Novel ATP-competitive kinesin spindle protein inhibitors

Journal of Medicinal Chemistry

Volumn 50, Issue 20, 2007, Pages 4939-4952

  Parrish, Cynthia A ^a   Adams, Nicholas D ^a   Auger, Kurt R ^a   Burgess, Joelle L ^a   Carson, Jeffrey D ^a   Chaudhari, Amita M ^a   Copeland, Robert A ^a   Diamond, Melody A ^a   Donatelli, Carla A ^a   Duffy, Kevin J ^a   Faucette, Leo F ^a   Finer, Jeffrey T ^b   Huffman, William F ^a   Hugger, Erin D ^a   Jackson, Jeffrey R ^a   Knight, Steven D ^a   Luo, Lusong ^a   Moore, Michael L ^a   Newlander, Ken A ^a   Ridgers, Lance H ^a   Sakowicz, Roman ^b   Shaw, Antony N ^a   Sung, Chiu Mei M ^a   Sutton, David ^a   Wood, Kenneth W ^b   Zhang, Shu Yun ^a   Zimmerman, Michael N ^a   Dhanak, Dashyant ^a   more..

^a GLAXOSMITHKLINE   (United States)

^b Cytokinetics Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; BIPHENYL DERIVATIVE; KINESIN SPINDLE PROTEIN; KINESIN SPINDLE PROTEIN INHIBITOR; N [4' (TRIFLUOROMETHYL) 4 BIPHENYL]SULFAMIDE; SULFAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CANCER INHIBITION; CELL STRAIN HCT116; COLORECTAL CANCER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN; HUMAN CELL; MAXIMUM PLASMA CONCENTRATION; MAXIMUM TOLERATED DOSE; NUDE MOUSE; OVARY CANCER; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTINEOPLASTIC AGENTS; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; KINESIN; MICE; MICE, NUDE; MUTATION; NEOPLASM TRANSPLANTATION; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 34948846564     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070435y     Document Type: Article

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