Target promiscuity and heterogeneous effects of tarantula venom peptides affecting Na+ and K+ ion channels

Journal of Biological Chemistry

Volumn 285, Issue 6, 2010, Pages 4130-4142

  Redaelli, Elisa ^a   Cassulini, Rita Restano ^a,b   Silva, Deyanira Fuentes ^c   Clement, Herlinda ^b   Schiavon, Emanuele ^a   Zamudio, Fernando Z ^b   Odell, George ^b   Arcangeli, Annarosa ^d   Clare, Jeffrey J ^e   Alago, Alejandro ^b   Rodríguez De La Vega, Ricardo C ^b,f   Possani, Lourival D ^b   Wanke, Enzo ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^c UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^d UNIVERSITY OF FLORENCE   (Italy)

^e GLAXOSMITHKLINE   (United Kingdom)

^f EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEX EFFECTS; EDMAN DEGRADATION; ELECTROPHYSIOLOGICAL TECHNIQUES; HETEROGENEOUS EFFECTS; ION CHANNEL; ION CONDUCTION; ION-CHANNEL GATING; ISOFORMS; MASS SPECTROMETRY ANALYSIS; MECHANISTIC INTERPRETATIONS; MODE OF ACTION; MOLECULAR MOTIONS; MULTIMODES; POSITIVE POTENTIAL; SEQUENCE DIVERSITY; SPIDER TOXINS; STRUCTURE-FUNCTION STUDIES; VOLTAGE GATED ION CHANNELS;

ANTIGENS; ETHERS; FEATURE EXTRACTION; MASS SPECTROMETRY; METABOLITES; PEPTIDES; TARGETS; TOXIC MATERIALS;

IONS;

POTASSIUM CHANNEL HERG; SHAKER POTASSIUM CHANNEL; SODIUM CHANNEL; SODIUM CHANNEL NAV1.1; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.3; SODIUM CHANNEL NAV1.4; SODIUM CHANNEL NAV1.5; SODIUM CHANNEL NAV1.6; SODIUM CHANNEL NAV1.7; SPIDER VENOM; TETRODOTOXIN; VOLTAGE GATED POTASSIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL; KCNH1 PROTEIN, HUMAN; PEPTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL BLOCKING AGENT;

ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; HUMAN; HUMAN CELL; INHIBITION KINETICS; ION CONDUCTANCE; MASS SPECTROMETRY; MOLECULAR MECHANICS; POISONOUS SPIDER; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN TARGETING; SEQUENCE ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; CELL MEMBRANE POTENTIAL; CHEMISTRY; CHO CELL; CRICETULUS; DRUG EFFECT; GENETICS; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; MOLECULAR GENETICS; PATCH CLAMP; PHYSIOLOGY;

ARANEAE; GRAMMOSTOLA; TARANTULA; THERAPHOSIDAE;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; CRICETULUS; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MASS SPECTROMETRY; MEMBRANE POTENTIALS; MOLECULAR SEQUENCE DATA; PATCH-CLAMP TECHNIQUES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; SEQUENCE ANALYSIS, PROTEIN; SHAKER SUPERFAMILY OF POTASSIUM CHANNELS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS;

EID: 77950513176     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.054718     Document Type: Article

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