Synthesis, solution structure, and phylum selectivity of a spider δ-toxin that slows inactivation of specific voltage-gated sodium channel subtypes

Journal of Biological Chemistry

Volumn 284, Issue 36, 2009, Pages 24568-24582

  Yamaji, Nahoko ^a   Little, Michelle J ^b   Nishio, Hideki ^c   Billen, Bert ^d   Villegas, Elba ^e   Nishiuchi, Yuji ^c   Tytgat, Jan ^d   Nicholson, Graham M ^b   Corzo, Gerardo ^f  

^a SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^b UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^c Protein Research Foundation   (Japan)

^d UNIVERSITY OF LEUVEN   (Belgium)

^e UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^f INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

BONDING PATTERNS; CHANNEL SELECTIVITY; CHANNEL STRUCTURES; GIGAS; HIGH AFFINITY; INSECT NEURONS; NERVE IMPULSE; NEUROTOXIC PEPTIDES; NMR SPECTROSCOPY; PEPTIDE TOXIN; RAT BRAIN; RECEPTOR SITES; SEQUENCE HOMOLOGY; SODIUM CHANNEL; SOLUTION STRUCTURES; SPECIFIC ACTIVITY; SPECIFIC TOOL; SPECIFIC VOLTAGES; THREE-DIMENSIONAL SOLUTIONS; WEB SPIDERS;

AMINES; MAMMALS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; SYNTHESIS (CHEMICAL); TOXIC MATERIALS;

SODIUM;

ALPHA TOXIN; DELTA HEXATOXIN MG1A; DISULFIDE; SPIDER VENOM; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL 1; VOLTAGE GATED SODIUM CHANNEL 1.1; VOLTAGE GATED SODIUM CHANNEL 1.3; VOLTAGE GATED SODIUM CHANNEL 1.6;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; INSECT CELL; MALE; NERVE CELL; NERVE CONDUCTION; NEWBORN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYLUM; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; SCORPION; SEQUENCE HOMOLOGY; SPIDER; TISSUE SPECIFICITY; TOXIN STRUCTURE; TOXIN SYNTHESIS;

ANIMALS; INSECT PROTEINS; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PERIPLANETA; PROTEIN STRUCTURE, TERTIARY; RATS; SODIUM CHANNELS; SPIDER VENOMS; XENOPUS LAEVIS;

ARANEAE; DIPLURIDAE; HEXAPODA; HEXATHELIDAE; MACROTHELE GIGAS; MAMMALIA; RATTUS; SCORPIONES;

EID: 69949170794     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.030841     Document Type: Article

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