genome stability in Saccharomyces cerevisiae. Science 297 (2002) 552-557
-
(2002)
Science
, vol.297
, pp. 552-557
-
-
Kolodner, R.D.1
Putnam, C.D.2
Myung, K.3
-
29
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons D.W., Jones S., Zhang X., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Siu I.M., Gallia G.L., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321 (2008) 1807-1812
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Siu, I.M.9
Gallia, G.L.10
-
30
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
McLendon R., Friedman A., Bigner D., Van Meir E.G., Brat D.J., Mastrogianakis M., Olson J.J., Mikkelsen T., Lehman N., Aldape K., et al. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008) 1061-1068
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
McLendon, R.1
Friedman, A.2
Bigner, D.3
Van Meir, E.G.4
Brat, D.J.5
Mastrogianakis, M.6
Olson, J.J.7
Mikkelsen, T.8
Lehman, N.9
Aldape, K.10
-
31
-
-
52149123619
-
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
-
Jones S., Zhang X., Parsons D.W., Lin J.C., Leary R.J., Angenendt P., Mankoo P., Carter H., Kamiyama H., Jimeno A., et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321 (2008) 1801-1806
-
(2008)
Science
, vol.321
, pp. 1801-1806
-
-
Jones, S.1
Zhang, X.2
Parsons, D.W.3
Lin, J.C.4
Leary, R.J.5
Angenendt, P.6
Mankoo, P.7
Carter, H.8
Kamiyama, H.9
Jimeno, A.10
-
32
-
-
40849149557
-
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
-
In this study 102 human homologues of 96 yeast CIN genes were sequenced and 11 somatic mutations distributed among five genes in a panel of 132 colorectal cancers were identified.
-
Barber T.D., McManus K., Yuen K.W., Reis M., Parmigiani G., Shen D., Barrett I., Nouhi Y., Spencer F., Markowitz S., et al. Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A 105 (2008) 3443-3448. In this study 102 human homologues of 96 yeast CIN genes were sequenced and 11 somatic mutations distributed among five genes in a panel of 132 colorectal cancers were identified.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3443-3448
-
-
Barber, T.D.1
McManus, K.2
Yuen, K.W.3
Reis, M.4
Parmigiani, G.5
Shen, D.6
Barrett, I.7
Nouhi, Y.8
Spencer, F.9
Markowitz, S.10
-
33
-
-
10944236159
-
Can chromosomal instability initiate tumorigenesis?
-
Michor F., Iwasa Y., Vogelstein B., Lengauer C., and Nowak M.A. Can chromosomal instability initiate tumorigenesis?. Semin Cancer Biol 15 (2005) 43-49
-
(2005)
Semin Cancer Biol
, vol.15
, pp. 43-49
-
-
Michor, F.1
Iwasa, Y.2
Vogelstein, B.3
Lengauer, C.4
Nowak, M.A.5
-
34
-
-
36649000489
-
Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles
-
Frohling S., Scholl C., Levine R.L., Loriaux M., Boggon T.J., Bernard O.A., Berger R., Dohner H., Dohner K., Ebert B.L., et al. Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. Cancer Cell 12 (2007) 501-513
-
(2007)
Cancer Cell
, vol.12
, pp. 501-513
-
-
Frohling, S.1
Scholl, C.2
Levine, R.L.3
Loriaux, M.4
Boggon, T.J.5
Bernard, O.A.6
Berger, R.7
Dohner, H.8
Dohner, K.9
Ebert, B.L.10
-
35
-
-
0037444168
-
Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas
-
Pihan G.A., Wallace J., Zhou Y., and Doxsey S.J. Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res 63 (2003) 1398-1404
-
(2003)
Cancer Res
, vol.63
, pp. 1398-1404
-
-
Pihan, G.A.1
Wallace, J.2
Zhou, Y.3
Doxsey, S.J.4
-
36
-
-
36448987217
-
Oncogenes and tumour suppressors take on centrosomes
-
Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 7 (2007) 911-924
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 911-924
-
-
