Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes

Molecular Pharmacology

Volumn 69, Issue 2, 2006, Pages 419-429

  Bosmans, Frank ^b   Rash, Lachlan ^a   Zhu, Shunyi ^a,c   Diochot, Sylvie ^a   Lazdunski, Michel ^a   Escoubas, Pierre ^a   Tytgat, Jan ^b  

^a CNRS   (France)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c INSTITUTE OF ZOOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CERATOTOXIN 1; CERATOTOXIN 2; CERATOTOXIN 3; PHRIXOTOXIN 3; SPIDER VENOM; TETRODOTOXIN; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; CERATOGYRUS CORNUATUS; CONTROLLED STUDY; DEPOLARIZATION; ELECTROPHYSIOLOGY; IC 50; ISOLATION PROCEDURE; KINETICS; MEASUREMENT; MOLECULAR MODEL; MOUSE; NONHUMAN; OOCYTE; PHRIXOTRICHUS AURATUS; PRIORITY JOURNAL; SODIUM CURRENT; SPIDER; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; ARACHNIDA; CALCIUM; EVOLUTION, MOLECULAR; INHIBITORY CONCENTRATION 50; ION CHANNEL GATING; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; NEURONS; OOCYTES; PROTEIN CONFORMATION; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS; TOXINS, BIOLOGICAL; XENOPUS LAEVIS;

EID: 31044432475     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.015941     Document Type: Article

References (40)

