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Volumn 32, Issue , 2012, Pages 343-368

Inflammation in alcoholic liver disease

Author keywords

Complement; Cytokines; Ethanol; Hepatic macrophage; Inflammasome; Liver injury

Indexed keywords

ACETALDEHYDE; ACETIC ACID; ACETYLCYSTEINE; ADIPONECTIN; ANTIOXIDANT; COMPLEMENT; CORTICOSTEROID; FATTY ACID; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PENTOXIFYLLINE; PROBIOTIC AGENT; REACTIVE OXYGEN METABOLITE; S ADENOSYLMETHIONINE; STAT3 PROTEIN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INHIBITOR;

EID: 84864216017     PISSN: 01999885     EISSN: 15454312     Source Type: Book Series    
DOI: 10.1146/annurev-nutr-072610-145138     Document Type: Review
Times cited : (249)

References (159)
  • 1
    • 0028108372 scopus 로고
    • Inactivation of Kupffer cells prevents early alcohol-induced liver injury
    • DOI 10.1016/0270-9139(94)90199-6
    • Adachi Y, Bradford BU, GaoW, Bojes HK, Thurman RG.1994. Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20:453-60 (Pubitemid 24233374)
    • (1994) Hepatology , vol.20 , Issue.2 , pp. 453-460
    • Adachi, Y.1    Bradford, B.U.2    Gao, W.3    Bojes, H.K.4    Thurman, R.G.5
  • 2
    • 0028796860 scopus 로고
    • Antibiotics prevent liver injury in rats following long-term exposure to ethanol
    • Adachi Y, Moore LE, Bradford BU, Gao W, Thurman RG. 1995. Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108:218-24
    • (1995) Gastroenterology , vol.108 , pp. 218-224
    • Adachi, Y.1    Moore, L.E.2    Bradford, B.U.3    Gao, W.4    Thurman, R.G.5
  • 3
    • 0032917769 scopus 로고    scopus 로고
    • Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-alpha production in rat Kupffer cells
    • Aldred A, Nagy LE. 1999. Ethanol dissociates hormone-stimulated cAMP production from inhibition of TNF-alpha production in rat Kupffer cells. Am. J. Physiol. 276:G98-106
    • (1999) Am. J. Physiol , vol.276
    • Aldred, A.1    Nagy, L.E.2
  • 5
    • 79955663416 scopus 로고    scopus 로고
    • Genetics of alcoholic and nonalcoholic fatty liver disease
    • Anstee QM, Daly AK, Day CP. 2011. Genetics of alcoholic and nonalcoholic fatty liver disease. Semin. Liver Dis. 31:128-46
    • (2011) Semin. Liver Dis , vol.31 , pp. 128-146
    • Anstee, Q.M.1    Daly, A.K.2    Day, C.P.3
  • 6
    • 0029781891 scopus 로고    scopus 로고
    • Acute alcohol produces hypoxia directly in rat liver tissue in vivo: Role of Kupffer cells
    • Arteel GE, Raleigh JA, Bradford BU, Thurman RG. 1996. Acute alcohol produces hypoxia directly in rat liver tissue in vivo: role of Kupffer cells. Am. J. Physiol. 271:G494-500
    • (1996) Am. J. Physiol , vol.271
    • Arteel, G.E.1    Raleigh, J.A.2    Bradford, B.U.3    Thurman, R.G.4
  • 8
    • 0031015028 scopus 로고    scopus 로고
    • Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver
    • Bautista AP. 1997. Chronic alcohol intoxication induces hepatic injury through enhanced macrophage inflammatory protein-2 production and intercellular adhesion molecule-1 expression in the liver. Hepatology 25:335-42 (Pubitemid 27069052)
    • (1997) Hepatology , vol.25 , Issue.2 , pp. 335-342
    • Bautista, A.P.1
  • 9
    • 0036017173 scopus 로고    scopus 로고
    • Neutrophilic infiltration in alcoholic hepatitis
    • DOI 10.1016/S0741-8329(02)00206-9, PII S0741832902002069
    • Bautista AP. 2002. Neutrophilic infiltration in alcoholic hepatitis. Alcohol 27:17-21 (Pubitemid 34626479)
    • (2002) Alcohol , vol.27 , Issue.1 , pp. 17-21
    • Bautista, A.P.1
  • 10
    • 51649111509 scopus 로고    scopus 로고
    • Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells
    • Blanco AM, Perez-Arago A, Fernandez-Lizarbe S, Guerri C. 2008. Ethanol mimics ligand-mediated activation and endocytosis of IL-1RI/TLR4 receptors via lipid rafts caveolae in astroglial cells. J. Neurochem. 106:625-39
    • (2008) J. Neurochem , vol.106 , pp. 625-639
    • Blanco, A.M.1    Perez-Arago, A.2    Fernandez-Lizarbe, S.3    Guerri, C.4
  • 11
    • 27744562724 scopus 로고    scopus 로고
    • Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes
    • Blanco AM, Valles SL, PascualM, Guerri C. 2005. Involvement of TLR4/type I IL-1 receptor signaling in the induction of inflammatory mediators and cell death induced by ethanol in cultured astrocytes. J. Immunol. 175:6893-99 (Pubitemid 41599911)
    • (2005) Journal of Immunology , vol.175 , Issue.10 , pp. 6893-6899
    • Blanco, A.M.1    Valles, S.L.2    Pascual, M.3    Guerri, C.4
  • 12
    • 0023145010 scopus 로고
    • Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess
    • DOI 10.1016/S0168-8278(87)80003-X
    • Bode C, Kugler V, Bode JC. 1987. Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J. Hepatol. 4:8-14 (Pubitemid 17045538)
    • (1987) Journal of Hepatology , vol.4 , Issue.1 , pp. 8-14
    • Bode, C.1    Kugler, V.2    Bode, J.C.3
  • 13
    • 57249086241 scopus 로고    scopus 로고
    • A randomized, double-blinded, placebo-controlledmulticenter trial of etanercept in the treatment of alcoholic hepatitis
    • Boetticher NC, Peine CJ, Kwo P, Abrams GA, Patel T, et al. 2008. A randomized, double-blinded, placebo-controlledmulticenter trial of etanercept in the treatment of alcoholic hepatitis. Gastroenterology 135:1953-60
    • (2008) Gastroenterology , vol.135 , pp. 1953-1960
    • Boetticher, N.C.1    Peine, C.J.2    Kwo, P.3    Abrams, G.A.4    Patel, T.5
  • 14
    • 67651158824 scopus 로고    scopus 로고
    • Role of oxidative stress in alcohol-induced liver injury
    • Cederbaum AI, Lu Y, WuD. 2009. Role of oxidative stress in alcohol-induced liver injury. Arch. Toxicol. 83:519-48
    • (2009) Arch. Toxicol , vol.83 , pp. 519-548
    • Cederbaum, A.I.1    Lu, Y.2    Wu, D.3
  • 15
    • 0031590415 scopus 로고    scopus 로고
    • Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver
    • DOI 10.1006/bbrc.1997.7531
    • Chen J, Bao H, Sawyer S, Kunos G, Gao B. 1997. Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver. Biochem. Biophys. Res. Commun. 239:666-69 (Pubitemid 27504158)
    • (1997) Biochemical and Biophysical Research Communications , vol.239 , Issue.3 , pp. 666-669
    • Chen, J.1    Bao, H.2    Sawyer, S.3    Kunos, G.4    Gao, B.5
  • 17
    • 66149129923 scopus 로고    scopus 로고
    • Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats
    • Chen X, Sebastian BM, Tang H, McMullen MM, Axhemi A, et al. 2009. Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats. Hepatology 49:1554-62
    • (2009) Hepatology , vol.49 , pp. 1554-1562
    • Chen, X.1    Sebastian, B.M.2    Tang, H.3    McMullen, M.M.4    Axhemi, A.5
  • 18
    • 0014981989 scopus 로고
    • Lipogranulomas in human liver biopsies with fatty change. A morphological, biochemical and clinical investigation
