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Volumn 4, Issue 1, 2012, Pages 38-47

Harnessing memory adaptive regulatory T cells to control autoimmunity in type 1 diabetes

Author keywords

adaptive regulatory T cells; autoimmunity; immunotherapy; type 1 diabetes

Indexed keywords

TRANSCRIPTION FACTOR FOXP3;

EID: 84863051225     PISSN: 16742788     EISSN: 17594685     Source Type: Journal    
DOI: 10.1093/jmcb/mjr040     Document Type: Review
Times cited : (16)

References (125)
  • 2
    • 0038638583 scopus 로고    scopus 로고
    • An epigenetic view of helper T cell differentiation
    • DOI 10.1038/ni0703-616
    • Ansel, K.M., Lee, D.U., and Rao, A. (2003). An epigenetic view of helper T cell differentiation. Nat. Immunol. 4, 616-623. (Pubitemid 36880738)
    • (2003) Nature Immunology , vol.4 , Issue.7 , pp. 616-623
    • Ansel, K.M.1    Lee, D.U.2    Rao, A.3
  • 3
    • 21244454753 scopus 로고    scopus 로고
    • Thirty years of investigating the autoimmune basis for type 1 diabetes: Why can't we prevent or reverse this disease?
    • DOI 10.2337/diabetes.54.5.1253
    • Atkinson, M.A. (2005). ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: Why can't we prevent or reverse this disease? Diabetes 54, 1253-1263. (Pubitemid 40586652)
    • (2005) Diabetes , vol.54 , Issue.5 , pp. 1253-1263
    • Atkinson, M.A.1
  • 4
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach, J.F. (2002). The effect of infections on susceptibility to autoimmune and allergic diseases. N. Engl. J. Med. 347, 911-920.
    • (2002) N. Engl. J. Med. , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 6
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    • Barrett, J.C., Clayton, D.G., Concannon, P., et al. (2009). Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat. Genet. 41, 703-707.
    • (2009) Nat. Genet. , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 9
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • DOI 10.1038/nri1032
    • Bluestone, J.A., and Abbas, A.K. (2003). Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3, 253-257. (Pubitemid 37323210)
    • (2003) Nature Reviews Immunology , vol.3 , Issue.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 11
    • 70149100480 scopus 로고    scopus 로고
    • + regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta
    • + regulatory T cell persistence and function via production of IL-2, IL-10, and TGF-beta. J. Immunol. 183, 2232-2241.
    • (2009) J. Immunol. , vol.183 , pp. 2232-2241
    • Bollyky, P.L.1    Falk, B.A.2    Long, S.A.3
  • 12
    • 33646392755 scopus 로고    scopus 로고
    • Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs
    • Bresson, D., Togher, L., Rodrigo, E., et al. (2006). Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J. Clin. Invest. 116, 1371-1381.
    • (2006) J. Clin. Invest. , vol.116 , pp. 1371-1381
    • Bresson, D.1    Togher, L.2    Rodrigo, E.3
  • 17
    • 79954559096 scopus 로고    scopus 로고
    • T-cell tolerance and themulti-functional role of IL-2R signaling in T-regulatory cells
    • Cheng, G., Yu, A., andMalek, T.R. (2011). T-cell tolerance and themulti-functional role of IL-2R signaling in T-regulatory cells. Immunol. Rev. 241, 63-76.
    • (2011) Immunol. Rev. , vol.241 , pp. 63-76
    • Cheng, G.1    Yu, A.2    Malek, T.R.3
  • 21
    • 33644666732 scopus 로고    scopus 로고
    • Antigen processing by autoreactive B cells promotes determinant spreading
    • Dai, Y.D., Carayanniotis, G., and Sercarz, E. (2005). Antigen processing by autoreactive B cells promotes determinant spreading. Cell. Mol. Immunol. 2, 169-175.
    • (2005) Cell. Mol. Immunol. , vol.2 , pp. 169-175
    • Dai, Y.D.1    Carayanniotis, G.2    Sercarz, E.3
  • 23
    • 56649095825 scopus 로고    scopus 로고
    • The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice
    • Dendrou, C.A., and Wicker, L.S. (2008). The IL-2/CD25 pathway determines susceptibility to T1D in humans and NOD mice. J. Clin. Immunol. 28, 685-696.
    • (2008) J. Clin. Immunol. , vol.28 , pp. 685-696
    • Dendrou, C.A.1    Wicker, L.S.2
  • 24
    • 79151474882 scopus 로고    scopus 로고
    • + T-cell clones specific for pancreatic islet autoantigens
    • + T-cell clones specific for pancreatic islet autoantigens. J. Autoimmun. 36, 47-55.
    • (2011) J. Autoimmun. , vol.36 , pp. 47-55
    • Dromey, J.A.1    Lee, B.H.2    Yu, H.3
  • 26
    • 67649170980 scopus 로고    scopus 로고
    • + regulatory T cells: Differentiation, specification, subphenotypes
    • + regulatory T cells: Differentiation, specification, subphenotypes. Nat. Immunol. 10, 689-695.
    • (2009) Nat. Immunol. , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3
  • 27
    • 77950527805 scopus 로고    scopus 로고
    • Genomic definition of multiple ex vivo regulatory T cell subphenotypes
    • Feuerer, M., Hill, J.A., Kretschmer, K., et al. (2010). Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc. Natl Acad. Sci. USA 107, 5919-5924.
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 5919-5924
    • Feuerer, M.1    Hill, J.A.2    Kretschmer, K.3
  • 28
    • 33846980131 scopus 로고    scopus 로고
    • Epigenetic control of the foxp3 locus in regulatory T cells
    • Floess, S., Freyer, J., Siewert, C., et al. (2007). Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 5, e38.
    • (2007) PLoS Biol. , vol.5
    • Floess, S.1    Freyer, J.2    Siewert, C.3
  • 30
    • 0019400455 scopus 로고
    • The pancreatic islets in diabetes
    • Gepts, W., and Lecompte, P.M. (1981). The pancreatic islets in diabetes. Am. J. Med. 70, 105-115.
    • (1981) Am. J. Med. , vol.70 , pp. 105-115
    • Gepts, W.1    Lecompte, P.M.2
  • 31
    • 49649095420 scopus 로고    scopus 로고
    • Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells
    • Godebu, E., Summers-Torres, D., Lin, M.M., et al. (2008). Polyclonal adaptive regulatory CD4 cells that can reverse type I diabetes become oligoclonal long-term protective memory cells. J. Immunol. 181, 1798-1805.
    • (2008) J. Immunol. , vol.181 , pp. 1798-1805
    • Godebu, E.1    Summers-Torres, D.2    Lin, M.M.3
  • 35
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3γ1(ala-ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes
    • DOI 10.2337/diabetes.54.6.1763
    • Herold, K.C., Gitelman, S.E., Masharani, U., et al. (2005). A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes. Diabetes 54, 1763-1769. (Pubitemid 40770766)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3    Hagopian, W.4    Bisikirska, B.5    Donaldson, D.6    Rother, K.7    Diamond, B.8    Harlan, D.M.9    Bluestone, J.A.10
  • 37
    • 79958814636 scopus 로고    scopus 로고
    • Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease
    • Hippen, K.L., Merkel, S.C., Schirm, D.K., et al. (2011a). Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am. J. Transplant. 11, 1148-1157.
    • (2011) Am. J. Transplant. , vol.11 , pp. 1148-1157
    • Hippen, K.L.1    Merkel, S.C.2    Schirm, D.K.3
  • 38
    • 82755197890 scopus 로고    scopus 로고
    • Clinical perspectives for regulatory T cells in transplantation tolerance
    • Hippen, K.L., Riley, J.L., June, C.H., et al. (2011b). Clinical perspectives for regulatory T cells in transplantation tolerance. Semin. Immunol. 23, 462-468.
