An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex

Biochemical Journal

Volumn 425, Issue 1, 2010, Pages 55-60

  Kaan, Hung Yi Kristal ^a   Ulaganathan, Venkatasubramanian ^a   Hackney, David D ^b   Kozielski, Frank ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Eg5; Kinesin; Mitosis; S trityl L cysteine

Indexed keywords

ALLOSTERIC TRANSITION; ASYMMETRIC UNIT; BINDING POCKETS; BIPOLAR SPINDLES; BOUND STATE; CANCER CHEMOTHERAPY; CLINICAL TRIAL; CONFORMATIONAL CHANGE; DRUG TARGETS; INHIBITOR COMPLEX; INTERMEDIATE STATE; KINESINS; L-CYSTEINE; MOTOR DOMAIN; SPACE GROUPS; STRUCTURAL CHANGE; STRUCTURAL EVIDENCE;

CHEMOTHERAPY; CRYSTAL STRUCTURE; ENZYME INHIBITION; FLUORINE CONTAINING POLYMERS; MOLECULES;

CONFORMATIONS;

ANTIMITOTIC AGENT; KINESIN; KINESIN EG5; TRITYL DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLIZATION; DNA HELIX; HUMAN; MITOSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ALLOSTERIC REGULATION; ALLOSTERIC SITE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; HUMANS; KINESIN; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72449183762     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091207     Document Type: Article

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