    • Christoffersen P, Braendstrup O, Juhl E, Poulsen H. 1971. Lipogranulomas in human liver biopsies with fatty change. A morphological, biochemical and clinical investigation. Acta Pathol.Microbiol. Scand. A 79:150-58
    • (1971) Acta Pathol.Microbiol. Scand. A , vol.79 , pp. 150-158
    • Christoffersen, P.1    Braendstrup, O.2    Juhl, E.3    Poulsen, H.4
  • 19
    • 77955474503 scopus 로고    scopus 로고
    • Complement and alcoholic liver disease: Role of C1q in the pathogenesis of ethanol-induced liver injury in mice
    • Cohen JI, Roychowdhury S, McMullenMR, Stavitsky AB, Nagy LE. 2010. Complement and alcoholic liver disease: role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology 139:664-74.e1
    • (2010) Gastroenterology , vol.139
    • Cohen, J.I.1    Roychowdhury, S.2    McMullen, M.R.3    Stavitsky, A.B.4    Nagy, L.E.5
  • 22
    • 79959573042 scopus 로고    scopus 로고
    • Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells
    • Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G. 2011. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology 54:133-44
    • (2011) Hepatology , vol.54 , pp. 133-144
    • Csak, T.1    Ganz, M.2    Pespisa, J.3    Kodys, K.4    Dolganiuc, A.5    Szabo, G.6
  • 23
    • 79954523464 scopus 로고    scopus 로고
    • Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice
    • Csak T, Velayudham A, Hritz I, Petrasek J, Levin I, et al. 2011. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 300:G433-41
    • (2011) Am. J. Physiol. Gastrointest. Liver Physiol , vol.300
    • Csak, T.1    Velayudham, A.2    Hritz, I.3    Petrasek, J.4    Levin, I.5
  • 24
    • 58149380812 scopus 로고    scopus 로고
    • Ethanol and arachidonic acid synergize to activateKupffer cells andmodulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms
    • Cubero FJ, Nieto N. 2008. Ethanol and arachidonic acid synergize to activateKupffer cells andmodulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. Hepatology 48:2027-39
    • (2008) Hepatology , vol.48 , pp. 2027-2039
    • Cubero, F.J.1    Nieto, N.2
  • 25
    • 78650999124 scopus 로고
    • Cirrhosis of the liver associated with alcoholism; Report of acute exacerbation with serial liver biopsies
    • Davis WD Jr, Culpepper WS. 1948. Cirrhosis of the liver associated with alcoholism; report of acute exacerbation with serial liver biopsies. Ann. Intern. Med. 29:942-58
    • (1948) Ann. Intern. Med , vol.29 , pp. 942-958
    • Davis Jr., W.D.1    Culpepper, W.S.2
  • 26
    • 36448960897 scopus 로고    scopus 로고
    • Treatment of alcoholic liver disease
    • DOI 10.1002/lt.21336
    • Day CP. 2007. Treatment of alcoholic liver disease. Liver Transpl. 13:S69-75 (Pubitemid 350168178)
    • (2007) Liver Transplantation , vol.13 , Issue.11 SUPPL. 2
    • Day, C.P.1
  • 28
    • 10844222972 scopus 로고    scopus 로고
    • Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells
    • DOI 10.1097/01.ALC.0000148115.90045.C5
    • Duryee MJ, Klassen LW, Freeman TL, Willis MS, Tuma DJ, Thiele GM. 2004. Lipopolysaccharide is a cofactor for malondialdehyde-acetaldehyde adduct-mediated cytokine/chemokine release by rat sinusoidal liver endothelial and Kupffer cells. Alcohol. Clin. Exp. Res. 28:1931-38 (Pubitemid 39665212)
    • (2004) Alcoholism: Clinical and Experimental Research , vol.28 , Issue.12 , pp. 1931-1938
    • Duryee, M.J.1    Klassen, L.W.2    Freeman, T.L.3    Willis, M.S.4    Tuma, D.J.5    Thiele, G.M.6
  • 29
    • 58849151813 scopus 로고    scopus 로고
    • Cutting edge: Critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells
    • Eigenbrod T, Park JH, Harder J, Iwakura Y, Nunez G. 2008. Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells. J. Immunol. 181:8194-98
    • (2008) J. Immunol , vol.181 , pp. 8194-8198
    • Eigenbrod, T.1    Park, J.H.2    Harder, J.3    Iwakura, Y.4    Nunez, G.5
  • 30
    • 12744259191 scopus 로고    scopus 로고
    • IL-6-deficient mice are susceptible to ethanolinduced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver
    • El-AssalO, Hong F, Kim WH, Radaeva S, Gao B. 2004. IL-6-deficient mice are susceptible to ethanolinduced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver. Cell Mol. Immunol. 1:205-11
    • (2004) Cell Mol. Immunol , vol.1 , pp. 205-211
    • El-Assalo Hong, F.1    Kim, W.H.2    Radaeva, S.3    Gao, B.4
  • 35
    • 61349161828 scopus 로고    scopus 로고
    • LactobacillusGGtreatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis
    • Forsyth CB, Farhadi A, Jakate SM, Tang Y, ShaikhM, Keshavarzian A. 2009. LactobacillusGGtreatment ameliorates alcohol-induced intestinal oxidative stress, gut leakiness, and liver injury in a rat model of alcoholic steatohepatitis. Alcohol 43:163-72
    • (2009) Alcohol , vol.43 , pp. 163-172
    • Forsyth, C.B.1    Farhadi, A.2    Jakate, S.M.3    Tang, Y.4    Shaikh, M.5    Keshavarzian, A.6
  • 36
    • 0034014905 scopus 로고    scopus 로고
    • Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: Relation to severity of liver disturbance
    • Fujimoto M, Uemura M, Nakatani Y, Tsujita S, Hoppo K, et al. 2000. Plasma endotoxin and serum cytokine levels in patients with alcoholic hepatitis: relation to severity of liver disturbance. Alcohol. Clin. Exp. Res. 24:48-54S
    • (2000) Alcohol. Clin. Exp. Res , vol.24
    • Fujimoto, M.1    Uemura, M.2    Nakatani, Y.3    Tsujita, S.4    Hoppo, K.5
  • 37
    • 32044448775 scopus 로고    scopus 로고
    • Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure
    • FukuiH. 2005. Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure. Alcohol. Clin. Exp. Res. 29:172-79S
    • (2005) Alcohol. Clin. Exp. Res , vol.29
    • Fukui, H.1
  • 38
    • 12744276080 scopus 로고    scopus 로고
    • Therapeutic potential of interleukin-6 in preventing obesity-and alcohol-associated fatty liver transplant failure
    • Gao B. 2004. Therapeutic potential of interleukin-6 in preventing obesity-and alcohol-associated fatty liver transplant failure. Alcohol 34:59-65
    • (2004) Alcohol , vol.34 , pp. 59-65
    • Gao, B.1
  • 39
    • 80054872790 scopus 로고    scopus 로고
    • Alcoholic liver disease: Pathogenesis and new therapeutic targets
    • Gao B, Bataller R. 2011. Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterology 141:1572-85
    • (2011) Gastroenterology , vol.141 , pp. 1572-1585
    • Gao, B.1    Bataller, R.2
  • 41
    • 0031009602 scopus 로고    scopus 로고
    • Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis
    • Grove J, Daly AK, Bassendine MF, Day CP. 1997. Association of a tumor necrosis factor promoter polymorphism with susceptibility to alcoholic steatohepatitis. Hepatology 26:143-46 (Pubitemid 27280318)
    • (1997) Hepatology , vol.26 , Issue.1 , pp. 143-146
    • Grove, J.1    Daly, A.K.2    Bassendine, M.F.3    Day, C.P.4
  • 42
