μo-Conotoxins inhibit Nav channels by interfering with their voltage sensors in domain-2

Channels

Volumn 1, Issue 4, 2007, Pages 253-262

  Leipold, Enrico ^a   De Bie, Herbert ^a   Zorn, Stefan ^a   Borges, Adolfo ^b   Olivera, Baldomero M ^c   Terlau, Heinrich ^d   Heinemann, Stefan H ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF LÜBECK   (Germany)

Author keywords

Conotoxin; Gating; Pain; Patch clamp; Sodium channel; Voltage sensor

Indexed keywords

CONOTOXIN; CONOTOXIN G3; MUO CONOTOXIN MRVIA; MUO-CONOTOXIN MRVIA; MUSCLE PROTEIN; NA(V)1.4 PROTEIN, RAT; SCORPION VENOM; SODIUM; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL; ARTICLE; CELL LINE; CELL MEMBRANE POTENTIAL; CHANNEL GATING; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MUTATION; PATCH CLAMP; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RAT; SITE DIRECTED MUTAGENESIS;

ANIMALS; CELL LINE; CONOTOXINS; HUMANS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PATCH-CLAMP TECHNIQUES; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; SCORPION VENOMS; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TRANSFECTION;

EID: 48249096854     PISSN: 19336950     EISSN: 19336969     Source Type: Journal    
DOI: 10.4161/chan.4847     Document Type: Article

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