Fukasawa, K.1
-
37
-
-
34249018619
-
Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells
-
Gonzalez C. Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat Rev Genet 8 (2007) 462-472
-
(2007)
Nat Rev Genet
, vol.8
, pp. 462-472
-
-
Gonzalez, C.1
-
38
-
-
49649092093
-
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability
-
Castellanos E., Dominguez P., and Gonzalez C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol 18 (2008) 1209-1214
-
(2008)
Curr Biol
, vol.18
, pp. 1209-1214
-
-
Castellanos, E.1
Dominguez, P.2
Gonzalez, C.3
-
39
-
-
27144555447
-
Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster
-
Caussinus E., and Gonzalez C. Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat Genet 37 (2005) 1125-1129
-
(2005)
Nat Genet
, vol.37
, pp. 1125-1129
-
-
Caussinus, E.1
Gonzalez, C.2
-
40
-
-
44649117902
-
Centrosome amplification can initiate tumorigenesis in flies
-
This study demonstrates that centrosome amplification in flies does not lead to gross aneuploidy, but can initiate tumorigenesis by disrupting asymmetric cell division.
-
Basto R., Brunk K., Vinadogrova T., Peel N., Franz A., Khodjakov A., and Raff J.W. Centrosome amplification can initiate tumorigenesis in flies. Cell 133 (2008) 1032-1042. This study demonstrates that centrosome amplification in flies does not lead to gross aneuploidy, but can initiate tumorigenesis by disrupting asymmetric cell division.
-
(2008)
Cell
, vol.133
, pp. 1032-1042
-
-
Basto, R.1
Brunk, K.2
Vinadogrova, T.3
Peel, N.4
Franz, A.5
Khodjakov, A.6
Raff, J.W.7
-
41
-
-
49849103726
-
Aneuploidy: cells losing their balance
-
Torres E.M., Williams B.R., and Amon A. Aneuploidy: cells losing their balance. Genetics 179 (2008) 737-746
-
(2008)
Genetics
, vol.179
, pp. 737-746
-
-
Torres, E.M.1
Williams, B.R.2
Amon, A.3
-
43
-
-
0021918226
-
Triploid meiosis and aneuploidy in Schizosaccharomyces pobe: an unstable aneuploid disomic for chromosome III
-
Niwa O., and Yanagida M. Triploid meiosis and aneuploidy in Schizosaccharomyces pobe: an unstable aneuploid disomic for chromosome III. Curr Genet 9 (1985) 463-470
-
(1985)
Curr Genet
, vol.9
, pp. 463-470
-
-
Niwa, O.1
Yanagida, M.2
-
44
-
-
34548131710
-
Effects of aneuploidy on cellular physiology and cell division in haploid yeast
-
The study characterized the changes in physiology in that occur in aneuploid yeast. The paper describes responses to aneuploidy that are not specific to a given chromosome.
-
Torres E.M., Sokolsky T., Tucker C.M., Chan L.Y., Boselli M., Dunham M.J., and Amon A. Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317 (2007) 916-924. The study characterized the changes in physiology in that occur in aneuploid yeast. The paper describes responses to aneuploidy that are not specific to a given chromosome.
-
(2007)
Science
, vol.317
, pp. 916-924
-
-
Torres, E.M.1
Sokolsky, T.2
Tucker, C.M.3
Chan, L.Y.4
Boselli, M.5
Dunham, M.J.6
Amon, A.7
-
45
-
-
55349112533
-
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
-
••]), this paper describes proliferative and physiological changes in primary mouse cell lines with four distinct trisomies. The authors show that trisomy affects the rate of immortalization. This effect on immortalization varies with the identity of the extra chromosome.
-
••]), this paper describes proliferative and physiological changes in primary mouse cell lines with four distinct trisomies. The authors show that trisomy affects the rate of immortalization. This effect on immortalization varies with the identity of the extra chromosome.
