Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure

Alcohol

Volumn 34, Issue 1, 2004, Pages 59-65

  Gao, Bin ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

Alcohol; Fatty liver transplantation; IL 6; STAT3

Indexed keywords

ALCOHOL; INTERLEUKIN 6;

ALCOHOL OXIDATION; ALCOHOLIC FATTY LIVER; CADAVER; CELL DEATH; CONFERENCE PAPER; CORRELATION ANALYSIS; DRUG EFFICACY; DRUG POTENCY; HUMAN; IN VITRO STUDY; LIVER CELL; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; MORTALITY; NONHUMAN; OBESITY; ORGAN DONOR; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE;

ANIMALS; FATTY LIVER, ALCOHOLIC; GRAFT REJECTION; HUMANS; INTERLEUKIN-6; LIVER TRANSPLANTATION; OBESITY; PREVALENCE;

EID: 12744276080     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.alcohol.2004.07.006     Document Type: Conference Paper

References (54)

1. F. Amersi, R. Buelow, H. Kato, B. Ke, A.J. Coito, X.-D. Shen, D. Zhao, J. Zaky, J. Melinek, C.R. Lassman, J.K. Kolls, J. Alam, T. Ritter, H.-D. Volk, D.G. Farmer, R.M. Ghobrial, R.W. Busuttil, and J.W. Kupiec-Weglinski Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury J Clin Invest 104 1999 1631 1639
2. 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury Am J Pathol 162 2003 1229 1239
3. R.W. Busuttil, and K. Tanaka The utility of marginal donors in liver transplantation Liver Transpl 9 2003 651 663
4. C.A. Camargo Jr., J.F. Madden, W. Gao, R.S. Selvan, and P.A. Clavien Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent Hepatology 26 1997 1513 1520
5. R. Carini, and E. Albano Recent insights on the mechanisms of liver preconditioning Gastroenterology 125 2003 1480 1491
6. J. Chen, H. Bao, S. Sawyer, G. Kunos, and B. Gao Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver Biochem Biophys Res Commun 239 1997 666 669
7. J. Chen, D.L. Clemens, A.I. Cederbaum, and B. Gao Ethanol inhibits the JAK-STAT signaling pathway in freshly isolated rat hepatocytes but not in cultured hepatocytes or HepG2 cells: evidence for a lack of involvement of ethanol metabolism Clin Biochem 34 2001 203 209
8. J. Chen, G. Kunos, and B. Gao Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes FEBS Lett 457 1999 162 168
9. R.-H. Chen, M.-C. Chang, Y.-H. Su, Y.-T. Tsai, and M.-L. Kuo Interleukin-6 inhibits transforming growth factor-β-induced apoptosis through the phosphatidylinositol 3-kinase/Akt and signal transducers and activators of transcription 3 pathways J Biol Chem 274 1999 23013 23019
10. D.E. Cressman, L.E. Greenbaum, R.A. DeAngelis, G. Ciliberto, E.E. Furth, V. Poli, and R. Taub Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice Science 274 1996 1379 1383
11. R. Cursio, J. Gugenheim, J.E. Ricci, D. Crenesse, P. Rostagno, L. Maulon, M.-C. Saint-Paul, B. Ferrua, and A.P. Auberger A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis FASEB J 13 1999 253 261
12. O. El-Assal, F. Hong, W. Kim, S. Radaeva, and B. Gao IL-6-deficient mice are susceptible to ethanol-induced hepatic steatosis: IL-6 protects against ethanol-induced oxidative stress and mitochondrial permeability transition in the liver Cell Mol Immunol 1 2004 205 211
13. W. Gao, R.C. Bentley, J.F. Madden, and P.-A. Clavien Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation Hepatology 27 1998 1652 1660
14. M.A. García Ureña, F. Colina Ruiz-Delgado, E. Moreno González, C. Jiménez Romero, I. García García, C. Loinzaz Segurola, I. González-Pinto, and R. Gómez Sanz Hepatic steatosis in liver transplant donors: common feature of donor population? World J Surg 22 1998 837 844
15. S. Haga, K. Terui, H.Q. Zhang, S. Enosawa, W. Ogawa, H. Inoue, T. Okuyama, K. Takeda, S. Akira, T. Ogino, K. Irani, and M. Ozaki Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms J Clin Invest 112 2003 989 998