    • 0034625372 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor necrosis factor α gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and - independent pathways
    • DOI 10.1074/jbc.275.23.17728
    • Guha M, Bai W, Nadler JL, Natarajan R. 2000. Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and -independent pathways. J. Biol. Chem. 275:17728-39 (Pubitemid 30430822)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.23 , pp. 17728-17739
    • Guha, M.1    Bai, W.2    Nadler, J.L.3    Natarajan, R.4
  • 45
    • 0037011992 scopus 로고    scopus 로고
    • L proteins
    • DOI 10.1038/sj.onc.1205016
    • Hong F, Kim WH, Tian Z, Jaruga B, Ishac E, et al. 2002. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins. Oncogene 21:32-43 (Pubitemid 34076376)
    • (2002) Oncogene , vol.21 , Issue.1 , pp. 32-43
    • Hong, F.1    Kim, W.-H.2    Tian, Z.3    Jaruga, B.4    Ishac, E.5    Shen, X.6    Gao, B.7
  • 46
    • 4644237206 scopus 로고    scopus 로고
    • Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
    • DOI 10.1002/hep.20400
    • Hong F, Radaeva S, Pan HN, Tian Z, Veech R, Gao B. 2004. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology 40:933-41 (Pubitemid 39288127)
    • (2004) Hepatology , vol.40 , Issue.4 , pp. 933-941
    • Hong, F.1    Radaeva, S.2    Pan, H.-N.3    Tian, Z.4    Veech, R.5    Gao, B.6
  • 47
    • 34447284943 scopus 로고    scopus 로고
    • Liver regeneration is suppressed in alcoholic cirrhosis: Correlation with decreased STAT3 activation
    • DOI 10.1016/j.alcohol.2007.04.008, PII S074183290700078X
    • Horiguchi N, Ishac EJ, Gao B. 2007. Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation. Alcohol 41:271-80 (Pubitemid 47042332)
    • (2007) Alcohol , vol.41 , Issue.4 , pp. 271-280
    • Horiguchi, N.1    Ishac, E.J.N.2    Gao, B.3
  • 48
    • 77951428317 scopus 로고    scopus 로고
    • Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice
    • Horiguchi N, Lafdil F, Miller AM, Park O, Wang H, et al. 2010. Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice. Hepatology 51:1724-34
    • (2010) Hepatology , vol.51 , pp. 1724-1734
    • Horiguchi, N.1    Lafdil, F.2    Miller, A.M.3    Park, O.4    Wang, H.5
  • 50
    • 54449092214 scopus 로고    scopus 로고
    • The critical role of tolllike receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88
    • Hritz I, Mandrekar P, Velayudham A, Catalano D, Dolganiuc A, et al. 2008. The critical role of tolllike receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88. Hepatology 48:1224-31
    • (2008) Hepatology , vol.48 , pp. 1224-1231
    • Hritz, I.1    Mandrekar, P.2    Velayudham, A.3    Catalano, D.4    Dolganiuc, A.5
  • 51
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Iimuro Y, Gallucci RM, LusterMI, Kono H, Thurman RG. 1997. Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26:1530-37 (Pubitemid 27520019)
    • (1997) Hepatology , vol.26 , Issue.6 , pp. 1530-1537
    • Iimuro, Y.1    Gallucci, R.M.2    Luster, M.3    Kono, H.4    Thurman, R.G.5
  • 52
    • 79956224825 scopus 로고    scopus 로고
    • Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor beta1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation
    • Ikeda R, Ishii K, Hoshikawa Y, Azumi J, Arakaki Y, et al. 2011. Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor beta1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation. Inflamm. Res. 60:597-604
    • (2011) Inflamm. Res , vol.60 , pp. 597-604
    • Ikeda, R.1    Ishii, K.2    Hoshikawa, Y.3    Azumi, J.4    Arakaki, Y.5
  • 53
    • 61749099391 scopus 로고    scopus 로고
    • Acetaminopheninduced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome
    • Imaeda AB, Watanabe A, Sohail MA, Mahmood S, Mohamadnejad M, et al. 2009. Acetaminopheninduced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. J. Clin. Invest. 119:305-14
    • (2009) J. Clin. Invest , vol.119 , pp. 305-314
    • Imaeda, A.B.1    Watanabe, A.2    Sohail, M.A.3    Mahmood, S.4    Mohamadnejad, M.5
  • 54
    • 79959811718 scopus 로고    scopus 로고
    • Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice
    • Inokuchi S, Tsukamoto H, Park E, Liu ZX, Brenner DA, Seki E. 2011. Toll-like receptor 4 mediates alcohol-induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice. Alcohol. Clin. Exp. Res. 35:1509-18
    • (2011) Alcohol. Clin. Exp. Res , vol.35 , pp. 1509-1518
    • Inokuchi, S.1    Tsukamoto, H.2    Park, E.3    Liu, Z.X.4    Brenner, D.A.5    Seki, E.6
  • 56
    • 1842329163 scopus 로고    scopus 로고
    • Mechanisms of neutrophil-induced parenchymal cell injury
    • Jaeschke H, Smith CW. 1997. Mechanisms of neutrophil-induced parenchymal cell injury. J. Leukoc. Biol. 61:647-53 (Pubitemid 27276056)
    • (1997) Journal of Leukocyte Biology , vol.61 , Issue.6 , pp. 647-653
    • Jaeschke, H.1    Smith, C.W.2
  • 58
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
    • Kawai T, Akira S. 2010. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat. Immunol. 11:373-84
    • (2010) Nat. Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 59
    • 77952695807 scopus 로고    scopus 로고
    • Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis
    • Kendrick SF, O'Boyle G, Mann J, Zeybel M, Palmer J, et al. 2010. Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology 51:1988-97
    • (2010) Hepatology , vol.51 , pp. 1988-1997
    • Kendrick, S.F.1    O'boyle, G.2    Mann, J.3    Zeybel, M.4    Palmer, J.5
  • 60
    • 0026026639 scopus 로고
    • Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients
    • Khoruts A, Stahnke L, McClain CJ, Logan G, Allen JI. 1991. Circulating tumor necrosis factor, interleukin-1 and interleukin-6 concentrations in chronic alcoholic patients. Hepatology 13:267-76
    • (1991) Hepatology , vol.13 , pp. 267-276
    • Khoruts, A.1    Stahnke, L.2    McClain, C.J.3    Logan, G.4    Allen, J.I.5
  • 61
    • 77957946415 scopus 로고    scopus 로고
    • Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: Role of signal transducer and activator of transcription 3
    • Ki SH, ParkO, Zheng M, Morales-Ibanez O, Kolls JK, et al. 2010. Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. Hepatology 52:1291-300
    • (2010) Hepatology , vol.52 , pp. 1291-1300
    • Ki, S.H.1    Parko Zheng, M.2    Morales-Ibanez, O.3    Kolls, J.K.4
  • 62
    • 56349169101 scopus 로고    scopus 로고
    • Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: A pilot study
    • Kirpich IA, Solovieva NV, Leikhter SN, Shidakova NA, Lebedeva OV, et al. 2008. Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury: a pilot study. Alcohol 42:675-82
    • (2008) Alcohol , vol.42 , pp. 675-682
    • Kirpich, I.A.1    Solovieva, N.V.2    Leikhter, S.N.3    Shidakova, N.A.4    Lebedeva, O.V.5
  • 64
    • 0035834684 scopus 로고    scopus 로고