    • (2011) Semin. Immunol. , vol.23 , pp. 462-468
    • Hippen, K.L.1    Riley, J.L.2    June, C.H.3
  • 39
    • 0031874342 scopus 로고    scopus 로고
    • Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry
    • DOI 10.1038/nm0798-781
    • Horwitz, M.S., Bradley, L.M., et al. (1998). Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry. Nat. Med. 4, 781-785. (Pubitemid 28331018)
    • (1998) Nature Medicine , vol.4 , Issue.7 , pp. 781-785
    • Horwitz, M.S.1    Bradley, L.M.2    Harbertson, J.3    Krahl, T.4    Lee, J.5    Sarvetnick, N.6
  • 41
    • 0034885547 scopus 로고    scopus 로고
    • + T cell effectors can become memory cells with high efficiency and without further division
    • DOI 10.1038/90643
    • + T cell effectors can become memory cells with high efficiency and without further division. Nat. Immunol. 2, 705-710. (Pubitemid 32747159)
    • (2001) Nature Immunology , vol.2 , Issue.8 , pp. 705-710
    • Hu, H.1    Huston, G.2    Duso, D.3    Lepak, N.4    Roman, E.5    Swain, S.L.6
  • 42
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz, S.Z., and Rudensky, A. (2009). Control of regulatory T cell lineage commitment and maintenance. Immunity 30, 616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2
  • 43
    • 0033853921 scopus 로고    scopus 로고
    • β-Cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy
    • Kassem, S.A., Ariel, I., Thornton, P.S., et al. (2000). Beta-cell proliferation and apoptosis in the developing normal human pancreas and in hyperinsulinism of infancy. Diabetes 49, 1325-1333. (Pubitemid 30624233)
    • (2000) Diabetes , vol.49 , Issue.8 , pp. 1325-1333
    • Kassem, S.A.1    Ariel, I.2    Thornton, P.S.3    Scheimberg, I.4    Glaser, B.5
  • 44
    • 78049320362 scopus 로고    scopus 로고
    • Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study
    • Keenan, H.A., Sun, J.K., Levine, J., et al. (2010). Residual insulin production and pancreatic ss-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes 59, 2846-2853.
    • (2010) Diabetes , vol.59 , pp. 2846-2853
    • Keenan, H.A.1    Sun, J.K.2    Levine, J.3
  • 46
    • 0037037541 scopus 로고    scopus 로고
    • Alpha E: No more rejection?
    • Kilshaw, P.J., and Higgins, J.M. (2002). Alpha E: No more rejection? J. Exp. Med. 196, 873-875.
    • (2002) J. Exp. Med. , vol.196 , pp. 873-875
    • Kilshaw, P.J.1    Higgins, J.M.2
  • 48
    • 34548751712 scopus 로고    scopus 로고
    • De novo production of antigen-specific suppressor cells in vivo
    • Kretschmer, K., Heng, T.S., and von Boehmer, H. (2006). De novo production of antigen-specific suppressor cells in vivo. Nat. Protoc. 1, 653-661.
    • (2006) Nat. Protoc. , vol.1 , pp. 653-661
    • Kretschmer, K.1    Heng, T.S.2    Von Boehmer, H.3
  • 50
    • 55449111318 scopus 로고    scopus 로고
    • +CD25 hi regulatory T cell-mediated suppression in patients with type 1 diabetes
    • +CD25 hi regulatory T cell-mediated suppression in patients with type 1 diabetes. Clin. Exp. Immunol. 154, 353-359.
    • (2008) Clin. Exp. Immunol. , vol.154 , pp. 353-359
    • Lawson, J.M.1    Tremble, J.2    Dayan, C.3
  • 51
    • 70349745490 scopus 로고    scopus 로고
    • T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event
    • Lennon, G.P., Bettini, M., Burton, A.R., et al. (2009). T cell islet accumulation in type 1 diabetes is a tightly regulated, cell-autonomous event. Immunity 31, 643-653.
    • (2009) Immunity , vol.31 , pp. 643-653
    • Lennon, G.P.1    Bettini, M.2    Burton, A.R.3
  • 52
    • 80755139636 scopus 로고    scopus 로고
    • + adaptive Treg cells that reverse diabetes in NOD mice via integrin-beta7-dependent localization
    • + adaptive Treg cells that reverse diabetes in NOD mice via integrin-beta7-dependent localization. J. Autoimmun. 37, 217-227.