16. M. Hertl, M.C. Hertl, M. Malagó, and C.E. Broelsch In vivo protection of the pig liver against ischemia/reperfusion injury by tauroursodeoxycholate Langenbecks Arch Surg 384 1999 461 466
17. F. Hong, B. Jaruga, W.H. Kim, S. Radaeva, O.N. El-Assal, Z. Tian, V.-A. Nguyen, and B. Gao Opposing roles of STAT1 and STAT3 in T cell-mediated hepatitis: regulation by SOCS J Clin Invest 110 2002 1503 1513
18. L proteins Oncogene 21 2002 32 43
19. H. Jaeschke Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning Am J Physiol Gastrointest Liver Physiol 284 2003 G15 G26
20. Y. Kato, M. Shimazu, M. Kondo, K. Uchida, Y. Kumamoto, G. Wakabayashi, M. Kitajima, and M. Suematsu Bilirubin rinse: a simple protectant against the rat liver graft injury mimicking heme oxygenase-1 preconditioning Hepatology 38 2003 364 373
21. V. Kohli, M. Selzner, J.F. Madden, R.C. Bentley, and P.-A. Clavien Endothelial cell and hepatocyte deaths occur by apoptosis after ischemia-reperfusion injury in the rat liver Transplantation 67 1999 1099 1105
22. K. Kovalovich, R.A. DeAngelis, W. Li, E.E. Furth, G. Ciliberto, and R. Taub Increased toxin-induced liver injury and fibrosis in interleukin-6- deficient mice Hepatology 31 2000 149 159
23. L J Biol Chem 276 2001 26605 26613
24. T.G. Lehmann, M.D. Wheeler, M. Froh, R.F. Schwabe, H. Bunzendahl, R.J. Samulski, J.J. Lemasters, D.A. Brenner, and R.G. Thurman Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat Transplantation 76 2003 28 37
25. T.G. Lehmann, M.D. Wheeler, R.F. Schwabe, H.D. Connor, R. Schoonhoven, H. Bunzendahl, D.A. Brenner, R.J. Samulski, Z. Zhong, and R.G. Thurman Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat Hepatology 32 2000 1255 1264
26. J.J. Lemasters, and R.G. Thurman Reperfusion injury after liver preservation for transplantation Annu Rev Pharmacol Toxicol 37 1997 327 338
27. W. Li, X. Liang, C. Kellendonk, V. Poli, and R. Taub STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration J Biol Chem 277 2002 28411 28417
28. W.A. Marsman, R.H. Wiesner, L. Rodriguez, K.P. Batts, M.K. Porayko, J.E. Hay, G.J. Gores, and R.A.F. Krom Use of fatty donor liver is associated with diminished early patient and graft survival Transplantation 62 1996 1246 1251
29. Y. Masubuchi, M. Bourdi, T.P. Reilly, M.L.M. Graf, J.W. George, and L.R. Pohl Role of interleukin-6 in hepatic heat shock protein expression and protection against acetaminophen-induced liver disease Biochem Biophys Res Commun 304 2003 207 212
30. H. Mizuhara, M. Uno, N. Seki, M. Yamashita, M. Yamaoka, T. Ogawa, K. Kaneda, T. Fujii, H. Senoh, and H. Fujiwara Critical involvement of interferon γ in the pathogenesis of T-cell activation-associated hepatitis and regulatory mechanisms of interleukin-6 for the manifestations of hepatitis Hepatology 23 1996 1608 1615
31. A.R.N. Rao, A.K.K. Chui, L.W. Shi, L. Tsai, C.D. Leon, and A.G.R. Sheil Is donor obesity related to liver steatosis and liver graft dysfunction in liver transplantation? Transplant Proc 32 2000 2103
32. M.E. Rinella, E. Alonso, S. Rao, P. Whitington, J. Fryer, M. Abecassis, R. Superina, S.L. Flamm, and A.T. Blei Body mass index as a predictor of hepatic steatosis in living liver donors Liver Transpl 7 2001 409 414
33. A.M. Seifalian, V. Chidambaram, K. Rolles, and B.R. Davidson In vivo demonstration of impaired microcirculation in steatotic human liver grafts Liver Transpl Surg 4 1998 71 77
34. A.M. Seifalian, C. Piasecki, A. Agarwal, and B.R. Davidson The effect of graded steatosis on flow in the hepatic parenchymal microcirculation Transplantation 68 1999 780 784
