High glucose stimulates TNFα and MCP-1 expression in rat microglia via ROS and NF-κB pathways

Acta Pharmacologica Sinica

Volumn 32, Issue 2, 2011, Pages 188-193

  Quan, Yi ^a   Jiang, Chang Tao ^a   Xue, Bing ^b   Zhu, Shi Gong ^a   Wang, Xian ^a,b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

high glucose; microglia; NF B; reactive oxygen species; tumor necrosis factor monocyte chemotactic protein 1

Indexed keywords

GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; IN VITRO STUDY; MICROGLIA; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANIMALS; CELLS, CULTURED; CHEMILUMINESCENT MEASUREMENTS; CHEMOKINE CCL2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCOSE; INFLAMMATION MEDIATORS; MICROGLIA; NF-KAPPA B; POLYMERASE CHAIN REACTION; RATS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79551671360     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.174     Document Type: Article

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