    • (2011) J. Autoimmun. , vol.37 , pp. 217-227
    • Li, C.R.1    Deiro, M.F.2    Godebu, E.3
  • 53
    • 0031595503 scopus 로고    scopus 로고
    • The β7 integrin gene (Itgb-7) promoter is responsive to TGF-β1: Defining control regions
    • DOI 10.1007/s002510050422
    • Lim, S.P., Leung, E., and Krissansen, G.W. (1998). The beta7 integrin gene (Itgb-7) promoter is responsive to TGF-beta1: Defining control regions. Immunogenetics 48, 184-195. (Pubitemid 28352184)
    • (1998) Immunogenetics , vol.48 , Issue.3 , pp. 184-195
    • Lim, S.P.1    Leung, E.2    Krissansen, G.W.3
  • 55
    • 33845698122 scopus 로고    scopus 로고
    • Peptide-pulsed immature dendritic cells reduce response to β cell target antigens and protect NOD recipients from type I diabetes
    • DOI 10.1196/annals.1375.023, Immunology of Diabetes IV: Progress in Our Understanding
    • Lo, J., Peng, R.H., Barker, T., et al. (2006). Peptide-pulsed immature dendritic cells reduce response to beta cell target antigens and protect NOD recipients from type I diabetes. Ann. NY Acad. Sci. 1079, 153-156. (Pubitemid 44968716)
    • (2006) Annals of the New York Academy of Sciences , vol.1079 , pp. 153-156
    • Lo, J.1    Rui, H.P.2    Barker, T.3    Xia, C.-Q.4    Clare-Salzler, M.J.5
  • 59
    • 78650723379 scopus 로고    scopus 로고
    • + regulatory T cells generated with IL-2, TGF-beta and retinoic acid
    • + regulatory T cells generated with IL-2, TGF-beta and retinoic acid. PLoS One 5, e15150.
    • (2010) PLoS One , vol.5
    • Lu, L.1    Zhou, X.2    Wang, J.3
  • 61
    • 77951901513 scopus 로고    scopus 로고
    • Immunotherapy of type 1 diabetes: Where are we and where should we be going?
    • Luo, X., Herold, K.C., and Miller, S.D. (2010). Immunotherapy of type 1 diabetes: Where are we and where should we be going? Immunity 32, 488-499.
    • (2010) Immunity , vol.32 , pp. 488-499
    • Luo, X.1    Herold, K.C.2    Miller, S.D.3
  • 62
    • 78149277909 scopus 로고    scopus 로고
    • How tolerogenic dendritic cells induce regulatory T cells
    • Maldonado, R.A., and von Andrian, U.H. (2010). How tolerogenic dendritic cells induce regulatory T cells. Adv. Immunol. 108, 111-165.
    • (2010) Adv. Immunol. , vol.108 , pp. 111-165
    • Maldonado, R.A.1    Von Andrian, U.H.2
  • 63
    • 79955028001 scopus 로고    scopus 로고
    • Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes
    • McClymont, S.A., Putnam, A.L., Lee, M.R., et al. (2011). Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. J. Immunol. 186, 3918-3926.
    • (2011) J. Immunol. , vol.186 , pp. 3918-3926
    • McClymont, S.A.1    Putnam, A.L.2    Lee, M.R.3
  • 65
    • 77954417145 scopus 로고    scopus 로고
    • PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors
    • Merkenschlager, M., and von Boehmer, H. (2010). PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors. J. Exp. Med. 207, 1347-1350.
    • (2010) J. Exp. Med. , vol.207 , pp. 1347-1350
    • Merkenschlager, M.1    Von Boehmer, H.2
  • 66
    • 0021802879 scopus 로고
    • Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: A longitudinal study
    • Miyazaki, A., Hanafusa, T., Yamada, K., et al. (1985). Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: A longitudinal study. Clin. Exp. Immunol. 60, 622-630. (Pubitemid 15021367)
    • (1985) Clinical and Experimental Immunology , vol.60 , Issue.3 , pp. 622-630
    • Miyazaki, A.1    Hanafusa, T.2    Yamada, K.3
  • 67
    • 34447503805 scopus 로고    scopus 로고
    • H17 and regulatory T cell differentiation mediated by retinoic acid
    • DOI 10.1126/science.1145697
    • Mucida, D., Park, Y., Kim, G., et al. (2007). Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317, 256-260. (Pubitemid 47076203)
    • (2007) Science , vol.317 , Issue.5835 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6    Cheroutre, H.7
  • 68
    • 70350464351 scopus 로고    scopus 로고
    • Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis
    • Murai, M., Turovskaya, O., Kim, G., et al. (2009). Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat. Immunol. 10, 1178-1184.