35. M. Selzner, C.A. Camargo, and P.-A. Clavien Ischemia impairs liver regeneration after major tissue loss in rodents: protective effects of interleukin-6 Hepatology 30 1999 469 475
36. M. Selzner, and P.-A. Clavien Fatty liver in liver transplantation and surgery Semin Liver Dis 21 2001 105 113
37. M. Selzner, R. Graf, and P.-A. Clavien IL-6: a magic potion for liver transplantation? Gastroenterology 125 2003 256 259
38. M. Selzner, H.A. Rüdiger, D. Sindram, J. Madden, and P.-A. Clavien Mechanisms of ischemic injury are different in the steatotic and normal rat liver Hepatology 32 2000 1280 1288
39. N. Selzner, H. Rüdiger, R. Graf, and P.-A. Clavien Protective strategies against ischemic injury of the liver Gastroenterology 125 2003 917 936
40. N. Selzner, M. Selzner, W. Jochum, and P.-A. Clavien Ischemic preconditioning protects the steatotic mouse liver against reperfusion injury: an ATP dependent mechanism J Hepatol 39 2003 55 61
41. N. Selzner, M. Selzner, Y. Tian, Z. Kadry, and P.-A. Clavien Cold ischemia decreases liver regeneration after partial liver transplantation in the rat: a TNF-α/IL-6-dependent mechanism Hepatology 36 2002 812 818
42. A. Serafin, J. Roselló-Catafau, N. Prats, C. Xaus, E. Gelpí, and C. Peralta Ischemic preconditioning increases the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat Am J Pathol 161 2002 587 601
43. K.L. Streetz, F. Tacke, L. Leifeld, T. Wüstefeld, A. Graw, C. Klein, K. Kamino, U. Spengler, H. Kreipe, S. Kubicka, W. Müller, M.P. Manns, and C. Trautwein Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases Hepatology 38 2003 218 229
44. K.L. Streetz, T. Wüstefeld, C. Klein, K.-J. Kallen, F. Tronche, U.A.K. Betz, G. Schütz, M.P. Manns, W. Müller, and C. Trautwein Lack of gp130 expression in hepatocytes promotes liver injury Gastroenterology 125 2003 532 543
45. C.-K. Sun, X.-Y. Zhang, A. Zimmermann, G. Davis, and A.M. Wheatley Effect of ischemia-reperfusion injury on the microcirculation of the steatotic liver of the Zucker rat Transplantation 72 2001 1625 1631
46. Z. Sun, A.S. Klein, S. Radaeva, F. Hong, O. El-Assal, H.-N. Pan, B. Jaruga, S. Batkai, S. Hoshino, Z. Tian, G. Kunos, A.M. Diehl, and B. Gao In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats Gastroenterology 125 2003 202 215
47. T. Taga, and T. Kishimoto gp130 and the interleukin-6 family of cytokines Annu Rev Immunol 15 1997 797 819
48. R. Taub Hepatoprotection via the IL-6/Stat3 pathway J Clin Invest 112 2003 978 980
49. K. Teramoto, J.L. Bowers, J.B. Kruskal, and M.E. Clouse Hepatic microcirculatory changes after reperfusion in fatty and normal liver transplantation in the rat Transplantation 56 1993 1076 1082
50. S. Todo, A.J. Demetris, L. Makowka, L. Teperman, L. Podesta, T. Shaver, A. Tzakis, and T.E. Starzl Primary nonfunction of hepatic allografts with preexisting fatty infiltration Transplantation 47 1989 903 905
51. T. Wuestefeld, C. Klein, K.L. Streetz, U. Betz, J. Lauber, J. Buer, M.P. Manns, W. Müller, and C. Trautwein Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration J Biol Chem 278 2003 11281 11288
52. I. Yokoyama, T. Kobayashi, M. Negita, S. Hayashi, M. Yasutomi, A. Katayama, K. Uchida, and H. Takagi Liberation of vasoactive substances and its prevention with thromboxane A2 synthase inhibitor in pig liver transplantation Transpl Int 9 1996 76 81
53. F. Zamboni, A. Franchello, E. David, G. Rocca, A. Ricchiuti, B. Lavezzo, M. Rizzetto, and M. Salizzoni Effect of macrovescicular steatosis and other donor and recipient characteristics on the outcome of liver transplantation Clin Transplant 15 2001 53 57
54. Z. Zhong, and J.J. Lemasters Role of free radicals in failure of fatty liver grafts caused by ethanol Alcohol 34 2004 49 58