The changing epidemiology of type 1 diabetes: Why is it going through the roof?

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 1, 2011, Pages 3-13

  Vehik, Kendra ^a   Dabelea, Dana ^b  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Epidemiology; Incidence; Type 1 diabetes

Indexed keywords

AGE DISTRIBUTION; CHILD GROWTH; ENVIRONMENTAL FACTOR; EPIDEMIOLOGICAL DATA; ETHNICITY; FEEDING BEHAVIOR; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; HIGH RISK POPULATION; HUMAN; INCIDENCE; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; MEDICAL RESEARCH; METABOLOMICS; MUCOSAL IMMUNITY; OBESITY; ONSET AGE; PRIORITY JOURNAL; RACE DIFFERENCE; REVIEW; RISK FACTOR; SEASONAL VARIATION; VIRUS PATHOGENESIS; VITAMIN D DEFICIENCY;

DIABETES MELLITUS, TYPE 1; HUMANS; RISK FACTORS;

EID: 78651087067     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1141     Document Type: Review

References (107)

1. Mayer-Davis EJ, Bell RA, Dabelea D, et al. The many faces of diabetes in American youth: type 1 and type 2 diabetes in five race and ethnic populations: the SEARCH for Diabetes in Youth Study. Diab Care 2009; 32(Suppl. 2): S99S101.
2. DiaMond Project Group. Incidence and trends of childhood type 1 diabetes worldwide 1990-1999. Diabet Med 2006; 23(8): 857-866.
3. EURODIAB ACE Study Group. Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group. Lancet 2000; 355(9207): 873-876.
4. DERI Study Group. Secular trends in incidence of childhood IDDM in 10 countries. Diabetes Epidemiology Research International Group. Diabetes 1990; 39: 858-864.
5. Lernmark A, Ott J. Sometimes it's hot, sometimes it's not. Nat Genet 1998; 19(3): 213-214.
6. Norris JM, Barriga K, Klingensmith G, et al. Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 2003; 290(13): 1713-1720.
7. Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide increase in incidence of type I diabetes-the analysis of the data on published incidence trends. Diabetologia 1999; 42(12): 1395-1403.
8. Padaiga Z, Tuomilehto J, Karvonen M, et al. Seasonal variation in the incidence of type 1 diabetes mellitus during 1983 to 1992 in the countries around the Baltic Sea. Diabet Med 1999; 16(9): 736-743.
9. Pitkaniemi J, Onkamo P, Tuomilehto J, Arjas E. Increasing incidence of type 1 diabetes-role for genes? BMC Genet 2004; 5(1): 5.
10. Rayfield EJ, Seto Y. Viruses and the pathogenesis of diabetes mellitus. Diabetes 1978; 27(11): 1126-1140.
11. Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E. Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 2003; 290(13): 1721-1728.
12. Hypponen E, Virtanen SM, Kenward MG, Knip M, Akerblom HK. Obesity, increased linear growth, and risk of type 1 diabetes in children. Diab Care 2000; 23(12): 1755-1760.
13. Colman PG, McNair PD, Gellert S, et al. Development of autoantibodies to islet antigens during childhood: implications for preclinical type 1 diabetes screening. Pediatr Diabetes 2002; 3(3): 144-148.
14. Orban T, Sosenko JM, Cuthbertson D, et al. Pancreatic islet autoantibodies as predictors of type 1 diabetes in the Diabetes Prevention Trial-Type 1. Diab Care 2009; 32(12): 2269-2274.
15. Wenzlau JM, Moua O, Sarkar SA, et al. SlC30A8 is a major target of humoral autoimmunity in type 1 diabetes and a predictive marker in prediabetes. Ann N Y Acad Sci 2008; 1150: 256-259.
16. Chimienti F, Devergnas S, Favier A, Seve M. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53(9): 2330-2337.
17. Achenbach P, Lampasona V, Landherr U, et al. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009; 52(9): 1881-1888.
18. Vehik K, Hamman RF, Lezotte D, et al. Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes. Diab Care 2008; 31(7): 1392-1396.
19. Fourlanos S, Varney MD, Tait BD, et al. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diab Care 2008; 31(8): 1546-1549.
