Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis

Journal of Hepatology

Volumn 43, Issue 4, 2005, Pages 687-695

  Stärkel, Peter ^a   De Saeger, Christine ^a   Leclercq, Isabelle ^a   Strain, Alastair ^b   Horsmans, Yves ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Alcohol; Apoptosis; Cell cycle; Cirrhosis; Hepatitis C; Transcription factors

Indexed keywords

CASPASE 3; CYCLIN D1; PROTEIN; PROTEIN BCL 2; PROTEIN PIAS3; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; UNCLASSIFIED DRUG;

ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; HEPATITIS C; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

APOPTOSIS; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEPATITIS C; HUMANS; LIVER CIRRHOSIS; LIVER CIRRHOSIS, ALCOHOLIC; LIVER TRANSPLANTATION; MOLECULAR CHAPERONES; PROTEIN INHIBITORS OF ACTIVATED STAT;

EID: 24344465888     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2005.03.024     Document Type: Article

References (46)

1. A.J. Strain A.M. Diehl Liver growth and repair 1998 Chapman and Hall London
2. R. Taub Hepatoprotection via the IL-6/Stat3 pathway J Clin Invest 112 2003 978 980
3. R.H. Costa, V.V. Kalinichenko, A.X. Holterman, and X. Wang Transcription factors in liver development, differentiation, and regeneration Hepatology 38 2003 1331 1347
4. D. Mangnall, N.C. Bird, and A.W. Majeed The molecular physiology of liver regeneration following partial hepatectomy Liver Int 23 2003 124 138
5. Y. Yamada, I. Kirillova, J.J. Peschon, and N. Fausto Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor Proc Natl Acad Sci USA 94 1997 1441 1446
6. D.E. Cressman, L.E. Greenbaum, R.A. DeAgelis, G. Ciliberto, E.E. Furth, and V. Poli Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice Science 274 1996 1379 1383
7. J. Chen, H. Bao, S. Sawyer, G. Kunos, and B. Gao Effects of short and long term ethanol on the activation of signal transducer and activator transcription factor 3 in normal and regenerating liver Biochem Biophys Res Commun 239 1997 666 669
8. J. Chen, G. Kunos, and B. Gao Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes FEBS Lett 457 1999 162 168
9. M. Degawa-Yamauchi, S. Uotani, Y. Yamaguchi, R. Takahashi, T. Abe, and H. Kuwahara Ethanol inhibits leptin-induced STAT3 activation in Huh7 cells FEBS Lett 525 2002 116 120
10. Jaruga B, Hong F, Kim WH, Sun R, Fan S, Gao B. Chronic alcohol consumption accelerates liver injury in t cell-mediated hepatitis: alcohol dysregulation of NF-kappa B and Stat signaling pathways. Am J Physiol Gastrointest Liver Physiol 2004;287:G471-G479.
11. A. Hosui, K. Ohkawa, H. Ishida, A. Sato, F. Nakanishi, and K. Ueda Hepatitis C virus core protein differently regulates the Jak-Stat signaling pathway under interleukin-6 and interferon-gamma stimuli J Biol Chem 278 2003 28562 28571
12. G. Waris, K.D. Tardif, and A. Siddiqui Endoplasmic reticulum (ER) stress: hepatitis C virus induces an ER-nucleus signal transduction pathway and activates NF-kappaB and Stat-3 Biochem Pharmacol 64 2002 1425 1430
13. T. Yoshida, T. Hanada, T. Tokuhisa, K. Kosai, M. Sata, and M. Kohara Activation of Stat3 by the hepatitis C virus core protein leads to cellular transformation J Exp Med 196 2002 641 653
14. G. Gong, G. Waris, R. Tanveer, and A. Siddiqui Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates Stat-3 and NF-kappa B Proc Natl Acad Sci USA 98 2001 9599 9604
15. A.K. Ghosh, R. Steele, K. Meyer, R Ray, and R.B. Ray Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth J Gen Virol 80 1999 1179 1183
16. N.A. Shackel, P.H. McGuinness, C.A. Abbott, M.D. Correll, and G.W. McCaughan Insights into pathobiology of hepatitis C virus-associated cirrhosis: analysis of intrahepatic differential gene expression Am J Pathol 160 2002 641 654
17. P. Papakyriakou, M. Tzardi, V. Valatas, P. Kanavaros, E. Karydi, and G. Notas Apoptosis and apoptosis related proteins in chronic viral liver disease Apoptosis 7 2002 133 141
18. A. Floreani, M. Guido, M. Bortolami, G. Della Zentil, C. Venturi, and N. Pennelli Relationship between apoptosis, tumor necrosis factor, and cell proliferation in chronic cholestasis Dig Liver Dis 33 2001 570 575
19. F. Farinati, R. Cardin, M. Fiorentino, A. D'errico, W. Grigioni, and A. Cecchet Imbalance between cytoproliferation and apoptosis in hepatitis C virus related chronic liver disease J Viral Hepat 8 2001 34 40
20. H. Bantel, and K. Schulze-Osthoff Apoptosis in hapatitis C virus infection Cell Death Differ 10 2003 S48 S58