    • (2009) Nat. Immunol. , vol.10 , pp. 1178-1184
    • Murai, M.1    Turovskaya, O.2    Kim, G.3
  • 69
    • 79952946257 scopus 로고    scopus 로고
    • Quantitative events determine the differentiation and function of helper T cells
    • O'Garra, A., Gabrysova, L., and Spits, H. (2011). Quantitative events determine the differentiation and function of helper T cells. Nat. Immunol. 12, 288-294.
    • (2011) Nat. Immunol. , vol.12 , pp. 288-294
    • O'Garra, A.1    Gabrysova, L.2    Spits, H.3
  • 72
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
    • Powell, J.D., and Delgoffe, G.M. (2010). The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism. Immunity 33, 301-311.
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 74
    • 79954629524 scopus 로고    scopus 로고
    • Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease
    • Qian, X., Wang, K., Wang, X., et al. (2011). Generation of human regulatory T cells de novo with suppressive function prevent xenogeneic graft versus host disease. Int. Immunopharmacol. 11, 630-637.
    • (2011) Int. Immunopharmacol. , vol.11 , pp. 630-637
    • Qian, X.1    Wang, K.2    Wang, X.3
  • 75
    • 0030903840 scopus 로고    scopus 로고
    • Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
    • DOI 10.1210/en.138.4.1736
    • Scaglia, L., Cahill, C.J., Finegood, D.T., et al. (1997). Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138, 1736-1741. (Pubitemid 27137129)
    • (1997) Endocrinology , vol.138 , Issue.4 , pp. 1736-1741
    • Scaglia, L.1    Cahill, C.J.2    Finegood, D.T.3    Bonner-Weir, S.4
  • 77
    • 34548733134 scopus 로고    scopus 로고
    • A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta
    • following 1390
    • Selvaraj, R.K., and Geiger, T.L. (2007). A kinetic and dynamic analysis of Foxp3 induced in T cells by TGF-beta. J. Immunol. 179, 11 p following 1390.
    • (2007) J. Immunol. , vol.179 , pp. 11
    • Selvaraj, R.K.1    Geiger, T.L.2
  • 78
    • 15444374646 scopus 로고    scopus 로고
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization
    • DOI 10.1084/jem.20041982
    • + regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J. Exp. Med. 201, 723-735. (Pubitemid 40395118)
    • (2005) Journal of Experimental Medicine , vol.201 , Issue.5 , pp. 723-735
    • Setoguchi, R.1    Hori, S.2    Takahashi, T.3    Sakaguchi, S.4
  • 79
    • 44849133287 scopus 로고    scopus 로고
    • The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function
    • Shevach, E.M., Tran, D.Q., Davidson, T.S., et al. (2008). The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function. Eur. J. Immunol. 38, 915-917.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 915-917
    • Shevach, E.M.1    Tran, D.Q.2    Davidson, T.S.3
  • 81
    • 77951905379 scopus 로고    scopus 로고
    • Molecular targeting of islet autoantigens
    • Stadinski, B., Kappler, J., and Eisenbarth, G.S. (2010). Molecular targeting of islet autoantigens. Immunity 32, 446-456.
    • (2010) Immunity , vol.32 , pp. 446-456
    • Stadinski, B.1    Kappler, J.2    Eisenbarth, G.S.3
  • 82
    • 0642307067 scopus 로고    scopus 로고
    • Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: A large, population-based, case-control study
    • Stene, L.C., and Joner, G. (2003). Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: A large, population-based, case-control study. Am. J. Clin. Nutr. 78, 1128-1134. (Pubitemid 39663453)
    • (2003) American Journal of Clinical Nutrition , vol.78 , Issue.6 , pp. 1128-1134
    • Stene, L.C.1    Joner, G.2
  • 84
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang, Q., Adams, J.Y., Penaranda, C., et al. (2008). Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28, 687-697.
