A macromolecular complex involving the amyloid precursor protein (APP) and the cytosolic adapter FE65 is a negative regulator of axon branching

Molecular and Cellular Neuroscience

Volumn 35, Issue 1, 2007, Pages 57-63

  Ikin, Annat F ^a,d   Sabo, Shasta L ^b   Lanier, Lorene M ^c   Buxbaum, Joseph D ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; APP; Branching; FE65; Mena; Neurite outgrowth

Indexed keywords

AMYLOID PRECURSOR PROTEIN; PROTEIN FE65;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL MATURATION; CONTROLLED STUDY; HIPPOCAMPUS; MOUSE; NERVE FIBER GROWTH; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONS; CELL SHAPE; CELLS, CULTURED; CYTOSOL; DENDRITES; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; MACROMOLECULAR SUBSTANCES; MICE; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; NUCLEAR PROTEINS;

ADENOVIRIDAE;

EID: 34247349579     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2007.02.003     Document Type: Article

References (31)

1. Allinquant B., Hantraye P., Mailleux P., Moya K., Bouillot C., and Prochiantz A. Downregulation of amyloid precursor protein inhibits neurite outgrowth in vitro. J. Cell Biol. 128 (1995) 919-927
2. Banker G., and Goslin K. Culturing Nerve Cells. 2nd edition (1998), Massachusetts Institute of Technology
3. Borg J.P., Ooi J., Levy E., and Margolis B. The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein. Mol. Cell. Biol. 16 (1996) 6229-6241
4. Dickson T.C., King C.E., McCormack G.H., and Vickers J.C. Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease. Exp. Neurol. 156 (1999) 100-110
5. Ermekova K.S., Zambrano N., Linn H., Minopoli G., Gertler F., Russo T., and Sudol. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled. J. Biol. Chem. 272 (1997) 32869-32877
6. Geddes J.W., Anderson K.J., and Cotman C.W. Senile plaques as aberrant sprout-stimulating structures. Exp. Neurol. 94 (1986) 767-776
7. Gertler F.B., Doctor J.S., and Hoffmann F.M. Genetic suppression of mutations in the Drosophila Abl proto-oncogene homolog. Science 248 (1990) 857-860
8. Gertler F.B., Comer A.R., Juang J.L., Ahern S.M., Clark M.J., Liebl E.C., and Hoffmann F.M. Enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes Dev. 9 (1995) 521-533
9. Goh K.L., Cai L., and Cepko C.L. Ena/VASP proteins regulate cortical neuronal positioning. Curr. Biol. 12 (2002) 565-569
10. Guenette S.Y., Chen J., Ferland A., Haass C., Capell A., and Tanzi R.E. hFE65L influences amyloid precursor protein maturation and secretion. J. Neurochem. 73 (1999) 985-993
11. Guenette S., Chang Y., Hiesberger T., Richardson J.A., Eckman C.B., Eckman E.A., Hammer R.E., and Herz J. Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development. EMBO J. 25 (2006) 420-431
12. Herms J., Anliker B., Heber S., Ring S., Fuhrmann M., Kretzschmar H., and Sisodia S. Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members. EMBO J. 23 (2004) 4106-4115
13. Hernandez-Deviez D.J., Roth M.G., and Casanova J.E. ARNO and ARF6 regulate axonal elongation and branching through downstream activation of phosphatidylinositol 4-phosphate 5-kinase alpha. Mol. Biol. Cell 15 (2004) 111-120
14. Hu Q., Jin L.W., Starbuck M.Y., and Martin M.Y. Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions. J. Neurosci. Res. 60 (2000) 73-86
15. Hung A.Y., Koo E.H., Haass C., and Selkoe D.J. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proc. Natl. Acad. Sci. U. S. A. 89 (1992) 9439-9443
16. Jin L.W., Ninomiya H., Roch J.M., Schubert D., Masliah E., and Otero D.A. Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J. Neurosci. 14 (1994) 5461-5470
17. Lanier L.M., and Gertler F.B. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility. Curr. Opin. Neurobiol. 10 (2000) 80-87
18. Lanier L.M., Gates M.A., Witke W., Menzies A.S., Wehman A.M., Macklis J.D., Kwiatkowski D., Soriano P., and Gertler F.B. Mena is required for neurulation and commissure formation. Neuron 22 (1999) 313-325
19. LeBlanc A.C., Kovacs D.M., Chen H.Y., Villare F., Tykocinski M., Autilio-Gambetti L., and Gambetti P. Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells. J. Neurosci. Res. 31 (1992) 635-645
20. Lebrand C., Dent E.W., Strasser G.A., Lanier L.M., Krause M., Svitkina T.M., and Borisy G.G. Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron 42 (2004) 37-49
21. Leyssen M., Ayaz D., Hebert S.S., Reeve S., De Strooper B., and Hassan B.A. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J. 24 (2005) 2944-2955
22. Majocha R.E., Agrawal S., Tang J.Y., Humke E.W., and Morotta C.A. Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein. Cell. Mol. Neurobiol. 14 (1994) 425-437
23. Merdes G., Soba P., Loewer A., Bilic M.V., and Beyreuther K. Interference of human and Drosophila APP and APP-like proteins with PNS development in Drosophila. EMBO J. 23 (2004) 4082-4095
24. Milward E.A., Papadopoulos R., Fuller S.J., Moir R.D., Small D., and Beyreuther K. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9 (1992) 129-137
25. Moya K.L., Benowitz L.I., Schneider G.E., and Allinquant B. The amyloid precursor protein is developmentally regulated and correlated with synaptogenesis. Dev. Biol. 161 (1994) 597-603
26. Perez R.G., Zheng H., Van der Ploeg L.H., and Koo E.H. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 17 (1997) 9407-9414
27. Sabo S.L., Lanier L.M., Ikin A.F., Khorkova O., Sahasrabudhe S., Greengard P., and Buxbaum J.D. Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein. J. Biol. Chem. 274 (1999) 7952-7957
28. Sabo S.L., Ikin A.F., Buxbaum J.D., and Greengard P. The Alzheimer amyloid precursor protein (APP) and FE65, an APP-binding protein, regulate cell movement. J. Cell Biol. 153 (2001) 1403-1414
29. Sabo S.L., Ikin A.F., and Buxbaum J.D. The amyloid precursor protein and its regulatory protein, FE65, in growth cones and synapses in vitro and in vivo. J. Neurosci. 23 (2003) 5407-5415
30. Small D.H., Nurcombe V., Ree G., Clarris H., Moi R., Beyreuther K., and Masters C.L. A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth. J. Neurosci. 14 (1994) 2117-2127
31. Szebenyi G., Callaway J.L., and Dent E.W. Interstitial branches develop from active regions of the axon demarcated by the primary growth cone during pausing behaviors. J. Neurosci. 18 (1998) 7930-7940