Detection of circulating antibodies against malondialdehyde-acetaldehyde adducts in patients with alcohol-induced liver disease

Hepatology

Volumn 31, Issue 4, 2000, Pages 878-884

  Rolla, Roberta ^a   Vay, Daria ^a   Mottaran, Elisa ^a   Parodi, Monica ^a   Traverso, Nicola ^b   Aricó, Sarino ^c   Sartori, Massimo ^a   Bellomo, Giorgio ^a   Klassen, Lynell W ^d   Thiele, Geoffrey M ^d   Tuma, Dean J ^d   Albano, Emanuele ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

^c MAURIZIANO HOSPITAL   (Italy)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ALCOHOL; ALDEHYDE DERIVATIVE; IMMUNOGLOBULIN G; MALONALDEHYDE; MALONALDEHYDE ACETALDEHYDE ADDUCT; UNCLASSIFIED DRUG;

ADULT; AGED; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; ANALYTIC METHOD; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPLEX FORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; IMMUNE RESPONSE; MALE; PRIORITY JOURNAL;

EID: 17544373959     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/he.2000.5373     Document Type: Article

References (6)

1. Paronetto F. Immunologic reactions in alcoholic liver disease. Semin Liver Dis 1993;13:183-195.
2. Klassen LW, Tuma D, Sorrell MF. Immune mechanisms of alcohol-induced liver disease. HEPATOLOGY 1995;22:355-357.
3. Tuma D, Klassen LW. Immune response to acetaldehyde-protein adducts in alcoholic liver disease. Gastroenterology 1992;103:1969-1973.
4. Nicholls R, De Jersey J, Worrall S, Wilce P. Modification of proteins and other biological molecules by acetaldehyde: adduct structure and functional significance. Int J Biochem 1992;24:1899-1906.
5. Israel Y, Hurwitz E, Niemela O, Arnon R. Monoclonal and polyclonal antibodies against acetaldehyde-containing epitopes in acetaldehyde-protein adducts. Proc Natl Acad Sci U S A 1986;83:7923-7927.
6. Worrall S, De Jersey J, Shanley BC, Wilce PA. Ethanol induces the production of antibodies to acetaldehyde-modified epitopes in rats. Alcohol Alcohol 1989;24:217-223.