-
(2008)
Science
, vol.322
, pp. 703-709
-
-
Williams, B.R.1
Prabhu, V.R.2
Hunter, K.E.3
Glazier, C.M.4
Whittaker, C.A.5
Housman, D.E.6
Amon, A.7
-
46
-
-
4944234694
-
Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells
-
Upender M.B., Habermann J.K., McShane L.M., Korn E.L., Barrett J.C., Difilippantonio M.J., and Ried T. Chromosome transfer induced aneuploidy results in complex dysregulation of the cellular transcriptome in immortalized and cancer cells. Cancer Res 64 (2004) 6941-6949
-
(2004)
Cancer Res
, vol.64
, pp. 6941-6949
-
-
Upender, M.B.1
Habermann, J.K.2
McShane, L.M.3
Korn, E.L.4
Barrett, J.C.5
Difilippantonio, M.J.6
Ried, T.7
-
47
-
-
33644547983
-
Relationship of gene expression and chromosomal abnormalities in colorectal cancer
-
Tsafrir D., Bacolod M., Selvanayagam Z., Tsafrir I., Shia J., Zeng Z., Liu H., Krier C., Stengel R.F., Barany F., et al. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res 66 (2006) 2129-2137
-
(2006)
Cancer Res
, vol.66
, pp. 2129-2137
-
-
Tsafrir, D.1
Bacolod, M.2
Selvanayagam, Z.3
Tsafrir, I.4
Shia, J.5
Zeng, Z.6
Liu, H.7
Krier, C.8
Stengel, R.F.9
Barany, F.10
-
48
-
-
33745756364
-
Apoptosis regulation in tetraploid cancer cells
-
Castedo M., Coquelle A., Vivet S., Vitale I., Kauffmann A., Dessen P., Pequignot M.O., Casares N., Valent A., Mouhamad S., et al. Apoptosis regulation in tetraploid cancer cells. EMBO J 25 (2006) 2584-2595
-
(2006)
EMBO J
, vol.25
, pp. 2584-2595
-
-
Castedo, M.1
Coquelle, A.2
Vivet, S.3
Vitale, I.4
Kauffmann, A.5
Dessen, P.6
Pequignot, M.O.7
Casares, N.8
Valent, A.9
Mouhamad, S.10
-
49
-
-
0033538465
-
Ploidy regulation of gene expression
-
Galitski T., Saldanha A.J., Styles C.A., Lander E.S., and Fink G.R. Ploidy regulation of gene expression. Science 285 (1999) 251-254
-
(1999)
Science
, vol.285
, pp. 251-254
-
-
Galitski, T.1
Saldanha, A.J.2
Styles, C.A.3
Lander, E.S.4
Fink, G.R.5
-
50
-
-
33749506269
-
Genome-wide genetic analysis of polyploidy in yeast
-
Storchova Z., Breneman A., Cande J., Dunn J., Burbank K., O'Toole E., and Pellman D. Genome-wide genetic analysis of polyploidy in yeast. Nature 443 (2006) 541-547
-
(2006)
Nature
, vol.443
, pp. 541-547
-
-
Storchova, Z.1
Breneman, A.2
Cande, J.3
Dunn, J.4
Burbank, K.5
O'Toole, E.6
Pellman, D.7
-
51
-
-
33846065784
-
Aneuploidy acts both oncogenically and as a tumor suppressor
-
Heterozygous Cenp-e mice were shown to develop aneuploidy and chromosome instability, leading to the development of spontaneous tumors in certain tissues. However, on other genetic backgrounds this mutation suppressed tumor formation.
-
Weaver B.A., Silk A.D., Montagna C., Verdier-Pinard P., and Cleveland D.W. Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell 11 (2007) 25-36. Heterozygous Cenp-e mice were shown to develop aneuploidy and chromosome instability, leading to the development of spontaneous tumors in certain tissues. However, on other genetic backgrounds this mutation suppressed tumor formation.