1. Bosmans F, Aneiros A, and Tytgat J (2002) The sea anemone Bunodosoma granulifera contains surprisingly efficacious and potent insect-selective toxins. FEBS Lett 532:131-134.
2. V2.3) calcium channels. Biophys J 81:79-88.
3. Craik DJ, Daly NL, and Waine C (2001) The cystine knot motif in toxins and implications for drug design. Toxicon 39:43-60.
4. 2+ exchanger. Proc Natl Acad Sci USA 101:8168-8173.
5. + channels. J Biol Chem 275:25116-25121.
6. Escoubas P, Diochot S, Celerier ML, Nakajima T, and Lazdunski M (2002) Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol 62:48-57.
7. Escoubas P, Diochot S, and Corzo G (2000b) Structure and pharmacology of spider venom neurotoxins. Biochimie 82:893-907.
8. Escoubas P and Rash L (2004) Tarantulas: eight-legged pharmacists and combinatorial chemists. Toxicon 43:555-574.
9. French RJ and Terlau H (2004) Sodium channel toxins-receptor targeting and therapeutic potential. Curr Med Chem 11:3053-3064.
10. Head C and Gardiner M (2003) Paroxysms of excitement: sodium channel dysfunction in heart and brain. Bioessays 25:981-993.
11. Julius D and Basbaum AI (2001) Molecular mechanisms of nociception. Nature (Lond) 413:203-210.
12. Kayano T, Noda M, Flockerzi V, Takahashi H, and Numa S (1988) Primary structure of rat brain sodium channel III deduced from the cDNA sequence. FEBS Lett 228:187-194.
13. Lee CW, Kim S, Roh SH, Endoh H, Kodera Y, Maeda T, Kohno T, Wang JM, Swartz KJ, and Kim JI (2004) Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating. Biochemistry 43:890-897.
14. Lewis RJ and Garcia ML (2003) Therapeutic potential of venom peptides. Nat Rev Drug Discov 2:790-802.
15. Li D, Xiao Y, Hu W, Xie J, Bosmans F, Tytgat J, and Liang S (2003) Function and solution structure of hainantoxin-I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana. FEBS Lett 555:616-622.
16. Li D, Xiao Y, Xu X, Xiong X, Lu S, Liu Z, Zhu Q, Wang M, Gu X, and Liang S (2004) Structure-activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers. J Biol Chem 279:37734-37740.
17. + channels. Proc Natl Acad Sci USA 95:8585-8589.
18. McDonough SI, Lampe RA, Keith RA, and Bean BP (1997) Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin ω-grammotoxin-SIA. Mol Pharmacol 52:1095-1104.
19. Middleton RE, Warren VA, Kraus RL, Hwang JC, Liu CJ, Dai G, Brochu RM, Kohler MG, Gao YD, Garsky VM, et al. (2002) Two tarantula peptides inhibit activation of multiple sodium channels. Biochemistry 41:14734-14747.
20. Nassar MA, Stirling LC, Forlani G, Baker MD, Matthews EA, Dickenson AH, and Wood JN (2004) Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc Natl Acad Sci USA 101:12706-12711.
21. Newcomb R, Szoke B, Palma A, Wang G, Chen X, Hopkins W, Cong R, Miller J, Urge L, Tarczy-Hornoch K, et al. (1998) Selective peptide antagonist of the class E calcium channel from the venom of the tarantula Hysterocrates gigas. Biochemistry 37:15353-15362.
22. Peng K, Shu Q, Liu Z, and Liang S (2002) Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena. J Biol Chem 277:47564-47571.
23. +-channels. Eur J Biochem 264:287-300.
24. Rash LD and Hodgson WC (2002) Pharmacology and biochemistry of spider venoms. Toxicon 40:225-254.
25. Smith JJ, Alphy S, Seibert AL, and Blumenthal KM (2005) Differential phospholipid binding by site 3 and site 4 toxins: Implications for structural variability between voltage-sensitive sodium channel domains. J Biol Chem. 25:11127-11133.
26. Smith RD and Goldin AL (1998) Functional analysis of the rat I sodium channel in Xenopus oocytes. J Neurosci 18:811-820.
27. Sollod BL, Wilson D, Zhaxybayeva O, Gogarten JP, Drinkwater R, and King GF (2005) Were arachnids the first to use combinatorial peptide libraries? Peptides 26:131-139.
28. Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, and Sachs F (2000) Identification of a peptide toxin from Grammostola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol 115:583-598.
29. Swanson R, Marshall J, Smith JS, Williams JB, Boyle MB, Folander K, Luneau CJ, Antanavage J, Oliva C, Buhrow SA and et al. (1990) Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain. Neuron 4:929-939.
30. Swartz KJ and MacKinnon R (1995) An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15:941-949.
31. + channels: common surface features of gating modifier toxins. J Mol Biol 297:771-780.
32. Wang JM, Roh SH, Kim S, Lee CW, Kim JI, and Swartz KJ (2004) Molecular surface of tarantula toxins interacting with voltage sensors in K(v) channels. J Gen Physiol 123:455-467.
33. Wang SY and Wang GK (2003) Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cell Signal 15:151-159.
34. Winterfield JR and Swartz KJ (2000) A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels. J Gen Physiol 116:637-644.
35. Wood JN, Boorman JP, Okuse K, and Baker MD (2004) Voltage-gated sodium channels and pain pathways. J Neurobiol 61:55-71.
36. + channels by two spider toxins: hainantoxin-III and hainantoxin-IV. Eur J Pharmacol 477:1-7.
37. Xiao Y, Tang J, Yang Y, Wang M, Hu W, Xie J, Zeng X, and Liang S (2004) Jingzhaotoxin-III, a novel spider toxin inhibiting activation of voltage-gated sodium channel in rat cardiac myocytes. J Biol Chem 279:26220-26226.
38. Yu FH and Catterall WA (2003) Overview of the voltage-gated sodium channel family. Genome Biol 4:207.
39. Yu FH, Westenbroek RE, Silos-Santiago I, McCormick KA, Lawson D, Ge P, Ferriera H, Lilly J, DiStefano PS, Catterall WA, et al. (2003) Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2. J Neurosci 23:7577-7585.
40. Zhu S, Huys I, Dyason K, Verdonck F, and Tytgat J (2004) Evolutionary trace analysis of scorpion toxins specific for K-channels. Proteins 54:361-370.