20. Gillespie KM, Bain SC, Barnett AH, et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet 2004; 364(9446): 1699-1700.
21. Gale EA. Spring harvest? Reflections on the rise of type 1 diabetes. Diabetologia 2005; 48(12): 2445-2450.
22. Nystrom L, Dahlquist G, Rewers M, Wall S. The Swedish childhood diabetes study. An analysis of the temporal variation in diabetes incidence 1978-1987. Int J Epidemiol 1990; 19: 141-146.
23. Tuomilehto J, Virtala E, Karvonen M, et al. Increase in incidence of insulin-dependent diabetes mellitus among children in Finland. Int J Epidemiol 1995; 24(5): 984-992.
24. Dokheel TM. An epidemic of childhood diabetes in the United States? Evidence from Allegheny County, Pennsylvania. Pittsburgh Diabetes Epidemiology Research Group. Diab Care 1993; 16(12): 1606-1611.
25. Joner G, Sovik O. Increasing incidence of diabetes mellitus in Norwegian children 0-14 years of age 1973-1982. Diabetologia 1989; 32: 79-83.
26. Songini M, Loche M, Stabilini M, et al. The incidence of type 1 diabetes is rapidly increasing in Sardinian male army conscripts. 1992; 35(Suppl. 1): A25.
27. Rewers M, LaPorte R, Walczak M, Dmochowski K, Bogaczynska E. Apparent epidemic of insulin-dependent diabetes mellitus in midwestern Poland. Diabetes 1987; 36: 106-113.
28. Kostraba JN, Gay EC, Cai Y, et al. Incidence of insulin-dependent diabetes mellitus in Colorado. Epidemiology 1992; 3(3): 232-238.
29. Scott RS, Brown LJ, Darlow BA, Forbes LV, Moore MP. Temporal variation in incidence of IDDM in Canterbury, New Zealand. Diab Care 1992; 15: 895-899.
30. Bruno G, Merletti F, De Salvia A, Lezo A, Arcari R, Pagano G. Comparison of incidence of insulin-dependent diabetes mellitus in children and young adults in the Province of Turin, Italy, 1984-91. Piedmont Study Group for Diabetes Epidemiology. Diabet Med 1997; 14(11): 964-969.
31. Padaiga Z, Tuomilehto J, Karvonen M, et al. Incidence trends in childhood onset IDDM in four countries around the Baltic sea during 1983-1992. Diabetologia 1997; 40(2): 187-192.
32. LaPorte RE, Orchard TJ, Kuller LH, et al. The Pittsburgh Insulin Dependent Diabetes Mellitus Registry: the relationship of insulin dependent diabetes mellitus incidence to social class. Am J Epidemiol 1981; 114(3): 379-384.
33. Green A, Patterson CC, The EURODIAB TIGER Study Group. Europe and Diabetes. Trends in the incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 2001; 44(Suppl. 8): B9-B16.
34. Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009; 373(9680): 2027-2033.
35. Vehik K, Hamman RF, Lezotte D, et al. Increasing incidence of type 1 diabetes in 0- to 17-year-old Colorado youth. Diab Care 2007; 30(3): 503-509.
36. Carrasco E, Perez-Bravo F, Dorman J, Mondragon A, Santos JL. Increasing incidence of type 1 diabetes in population from Santiago of Chile: trends in a period of 18 years (1986-2003). Diabetes Metab Res Rev 2006; 22(1): 34-37.
37. Charkaluk ML, Czernichow P, Levy-Marchal C. Incidence data of childhood-onset type I diabetes in France during 1988-1997: the case for a shift toward younger age at onset. Pediatr Res 2002; 52(6): 859-862.
38. Bratina NU, Tahirovic H, Battelino T, Krzisnik C. Incidence of childhood-onset type I diabetes in Slovenia and the Tuzia region (Bosnia and Herzegovina) in the period 1990-1998. Diabetologia 2001; 44(Suppl. 3): B27-B31.
39. Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA. Continued increase in the incidence of childhood type 1 diabetes in a population-based Australian sample (1985-2002). Diabetologia 2004; 47(5): 866-870.
40. Tuomilehto J, Karvonen M, Pitkaniemi J, et al. Record-high incidence of type I (insulin-dependent) diabetes mellitus in Finnish children. The Finnish Childhood Type I Diabetes Registry Group. Diabetologia 1999; 42(6): 655-660.