    • Stabilization of tumor necrosis factor alpha mRNA by chronic ethanol: Role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathway
    • Kishore R, McMullen MR, Nagy LE. 2001. Stabilization of tumor necrosis factor alpha mRNA by chronic ethanol: role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathway. J. Biol. Chem. 276:41930-37
    • (2001) J. Biol. Chem , vol.276 , pp. 41930-41937
    • Kishore, R.1    McMullen, M.R.2    Nagy, L.E.3
  • 65
    • 77952769075 scopus 로고    scopus 로고
    • Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death
    • Kono H, Karmarkar D, Iwakura Y, Rock KL. 2010. Identification of the cellular sensor that stimulates the inflammatory response to sterile cell death. J. Immunol. 184:4470-78
    • (2010) J. Immunol , vol.184 , pp. 4470-4478
    • Kono, H.1    Karmarkar, D.2    Iwakura, Y.3    Rock, K.L.4
  • 66
    • 0033802236 scopus 로고    scopus 로고
    • NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease
    • Kono H, Rusyn I, Yin M, Gabele E, Yamashina S, et al. 2000. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J. Clin. Invest. 106:867-72
    • (2000) J. Clin. Invest , vol.106 , pp. 867-872
    • Kono, H.1    Rusyn, I.2    Yin, M.3    Gabele, E.4    Yamashina, S.5
  • 67
    • 77951665499 scopus 로고    scopus 로고
    • Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum
    • Kotronen A, Seppanen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, et al. 2010. Comparison of lipid and fatty acid composition of the liver, subcutaneous and intra-abdominal adipose tissue, and serum. Obesity (Silver Spring) 18:937-44
    • (2010) Obesity (Silver Spring) , vol.18 , pp. 937-944
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5
  • 68
    • 70749102261 scopus 로고    scopus 로고
    • Myeloid STAT3 inhibitsTcell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production
    • Lafdil F, Wang H, Park O, ZhangW, Moritoki Y, et al. 2009. Myeloid STAT3 inhibitsTcell-mediated hepatitis by regulating T helper 1 cytokine and interleukin-17 production. Gastroenterology 137:2125-35.e2
    • (2009) Gastroenterology , vol.137
    • Lafdil, F.1    Wang, H.2    Park, O.3    Zhang, W.4    Moritoki, Y.5
  • 69
    • 0031436304 scopus 로고    scopus 로고
    • 2 and tumor necrosis factor-α in endothelial and epithelial cells
    • DOI 10.1074/jbc.272.52.32910
    • Lakshminarayanan V, Beno DW, Costa RH, Roebuck KA. 1997. Differential regulation of interleukin-8 and intercellular adhesion molecule-1 by H2O2 and tumor necrosis factor-alpha in endothelial and epithelial cells. J. Biol. Chem. 272:32910-18 (Pubitemid 28023627)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.52 , pp. 32910-32918
    • Lakshminarayanan, V.1    Beno, D.W.A.2    Costa, R.H.3    Roebuck, K.A.4
  • 70
    • 21344457230 scopus 로고    scopus 로고
    • Immune responses to ethanol metabolites and cytokine profiles differentiate alcoholics with or without liver disease
    • DOI 10.1111/j.1572-0241.2005.41509.x
    • Latvala J, Hietala J, Koivisto H, Jarvi K, Anttila P, Niemela O. 2005. Immune responses to ethanol metabolites and cytokine profiles differentiate alcoholics with or without liver disease.Am. J. Gastroenterol. 100:1303-10 (Pubitemid 40904353)
    • (2005) American Journal of Gastroenterology , vol.100 , Issue.6 , pp. 1303-1310
    • Latvala, J.1    Hietala, J.2    Koivisto, H.3    Jarvi, K.4    Anttila, P.5    Niemela, O.6
  • 71
    • 0035907302 scopus 로고    scopus 로고
    • Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4
    • Lee JY, Sohn KH, Rhee SH, Hwang D. 2001. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J. Biol. Chem. 276:16683-89
    • (2001) J. Biol. Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 72
    • 61949356502 scopus 로고    scopus 로고
    • The interleukin-17 pathway is involved in human alcoholic liver disease
    • Lemmers A, Moreno C, Gustot T, Marechal R, Degre D, et al. 2009. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology 49:646-57
    • (2009) Hepatology , vol.49 , pp. 646-657
    • Lemmers, A.1    Moreno, C.2    Gustot, T.3    Marechal, R.4    Degre, D.5
  • 74
    • 80053314254 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice
    • Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, et al. 2011. Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology 54:1217-26
    • (2011) Hepatology , vol.54 , pp. 1217-1226
    • Louvet, A.1    Teixeira-Clerc, F.2    Chobert, M.N.3    Deveaux, V.4    Pavoine, C.5
  • 76
    • 0018216649 scopus 로고
    • Granulocyte function and levels of immunoglobulins and complement in patients admitted for withdrawal from alcohol
    • MacGregor RR, Gluckman SJ, Senior JR. 1978. Granulocyte function and levels of immunoglobulins and complement in patients admitted for withdrawal from alcohol. J. Infect. Dis. 138:747-55
    • (1978) J. Infect. Dis , vol.138 , pp. 747-755
    • MacGregor, R.R.1    Gluckman, S.J.2    Senior, J.R.3
  • 77
    • 56649094325 scopus 로고    scopus 로고
    • Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease
    • Malhi H, Gores GJ. 2008. Molecular mechanisms of lipotoxicity in nonalcoholic fatty liver disease. Semin. Liver Dis. 28:360-69
    • (2008) Semin. Liver Dis , vol.28 , pp. 360-369
    • Malhi, H.1    Gores, G.J.2
  • 79
    • 77950625277 scopus 로고    scopus 로고
    • The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells
    • Mandal P, Park PH, McMullen MR, Pratt BT, Nagy LE. 2010. The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells. Hepatology 51:1420-29
    • (2010) Hepatology , vol.51 , pp. 1420-1429
    • Mandal, P.1    Park, P.H.2    McMullen, M.R.3    Pratt, B.T.4    Nagy, L.E.5
  • 80
    • 79953863868 scopus 로고    scopus 로고
    • Molecular mechanism for adiponectindependent M2 macrophage polarization: Link between the metabolic and innate immune activity of full-length adiponectin
    • Mandal P, Pratt BT, Barnes M, McMullenMR, Nagy LE. 2011. Molecular mechanism for adiponectindependent M2 macrophage polarization: link between the metabolic and innate immune activity of full-length adiponectin. J. Biol. Chem. 286:13460-69
    • (2011) J. Biol. Chem , vol.286 , pp. 13460-13469
    • Mandal, P.1    Pratt, B.T.2    Barnes, M.3    McMullenmr Nagy, L.E.4
  • 81
    • 78049492112 scopus 로고    scopus 로고
    • Adiponectin and heme oxygenase-1 suppress TLR4/MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure
    • Mandal P, Roychowdhury S, Park PH, Pratt BT, Roger T, Nagy LE. 2010. Adiponectin and heme oxygenase-1 suppress TLR4/MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure. J. Immunol. 185:4928-37
    • (2010) J. Immunol , vol.185 , pp. 4928-4937
    • Mandal, P.1    Roychowdhury, S.2    Park, P.H.3    Pratt, B.T.4    Roger, T.5    Nagy, L.E.6
  • 82
    • 82455167937 scopus 로고    scopus 로고
