-
1
-
-
37749053679
-
Determinants of alcohol use and abuse: impact of quantity and frequency patterns on liver disease
-
Zakhari S., and Li T.K. Determinants of alcohol use and abuse: impact of quantity and frequency patterns on liver disease. Hepatology 46 (2007) 2032-2039
-
(2007)
Hepatology
, vol.46
, pp. 2032-2039
-
-
Zakhari, S.1
Li, T.K.2
-
2
-
-
33748301260
-
Global challenges in liver disease
-
Williams R. Global challenges in liver disease. Hepatology 44 (2006) 521-526
-
(2006)
Hepatology
, vol.44
, pp. 521-526
-
-
Williams, R.1
-
3
-
-
0035013288
-
Current concepts in the pathogenesis of alcoholic liver injury
-
Tsukamoto H., and Lu S.C. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J 15 (2001) 1335-1349
-
(2001)
FASEB J
, vol.15
, pp. 1335-1349
-
-
Tsukamoto, H.1
Lu, S.C.2
-
4
-
-
33644527617
-
Alcohol and oxidative liver injury
-
Dey A., and Cederbaum A.I. Alcohol and oxidative liver injury. Hepatology 43 (2006) S63-S74
-
(2006)
Hepatology
, vol.43
-
-
Dey, A.1
Cederbaum, A.I.2
-
5
-
-
33748892142
-
Review article: alcoholic liver disease-pathophysiological aspects and risk factors
-
Gramenzi A., Caputo F., Biselli M., et al. Review article: alcoholic liver disease-pathophysiological aspects and risk factors. Aliment Pharmacol Ther 24 (2006) 1151-1161
-
(2006)
Aliment Pharmacol Ther
, vol.24
, pp. 1151-1161
-
-
Gramenzi, A.1
Caputo, F.2
Biselli, M.3
-
6
-
-
0037371816
-
Oxidants and antioxidants in alcohol-induced liver disease
-
Arteel G.E. Oxidants and antioxidants in alcohol-induced liver disease. Gastroenterology 124 (2003) 778-790
-
(2003)
Gastroenterology
, vol.124
, pp. 778-790
-
-
Arteel, G.E.1
-
7
-
-
0036017180
-
Ethanol, oxidative stress, and cytokine-induced liver cell injury
-
Hoek J.B., and Pastorino J.G. Ethanol, oxidative stress, and cytokine-induced liver cell injury. Alcohol 27 (2002) 63-68
-
(2002)
Alcohol
, vol.27
, pp. 63-68
-
-
Hoek, J.B.1
Pastorino, J.G.2
-
8
-
-
0141625009
-
Recent insights into the role of the innate immune system in the development of alcoholic liver disease
-
Nagy L.E. Recent insights into the role of the innate immune system in the development of alcoholic liver disease. Exp Biol Med (Maywood) 228 (2003) 882-890
-
(2003)
Exp Biol Med (Maywood)
, vol.228
, pp. 882-890
-
-
Nagy, L.E.1
-
9
-
-
0037087374
-
Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice
-
Uesugi T., Froh M., Arteel G.E., et al. Role of lipopolysaccharide-binding protein in early alcohol-induced liver injury in mice. J Immunol 168 (2002) 2963-2969
-
(2002)
J Immunol
, vol.168
, pp. 2963-2969
-
-
Uesugi, T.1
Froh, M.2
Arteel, G.E.3
-
10
-
-
0032835529
-
Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice
-
Yin M., Wheeler M.D., Kono H., et al. Essential role of tumor necrosis factor alpha in alcohol-induced liver injury in mice. Gastroenterology 117 (1999) 942-952
-
(1999)
Gastroenterology
, vol.117
, pp. 942-952
-
-
Yin, M.1
Wheeler, M.D.2
Kono, H.3
-
11
-
-
4043064391
-
Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury
-
Ji C., Deng Q., and Kaplowitz N. Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. Hepatology 40 (2004) 442-451
-
(2004)
Hepatology
, vol.40
, pp. 442-451
-
-
Ji, C.1
Deng, Q.2
Kaplowitz, N.3
-
12
-
-
24144496133
-
Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice
-
You M., Considine R.V., Leone T.C., et al. Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice. Hepatology 42 (2005) 568-577
-
(2005)
Hepatology
, vol.42
, pp. 568-577
-
-
You, M.1
Considine, R.V.2
Leone, T.C.3
-
13
-
-
0041302377
-
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
-
Xu A., Wang Y., Keshaw H., et al. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 112 (2003) 91-100
-
(2003)
J Clin Invest
, vol.112
, pp. 91-100
-
-
Xu, A.1
Wang, Y.2
Keshaw, H.3
-
14
-
-
0037011992
-
Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins
-
Hong F., Kim W.H., Tian Z., et al. Elevated interleukin-6 during ethanol consumption acts as a potential endogenous protective cytokine against ethanol-induced apoptosis in the liver: involvement of induction of Bcl-2 and Bcl-x(L) proteins. Oncogene 21 (2002) 32-43
-
(2002)
Oncogene
, vol.21
, pp. 32-43
-
-
Hong, F.1
Kim, W.H.2
Tian, Z.3
-
15
-
-
4644237206
-
Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
-
Hong F., Radaeva S., Pan H.N., et al. Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease. Hepatology 40 (2004) 933-941
-
(2004)
Hepatology
, vol.40
, pp. 933-941
-
-
Hong, F.1
Radaeva, S.2
Pan, H.N.3
-
16
-
-
0038575467
-
In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats
-
Sun Z., Klein A.S., Radaeva S., et al. In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. Gastroenterology 125 (2003) 202-215
-
(2003)
Gastroenterology
, vol.125
, pp. 202-215
-
-
Sun, Z.1
Klein, A.S.2
Radaeva, S.3
-
17
-
-
32944463507
-
Cytokines, STATs and liver disease
-
Gao B. Cytokines, STATs and liver disease. Cell Mol Immunol 2 (2005) 92-100
-
(2005)
Cell Mol Immunol
, vol.2
, pp. 92-100
-
-
Gao, B.1
-
18
-
-
0037784230
-
Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases
-
Streetz K.L., Tacke F., Leifeld L., et al. Interleukin 6/gp130-dependent pathways are protective during chronic liver diseases. Hepatology 38 (2003) 218-229
-
(2003)
Hepatology
, vol.38
, pp. 218-229
-
-
Streetz, K.L.1
Tacke, F.2
Leifeld, L.3
-
19
-
-
0035131190
-
Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver
-
Alonzi T., Maritano D., Gorgoni B., et al. Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol Cell Biol 21 (2001) 1621-1632
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1621-1632
-
-
Alonzi, T.1
Maritano, D.2
Gorgoni, B.3
-
20
-
-
0037047360
-
STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
-
Li W., Liang X., Kellendonk C., et al. STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem 277 (2002) 28411-28417
-
(2002)
J Biol Chem
, vol.277
, pp. 28411-28417
-
-
Li, W.1
Liang, X.2
Kellendonk, C.3
-
21
-
-
33847738629
-
Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation
-
Yeoh G.C., Ernst M., Rose-John S., et al. Opposing roles of gp130-mediated STAT-3 and ERK-1/2 signaling in liver progenitor cell migration and proliferation. Hepatology 45 (2007) 486-494
-
(2007)
Hepatology
, vol.45
, pp. 486-494
-
-
Yeoh, G.C.1
Ernst, M.2
Rose-John, S.3
-
22
-
-
0242348793
-
Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms
-
Haga S., Terui K., Zhang H.Q., et al. Stat3 protects against Fas-induced liver injury by redox-dependent and -independent mechanisms. J Clin Invest 112 (2003) 989-998
-
(2003)
J Clin Invest
, vol.112
, pp. 989-998
-
-
Haga, S.1
Terui, K.2
Zhang, H.Q.3
-
23
-
-
16844387413
-
The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury
-
Klein C., Wustefeld T., Assmus U., et al. The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury. J Clin Invest 115 (2005) 860-869
-
(2005)
J Clin Invest
, vol.115
, pp. 860-869
-
-
Klein, C.1
Wustefeld, T.2
Assmus, U.3
-
24
-
-
0043167910
-
Lack of gp130 expression in hepatocytes promotes liver injury
-
Streetz K.L., Wustefeld T., Klein C., et al. Lack of gp130 expression in hepatocytes promotes liver injury. Gastroenterology 125 (2003) 532-543
-
(2003)
Gastroenterology
, vol.125
, pp. 532-543
-
-
Streetz, K.L.1
Wustefeld, T.2
Klein, C.3
-
25
-
-
11144357516
-
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
-
Inoue H., Ogawa W., Ozaki M., et al. Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo. Nat Med 10 (2004) 168-174
-
(2004)
Nat Med
, vol.10
, pp. 168-174
-
-
Inoue, H.1
Ogawa, W.2
Ozaki, M.3
-
26
-
-
33746139034
-
Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies
-