41. Newhook LA, Curtis J, Hagerty D, et al. High incidence of childhood type 1 diabetes in the Avalon Peninsula, Newfoundland, Canada. Diab Care 2004; 27(4): 885-888.
42. Matsuura N, Fukuda K, Okuno A, et al. Descriptive epidemiology of IDDM in Hokkaido, Japan: the Childhood IDDM Hokkaido Registry. Diab Care 1998; 21(10): 1632-1636.
43. Weets I, De L, Du Caju IMV, et al. The incidence of type 1 diabetes in the age group 0-39 years has not increased in Antwerp (Belgium) between 1989 and 2000: evidence for earlier disease manifestation. Diab Care 2002; 25(5): 840-846.
44. Libman IM, LaPorte RE. Changing trends in epidemiology of type 1 diabetes mellitus throughout the world: how far have we come and where do we go from here. Pediatr Diabetes 2005; 6(3): 119-121.
45. Bell RA, Mayer-Davis EJ, Beyer JW, et al. Diabetes in non-Hispanic white youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diab Care 2009; 32(Suppl. 2): S102-S111.
46. Dorman JS, McCarthy J, O'Leary L, Koehler AN.Diabetes in America, Chapter 8, (2nd edn). NIDDK: Bethesda, MD, 1995; 165-177.
47. Rewers M, Norris JM, Dabelea D. Immunology of Type 1 Diabetes, 2nd Edition, Chapter 9: Epidemiology of type 1 diabetes mellitus. Springer/Kluwer Academic/Plenum Publishers: New York, NY, USA.
48. Mayer-Davis EJ, Beyer J, Bell RA, et al. Diabetes in African American youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diab Care 2009; 32(Suppl. 2): S112-S122.
49. Lawrence JM, Mayer-Davis EJ, Reynolds K, et al. Diabetes in Hispanic American youth: prevalence, incidence, demographics, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diab Care 2009; 32(Suppl. 2): S123-S132.
50. Liu LL, Yi JP, Beyer J, et al. Type 1 and type 2 diabetes in Asian and Pacific Islander U.S. youth: the SEARCH for Diabetes in Youth Study. Diab Care 2009; 32(Suppl. 2): S133-S140.
51. Dabelea D, Bell RA, D'Agostino RB Jr, et al. Incidence of diabetes in youth in the United States. JAMA 2007; 297(24): 2716-2724.
52. Libman IM, LaPorte RE, Becker D, Dorman JS, Drash AL, Kuller L. Was there an epidemic of diabetes in nonwhite adolescents in Allegheny County, Pennsylvania? Diab Care 1998; 21(8): 1278-1281.
53. Lipman TH, Chang Y, Murphy KM. The epidemiology of type 1 diabetes in children in Philadelphia 1990-1994: evidence of an epidemic. Diab Care 2002; 25(11): 1969-1975.
54. Moore KR, Harwell TS, McDowall JM, Helgerson SD, Gohdes D. Three-year prevalence and incidence of diabetes among American Indian youth in Montana and Wyoming, 1999 to 2001. J Pediatr 2003; 143(3): 368-371.
55. Cutfield WS. Escher's stairs and type 1 diabetes incidence in childhood. Pediatr Diabetes 2008; 9(3Pt1): 175-177.
56. Schober E, Rami B, Waldhoer T. Steep increase of incidence of childhood diabetes since 1999 in Austria. Time trend analysis 1979-2005. A nationwide study. Eur J Pediatr 2008; 167(3): 293-297.
57. Karvonen M, Pitkaniemi J, Tuomilehto J. The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group. Diab Care 1999; 22(7): 1066-1070.
58. Pundziute-Lycka A, Dahlquist G, Nystrom L, et al. The incidence of type I diabetes has not increased but shifted to a younger age at diagnosis in the 0-34 years group in Sweden 1983-1998. Diabetologia 2002; 45(6): 783-791.
59. Gardner SG, Bingley PJ, Sawtell PA, Weeks S, Gale EA. Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis. The Bart's-Oxford Study Group. BMJ 1997; 315(7110): 713-717.
