Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis

Journal of Hepatology

Volumn 34, Issue 2, 2001, Pages 248-253

  Natori, Shiho ^a   Rust, Christian ^a   Stadheim, Linda M ^a   Srinivasan, Anu ^b   Burgart, Lawrence J ^c   Gores, Gregory J ^a  

^a MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^b PFIZER INC   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Bilirubin; Caspase 3; Fas; Tumor necrosis factor

Indexed keywords

BILIRUBIN; CASPASE 3; FAS ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ALCOHOL LIVER DISEASE; APOPTOSIS; ARTICLE; BILIRUBIN BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FATTY LIVER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER BIOPSY; LIVER CELL DAMAGE; LIVER INJURY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTIGENS, CD; ANTIGENS, CD95; APOPTOSIS; CASE-CONTROL STUDIES; CASPASE 3; CASPASES; HEPATITIS, ALCOHOLIC; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MODELS, BIOLOGICAL; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; UP-REGULATION;

EID: 0035111054     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)00089-1     Document Type: Article

References (31)

1. The treatment of alcoholic hepatitis
2. Alcoholic hepatitis: Clinicopathologic features and therapy
3. Alcoholic hepatitis
4. Nuclear changes in apoptosis
5. Inhibition of apoptosis induced by ischemia-reperfusion prevents inflammation
6. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis
7. Apoptosis is induced by transforming growth factor-beta 1 within 5 hours in regressing liver without significant fragmentation of the DNA
8. Liver apoptosis
9. Lethal effect of the anti-Fas antibody in mice
10. Dysregulation of apoptosis as a mechanism of liver disease: An overview
11. Apoptosis and alcoholic liver disease
12. Apoptotic bodies in a routine model of alcoholic liver disease: Reversibility of ethanol-induced changes
13. Is apoptosis involved in alcoholic hepatitis?
14. Histological grading and staging of chronic hepatitis
15. Measurement of cell death
16. Caspases: The executioners of apoptosis
17. Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication
18. Chronic ethanol feeding increases apoptosis and cell proliferation in rat liver
19. Ethanol administration results in increased susceptibility to apoptosis in isolated rat hepatocytes
20. Cytochrome P450 2E1: Its physiological and pathophysiological role
21. Ethanol-inducible cytochrome P450 2E1: Regulation, enzymology and molecular biology
22. The central executioners of apoptosis: Caspases or mitochondria?
23. Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage
24. Modulation of caspase-3 activity and Fas ligand mRNA expression in rat liver cells in vivo by alcohol and llpopolysaccharide
25. Involvement of the CD95 system in alcohol-induced liver damage
26. Raised plasma soluble Fas and Fas-ligand in alcoholic liver disease
27. Selective glutathione depletion of mitochondria by ethanol sensitizes hepatocytes to tumor necrosis factor
28. Increased plasma tumor necrosis factor in severe alcoholic hepatitis
29. Cytokines in alcoholic liver disease
30. Glucocorticoids are ineffective in alcoholic hepatitis: A meta-analysis adjusting for confounding variables
31. Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat