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Volumn 67, Issue 2, 2011, Pages 447-454
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A first in human study of SB-743921, a kinesin spindle protein inhibitor, to determine pharmacokinetics, biologic effects and establish a recommended phase II dose
a
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Author keywords
Kinesin spindle protein; Mitosis; Pharmacokinetics; Phase I; Safety; SB 743921
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Indexed keywords
ANTINEOPLASTIC AGENT;
SB 743921;
UNCLASSIFIED DRUG;
BENZAMIDE DERIVATIVE;
CHROMONE DERIVATIVE;
ENZYME INHIBITOR;
KIF11 PROTEIN, HUMAN;
KINESIN;
ABDOMINAL PAIN;
ADULT;
ADVANCED CANCER;
AGED;
ALANINE AMINOTRANSFERASE BLOOD LEVEL;
ALKALINE PHOSPHATASE BLOOD LEVEL;
ALOPECIA;
ANEMIA;
ANTINEOPLASTIC ACTIVITY;
APPENDIX TUMOR;
AREA UNDER THE CURVE;
ARTHRALGIA;
ARTICLE;
ASPARTATE AMINOTRANSFERASE BLOOD LEVEL;
BACKACHE;
BILE DUCT TUMOR;
BILIRUBIN BLOOD LEVEL;
BLADDER CANCER;
BONE MARROW SUPPRESSION;
CANCER CHEMOTHERAPY;
CANCER RELAPSE;
CHILL;
CLINICAL ARTICLE;
COLON CANCER;
CONSTIPATION;
CONTROLLED STUDY;
COUGHING;
DIARRHEA;
DIZZINESS;
DOSE RESPONSE;
DRUG BLOOD LEVEL;
DRUG CLEARANCE;
DRUG DOSE ESCALATION;
DRUG EFFICACY;
DRUG FEVER;
DRUG HALF LIFE;
DRUG INDUCED HEADACHE;
DRUG POTENCY;
DYSPNEA;
ESOPHAGUS CANCER;
FATIGUE;
FEBRILE NEUTROPENIA;
FEMALE;
HUMAN;
HYPERBILIRUBINEMIA;
HYPERTRANSAMINASEMIA;
HYPONATREMIA;
HYPOPHOSPHATEMIA;
LEUKOPENIA;
LIVER CELL CARCINOMA;
LUNG EMBOLISM;
LUNG NON SMALL CELL CANCER;
LYMPHOMA;
MALE;
MAXIMUM TOLERATED DOSE;
MELANOMA;
MESOTHELIOMA;
MUCOSA INFLAMMATION;
MULTIPLE CYCLE TREATMENT;
NAUSEA;
NEUROENDOCRINE TUMOR;
NEUROPATHY;
NEUTROPENIA;
OPTIMAL DRUG DOSE;
OVARY CANCER;
PANCREAS CANCER;
PARAGANGLIOMA;
PERIPHERAL EDEMA;
PHARMACODYNAMICS;
PRIORITY JOURNAL;
RECOMMENDED DRUG DOSE;
RECTUM CANCER;
SIDE EFFECT;
SOLID TUMOR;
SUPERIOR CAVA VEIN SYNDROME;
TREATMENT RESPONSE;
VOMITING;
CHEMICALLY INDUCED DISORDER;
CLINICAL TRIAL;
DIGESTIVE SYSTEM DISEASE;
DRUG ANTAGONISM;
MIDDLE AGED;
MORTALITY;
NEOPLASM;
PHASE 1 CLINICAL TRIAL;
TREATMENT OUTCOME;
ADULT;
AGED;
AGED, 80 AND OVER;
ANTINEOPLASTIC AGENTS;
AREA UNDER CURVE;
BENZAMIDES;
CHROMONES;
DIGESTIVE SYSTEM DISEASES;
ENZYME INHIBITORS;
FEMALE;
HUMANS;
KINESIN;
MALE;
MAXIMUM TOLERATED DOSE;
MIDDLE AGED;
NEOPLASMS;
NEUTROPENIA;
PULMONARY EMBOLISM;
TREATMENT OUTCOME;
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EID: 79953770295
PISSN: 03445704
EISSN: None
Source Type: Journal
DOI: 10.1007/s00280-010-1346-5 Document Type: Article |
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Times cited : (64)
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References (8)
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