Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

Journal of Molecular Biology

Volumn 335, Issue 2, 2004, Pages 547-554

  Yan, Youwei ^a   Sardana, Vinod ^a   Xu, Bei ^a   Homnick, Carl ^a   Halczenko, Wasyl ^a   Buser, Carolyn A ^a   Schaber, Michael ^a   Hartman, George D ^a   Huber, Hans E ^a   Kuo, Lawrence C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Allosteric inhibition; Induced fit; Kinesin; Mitotic arrest; X ray structure

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE DIPHOSPHATE MAGNESIUM; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; KINESIN; MITOTIC MOTOR PROTEIN; MONASTROL; PROTEIN INHIBITOR; PROTEIN KSP; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING SITE; DRUG MECHANISM; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME INHIBITION; MITOSIS INHIBITION; MITOSIS SPINDLE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE;

EID: 10744220712     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2003.10.074     Document Type: Article

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