    • An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: Regulation of proinflammatory cytokines and hepatic steatosis in mice
    • Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. 2011. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology 54:2185-97
    • (2011) Hepatology , vol.54 , pp. 2185-2197
    • Mandrekar, P.1    Ambade, A.2    Lim, A.3    Szabo, G.4    Catalano, D.5
  • 83
    • 0036105350 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): Individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH
    • DOI 10.1016/S0168-8278(01)00289-6, PII S0168827801002896
    • Mathurin P, Mendenhall CL, Carithers RL Jr, RamondMJ, Maddrey WC, et al. 2002. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis (AH): individual data analysis of the last three randomized placebo controlled double blind trials of corticosteroids in severe AH. J. Hepatol. 36:480-87 (Pubitemid 34407335)
    • (2002) Journal of Hepatology , vol.36 , Issue.4 , pp. 480-487
    • Mathurin, P.1    Mendenhall, C.L.2    Carithers Jr., R.L.3    Ramond, M.-J.4    Maddrey, W.C.5    Garstide, P.6    Rueff, B.7    Naveau, S.8    Chaput, J.-C.9    Poynard, T.10
  • 84
    • 78651071021 scopus 로고    scopus 로고
    • Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: Meta-analysis of individual patient data
    • Mathurin P, O'Grady J, Carithers RL, Phillips M, Louvet A, et al. 2011. Corticosteroids improve short-term survival in patients with severe alcoholic hepatitis: meta-analysis of individual patient data. Gut 60:255-60
    • (2011) Gut , vol.60 , pp. 255-260
    • Mathurin, P.1    O'grady, J.2    Carithers, R.L.3    Phillips, M.4    Louvet, A.5
  • 86
    • 0020665065 scopus 로고
    • Hepatic free fatty acids in alcoholic liver disease and morbid obesity
    • Mavrelis PG, Ammon HV, Gleysteen JJ, Komorowski RA, Charaf UK. 1983. Hepatic free fatty acids in alcoholic liver disease and morbid obesity. Hepatology 3:226-31 (Pubitemid 13165374)
    • (1983) Hepatology , vol.3 , Issue.2 , pp. 226-231
    • Mavrelis, P.G.1    Ammon, H.V.2    Gleysteen, J.J.3
  • 88
    • 0036017179 scopus 로고    scopus 로고
    • Monocyte activation in alcoholic liver disease
    • DOI 10.1016/S0741-8329(02)00212-4, PII S0741832902002124
    • McClain CJ, Hill DB, Song Z, Deaciuc I, Barve S. 2002. Monocyte activation in alcoholic liver disease. Alcohol 27:53-61 (Pubitemid 34626485)
    • (2002) Alcohol , vol.27 , Issue.1 , pp. 53-61
    • McClain, C.J.1    Hill, D.B.2    Song, Z.3    Deaciuc, I.4    Barve, S.5
  • 89
    • 67651166871 scopus 로고    scopus 로고
    • Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells
    • McVicker BL, Tuma PL, Kharbanda KK, Lee SM, Tuma DJ. 2009. Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells. World J. Gastroenterol. 15:2609-16
    • (2009) World J. Gastroenterol , vol.15 , pp. 2609-2616
    • McVicker, B.L.1    Tuma, P.L.2    Kharbanda, K.K.3    Lee, S.M.4    Tuma, D.J.5
  • 90
    • 80052005701 scopus 로고    scopus 로고
    • Inflammation-associated IL-6/STAT3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in IL-10 deficient mice
    • Miller AM, Wang H, Bertola A, Park O, Horiguchi N, et al. 2011. Inflammation-associated IL-6/STAT3 activation ameliorates alcoholic and nonalcoholic fatty liver diseases in IL-10 deficient mice. Hepatology 54:846-56
    • (2011) Hepatology , vol.54 , pp. 846-856
    • Miller, A.M.1    Wang, H.2    Bertola, A.3    Park, O.4    Horiguchi, N.5
  • 91
    • 77949975840 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury
    • Miller AM, Wang H, Park O, Horiguchi N, Lafdil F, et al. 2010. Anti-inflammatory and anti-apoptotic roles of endothelial cell STAT3 in alcoholic liver injury. Alcohol. Clin. Exp. Res. 34:719-25
    • (2010) Alcohol. Clin. Exp. Res , vol.34 , pp. 719-725
    • Miller, A.M.1    Wang, H.2    Park, O.3    Horiguchi, N.4    Lafdil, F.5
  • 92
    • 77953891627 scopus 로고    scopus 로고
    • Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice
    • Miura K, Kodama Y, Inokuchi S, Schnabl B, Aoyama T, et al. 2010. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 139:323-34.e7
    • (2010) Gastroenterology , vol.139
    • Miura, K.1    Kodama, Y.2    Inokuchi, S.3    Schnabl, B.4    Aoyama, T.5
  • 93
    • 34548706468 scopus 로고    scopus 로고
    • Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome
    • DOI 10.1002/hep.21737
    • Mookerjee RP, Stadlbauer V, Lidder S, Wright GA, Hodges SJ, et al. 2007. Neutrophil dysfunction in alcoholic hepatitis superimposed on cirrhosis is reversible and predicts the outcome. Hepatology 46:831-40 (Pubitemid 47436130)
    • (2007) Hepatology , vol.46 , Issue.3 , pp. 831-840
    • Mookerjee, R.P.1    Stadlbauer, V.2    Lidder, S.3    Wright, G.A.K.4    Hodges, S.J.5    Davies, N.A.6    Jalan, R.7
  • 94
    • 0141625009 scopus 로고    scopus 로고
    • Recent insights into the role of the innate immune system in the development of alcoholic liver disease
    • Nagy LE. 2003. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp. Biol. Med. (Maywood ) 228:882-90 (Pubitemid 37163241)
    • (2003) Experimental Biology and Medicine , vol.228 , Issue.8 , pp. 882-890
    • Nagy, L.E.1
  • 95
    • 0024599719 scopus 로고
    • Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury
    • DOI 10.1016/0024-3205(89)90599-7
    • Nanji AA, FrenchSW.1989. Dietary linoleic acid is required for development of experimentally induced alcoholic liver injury. Life Sci. 44:223-27 (Pubitemid 19028929)
    • (1989) Life Sciences , vol.44 , Issue.3 , pp. 223-227
    • Nanji, A.A.1    French, S.W.2
  • 98
    • 0024350874 scopus 로고
    • Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease
    • DOI 10.1016/0014-4800(89)90014-2
    • Nanji AA, Tsukamoto H, French SW. 1989. Relationship between fatty liver and subsequent development of necrosis, inflammation and fibrosis in experimental alcoholic liver disease. Exp. Mol. Pathol. 51:141-48 (Pubitemid 20001028)
    • (1989) Experimental and Molecular Pathology , vol.51 , Issue.2 , pp. 141-148
    • Nanji, A.A.1    Tsukamoto, H.2    French, S.W.3
  • 99
    • 79955096123 scopus 로고    scopus 로고
    • Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice
    • Nath B, Levin I, Csak T, Petrasek J, Mueller C, et al. 2011. Hepatocyte-specific hypoxia-inducible factor-1alpha is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology 53:1526-37
    • (2011) Hepatology , vol.53 , pp. 1526-1537
    • Nath, B.1    Levin, I.2    Csak, T.3    Petrasek, J.4    Mueller, C.5
  • 100
    • 0035111054 scopus 로고    scopus 로고
    • Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis
    • DOI 10.1016/S0168-8278(00)00089-1, PII S0168827800000891
    • Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ. 2001. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis. J. Hepatol. 34:248-53 (Pubitemid 32176446)