-
(2007)
Cancer Cell
, vol.11
, pp. 25-36
-
-
Weaver, B.A.1
Silk, A.D.2
Montagna, C.3
Verdier-Pinard, P.4
Cleveland, D.W.5
-
52
-
-
33845986330
-
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice
-
Sotillo R., Hernando E., Diaz-Rodriguez E., Teruya-Feldstein J., Cordon-Cardo C., Lowe S.W., and Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell 11 (2007) 9-23
-
(2007)
Cancer Cell
, vol.11
, pp. 9-23
-
-
Sotillo, R.1
Hernando, E.2
Diaz-Rodriguez, E.3
Teruya-Feldstein, J.4
Cordon-Cardo, C.5
Lowe, S.W.6
Benezra, R.7
-
53
-
-
38049069895
-
Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome
-
Sussan T.E., Yang A., Li F., Ostrowski M.C., and Reeves R.H. Trisomy represses Apc(Min)-mediated tumours in mouse models of Down's syndrome. Nature 451 (2008) 73-75
-
(2008)
Nature
, vol.451
, pp. 73-75
-
-
Sussan, T.E.1
Yang, A.2
Li, F.3
Ostrowski, M.C.4
Reeves, R.H.5
-
54
-
-
17444446946
-
Widespread aneuploidy revealed by DNA microarray expression profiling
-
Hughes T.R., Roberts C.J., Dai H., Jones A.R., Meyer M.R., Slade D., Burchard J., Dow S., Ward T.R., Kidd M.J., et al. Widespread aneuploidy revealed by DNA microarray expression profiling. Nat Genet 25 (2000) 333-337
-
(2000)
Nat Genet
, vol.25
, pp. 333-337
-
-
Hughes, T.R.1
Roberts, C.J.2
Dai, H.3
Jones, A.R.4
Meyer, M.R.5
Slade, D.6
Burchard, J.7
Dow, S.8
Ward, T.R.9
Kidd, M.J.10
-
55
-
-
41749113291
-
An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1
-
This study demonstrated that aneuploidy was responsible for drug resistance in clinical isolates of Candida albicans.
-
Selmecki A., Gerami-Nejad M., Paulson C., Forche A., and Berman J. An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1. Mol Microbiol 68 (2008) 624-641. This study demonstrated that aneuploidy was responsible for drug resistance in clinical isolates of Candida albicans.
-
(2008)
Mol Microbiol
, vol.68
, pp. 624-641
-
-
Selmecki, A.1
Gerami-Nejad, M.2
Paulson, C.3
Forche, A.4
Berman, J.5
-
56
-
-
56349088536
-
Aneuploidy and polyploidy underlie adaptive evolution of yeast cells deprived of a conserved cytokinesis motor
-
In vitro evolution was used to identify yeast strains that adapted to a cytokinesis defect. Genomic methods, including genome re-sequencing, defined mechanisms leading to adaptation. Aneuploidy, possibly developing from polyploidy, appeared to the major mechanism of adaptation.
-
Rancati G., Pavelka N., Fleharty B., Noll A., Allen R., Walton K., Perera A., Staehling-Hampton K., Seidel C.W., and Li R. Aneuploidy and polyploidy underlie adaptive evolution of yeast cells deprived of a conserved cytokinesis motor. Cell 135 (2008) 879-893. In vitro evolution was used to identify yeast strains that adapted to a cytokinesis defect. Genomic methods, including genome re-sequencing, defined mechanisms leading to adaptation. Aneuploidy, possibly developing from polyploidy, appeared to the major mechanism of adaptation.
