The discovery of tetrahydro-β-carbolines as inhibitors of the kinesin Eg5

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 1, 2010, Pages 157-160

  Barsanti, Paul A ^a   Wang, Weibo ^a   Ni, Zhi Jie ^a   Duhl, David ^a   Brammeier, Nathan ^a   Martin, Eric ^a   Bussiere, Dirksen ^a   Walter, Annette O ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Eg5; Kinesin; KSP

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE INHIBITOR; KINESIN EG5; TRYPTOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CARBOLINES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; KINESIN; MODELS, MOLECULAR; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049103927     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.11.012     Document Type: Article

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