Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

Toxicon

Volumn 60, Issue 4, 2012, Pages 478-491

  Klint, Julie K ^a   Senff, Sebastian ^a   Rupasinghe, Darshani B ^a   Er, Sing Yan ^a   Herzig, Volker ^a   Nicholson, Graham M ^b   King, Glenn F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

Author keywords

Analgesic; ArachnoServer; Inhibitor cystine knot; Insecticide; Na V1.7; Peptide; Spider venom; Therapeutic; Voltage gated sodium channel

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CONOTOXIN; CYSTEINE; DELTA CONOTOXIN PN2A; HUWENTOXIN 1; INSECTICIDE; NASPTX FAMILY 1 PROTEIN; NASPTX FAMILY 10 PROTEIN; NASPTX FAMILY 11 PROTEIN; NASPTX FAMILY 12 PROTEIN; NASPTX FAMILY 2 PROTEIN; NASPTX FAMILY 3 PROTEIN; NASPTX FAMILY 4 PROTEIN; NASPTX FAMILY 5 PROTEIN; NASPTX FAMILY 6 PROTEIN; NASPTX FAMILY 7 PROTEIN; NASPTX FAMILY 8 PROTEIN; NASPTX FAMILY 9 PROTEIN; PEPTIDE; ROBUSTOXIN; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.3; SPIDER VENOM; SPIDER VENOM PEPTIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ACTION POTENTIAL; AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE DEPOLARIZATION; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONSENSUS SEQUENCE; DISULFIDE BOND; ENVENOMATION; IC 50; LD 50; NEUROTOXICITY; NONHUMAN; PAIN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; SODIUM CURRENT; SPIDER; SPIDER BITE;

AMINO ACID SEQUENCE; ANIMALS; DRUG DISCOVERY; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; PEPTIDES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS; SPIDERS;

ANIMALIA; ARANEAE; HEXAPODA; INVERTEBRATA; VERTEBRATA;

EID: 84863777217     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2012.04.337     Document Type: Article

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