Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels

Journal of Biological Chemistry

Volumn 282, Issue 7, 2007, Pages 4643-4652

  Corzo, Gerardo ^a,b   Sabo, Jennifer K ^c   Bosmans, Frank ^d,f   Billen, Bert ^d   Villegas, Elba ^e   Tytgat, Jan ^d   Norton, Raymond S ^c  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MÉXICO   (Mexico)

^f NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CENTRUROIDES SUFFUSUS SUFFUSUS; SOLUTION STRUCTURE; SPIDER TOXINS; TOXIN CHANNEL INTERACTIONS;

ACTIVATION ANALYSIS; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; PROTEINS; SODIUM COMPOUNDS; VIRUSES;

POLYPEPTIDES;

ALANINE; ATRACOTOXIN; JANUS KINASE; PROTEIN MAGI 23; PROTEIN MAGI 5; SCORPION VENOM; SPIDER VENOM; TOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; CSS4 PROTEIN, CENTRUROIDES SUFFUSUS SUFFUSUS; SODIUM CHANNEL;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; ELECTROPHYSIOLOGY; HYDROPHOBICITY; MAMMAL; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; STRUCTURAL HOMOLOGY; STRUCTURE ANALYSIS; SURFACE CHARGE; ANIMAL; CELL MEMBRANE POTENTIAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

ARANEAE; CENTRUROIDES SUFFUSUS SUFFUSUS; HEXAPODA; HEXATHELIDAE; MACROTHELE GIGAS; MAMMALIA; SCORPIONES;

ANIMALS; HUMANS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; SCORPION VENOMS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; SPIDER VENOMS; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 33947540122     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M605403200     Document Type: Article

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