Larrea E., Aldabe R., Molano E., et al. Altered expression and activation of signal transducers and activators of transcription (STATs) in hepatitis C virus infection: in vivo and in vitro studies. Gut 55 (2006) 1188-1196
-
(2006)
Gut
, vol.55
, pp. 1188-1196
-
-
Larrea, E.1
Aldabe, R.2
Molano, E.3
-
27
-
-
34447284943
-
Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation
-
Horiguchi N., Ishac E.J., and Gao B. Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation. Alcohol 41 (2007) 271-280
-
(2007)
Alcohol
, vol.41
, pp. 271-280
-
-
Horiguchi, N.1
Ishac, E.J.2
Gao, B.3
-
28
-
-
0037452789
-
STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity
-
Welte T., Zhang S.S., Wang T., et al. STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity. Proc Natl Acad Sci U S A 100 (2003) 1879-1884
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 1879-1884
-
-
Welte, T.1
Zhang, S.S.2
Wang, T.3
-
29
-
-
0033034365
-
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils
-
Takeda K., Clausen B.E., Kaisho T., et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10 (1999) 39-49
-
(1999)
Immunity
, vol.10
, pp. 39-49
-
-
Takeda, K.1
Clausen, B.E.2
Kaisho, T.3
-
30
-
-
0037047284
-
Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
-
You M., Fischer M., Deeg M.A., et al. Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277 (2002) 29342-29347
-
(2002)
J Biol Chem
, vol.277
, pp. 29342-29347
-
-
You, M.1
Fischer, M.2
Deeg, M.A.3
-
31
-
-
0034834253
-
Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide
-
Enomoto N., Schemmer P., Ikejima K., et al. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. Alcohol Clin Exp Res 25 (2001) 1360-1367
-
(2001)
Alcohol Clin Exp Res
, vol.25
, pp. 1360-1367
-
-
Enomoto, N.1
Schemmer, P.2
Ikejima, K.3
-
32
-
-
0036251153
-
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton J.D., Goldstein J.L., and Brown M.S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109 (2002) 1125-1131
-
(2002)
J Clin Invest
, vol.109
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
33
-
-
33749253713
-
Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
-
Ji C., Chan C., and Kaplowitz N. Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model. J Hepatol 45 (2006) 717-724
-
(2006)
J Hepatol
, vol.45
, pp. 717-724
-
-
Ji, C.1
Chan, C.2
Kaplowitz, N.3
-
34
-
-
0029797604
-
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
-
Shimano H., Horton J.D., Hammer R.E., et al. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98 (1996) 1575-1584
-
(1996)
J Clin Invest
, vol.98
, pp. 1575-1584
-
-
Shimano, H.1
Horton, J.D.2
Hammer, R.E.3
-
35
-
-
3142723189
-
Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
-
Ueki K., Kondo T., Tseng Y.H., et al. Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse. Proc Natl Acad Sci U S A 101 (2004) 10422-10427
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 10422-10427
-
-
Ueki, K.1
Kondo, T.2
Tseng, Y.H.3
-
36
-
-
12744276080
-
Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure
-
Gao B. Therapeutic potential of interleukin-6 in preventing obesity- and alcohol-associated fatty liver transplant failure. Alcohol 34 (2004) 59-65
-
(2004)
Alcohol
, vol.34
, pp. 59-65
-
-
Gao, B.1
-
37
-
-
33947384599
-
Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats
-
Roglans N., Vila L., Farre M., et al. Impairment of hepatic Stat-3 activation and reduction of PPARalpha activity in fructose-fed rats. Hepatology 45 (2007) 778-788
-
(2007)
Hepatology
, vol.45
, pp. 778-788
-
-
Roglans, N.1
Vila, L.2
Farre, M.3
-
38
-
-
33947320624
-
Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice
-
Pritchard M.T., McMullen M.R., Stavitsky A.B., et al. Differential contributions of C3, C5, and decay-accelerating factor to ethanol-induced fatty liver in mice. Gastroenterology 132 (2007) 1117-1126
-
(2007)