    • (2001) Journal of Hepatology , vol.34 , Issue.2 , pp. 248-253
    • Natori, S.1    Rust, C.2    Stadheim, L.M.3    Srinivasan, A.4    Burgart, L.J.5    Gores, G.J.6
  • 101
    • 70249099576 scopus 로고    scopus 로고
    • Interdependence of hypoxic and innate immune responses
    • Nizet V, Johnson RS. 2009. Interdependence of hypoxic and innate immune responses. Nat. Rev. Immunol. 9:609-17
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 609-617
    • Nizet, V.1    Johnson, R.S.2
  • 102
    • 78049526283 scopus 로고    scopus 로고
    • The role of intestinal endotoxin in liver injury: A long and evolving history
    • Nolan JP. 2010. The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology 52:1829-35
    • (2010) Hepatology , vol.52 , pp. 1829-1835
    • Nolan, J.P.1
  • 104
    • 33744901148 scopus 로고    scopus 로고
    • TLR2- and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes
    • Oak S, Mandrekar P, Catalano D, Kodys K, Szabo G. 2006. TLR2-and TLR4-mediated signals determine attenuation or augmentation of inflammation by acute alcohol in monocytes. J. Immunol. 176:7628-35 (Pubitemid 43849063)
    • (2006) Journal of Immunology , vol.176 , Issue.12 , pp. 7628-7635
    • Oak, S.1    Mandrekar, P.2    Catalano, D.3    Kodys, K.4    Szabo, G.5
  • 105
    • 0034641647 scopus 로고    scopus 로고
    • Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
    • OuchiN, Kihara S, Arita Y, OkamotoY, Maeda K, et al. 2000. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102:1296-301
    • (2000) Circulation , vol.102 , pp. 1296-1301
    • Ouchin Kihara, S.1    Arita, Y.2    Okamotoy Maeda, K.3
  • 106
    • 79955091590 scopus 로고    scopus 로고
    • The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologuesNOX1 and NOX2/gp91(phox)mediate hepatic fibrosis inmice
    • Paik YH, IwaisakoK, Seki E, Inokuchi S, Schnabl B, et al. 2011. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologuesNOX1 and NOX2/gp91(phox)mediate hepatic fibrosis inmice. Hepatology 53:1730-41
    • (2011) Hepatology , vol.53 , pp. 1730-1741
    • Paik, Y.H.1    Iwaisakok Seki, E.2    Inokuchi, S.3    Schnabl, B.4
  • 107
    • 79955776494 scopus 로고    scopus 로고
    • Vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression
    • Park O, Wang H, Weng H, Feigenbaum L, Li H, et al. 2011. In vivo consequences of liver-specific interleukin-22 expression in mice: implications for human liver disease progression. Hepatology 54:252-61
    • (2011) Hepatology , vol.54 , pp. 252-261
    • Park, O.1    Wang, H.2    Weng, H.3    Feigenbaum, L.4    Li, H.5
  • 108
    • 0034015563 scopus 로고    scopus 로고
    • Ethanol potentiates tumor necrosis factor-α cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition
    • Pastorino JG, Hoek JB. 2000. Ethanol potentiates tumor necrosis factor-alpha cytotoxicity in hepatoma cells and primary rat hepatocytes by promoting induction of the mitochondrial permeability transition. Hepatology 31:1141-52 (Pubitemid 30233240)
    • (2000) Hepatology , vol.31 , Issue.5 , pp. 1141-1152
    • Pastorino, J.G.1    Hoek, J.B.2
  • 110
    • 79251482742 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 and type i interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells
    • Petrasek J, Dolganiuc A, Csak T, Nath B, Hritz I, et al. 2011. Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology 53:649-60
    • (2011) Hepatology , vol.53 , pp. 649-660
    • Petrasek, J.1    Dolganiuc, A.2    Csak, T.3    Nath, B.4    Hritz, I.5
  • 111
    • 0019605549 scopus 로고    scopus 로고
    • Pathology of alcoholic liver diseases. Semin
    • PopperH, Thung SN, GerberMA. 1981. Pathology of alcoholic liver diseases. Semin. Liver Dis. 1:203-16
    • Liver Dis , pp. 1
    • Popperh Thung, S.N.1    Gerber, M.A.2
  • 112
    • 32044473030 scopus 로고    scopus 로고
    • Ethanol-induced liver injury: Potential roles for egr-1
    • Pritchard MT, Nagy LE. 2005. Ethanol-induced liver injury: potential roles for egr-1. Alcohol. Clin. Exp. Res. 29:146-50S
    • (2005) Alcohol. Clin. Exp. Res , vol.29
    • Pritchard, M.T.1    Nagy, L.E.2
  • 113
    • 33947320624 scopus 로고    scopus 로고
    • Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice
    • DOI 10.1053/j.gastro.2007.01.053, PII S0016508507001928
    • Pritchard MT, McMullenMR, Stavitsky AB, Cohen JI, Lin F, et al. 2007. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132:1117-26 (Pubitemid 46440876)
    • (2007) Gastroenterology , vol.132 , Issue.3 , pp. 1117-1126
    • Pritchard, M.T.1    McMullen, M.R.2    Stavitsky, A.B.3    Cohen, J.I.4    Lin, F.5    Medof, M.E.6    Nagy, L.E.7
  • 114
    • 35848968007 scopus 로고    scopus 로고
    • 5 PKC, and NF-κB pathways
    • DOI 10.1002/jnr.21421
    • Quan Y, Du J, Wang X. 2007. High glucose stimulates GRO secretion from rat microglia via ROS, PKC, and NF-kappaB pathways. J. Neurosci. Res. 85:3150-59 (Pubitemid 350057371)
    • (2007) Journal of Neuroscience Research , vol.85 , Issue.14 , pp. 3150-3159
    • Quan, Y.1    Du, J.2    Wang, X.3
  • 115
    • 79551671360 scopus 로고    scopus 로고
    • High glucose stimulates TNFalpha and MCP-1 expression in rat microglia via ROS and NF-kappaB pathways
    • Quan Y, Jiang CT, Xue B, Zhu SG, Wang X. 2011. High glucose stimulates TNFalpha and MCP-1 expression in rat microglia via ROS and NF-kappaB pathways. Acta Pharmacol. Sin. 32:188-93
    • (2011) Acta Pharmacol. Sin , vol.32 , pp. 188-193
    • Quan, Y.1    Jiang, C.T.2    Xue, B.3    Zhu, S.G.4    Wang, X.5
  • 116
    • 5144228946 scopus 로고    scopus 로고
    • Early-phase alcoholic liver disease: An update on animal models, pathology, and pathogenesis
    • DOI 10.1080/10915810490502069
    • Ramaiah S, Rivera C, Arteel G. 2004. Early-phase alcoholic liver disease: an update on animal models, pathology, and pathogenesis. Int. J. Toxicol. 23:217-31 (Pubitemid 39346621)
    • (2004) International Journal of Toxicology , vol.23 , Issue.4 , pp. 217-231
    • Ramaiah, S.K.1    Rivera, C.2    Arteel, G.E.3
  • 117
    • 34548380904 scopus 로고    scopus 로고
    • Hepatic neutrophil infiltration in the pathogenesis of alcohol-induced liver injury
    • DOI 10.1080/00952990701407702, PII 781826941
    • Ramaiah SK, Jaeschke H. 2007. Hepatic neutrophil infiltration in the pathogenesis of alcohol-induced liver injury. Toxicol. Mech. Methods 17:431-40 (Pubitemid 47360087)
    • (2007) Toxicology Mechanisms and Methods , vol.17 , Issue.7 , pp. 431-440
    • Ramaiah, S.K.1    Jaeschke, H.2
  • 118
    • 68949178506 scopus 로고    scopus 로고
    • Endotoxemia and gut barrier dysfunction in alcoholic liver disease
    • Rao R. 2009. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology 50:638-44
    • (2009) Hepatology , vol.50 , pp. 638-644
