Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana

Cellular and Molecular Life Sciences

Volumn 60, Issue 5, 2003, Pages 972-978

  Liu, Z ^a   Dai, J ^a   Chen, Z ^a   Hu, W ^a   Xiao, Y ^a   Liang, S ^a  

^a HUNAN NORMAL UNIVERSITY   (China)

Author keywords

Disulfide bridges; HNTX IV; HWTX IV; Inhibitor cystine knot (ICK) structural motif; Sodium channels; Spider toxin

Indexed keywords

HAINANTOXIN IV; HUWENTOIN IV; NEUROTOXIN; SODIUM CHANNEL; TETRODOTOXIN; UNCLASSIFIED DRUG;

AMIDATION; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; MALE; MASS SPECTROMETRY; NEUROTOXICITY; NONHUMAN; RAT; REDUCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SELENOCOSMIA HAINANA; SEQUENCE ANALYSIS; SPIDER; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; MICE; MOLECULAR SEQUENCE DATA; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPIDER VENOMS; SPIDERS; TETRODOTOXIN;

ANIMALIA; ARANEAE; AVES; INVERTEBRATA; ORNITHOCTONUS HAINANA; ORNITHOCTONUS HUWENA; THERAPHOSIDAE;

EID: 0038010666     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-003-2354-x     Document Type: Article

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