Reactive oxygen species and NADPH oxidase 4 induced by transforming growth factor β1 are the therapeutic targets of polyenylphosphatidylcholine in the suppression of human hepatic stellate cell activation

Inflammation Research

Volumn 60, Issue 6, 2011, Pages 597-604

  Ikeda, Remina ^a   Ishii, Kyoko ^a   Hoshikawa, Yoshiko ^a   Azumi, Junya ^a   Arakaki, Yuta ^a   Yasui, Toshihiro ^a   Matsuura, Shizuka ^a   Matsumi, Yoshiaki ^a   Kono, Yohei ^a   Mizuta, Yusuke ^a   Kurimasa, Akihiro ^a   Hisatome, Ichiro ^a   Friedman, Scott L ^b   Kawasaki, Hironaka ^c   Shiota, Goshi ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c SAN IN ROSAI HOSPITAL   (Japan)

Author keywords

Hepatic stellate cells; NADPH oxidase 4; Oxidative stress; Polyenylphosphatidylcholine

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLCHOLINE; POLYENE PHOSPHATIDYLCHOLINE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STELLATE CELL;

CELL LINE; HEPATIC STELLATE CELLS; HUMANS; NADPH OXIDASE; PHOSPHATIDYLCHOLINES; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79956224825     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-011-0309-6     Document Type: Article

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