Acetaldehyde and malondialdehyde react together to generate distinct protein adducts in the liver during long-term ethanol administration

Hepatology

Volumn 23, Issue 4, 1996, Pages 872-880

  Tuma, Dean J ^a,b,c   Thiele, Geoffrey M ^a,b   Xu, Dongsheng ^a,b   Klassen, Lynell W ^a,b   Sorrell, Michael F ^a,b  

^a VA Alcohol Research Center   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; BOVINE SERUM ALBUMIN; CARRIER PROTEIN; LIVER PROTEIN; MALONALDEHYDE; POLYCLONAL ANTIBODY;

ALCOHOL LIVER DISEASE; ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOGENICITY; LIPID PEROXIDATION; LIVER CYTOSOL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT;

EID: 0030001945     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v23.pm0008666344     Document Type: Article

References (10)

1. 14C]acetaldehyde to serum albumin. Arch Biochem Biophys 1983;220:239-246.
2. Tuma DJ, Newman MR, Donohue TM, Sorrell MF. Covalent binding of acetaldehyde to proteins: participation of lysine residues. Alcohol Clin Exp Res 1987;11:579-584.
3. Stevens VJ, Fantl WJ, Newman CB, Sims RV, Cerami A, Peterson CM. Acetaldehyde adducts with hemoglobin. J Clin Invest 1981;67:361-369.
4. Sorrell MF, Tuma DJ. Hypothesis: alcoholic liver injury and the covalent binding of acetaldehyde. Alcohol Clin Exp Res 1985;9:306-309.
5. Lin RC, Smith RS, Lumeng L. Detection of a protein-acetaldehyde adduct in the liver of rats fed alcohol chronically. J Clin Invest 1988;81:615-619.
6. Behrens UJ, Hoerner M, Lasker JM, Lieber CS. Formation of acetaldehyde adducts with ethanol-inducible P450IIE1 in vivo. Biochem Biophys Res Commun 1988;154:584-590.
7. Worrall S, De Jersey J, Shanley BC, Wilce PA. Detection of stable acetaldehyde-modified proteins in the livers of ethanol-fed rats. Alcohol Alcohol 1991;26:437-444.
8. Yokoyama H, Ishii H, Nagata S, Kato S, Tsuchiya M. Evidence for acetaldehyde adduct formation in hepatic microsomes and cytosol of guinea pig after chronic ethanol administration. Res Commun Subst Abuse 1991;12:173-180.
9. Niemela O, Juvonen T, Parkkila S. Immunohistochemical demonstration of acetaldehyde-modified epitopes in human liver after alcohol consumption. J Clin Invest 1991;87:1367-1374.
10. Tuma DJ, Sorrell MF. The role of acetaldehyde adducts in liver injury. In: Hall P, ed. Alcoholic liver disease: pathology and pathogenesis. 2nd ed. London: Edward Arnold; 1995:89-99.