Thirty years of investigating the autoimmune basis for type 1 diabetes: Why can't we prevent or reverse this disease?

Diabetes

Volumn 54, Issue 5, 2005, Pages 1253-1263

  Atkinson, Mark A ^a,b  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; IMMUNOMODULATING AGENT; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; AUTOIMMUNITY; CELL DESTRUCTION; CONFERENCE PAPER; CONTROLLED STUDY; EXPERIENCE; GENETIC PREDISPOSITION; GENETIC RISK; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN METABOLISM; LANGERHANS CELL; NONHUMAN; PANCREAS ISLET BETA CELL; PATIENT MONITORING; PREDICTION; PRIORITY JOURNAL; ANIMAL; ARTICLE; BIOLOGICAL MODEL; BLOOD; CHROMOSOME MAP; DISEASE MODEL; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; PANCREAS ISLET; PATHOLOGY; SECRETION;

ANIMALS; AUTOANTIBODIES; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; HUMANS; INFLAMMATION; INSULIN; ISLETS OF LANGERHANS; MODELS, BIOLOGICAL;

EID: 21244454753     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.54.5.1253     Document Type: Conference Paper

References (59)

1. Gepts W: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:610-633, 1965
2. Neel JV: The genetics of diabetes mellitus. Adv Metab Disord 1 (Suppl. 1):3-10, 1970
3. Nerup J, Bendixen G, Binder C: Autoimmunity in diabetes mellitus. Lancet 2:610-611, 1970
4. Nerup J, Platz P, Andersen OO, Christy M, Lyngsoe J, Paulsen JE, Ryder LP, Nielsen LS, Thomsen M, Svejgaard A: HL-A antigens and diabetes mellitus. Lancet 2:864-866, 1974
5. Bottazzo GF, Florin-Christensen A, Doniach D: Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies. Lancet 2:1279-1283, 1974
6. MacCuish AC, Irvine WJ, Barnes EW, Duncan LJ: Antibodies to pancreatic islet cells in insulin-dependent diabetics with coexistent autoimmune disease. Lancet 2:1029-1531, 1974
7. Ide A, Eisenbarth GS: Genetic susceptibility in type 1 diabetes and its associated autoimmune disorders. Rev Endocr Metab Disord 4:243-253, 2003
8. TIDBase: a bioinfarmatics resource for type 1 diabetes researchers. Available at http://tldbase.org/cgi-bin/welcome.cgi
9. Pearce SH, Leech NJ: Toward precise forecasting of autoimmune endocrinopathy. J Clin Endocrinol Metab 89:544-547, 2004
10. Christen U, von Herrath MG: Induction, acceleration or prevention of autoimmunity by molecular mimicry. Mol Immunot 40:1113-1120, 2004
11. Herold KC: Treatment of type 1 diabetes mellitus to preserve insulin secretion. Endocrinol Metab Clin North Am 33:93-111, ix, 2004
12. Roep BO, Atkinson M, von Herrath M: Opinion: satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes. Nat Rev Immunol 4:989-997, 2004
13. Serreze DV, Silveira PA: The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes. Curr Dir Autoimmun 6:212-227, 2003
14. Ricordi C, Strom TB: Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol 4:259-268, 2004
15. Rother KI, Harlan DM: Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus. J Clin Invest 114:877-883, 2004
16. Maclaren N, Atkinson M: Is insulin-dependent diabetes mellitus environmentally induced? N Engl J Med 327:348-349, 1992
17. Soltesz G: Diabetes in the young: a paediatric and epidemiological perspective. Diabetologia 46:447-454, 2003
18. Hyoty H, Taylor KW: The role of viruses in human diabetes. Diabetologia 45:1353-1361, 2002
19. Borch-Johnsen K, Joner G, Mandrup-Poulsen T, Christy M, Zachau-Christiansen B, Kastrup K, Nerup J: Relation between breast-feeding and incidence rates of insulin-dependent diabetes mellitus: a hypothesis. Lancet 2:1083-1086, 1984
20. Dahl-Jorgensen K, Joner G, Hanssen KF: Relationship between cows' milk consumption and incidence of IDDM in childhood. Diabetes Care 14:1081-1083, 1991
21. Martin JM, Trink B, Daneman D, Dosch HM, Robinson B: Milk proteins in the etiology of insulin-dependent diabetes mellitus (IDDM). Ann Med 23: 447-452, 1991
22. Classen JB, Classen DC: Vaccines modulate IDDM. Diabetologia 39:500-502, 1996
23. Gale EA: A missing link in the hygiene hypothesis? Diabetologia 45:588-594, 2002
24. Feillet H, Bach JF: On the mechanisms of the protective effect of infections on type 1 diabetes. Clin Dev Immunol 11:191-194, 2004
25. Norris JM, Barriga K, Klingensmith G, Hoffman M, Eisenbarth GS, Erlich HA, Rewers M: Timing of initial cereal exposure in infancy and risk of islet autoimmunity. JAMA 290:1713-1720, 2003
26. Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E: Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies. JAMA 290:1721-1728, 2003
27. Atkinson M, Gale EA: Infant diets and type 1 diabetes: too early, too late, or just too complicated? JAMA 290:1771-1772, 2003
28. Atkinson MA, Bowman MA, Kao KJ, Campbell L, Dush PJ, Shah SC, Simell O, Maclaren NK: Lack of immune responsiveness to bovine serum albumin in insulin-dependent diabetes. N Engl J Med 329:1853-1858, 1993
29. Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Akerblom HK, Dosch HM: A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 327:302-307, 1992
30. Pugliese A: Genetics of type 1 diabetes. Endocrinol Metab Clin North Am 33:1-16, vii, 2004
31. Eisenbarth GS: Type I diabetes mellitus: a chronic autoimmune disease. N Engl J Med 314:1360-1368, 1986
32. Abiru N, Yu L, Redondo M, Eisenbarth GS: Modification of the environment is not the most efficient way to prevent type 1 diabetes. Diabetes Technol Ther 2:609-616, 2000
33. Greenbaum CJ, Sears KL, Kahn SE, Palmer JP: Relationship of β-cell function and autoantibodies to progression and nonprogression of subclinical type 1 diabetes: follow-up of the Seattle Family Study. Diabetes 48: 170-175, 1999
34. Daaboul J, Schatz D: Overview of prevention and intervention trials for type 1 diabetes. Rev Endocr Metab Disord 4:317-323, 2003
35. Steele C, Hagopian WA, Gitelman S, Masharani U, Cavaghan M, Rother KI, Donaldson D, Harlan DM, Bluestone J, Herold KC: Insulin secretion in type 1 diabetes. Diabetes 53:426-433, 2004
36. Holland AM, Gonez LJ, Harrison LC: Progenitor cells in the adult pancreas. Diabetes Metab Res Rev 20:13-27, 2004
37. Atkinson MA, Eisenbarth GS: Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 358:221-229, 2001
38. Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, Porcelli S, Maclaren N: Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109:131-140, 2002
39. Eisenbarth GS: Insulin autoimmunity: immunogenetics/immunopathogenesis of type 1A diabetes. Ann N Y Acad Sci 1005:109-118, 2003
40. Achenbach P, Warncke K, Reiter J, Naserke HE, Williams AJ, Bingley PJ, Bonifacio E, Ziegler AG: Stratification of type 1 diabetes risk on the basis of islet autoantibody characteristics. Diabetes 53:384-392, 2004
41. Homo-Delarche F, Drexhage HA: Immune cells, pancreas development, regeneration and type 1 diabetes. Trends Immunol 25:222-229, 2004
42. Roep BO: Autoreactive T cells in endocrine/organ-specific autoimmunity: why has progress been so slow? Springer Semin Immunopathol 24:261-271, 2002
43. Atkinson MA, Kaufman DL, Campbell L, Gibbs KA, Shah SC, Bu DF, Erlander MG, Tobin AJ, Maclaren NK: Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet 339:458-459, 1992
44. Atkinson MA, Bowman MA, Campbell L, Darrow BL, Kaufman DL, Maclaren NK: Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94:2125-2129, 1994
45. Mallone R, Kochik SA, Laughlin EM, Gersuk VH, Reyonen H, Kwok WW, Nepom GT: Differential recognition and activation thresholds in human autoreactive GAD-specific T-cells. Diabetes 53:971-977, 2004
46. Arif S, Tree TI, Astill TP, Tremble JM, Bishop AJ, Dayan CM, Roep BO, Peakman M: Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest 113:451-463, 2004
47. Lernmark A: Type 1 diabetes as a model for prediction and diagnosis. Autoimmunity 37:341-345, 2004
48. Krischer JP, Cuthbertson DD, Yu L, Orban T, Maclaren N, Jackson R, Winter WE, Schatz DA, Palmer JP, Eisenbarth GS: Screening strategies for the identification of multiple antibody-positive relatives of individuals with type 1 diabetes. J Clin Endocrinol Metab 88:103-108, 2003
49. Hahl J, Simell T, Ilonen J, Knip M, Simell O: Costs of predicting IDDM. Diabetologia 41:79-85, 1998
50. Bowman MA, Leiter EH, Atkinson MA: Prevention of diabetes in the NOD mouse: implications for therapeutic intervention in human disease. Immunol Today 15:115-120, 1994
51. Atkinson MA, Leiter EH: The NOD mouse model of type 1 diabetes: as good as it gets? Nat Med 5:601-604, 1999
52. Roep BO, Atkinson M: Animal models have little to teach us about type 1 diabetes. 1. In support of this proposal. Diabetologia 47:1650-1656, 2004
53. Ader DN, Johnson SB, Huang SW, Riley WJ: Group size, cage shelf level, and emotionality in non-obese diabetic mice: impact on onset and incidence of IDDM. Psychosom Med 53:313-321, 1991
54. Winter WE, Schatz D: Prevention strategies for type 1 diabetes mellitus: current status and future directions. BioDrugs 17:39-64, 2003
55. Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA: Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346:1692-1698, 2002
56. Leiter EH, von Herrath M: Animal models have little to teach us about type 1 diabetes. 2. In opposition to this proposal. Diabetologia 47:1657-1660, 2004
57. Mestas J, Hughes CC: Of mice and not men: differences between mouse and human immunology. J Immunol 172:2731-2738, 2004
58. Sakaguchi S, Sakaguchi N, Shimizu J, Yamazaki S, Sakihama T, Itoh M, Kuniyasu Y, Nomura T, Toda M, Takahashi T: Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol Rev 182:18-32, 2001
59. Yudkin JS: Insulin for the world's poorest countries. Lancet 355:919-921, 2000