    • Rao, R.1
  • 121
    • 1842425830 scopus 로고    scopus 로고
    • Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty Acid Metabolism and Membrane Composition
    • Ronis MJ, Korourian S, Zipperman M, Hakkak R, Badger TM. 2004. Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition. J. Nutr. 134:904-12 (Pubitemid 38456262)
    • (2004) Journal of Nutrition , vol.134 , Issue.4 , pp. 904-912
    • Ronis, M.J.J.1    Korourian, S.2    Zipperman, M.3    Hakkak, R.4    Badger, T.M.5
  • 122
    • 65449171938 scopus 로고    scopus 로고
    • An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice
    • Roychowdhury S, McMullen MR, Pritchard MT, Hise AG, van Rooijen N, et al. 2009. An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice. Hepatology 49:1326-34
    • (2009) Hepatology , vol.49 , pp. 1326-1334
    • Roychowdhury, S.1    McMullen, M.R.2    Pritchard, M.T.3    Hise, A.G.4    Van Rooijen, N.5
  • 123
    • 0032696410 scopus 로고    scopus 로고
    • Corn oil rapidly activates nuclear factor-κB in hepatic Kupffer cells by oxidant-dependent mechanisms
    • DOI 10.1093/carcin/20.11.2095
    • Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA, et al. 1999. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis 20:2095-100 (Pubitemid 29535310)
    • (1999) Carcinogenesis , vol.20 , Issue.11 , pp. 2095-2100
    • Rusyn, I.1    Bradham, C.A.2    Cohn, L.3    Schoonhoven, R.4    Swenberg, J.A.5    Brenner, D.A.6    Thurman, R.G.7
  • 125
    • 0042393597 scopus 로고    scopus 로고
    • High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells
    • DOI 10.2337/diabetes.52.5.1256
    • Shanmugam N, Reddy MA, Guha M, Natarajan R. 2003. High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells. Diabetes 52:1256-64 (Pubitemid 36523365)
    • (2003) Diabetes , vol.52 , Issue.5 , pp. 1256-1264
    • Shanmugam, N.1    Reddy, M.A.2    Guha, M.3    Natarajan, R.4
  • 126
    • 66149115196 scopus 로고    scopus 로고
    • Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines
    • Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, et al. 2009. Role of SIRT1 in regulation of LPS-or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am. J. Physiol. Gastrointest. Liver Physiol. 296:G1047-53
    • (2009) Am. J. Physiol. Gastrointest. Liver Physiol , vol.296
    • Shen, Z.1    Ajmo, J.M.2    Rogers, C.Q.3    Liang Le, X.L.4
  • 127
    • 0027294661 scopus 로고
    • Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration
    • DOI 10.1016/0270-9139(93)90504-G
    • Sheron N, Bird G, Koskinas J, Portmann B, Ceska M, et al. 1993. Circulating and tissue levels of the neutrophil chemotaxin interleukin-8 are elevated in severe acute alcoholic hepatitis, and tissue levels correlate with neutrophil infiltration. Hepatology 18:41-46 (Pubitemid 23193615)
    • (1993) Hepatology , vol.18 , Issue.1 , pp. 41-46
    • Sheron, N.1    Bird, G.2    Koskinas, J.3    Portmann, B.4    Ceska, M.5    Lindley, I.6    Williams, R.7
  • 129
    • 43049181923 scopus 로고    scopus 로고
    • Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis
    • Stadlbauer V, Mookerjee RP, Hodges S, Wright GA, Davies NA, Jalan R. 2008. Effect of probiotic treatment on deranged neutrophil function and cytokine responses in patients with compensated alcoholic cirrhosis. J. Hepatol. 48:945-51
    • (2008) J. Hepatol , vol.48 , pp. 945-951
    • Stadlbauer, V.1    Mookerjee, R.P.2    Hodges, S.3    Wright, G.A.4    Davies, N.A.5    Jalan, R.6
  • 131
    • 24344465888 scopus 로고    scopus 로고
    • Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis
    • DOI 10.1016/j.jhep.2005.03.024, PII S0168827805003193
    • Starkel P, De Saeger C, Leclercq I, Strain A, Horsmans Y. 2005. Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis. J. Hepatol. 43:687-95 (Pubitemid 41253237)
    • (2005) Journal of Hepatology , vol.43 , Issue.4 , pp. 687-695
    • Starkel, P.1    De Saeger, C.2    Leclercq, I.3    Strain, A.4    Horsmans, Y.5
  • 132
    • 34347401402 scopus 로고    scopus 로고
    • A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis
    • DOI 10.1016/j.jhep.2007.03.027, PII S0168827807002553
    • Stewart S, PrinceM, BassendineM, Hudson M, James O, et al. 2007. A randomized trial of antioxidant therapy alone or with corticosteroids in acute alcoholic hepatitis. J. Hepatol. 47:277-83 (Pubitemid 47021256)
    • (2007) Journal of Hepatology , vol.47 , Issue.2 , pp. 277-283
    • Stewart, S.1    Prince, M.2    Bassendine, M.3    Hudson, M.4    James, O.5    Jones, D.6    Record, C.7    Day, C.P.8
  • 134
    • 0036708852 scopus 로고    scopus 로고
    • Bacterial translocation and peptidoglycan translocation by acute ethanol administration
    • DOI 10.1007/s005350200118
    • Tabata T, Tani T, Endo Y, Hanasawa K. 2002. Bacterial translocation and peptidoglycan translocation by acute ethanol administration. J. Gastroenterol. 37:726-31 (Pubitemid 35244114)
    • (2002) Journal of Gastroenterology , vol.37 , Issue.9 , pp. 726-731
    • Tabata, T.1    Tani, T.2    Endo, Y.3    Hanasawa, K.4
  • 135
    • 70350719344 scopus 로고    scopus 로고
    • Controversies in the management of alcoholic liver disease
    • Tan HH, Virmani S, Martin P. 2009. Controversies in the management of alcoholic liver disease. Mt. Sinai J. Med. 76:484-98
    • (2009) Mt. Sinai J. Med , vol.76 , pp. 484-498
    • Tan, H.H.1    Virmani, S.2    Martin, P.3
  • 137
    • 33745755554 scopus 로고    scopus 로고
    • Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: Role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-α production
    • DOI 10.1189/jlb.1005613
    • Thakur V, PritchardMT, McMullenMR, Wang Q, Nagy LE. 2006. Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J. Leukoc. Biol. 79:1348-56 (Pubitemid 44835570)
    • (2006) Journal of Leukocyte Biology , vol.79 , Issue.6 , pp. 1348-1356
    • Thakur, V.1    Pritchard, M.T.2    McMullen, M.R.3    Wang, Q.4    Nagy, L.E.5
  • 138
    • 78649606458 scopus 로고    scopus 로고
    • Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites
    • Thiele GM, Duryee MJ, Willis MS, Tuma DJ, Radio SJ, et al. 2010. Autoimmune hepatitis induced by syngeneic liver cytosolic proteins biotransformed by alcohol metabolites. Alcohol. Clin. Exp. Res. 34:2126-36
    • (2010) Alcohol. Clin. Exp. Res , vol.34 , pp. 2126-2136
    • Thiele, G.M.1    Duryee, M.J.2    Willis, M.S.3    Tuma, D.J.4    Radio, S.J.5
  • 140
    • 0021923933 scopus 로고
    • Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet
    • DOI 10.1002/hep.1840050212
    • TsukamotoH, French SW, Benson N, DelgadoG, Rao GA, et al. 1985. Severe and progressive steatosis and focal necrosis in rat liver induced by continuous intragastric infusion of ethanol and low fat diet. Hepatology 5:224-32 (Pubitemid 15115999)
    • (1985) Hepatology , vol.5 , Issue.2 , pp. 224-232