21. R.B. Ray, K. Meyer, and R. Ray Suppression of apoptotic cell death by hepatitis C virus core protein Virology 226 1996 176 182
22. M.W. Smith, Z.N. Yue, M.J. Korth, H.A. Do, L. Boix, and N. Fausto Hepatitis C virus and liver disease: global transcriptional profile and identification of potential markers Hepatology 38 2003 1458 1467
23. J. Tinmouth, M. Lee, I.R. Wanless, F.W. Tsui, R. Inman, and E.J. Heathcote Apoptosis of biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis Liver 22 2002 228 234
24. G. Ballardini, M. Guidi, M. Susca, S. Ghetti, A. Grassi, and F. Lari Bile duct cell apoptosis is a rare event in primary biliary cirrhosis Dig Liver Dis 33 2001 151 156
25. A.C. Tsamandas, K. Thomopoulos, V. Zolota, T. Kourelis, T. Karatzas, and P. Ravazoula Potential role of bcl-2 and bax mRNA and protein expression in chronic hepatitis type B and C: a clinicopathologic study Mod Pathol 16 2003 1273 1288
26. P. Starkel, K. Bishop, Y. Horsmans, and A.J. Strain Expression and DNA-binding activity of signal transducer and activator of transcription 3 in alcoholic cirrhosis compared to normal liver and primary biliary cirrhosis in humans Am J Pathol 162 2003 587 596
27. C. Picard, L. Lambotte, P. Starkel, C. Sempoux, A. Saliez, and V. Van den Berghe Retrorsine: a kinetic study of its influence on rat liver regeneration in the portal branch ligation model J Hepatol 39 2003 99 105
28. S. Gisselbrecht The CIS/SOCS proteins: a family of cytokine-indcible regulators of signaling Eur Cytokine Netw 10 1999 463 470
29. H. Yasukawa, A. Sasaki, and A. Yoshimura Negative regulation of cytokine signaling pathways Annu Rev Immunol 18 2000 143 164
30. C. Schindler, and J.E. Darnell Transcriptional responses to polypeptide ligands: the JAK-STAT pathway Annu Rev Biochem 154 1995 294 300
31. C.D. Chung, J. Liao, B. Liu, X. Rao, P. Jay, and P. Berta Specific inhibition of Stat3 signal transduction by PIAS3 Science 278 1997 1803 1805
32. W. Li, X. Liang, C. Kellendonk, V. Poli, and R. Taub STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration J Biol Chem 277 2002 28411 28417
33. T. Wuestefeld, C. Klein, K.L. Streetz, U. Betz, J. Lauber, and J. Buer Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration J Biol Chem 278 2003 11281 11288
34. J.I. Leu, M.A. Crissey, J.P. Leu, G. Ciliberto, and R. Taub Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury Mol Cell Biol 21 2001 414 424
35. S. Haga, K. Terui, H.Q. Zhang, S. Enosawa, W. Ogawa, and H. Inoue Stat3 protects against Fas-induced liver injury by redox-dependent and-independent mechanisms J Clin Invest 112 2003 989 998
36. J.G. Bode, S. Ludwig, C. Ehrhardt, U. Albrecht, A. Erhardt, and F. Schaper IFN-alpha antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3 Fed Am Soc Exp Biol J 17 2003 488 490
37. A. Blindenbacher, F.H. Duong, L. Hunziker, S.T. Stutvoet, X. Wang, and L. Terracciano Expression of hepatitis c virus proteins inhibits interferon alpha signaling in the liver of transgenic mice Gastroenterology 124 2003 1465 1475
38. M.H. Heim, D. Moradpour, and H.E. Blum Expression of hepatitis C virus proteins inhibits signal transduction through the Jak-Stat pathway J Virol 73 1999 8469 8475
39. F.H. Duong, M. Filipowicz, M. Tripodi, N. La Monica, and M.H. Heim Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A Gastroenterology 126 2004 263 277
40. M. Takada, K.C. Nadeau, W.W. Hancock, H.S. Mackenzie, G.D. Shaw, and A.M. Waaga Effects of explosive brain death on cytokine activation of peripheral organs in the rat Transplantation 65 1998 1533 1542
41. F. Hong, W.H. Kim, Z. Tian, B. Jaruga, E. Ishac, and X. Shen Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins Oncogene 21 2002 32 43
42. F. Hong, S. Radaeva, N.H. Pan, Z. Tian, R. Veech, and B. Gao Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease Hepatology 40 2004 933 941
43. L. Wang, and S. Banerjee Differential Pias3 expression in human malignancy Oncol Rep 11 2004 1319 1324
44. L. Nakopoulou, K. Stefanaki, C. Vourlakou, N. Manolaki, H. Gakiopoulou, and G. Michalopoulos Bcl-2 protein expression in acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma Pathol Res Pract 195 1999 19 24
45. M. Iwata, K. Harada, N. Kono, S. Kaneko, K. Kobayashi, and Y. Nakanuma Expression of Bcl-2 familial proteins is reduced in small bile duct lesions of primary biliary cirrhosis Hum Pathol 31 2000 179 184
46. H. Koga, S. Sakisaka, M. Ohishi, M. Sata, and K. Tanikawa Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis Hepatology 25 1997 1077 1084