Neurotrophic and neuroprotective effects of hAPP in transgenic mice

Annals of the New York Academy of Sciences

Volumn 777, Issue , 1996, Pages 82-88

  Mucke, L ^a   Abraham, C R ^b   Masliah, E ^c  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; KAINIC ACID; NEUROMODULIN; SYNAPTOPHYSIN; VIRUS GLYCOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY LABELING; ANTIGEN EXPRESSION; COMPUTER ANALYSIS; CONFERENCE PAPER; CONFOCAL LASER MICROSCOPY; DENTATE GYRUS; GLIA CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MICRODENSITOMETRY; MOUSE; NERVE DEGENERATION; NERVE TRANSECTION; NEUROTROPISM; NONHUMAN; REINNERVATION; SYNAPSE; SYNAPTOSOME; TRANSGENIC MOUSE;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MUS MUSCULUS;

EID: 0029924264     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1996.tb34405.x     Document Type: Conference Paper

References (20)

1. CLARK, R. F. & A. M. GOATE. 1993. Molecular genetics of Alzheimer's disease. Arch. Neurol. 50:1164-1172.
2. SCHUBERT, W., R. PRIOR, A. WEIDEMANN, H. DIRCKSEN, G. MULTHAUP, C. L. MASTERS & K. BEYREUTHER. 1991. Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res. 563: 184-194.
3. 2+ homeostasis in Alzheimer's disease. TINS 16: 409-414.
4. MUCKE, L., E. MASLIAH, W. B. JOHNSON, M. D. RUPPE, M. ALFORD, E. M. ROCKENSTEIN, S. FORSS-PETTER, M. PIETROPAOLO, M. MALLORY & C. R. ABRAHAM. 1994. Synaptotrophic effects of human amyloid β protein precursor in the cortex of transgenic mice. Brain Res. 666:151-167.
5. TOGGAS, S. M., E. MASLIAH, E. M. ROCKENSTEIN, G. F. RALL, C. R. ABRAHAM & A. MUCKE. 1994. Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature 367:188-193.
6. MASLIAH, E., M. MALLORY, M. ALFORD, N. GE & L. MUCKE. 1995. Abnormal synaptic regeneration in hAPP695 transgenic and ApoE knockout mice. In Research Advances in Alzheimer's Disease and Related Disorders. K. Iqbal, J. Mortimer, B. Winblad & H. Wisniewski, Eds. Chapter 44: 405-414. John Wiley & Sons, Ltd.
7. TOGGAS, S. M. & L. MUCKE. 1994. Transgenic models in the study of AIDS dementia complex. Curr. Top. Microbiol. Immunol. In press.
8. LIPTON, S. A. & P. A. ROSENBERG. 1994. Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders. N. Engl. J. Med. 330:613-622.
9. LIPTON, S. A. 1994. HIV-related neuronal injury: Potential therapeutic intervention with calcium channel antagonists and NMDA antagonists. Mol. Neurobiol. 8:181-196.
10. MUCKE, L., C. R. ABRAHAM, M. D. RUPPE, E. M. ROCKENSTEIN, S. T. TOGGAS, M. ALFORD & E. MASLIAH. 1995. Protection against HIV - 1 gp120-induced brain damage by neuraonal overexpression of amyloid protein precursor (APP). J. Exp. Med. 181:1551-1556.
11. ROCH, J-M., E. MASLIAH, A-C. ROCH-LEVECQ, M. P. SUNDSMO, D. A. C. OTERO, I. VEINBERGS & T. SAITOH. 1994. Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid β/A4 protein precursor. Proc. Natl. Acad. Sci. USA 91:7450-7454.
12. MASLIAH, E., M. MALLORY, N. GE & T. SAITOH. 1992. Amyloid precursor protein is localized in growing neurites of neonatal rat brain. Brain Res. 593: 323-328.
13. LÖFFLER, J. & G. HUBER. 1992. β-amyloid precursor protein isoforms in various rat brain regions and during brain development. J. Neurochem. 59: 1316-1324.
14. MATTSON, M. P., B. CHENG, A. R. CULWELL, F. S. ESCH, I. LIEBERBURG & R. E. RYDEL. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein. Neuron 10:243-254.
15. SMITH-SWINTOSKY, V. L., L. C. PETTIGREW, S. D. CRADDOCK, A. R. CULWELL, R. E. RYDEL & M. P. MATTSON. 1994. Secreted forms of β-amyloid precursor protein protect against schemic brain injury. J. Neurochem. 63: 781-784.
16. MIYAZAKI, K., M. HASEGAWA, K. FUNAHASHI & M. UMEDA. 1993. A metalloproteinase inhibitor domain in Alzheimer amyloid protein precursor. Nature 362:839-842.
17. ABRAHAM, C. R., K. KANEMARU & L. MUCKE. 1993. Expression of cathepsin G-like and α1-antichymotrypsin-like proteins in reactive astrocytes. Brain Res. 621:222-232.
18. AKOPYAN, T. 1991. Protein inhibitors of proteinases from brain. Neurochem. Res. 16:513-517.
19. OLTERSDORF, T., L. C. FRITZ, D. B. SCHENK, I. LIEBERBURG, K. L. JOHNSON WOOD, E. C. BEATTIE, P. J. WARD, R. W. BLACHER, H. F. DOVEY & S. SINHA. 1989. The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II. Nature 341:144-147.
20. VAN NOSTRAND, W. E., S. L. WAGNER, M. SUZUKI, B. H. CHOI, J. S. FARROW, J. W. GEDDES, C. W. COTMAN & D. D. CUNNINGHAM. 1989. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature 341:546-549.