Gastroenterology
, vol.132
, pp. 1117-1126
-
-
Pritchard, M.T.1
McMullen, M.R.2
Stavitsky, A.B.3
-
39
-
-
11144353882
-
Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury
-
Okada S., Nakamura M., Mikami Y., et al. Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury. J Neurosci Res 76 (2004) 265-276
-
(2004)
J Neurosci Res
, vol.76
, pp. 265-276
-
-
Okada, S.1
Nakamura, M.2
Mikami, Y.3
-
40
-
-
34447342587
-
Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization
-
Izumi-Nagai K., Nagai N., Ozawa Y., et al. Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization. Am J Pathol 170 (2007) 2149-2158
-
(2007)
Am J Pathol
, vol.170
, pp. 2149-2158
-
-
Izumi-Nagai, K.1
Nagai, N.2
Ozawa, Y.3
-
41
-
-
3042824524
-
Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway
-
Feldstein A.E., Werneburg N.W., Canbay A., et al. Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway. Hepatology 40 (2004) 185-194
-
(2004)
Hepatology
, vol.40
, pp. 185-194
-
-
Feldstein, A.E.1
Werneburg, N.W.2
Canbay, A.3
-
42
-
-
34250356015
-
Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
-
Yamaguchi K., Yang L., McCall S., et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology 45 (2007) 1366-1374
-
(2007)
Hepatology
, vol.45
, pp. 1366-1374
-
-
Yamaguchi, K.1
Yang, L.2
McCall, S.3
-
43
-
-
21244472975
-
IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
-
Maeda S., Kamata H., Luo J.L., et al. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121 (2005) 977-990
-
(2005)
Cell
, vol.121
, pp. 977-990
-
-
Maeda, S.1
Kamata, H.2
Luo, J.L.3
-
44
-
-
28544446111
-
Monocyte and macrophage heterogeneity
-
Gordon S., and Taylor P.R. Monocyte and macrophage heterogeneity. Nat Rev Immunol 5 (2005) 953-964
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 953-964
-
-
Gordon, S.1
Taylor, P.R.2
-
45
-
-
4444281108
-
The role of STATs in inflammation and inflammatory diseases
-
Pfitzner E., Kliem S., Baus D., et al. The role of STATs in inflammation and inflammatory diseases. Curr Pharm Des 10 (2004) 2839-2850
-
(2004)
Curr Pharm Des
, vol.10
, pp. 2839-2850
-
-
Pfitzner, E.1
Kliem, S.2
Baus, D.3
-
46
-
-
36348995922
-
Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice
-
Sakamori R., Takehara T., Ohnishi C., et al. Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice. Hepatology 46 (2007) 1564-1573
-
(2007)
Hepatology
, vol.46
, pp. 1564-1573
-
-
Sakamori, R.1
Takehara, T.2
Ohnishi, C.3
-
47
-
-
10744231991
-
Endothelial cells require STAT3 for protection against endotoxin-induced inflammation
-
Kano A., Wolfgang M.J., Gao Q., et al. Endothelial cells require STAT3 for protection against endotoxin-induced inflammation. J Exp Med 198 (2003) 1517-1525
-
(2003)
J Exp Med
, vol.198
, pp. 1517-1525
-
-
Kano, A.1
Wolfgang, M.J.2
Gao, Q.3
-
48
-
-
0036694589
-
IL-6 in autoimmune disease and chronic inflammatory proliferative disease
-
Ishihara K., and Hirano T. IL-6 in autoimmune disease and chronic inflammatory proliferative disease. Cytokine Growth Factor Rev 13 (2002) 357-368
-
(2002)
Cytokine Growth Factor Rev
, vol.13
, pp. 357-368
-
-
Ishihara, K.1
Hirano, T.2
-
50
-
-
0034284540
-
IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3
-
Shen X., Hong F., Nguyen V.A., et al. IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. FEBS Lett 480 (2000) 132-136
-
(2000)
FEBS Lett
, vol.480
, pp. 132-136
-
-
Shen, X.1
Hong, F.2
Nguyen, V.A.3
-
51
-
-
24344465888
-
Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis
-
Starkel P., De Saeger C., Leclercq I., et al. Deficient Stat3 DNA-binding is associated with high Pias3 expression and a positive anti-apoptotic balance in human end-stage alcoholic and hepatitis C cirrhosis. J Hepatol 43 (2005) 687-695
-
(2005)
J Hepatol
, vol.43
, pp. 687-695
-
-
Starkel, P.1
De Saeger, C.2
Leclercq, I.3
|