    • Tsukamoto, H.1    French, S.W.2    Benson, N.3
  • 141
    • 0025028967 scopus 로고
    • Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: Status report
    • Tsukamoto H, Gaal K, French SW. 1990. Insights into the pathogenesis of alcoholic liver necrosis and fibrosis: status report. Hepatology 12:599-608 (Pubitemid 20382029)
    • (1990) Hepatology , vol.12 , Issue.3 , pp. 599-608
    • Tsukamoto, H.1    Gaal, K.2    French, S.W.3
  • 142
    • 0030001945 scopus 로고    scopus 로고
    • Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration
    • DOI 10.1053/jhep.1996.v23.pm0008666344
    • Tuma DJ, Thiele GM, Xu D, Klassen LW, Sorrell MF. 1996. Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration. Hepatology 23:872-80 (Pubitemid 26112004)
    • (1996) Hepatology , vol.23 , Issue.4 , pp. 872-880
    • Tuma, D.J.1    Thiele, G.M.2    Xu, D.3    Klassen, L.W.4    Sorrell, M.F.5
  • 143
    • 0034950477 scopus 로고    scopus 로고
    • Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice
    • DOI 10.1053/jhep.2001.25350
    • Uesugi T, Froh M, Arteel GE, Bradford BU, Thurman RG. 2001. Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice. Hepatology 34:101-8 (Pubitemid 32591488)
    • (2001) Hepatology , vol.34 , Issue.1 , pp. 101-108
    • Uesugi, T.1    Froh, M.2    Arteel, G.E.3    Bradford, B.U.4    Thurman, R.G.5
  • 144
    • 20644453966 scopus 로고    scopus 로고
    • Serum IgA, IgG, and IgM antibodies directed against acetaldehyde- derived epitopes: Relationship to liver disease severity and alcohol consumption
    • DOI 10.1002/hep.510250619
    • Viitala K, Israel Y, Blake JE, Niemela O. 1997. Serum IgA, IgG, and IgM antibodies directed against acetaldehyde-derived epitopes: relationship to liver disease severity and alcohol consumption. Hepatology 25:1418-24 (Pubitemid 27250763)
    • (1997) Hepatology , vol.25 , Issue.6 , pp. 1418-1424
    • Vhtala, K.1    Israel, Y.2    Blake, J.E.3    Niemela, O.4
  • 145
    • 79955756575 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 3 in liver diseases: A novel therapeutic target
    • Wang H, Lafdil F, Kong X, Gao B. 2011. Signal transducer and activator of transcription 3 in liver diseases: a novel therapeutic target. Int. J. Biol. Sci. 7:536-50
    • (2011) Int. J. Biol. Sci , vol.7 , pp. 536-550
    • Wang, H.1    Lafdil, F.2    Kong, X.3    Gao, B.4
  • 146
    • 77950839525 scopus 로고    scopus 로고
    • Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development
    • Wang HJ, Zakhari S, Jung MK. 2010. Alcohol, inflammation, and gut-liver-brain interactions in tissue damage and disease development. World J. Gastroenterol. 16:1304-13
    • (2010) World J. Gastroenterol , vol.16 , pp. 1304-1313
    • Wang, H.J.1    Zakhari, S.2    Jung, M.K.3
  • 147
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, Jha S, Zhang L, et al. 2011. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat. Immunol. 12:408-15
    • (2011) Nat. Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5
  • 149
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • DOI 10.1172/JCI200317797
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. 2003. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J. Clin. Invest. 112:91-100 (Pubitemid 38056380)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.1 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.L.5    Cooper, G.J.S.6
  • 150
    • 84860389258 scopus 로고    scopus 로고
    • Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK
    • Xu J, Lai KK, Verlinsky A, Lugea A, French SW, et al. 2011. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J. Hepatol. 55:673-82
    • (2011) J. Hepatol , vol.55 , pp. 673-682
    • Xu, J.1    Lai, K.K.2    Verlinsky, A.3    Lugea, A.4    French, S.W.5
  • 151
    • 78751537350 scopus 로고    scopus 로고
    • Enteric dysbiosis associated with a mouse model of alcoholic liver disease
    • Yan AW, Fouts DE, Brandl J, Starkel P, Torralba M, et al. 2011. Enteric dysbiosis associated with a mouse model of alcoholic liver disease. Hepatology 53:96-105
    • (2011) Hepatology , vol.53 , pp. 96-105
    • Yan, A.W.1    Fouts, D.E.2    Brandl, J.3    Starkel, P.4    Torralba, M.5
  • 154
    • 84864186600 scopus 로고    scopus 로고
    • Adiponectin reverses impairment of Sirt1-TNFa axis by LPS or acetate through stimulating AMPK signaling in cultured rat Kupffer cells
    • You M. 2011. Adiponectin reverses impairment of Sirt1-TNFa axis by LPS or acetate through stimulating AMPK signaling in cultured rat Kupffer cells. Alcohol. Clin. Exp. Res. 35(Suppl. 1):302A
    • (2011) Alcohol. Clin. Exp. Res , vol.35 , Issue.SUPPL. 1
    • You, M.1
  • 155
    • 24144496133 scopus 로고    scopus 로고
    • Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
    • DOI 10.1002/hep.20821
    • You M, Considine RV, Leone TC, Kelly DP, Crabb DW. 2005. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42:568-77 (Pubitemid 41233649)
    • (2005) Hepatology , vol.42 , Issue.3 , pp. 568-577
    • You, M.1    Considine, R.V.2    Leone, T.C.3    Kelly, D.P.4    Crabb, D.W.5
  • 156
    • 34347252306 scopus 로고    scopus 로고
    • Overview: How is alcohol metabolized by the body?
    • Zakhari S. 2006. Overview: How is alcohol metabolized by the body? Alcohol. Res. Health 29:245-54
    • (2006) Alcohol. Res. Health , vol.29 , pp. 245-254
    • Zakhari, S.1
  • 157
    • 78649614542 scopus 로고    scopus 로고
    • Interleukin-6 is an important mediator for mitochondrial DNA repair after alcoholic liver injury in mice
    • Zhang X, Tachibana S, Wang H, Hisada M, Williams GM, et al. 2010. Interleukin-6 is an important mediator for mitochondrial DNA repair after alcoholic liver injury in mice. Hepatology 52:2137-47
    • (2010) Hepatology , vol.52 , pp. 2137-2147
    • Zhang, X.1    Tachibana, S.2    Wang, H.3    Hisada, M.4    Williams, G.M.5
  • 158
    • 51549118941 scopus 로고    scopus 로고
    • TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol
    • Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, et al. 2008. TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol. J. Immunol. 181:3049-56
    • (2008) J. Immunol , vol.181 , pp. 3049-3056
    • Zhao, X.J.1    Dong, Q.2    Bindas, J.3    Piganelli, J.D.4    Magill, A.5
  • 159
    • 0041422646 scopus 로고    scopus 로고
    • A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-α production
    • Zhou Z, Wang L, Song Z, Lambert JC, McClain CJ, Kang YJ. 2003. A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production. Am. J. Pathol. 163:1137-46 (Pubitemid 37040149)
    • (2003) American Journal of Pathology , vol.163 , Issue.3 , pp. 1137-1146
    • Zhou, Z.1    Wang, L.2    Song, Z.3    Lambert, J.C.4    McClain, C.J.5    Kang, Y.J.6


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