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 85
    • 2942692039 scopus 로고    scopus 로고
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes
    • DOI 10.1084/jem.20040180
    • + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J. Exp. Med. 199, 1467-1477. (Pubitemid 38780402)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.11 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 86
    • 0025787852 scopus 로고
    • A protective role of the environment in the development of type 1 diabetes?
    • Todd, J.A. (1991). A protective role of the environment in the development of type 1 diabetes? Diabet. Med. 8, 906-910.
    • (1991) Diabet. Med. , vol.8 , pp. 906-910
    • Todd, J.A.1
  • 88
    • 38349095578 scopus 로고    scopus 로고
    • Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    • Tone, Y., Furuuchi, K., Kojima, Y., et al. (2008). Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat. Immunol. 9, 194-202.
    • (2008) Nat. Immunol. , vol.9 , pp. 194-202
    • Tone, Y.1    Furuuchi, K.2    Kojima, Y.3
  • 89
    • 67650003971 scopus 로고    scopus 로고
    • Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner
    • Tonkin, D.R., and Haskins, K. (2009). Regulatory T cells enter the pancreas during suppression of type 1 diabetes and inhibit effector T cells and macrophages in a TGF-beta-dependent manner. Eur. J. Immunol. 39, 1313-1322.
    • (2009) Eur. J. Immunol. , vol.39 , pp. 1313-1322
    • Tonkin, D.R.1    Haskins, K.2
  • 90
    • 58149280846 scopus 로고    scopus 로고
    • Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo
    • Tonkin, D.R., He, J., Barbour, G., et al. (2008). Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J. Immunol. 181, 4516-4522.
    • (2008) J. Immunol. , vol.181 , pp. 4516-4522
    • Tonkin, D.R.1    He, J.2    Barbour, G.3
  • 91
    • 35448930435 scopus 로고    scopus 로고
    • - T cells by T-cell receptor stimulation is transforming growth factor-β-dependent but does not confer a regulatory phenotype
    • DOI 10.1182/blood-2007-06-094656
    • - T cells by T-cell receptor stimulation is transforming growth factor-beta dependent but does not confer a regulatory phenotype. Blood 110, 2983-2990. (Pubitemid 350006952)
    • (2007) Blood , vol.110 , Issue.8 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 92
    • 0345448056 scopus 로고    scopus 로고
    • Physiological β Cell Death Triggers Priming of Self-reactive T Cells by Dendritic Cells in a Type-1 Diabetes Model
    • DOI 10.1084/jem.20030966
    • Turley, S., Poirot, L., Hattori, M., et al. (2003). Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J. Exp. Med. 198, 1527-1537. (Pubitemid 37467167)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.10 , pp. 1527-1537
    • Turley, S.1    Poirot, L.2    Hattori, M.3    Benoist, C.4    Mathis, D.5
  • 94
    • 78651087067 scopus 로고    scopus 로고
    • The changing epidemiology of type 1 diabetes: Why is it going through the roof?
    • Vehik, K., and Dabelea, D. (2011). The changing epidemiology of type 1 diabetes: Why is it going through the roof? Diabetes Metab. Res. Rev. 27, 3-13.
    • (2011) Diabetes Metab. Res. Rev. , vol.27 , pp. 3-13
    • Vehik, K.1    Dabelea, D.2
  • 95
    • 77951168859 scopus 로고    scopus 로고
    • Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells
    • Vendrame, F., Pileggi, A., Laughlin, E., et al. (2010). Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes 59, 947-957.
    • (2010) Diabetes , vol.59 , pp. 947-957
    • Vendrame, F.1    Pileggi, A.2    Laughlin, E.3
  • 97
    • 79957899130 scopus 로고    scopus 로고
    • Immunomodulatory therapy to preserve pancreatic beta-cell function in type 1 diabetes
    • Waldron-Lynch, F., and Herold, K.C. (2011). Immunomodulatory therapy to preserve pancreatic beta-cell function in type 1 diabetes. Nat. Rev. Drug Discov. 10, 439-452.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 439-452
    • Waldron-Lynch, F.1    Herold, K.C.2
  • 101
    • 33645786794 scopus 로고    scopus 로고
    • Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo
    • Weber, S.E., Harbertson, J., Godebu, E., et al. (2006). Adaptive islet-specific regulatory CD4 T cells control autoimmune diabetes and mediate the disappearance of pathogenic Th1 cells in vivo. J. Immunol. 176, 4730-4739.