-
(2008)
Cell
, vol.135
, pp. 879-893
-
-
Rancati, G.1
Pavelka, N.2
Fleharty, B.3
Noll, A.4
Allen, R.5
Walton, K.6
Perera, A.7
Staehling-Hampton, K.8
Seidel, C.W.9
Li, R.10
-
58
-
-
39749114978
-
Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
-
Bristow R.G., and Hill R.P. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8 (2008) 180-192
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 180-192
-
-
Bristow, R.G.1
Hill, R.P.2
-
59
-
-
33750300823
-
Origin of mutations under selection: the adaptive mutation controversy
-
Roth J.R., Kugelberg E., Reams A.B., Kofoid E., and Andersson D.I. Origin of mutations under selection: the adaptive mutation controversy. Annu Rev Microbiol 60 (2006) 477-501
-
(2006)
Annu Rev Microbiol
, vol.60
, pp. 477-501
-
-
Roth, J.R.1
Kugelberg, E.2
Reams, A.B.3
Kofoid, E.4
Andersson, D.I.5
-
60
-
-
0033637153
-
Genomic expression programs in the response of yeast cells to environmental changes
-
Gasch A.P., Spellman P.T., Kao C.M., Carmel-Harel O., Eisen M.B., Storz G., Botstein D., and Brown P.O. Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11 (2000) 4241-4257
-
(2000)
Mol Biol Cell
, vol.11
, pp. 4241-4257
-
-
Gasch, A.P.1
Spellman, P.T.2
Kao, C.M.3
Carmel-Harel, O.4
Eisen, M.B.5
Storz, G.6
Botstein, D.7
Brown, P.O.8
-
61
-
-
0025007652
-
High levels of chromosome instability in polyploids of Saccharomyces cerevisiae
-
Mayer V.W., and Aguilera A. High levels of chromosome instability in polyploids of Saccharomyces cerevisiae. Mutat Res 231 (1990) 177-186
-
(1990)
Mutat Res
, vol.231
, pp. 177-186
-
-
Mayer, V.W.1
Aguilera, A.2
-
62
-
-
27144507868
-
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells
-
Fujiwara T., Bandi M., Nitta M., Ivanova E.V., Bronson R.T., and Pellman D. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437 (2005) 1043-1047
-
(2005)
Nature
, vol.437
, pp. 1043-1047
-
-
Fujiwara, T.1
Bandi, M.2
Nitta, M.3
Ivanova, E.V.4
Bronson, R.T.5
Pellman, D.6
-
63
-
-
49749092649
-
A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells
-
Roh M., Franco O.E., Hayward S.W., van der Meer R., and Abdulkadir S.A. A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. PLoS ONE 3 (2008) e2572
-
(2008)
PLoS ONE
, vol.3
-
-
Roh, M.1
Franco, O.E.2
Hayward, S.W.3
van der Meer, R.4
Abdulkadir, S.A.5
-
64
-
-
50049085789
-
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes
-
This study used RNAi to define the factors that suppress multipolar mitoses in cells with extra centrosomes. The study validates the idea that inhibiting centrosome clustering can kill cancer cells with extra centrosomes but not normal controls.
-
Kwon M., Godinho S.A., Chandhok N.S., Ganem N.J., Azioune A., Thery M., and Pellman D. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev 22 (2008) 2189-2203. This study used RNAi to define the factors that suppress multipolar mitoses in cells with extra centrosomes. The study validates the idea that inhibiting centrosome clustering can kill cancer cells with extra centrosomes but not normal controls.
-
(2008)
Genes Dev
, vol.22
, pp. 2189-2203
-
-
Kwon, M.1
Godinho, S.A.2
Chandhok, N.S.3
Ganem, N.J.4
Azioune, A.5
Thery, M.6
Pellman, D.7
-
65
-
-
38349088899
-
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
-
- patients.
-
- patients.
-
(2008)
Nature
, vol.451
, pp. 335-339
-
-
Ebert, B.L.1
Pretz, J.2
Bosco, J.3
Chang, C.Y.4
Tamayo, P.5
Galili, N.6
Raza, A.7
Root, D.E.8
Attar, E.9
Ellis, S.R.10
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