60. Pociot F, McDermott MF. Genetics of type 1 diabetes mellitus. Genes Immun 2002; 3(5): 235-249.
61. Hermann R, Knip M, Veijola R, et al. Temporal changes in the frequencies of HLA genotypes in patients with type 1 diabetes-indication of an increased environmental pressure? Diabetologia 2003; 46(3): 420-425.
62. Hyoty H, Taylor KW. The role of viruses in human diabetes. Diabetologia 2002; 45(10): 1353-1361.
63. Dahlquist GG. Viruses and other perinatal exposures as initiating events for beta-cell destruction. Ann Med 1997; 29(5): 413-417.
64. Salminen K, Sadeharju K, Lonnrot M, et al. Enterovirus infections are associated with the induction of beta-cell autoimmunity in a prospective birth cohort study. J Med Virol 2003; 69(1): 91-98.
65. Graves PM, Rotbart HA, Nix WA, et al. Prospective study of enteroviral infections and development of beta-cell autoimmunity. Diabetes autoimmunity study in the young (DAISY). Diabetes Res Clin Pract 2003; 59(1): 51-61.
66. Graves PM, Barriga KJ, Norris JM, et al. Lack of association between early childhood immunizations and beta-cell autoimmunity. Diab Care 1999; 22(10): 1694-1697.
67. DeStefano F, Mullooly JP, Okoro CA, et al. Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitus. Pediatrics 2001; 108(6): E112.
68. Montgomery SM, Ehlin AG, Ekbom A, Wakefield AJ. Pertussis infection in childhood and subsequent type 1 diabetes mellitus. Diabet Med 2002; 19(12): 986-993.
69. Hyoty H, Hiltunen M, Reunanen A, et al. Decline of mumps antibodies in type 1 (insulin-dependent) diabetic children and a plateau in the rising incidence of type 1 diabetes after introduction of the mumps-measles-rubella vaccine in Finland. Childhood Diabetes in Finland Study Group. Diabetologia 1993; 36(12): 1303-1308.
70. Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347(12): 911-920.
71. Gale EA. A missing link in the hygiene hypothesis? Diabetologia 2002; 45(4): 588-594.
72. Vaarala O, Atkinson MA, Neu J. The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 2008; 57(10): 2555-2562.
73. Marschan E, Kuitunen M, Kukkonen K, et al. Probiotics in infancy induce protective immune profiles that are characteristic for chronic low-grade inflammation. Clin Exp Allergy 2008; 38(4): 611-618.
74. Bosi E, Molteni L, Radaelli MG, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 2006; 49(12): 2824-2827.
75. Kuitunen M, Saukkonen T, Ilonen J, Akerblom HK, Savilahti E. Intestinal permeability to mannitol and lactulose in children with type 1 diabetes with the HLA-DQB1*02 allele. Autoimmunity 2002; 35(5): 365-368.
76. Watts T, Berti I, Sapone A, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci U S A 2005; 102(8): 2916-2921.
77. Westerholm-Ormio M, Vaarala O, Pihkala P, Ilonen J, Savilahti E. Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes 2003; 52(9): 2287-2295.
78. Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR). Pediatr Diabetes 2007; 8(3): 117-137.
79. Peechakara SV, Pittas AG. Vitamin D as a potential modifier of diabetes risk. Nat Clin Pract Endocrinol Metab 2008; 4(4): 182-183.
80. Bierschenk L, Alexander J, Wasserfall C, Haller M, Schatz D, Atkinson M. Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment. Diab Care 2009; 32(11): 1977-1979.
81. Moltchanova EV, Schreier N, Lammi N, Karvonen M. Seasonal variation of diagnosis of type 1 diabetes mellitus in children worldwide. Diabet Med 2009; 26(7): 673-678.
82. Dahlquist GG, Patterson C, Soltesz G. Perinatal risk factors for childhood type 1 diabetes in Europe. The EURODIAB Substudy 2 Study Group. Diab Care 1999; 22(10): 1698-1702.
83. McKinney PA, Parslow R, Gurney KA, Law GR, Bodansky HJ, Williams R. Perinatal and neonatal determinants of childhood type 1 diabetes. A case-control study in Yorkshire, U.K. Diab Care 1999; 22(6): 928-932.