    • (2006) J. Immunol. , vol.176 , pp. 4730-4739
    • Weber, S.E.1    Harbertson, J.2    Godebu, E.3
  • 102
    • 0026607639 scopus 로고
    • Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis
    • Weinberg, A.D., Whitham, R., Swain, S.L., et al. (1992). Transforming growth factor-beta enhances the in vivo effector function and memory phenotype of antigen-specific T helper cells in experimental autoimmune encephalomyelitis. J. Immunol. 148, 2109-2117.
    • (1992) J. Immunol. , vol.148 , pp. 2109-2117
    • Weinberg, A.D.1    Whitham, R.2    Swain, S.L.3
  • 103
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells
    • DOI 10.1034/j.1600-065X.2001.1820117.x
    • Weiner, H.L. (2001). Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol. Rev. 182, 207-214. (Pubitemid 33070220)
    • (2001) Immunological Reviews , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 104
    • 1342302624 scopus 로고    scopus 로고
    • The Effect of Innate Immunity on Autoimmune Diabetes and the Expression of Toll-Like Receptors on Pancreatic Islets
    • Wen, L., Peng, J., Li, Z., and Wong, F.S. (2004). The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J. Immunol. 172, 3173-3180. (Pubitemid 38263708)
    • (2004) Journal of Immunology , vol.172 , Issue.5 , pp. 3173-3180
    • Wen, L.1    Peng, J.2    Li, Z.3    Wong, F.S.4
  • 105
    • 54549122338 scopus 로고    scopus 로고
    • Innate immunity and intestinal microbiota in the development of type 1 diabetes
    • Wen, L., Ley, R.E., Volchkov, P.Y., et al. (2008). Innate immunity and intestinal microbiota in the development of type 1 diabetes. Nature 455, 1109-1113.
    • (2008) Nature , vol.455 , pp. 1109-1113
    • Wen, L.1    Ley, R.E.2    Volchkov, P.Y.3
  • 106
    • 79960743608 scopus 로고    scopus 로고
    • Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial
    • Wherrett, D.K., Bundy, B., Becker, D.J., et al. (2011). Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: A randomised double-blind trial. Lancet 378, 319-327.
    • (2011) Lancet , vol.378 , pp. 319-327
    • Wherrett, D.K.1    Bundy, B.2    Becker, D.J.3
  • 108
    • 58149299735 scopus 로고    scopus 로고
    • Analysis of islet inflammation in human type 1 diabetes
    • Willcox, A., Richardson, S.J., Bone, A.J., et al. (2009). Analysis of islet inflammation in human type 1 diabetes. Clin. Exp. Immunol. 155, 173-181.
    • (2009) Clin. Exp. Immunol. , vol.155 , pp. 173-181
    • Willcox, A.1    Richardson, S.J.2    Bone, A.J.3
  • 109
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing, K., and Sakaguchi, S. (2010). Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 11, 7-13.
    • (2010) Nat. Immunol. , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 110
    • 34548381245 scopus 로고    scopus 로고
    • TCR-based lineage tracing: No evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets
    • DOI 10.1084/jem.20070822
    • Wong, J., Mathis, D., and Benoist, C. (2007). TCR-based lineage tracing: No evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets. J. Exp. Med. 204, 2039-2045. (Pubitemid 47360866)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.9 , pp. 2039-2045
    • Wong, J.1    Mathis, D.2    Benoist, C.3
  • 111
    • 78650947473 scopus 로고    scopus 로고
    • Interplay of transcription factors in T-cell differentiation and function: The role of Runx
    • Wong, W.F., Kohu, K., Chiba, T., et al. (2011). Interplay of transcription factors in T-cell differentiation and function: The role of Runx. Immunology 132, 157-164.
