Withdrawal of stimulation may initiate the transition of effector to memory CD4 cells

Journal of Immunology

Volumn 168, Issue 3, 2002, Pages 1095-1102

  Harbertson, Judith ^a   Biederman, Elana ^a   Bennett, Kristin E ^a   Kondrack, Robyn M ^a   Bradley, Linda M ^a  

^a SIDNEY KIMMEL CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYTOKINE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DEATH; CELL DIVISION; CELL FUNCTION; CELL MATURATION; CELL STIMULATION; CELL SUBPOPULATION; CONTROLLED STUDY; EFFECTOR CELL; MEMORY CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL;

EID: 0036467327     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.3.1095     Document Type: Article

References (56)

1. L
2. Interleukin-2 expression by a subpopulation of primary T cells is linked to enhanced memory/effector function
3. T cell effector function and anergy avoidance are quantitatively linked to cell division
4. The composition of a primary T cell response is largely determined by the timing of recruitment of individual T cell clones
5. Coordinate regulation of complex T cell populations responding to bacterial infection
6. T cell affinity maturation by selective expansion during infection
7. Evolution of antigen-specific T cell receptors in vivo: Preimmune and antigen-driven selection of preferred complementarity-determining region 3 (CDR3) motifs
8. + T cell responses: Alternative approaches
9. Cytokines induce the development of functionally heterogeneous T helper subsets
10. Generation and in vivo persistence of polarized Th1 and Th2 memory cells
11. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
12. The duration of antigenic stimulation determines the fate of naive and effector cells
13. 1 and IL-2 prevent apoptosis and promote effector expansion
14. Homeostasis and self-tolerance in the immune system: Turning lymphocytes off
15. Class II-independent generation of CD4 memory T cells from effectors
16. A critical role for B cells in the development of memory CD4 cells
17. + T cell frequencies from acute infection into long term memory
18. Generation and maintenance of T memory cells
19. Selective development of CD4 T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
20. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4, 5 using modified cDNA expression vectors
21. Memory CD4 cells do not migrate into peripheral lymph nodes in the absence of antigen
22. Determination of lymphocyte division by flow cytometry
23. The cytokines IL-4, IFN-γ, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro
24. Interleukin-4 (IL-4) or IL-7 prevents the death of resting T cells: Stat6 is probably not required for the effect of IL-4
25. + memory T cells from the spleen lack MEL-14, the lymph node homing receptor
26. Cell division in the compartment of naive and memory T lymphocytes
27. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
28. - helper cells that secretes interleukin-2 (IL-2), IL-3, IL-4, and interferon-γ
29. + T cells
30. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
31. Antigen-specific development of primary and memory T cells in vivo
32. Altered patterns of T cell migration through lymph nodes and skin following antigen challenge
33. + cells of memory phenotype
34. + T cells during an acute virus infection
35. + T cells in primary and secondary influenza pneumonia
36. + T-cell memory determined by clonal burst size
37. Counting antigen-specific CD8 T cells: A reevaluation of bystander activation during viral infection
38. Immunological memory and protective immunity: Understanding their relation
39. Antigen localization regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
40. 4 integrins mediate lymphocyte attachment and rolling under physiologic flow
41. + T cells that exhibit a transendothelial migratory capacity
42. + T cells
43. CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation
44. + T cell effectors can become memory cells with high efficiency and without further division
45. Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal
46. L promote growth factor-independent survival through distinct effects on mitochondrial physiology
47. Persistence of memory CD8 T cells in MHC class I-deficient mice
48. Linear differentiation of cytotoxic effectors into memory lymphocytes
49. Following the development of a CD4 response in vivo: From activation to memory formation
50. Qualitative changes accompany memory T cell generation: Faster, more effective responses to lower doses of antigen
51. + T cells to antigen stimulation
52. Following the fate of individual T cells throughout activation and clonal expansion
53. Modeling T-cell memory by genetic marking of memory T cells in vivo
54. Interleukin-2 programs mouse αβ T lymphocytes for apoptosis
55. Preferential localization of effector memory cells in nonlymphoid tissue
56. Visualizing the generation of memory CD4 T cells in the whole body