84. Stene LC, Magnus P, Lie RT, Sovik O, Joner G. Maternal and paternal age at delivery, birth order, and risk of childhood onset type 1 diabetes: population based cohort study. BMJ 2001; 323(7309): 369.
85. Cardwell CR, Stene LC, Joner G, et al. Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia 2008; 51(5): 726-735.
86. Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia 2001; 44(7): 914-922.
87. Dahlquist G. Can we slow the rising incidence of childhood-onset autoimmune diabetes? The overload hypothesis. Diabetologia 2006; 49(1): 20-24.
88. Mokdad AH, Serdula MK, Dietz WH, Bowman BA, Marks JS, Koplan JP. The continuing epidemic of obesity in the United States. JAMA 2000; 284(13): 1650-1651.
89. Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA 2002; 288(14): 1728-1732.
90. Fourlanos S, Harrison LC, Colman PG. The accelerator hypothesis and increasing incidence of type 1 diabetes. Curr Opin Endocrinol Diabetes Obes 2008; 15(4): 321-325.
91. Larsson HE, Hansson G, Carlsson A, et al. Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes. Diabetologia 2008; 51(9): 1623-1630.
92. Lamb MM, Yin X, Zerbe GO, et al. Height growth velocity, islet autoimmunity and type 1 diabetes development: the Diabetes Autoimmunity Study in the Young. Diabetologia 2009; 52(10): 2064-2071.
93. Hypponen E, Kenward MG, Virtanen SM, et al. Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group. Diab Care 1999; 22(12): 1961-1965.
94. Dabelea D, D'Agostino RB Jr, Mayer-Davis EJ, et al. Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. Diab Care 2006; 29(2): 290-294.
95. Knerr I, Wolf J, Reinehr T, et al. The 'accelerator hypothesis': relationship between weight, height, body mass index and age at diagnosis in a large cohort of 9, 248 German and Austrian children with type 1 diabetes mellitus. Diabetologia 2005; 48(12): 2501-2504.
96. Couper JJ, Beresford S, Hirte C, et al. Weight gain in early life predicts risk of islet autoimmunity in children with a first-degree relative with type 1 diabetes. Diab Care 2009; 32(1): 94-99.
97. Betts P, Mulligan J, Ward P, Smith B, Wilkin TJ. Increasing body weight predicts earlier onset of insulin-dependent diabetes in childhood: testing the 'accelerator hypothesis' (2). Diabet Med 2005; 22: 144-151.
98. Kibirige M, Metcalf B, Renuka R, Wilkin TJ. Testing the accelerator hypothesis: the relationship between body mass and age at diagnosis of type 1 diabetes. Diab Care 2003; 26(10): 2865-2870.
99. Kordonouri O, Hartmann R. Higher body weight is associated with earlier onset of type 1 diabetes in children: confirming the 'accelerator hypothesis'. Diabet Med 2005; 22(12): 1783-1784.
100. Gimenez M, Aguilera E, Castell C, de LN, Nicolau J, Conget I. Relationship between BMI and age at diagnosis of type 1 diabetes in a Mediterranean area in the period of 1990-2004. Diab Care 2007; 30(6): 1593-1595.
101. Porter JR, Barrett TG. Braking the accelerator hypothesis? Diabetologia 2004; 47(2): 352-353.
102. Evertsen J, Alemzadeh R, Wang X. Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin: relationship with body weight at diagnosis. PLo S One 2009; 4(9): e6873.
103. Knip M, Reunanen A, Virtanen SM, Nuutinen M, Viikari J, Akerblom HK. Does the secular increase in body mass in children contribute to the increasing incidence of type 1 diabetes? Pediatr Diabetes 2008; 9(3 Pt 2): 46-49.
104. Vehik K, Hamman RF, Lezotte D, Norris JM, Klingensmith GJ, Dabelea D. Childhood growth and age at diagnosis with type 1 diabetes in Colorado young people. Diabet Med 2009; 26(10): 961-967.
105. Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445(7130): 881-885.
106. Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008; 205(13): 2975-2984.
107. Liu S, Wang H, Jin Y, et al. IFIH1 polymorphisms are significantly associated with type 1 diabetes and IFIH1 gene expression in peripheral blood mononuclear cells. Hum Mol Genet 2009; 18(2): 358-365.