    • (2011) Immunology , vol.132 , pp. 157-164
    • Wong, W.F.1    Kohu, K.2    Chiba, T.3
  • 112
    • 53149137849 scopus 로고    scopus 로고
    • + regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression
    • + regulatory T cells and inhibits development of Th17 cells by enhancing TGF-beta-driven Smad3 signaling and inhibiting IL-6 and IL-23 receptor expression. J. Immunol. 181, 2277-2284.
    • (2008) J. Immunol. , vol.181 , pp. 2277-2284
    • Xiao, S.1    Jin, H.2    Korn, T.3
  • 113
    • 0028607554 scopus 로고
    • A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice
    • Yang, X.D., Michie, S.A., Tisch, R., et al. (1994). A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice. Proc. Natl Acad. Sci. USA 91, 12604-12608.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 12604-12608
    • Yang, X.D.1    Michie, S.A.2    Tisch, R.3
  • 114
    • 0030863639 scopus 로고    scopus 로고
    • 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in nonobese diabetic mice
    • Yang, X.D., Sytwu, H.K., McDevitt, H.O., et al. (1997). Involvement of beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in the development of diabetes in obese diabetic mice. Diabetes 46, 1542-1547. (Pubitemid 27411227)
    • (1997) Diabetes , vol.46 , Issue.10 , pp. 1542-1547
    • Yang, X.-D.1    Sytwu, H.-K.2    McDevitt, H.O.3    Michie, S.A.4
  • 116
    • 77951693260 scopus 로고    scopus 로고
    • Immune modulation by Schistosoma mansoni antigens in NOD mice: Effects on both innate and adaptive immune systems
    • Zaccone, P., Burton, O.T., Gibbs, S., et al. (2010). Immune modulation by Schistosoma mansoni antigens in NOD mice: Effects on both innate and adaptive immune systems. J. Biomed. Biotechnol. 2010, 795210.
    • (2010) J. Biomed. Biotechnol. , vol.2010 , pp. 795210
    • Zaccone, P.1    Burton, O.T.2    Gibbs, S.3
  • 120
    • 47249166438 scopus 로고    scopus 로고
    • + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
    • + regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J. Immunol. 180, 7112-7116.
    • (2008) J. Immunol. , vol.180 , pp. 7112-7116
    • Zheng, S.G.1    Wang, J.2    Horwitz, D.A.3
  • 121
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses
    • Zheng, Y., Chaudhry, A., Kas, A., et al. (2009). Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses. Nature 458, 351-356.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3
  • 122
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • Zhou, X., Bailey-Bucktrout, S.L., Jeker, L.T., et al. (2009). Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat. Immunol. 10, 1000-1007.
    • (2009) Nat. Immunol. , vol.10 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 123
    • 78049373227 scopus 로고    scopus 로고
    • Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu
    • Zhou, X., Kong, N., Wang, J., et al. (2010). Cutting edge: All-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu. J. Immunol. 185, 2675-2679.
    • (2010) J. Immunol. , vol.185 , pp. 2675-2679
    • Zhou, X.1    Kong, N.2    Wang, J.3
  • 124
    • 33846340789 scopus 로고    scopus 로고
    • FOXP3: Not just for regulatory T cells anymore
    • DOI 10.1002/eji.200636929
    • Ziegler, S.F. (2007). FOXP3: Not just for regulatory T cells anymore. Eur. J. Immunol. 37, 21-23. (Pubitemid 46128782)
    • (2007) European Journal of Immunology , vol.37 , Issue.1 , pp. 21-23
    • Ziegler, S.F.1
  • 125
    • 79958043752 scopus 로고    scopus 로고
    • Accelerated progression from islet autoimmunity to diabetes is ausing the escalating incidence of type 1 diabetes in young children
    • Ziegler, A.G., Pflueger, M., Winkler, C., et al. (2011). Accelerated progression from islet autoimmunity to diabetes is ausing the escalating incidence of type 1 diabetes in young children. J. Autoimmun. 37, 3-7.
    • (2011) J. Autoimmun. , vol.37 , pp. 3-7
    • Ziegler, A.G.1    Pflueger, M.2    Winkler, C.3


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