Cytoprotective function of sAPPα in human keratinocytes

European Journal of Cell Biology

Volumn 83, Issue 11-12, 2004, Pages 701-708

  Wehner, Sven ^a,b   Siemes, Christina ^a   Kirfel, Gregor ^a   Herzog, Volker ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

AKT; Amyloid precursor protein; Apoptosis; Cell adhesion; Cytoprotection; Staurosporine; UV B

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; RECOMBINANT PROTEIN; STAUROSPORINE; UNCLASSIFIED DRUG; ALPHA SAPP PROTEIN, HUMAN; ALPHA-SAPP PROTEIN, HUMAN; EPIDERMAL GROWTH FACTOR; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SUNSCREEN;

APOPTOSIS; ARTICLE; CELL ADHESION; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; INHIBITION KINETICS; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; ULTRAVIOLET RADIATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; EPIDERMIS; METABOLISM; PHOSPHORYLATION; RADIATION EXPOSURE;

BOVINAE;

AMYLOID BETA-PROTEIN PRECURSOR; APOPTOSIS; CELL ADHESION; CELLS, CULTURED; CYTOPROTECTION; ENZYME ACTIVATION; EPIDERMAL GROWTH FACTOR; EPIDERMIS; HUMANS; KERATINOCYTES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS; STAUROSPORINE; SUNSCREENING AGENTS; ULTRAVIOLET RAYS;

EID: 12344259342     PISSN: 01719335     EISSN: None     Source Type: Journal    
DOI: 10.1078/0171-9335-00427     Document Type: Article

References (56)

1. Adams, J. C., Watt, F. M., 1990. Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Cell 63, 423-435.
2. Auf dem Keller, U., Krampert, M., Kümin, A., Braun, S., Werner, S., 2004. Keratinocyte growth factor: effects on keratinocytes and mechanisms of action. Eur. J. Cell Biol. 83, 607-612.
3. Beher, D., Hesse. L., Masters, C. L., Multhaup, G., 1996. Regulation of amyloid protein precursor (APP) binding to collagen and mapping of the binding sites on APP and collagen type I. J. Biol. Chem. 271, 1613-1620.
4. Boukamp, P., Petrussevska, R. T., Breitkreutz, D., Hornung, J., Markham, A., Fusenig, N. E., 1988. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761-771.
5. Braga, V. M., 2002. Cell-cell adhesion and signalling. Curr. Opin. Cell Biol. 14, 546-556.
6. Brazil, D.P., Hemmings, B.A., 2001. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26, 657-664.
7. Brunet, A., Bonni, A., Zigmond, M. J.. Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., Greenberg, M. E., 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868.
8. Burgering, B.M., Coffer, P. J., 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376, 599-602.
9. Bush, A. I., Beyreuther, K., Masters, C. L., 1993. The beta A4 amyloid protein precursor in human circulation. Ann. NY Acad. Sci. 695. 175-182.
10. Cardone, M. H., Roy, N., Stennicke. H. R., Salvesen, G. S., Franke, T. F., Stanbridge, E., Frisch, S., Reed, J. C., 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282, 1318-1321.
11. Cowin, P., Burke, B., 1996. Cytoskeleton-membrane interactions. Curr. Opin. Cell Biol. 8, 56-65.
12. Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., Greenberg, M. E., 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-741
13. Decraene, D., Agostinis, P., Bouillon, R., Degreef, H., Garmyn, M., 2002. Insulin-like growth factor-1-mediated AKT activation postpones the onset of ultraviolet B-induced apoptosis, providing more time for cyclobutane thymine dimer removal in primary human keratinocytes. J. Biol. Chem. 277, 32587-32595.
14. Demaerschalck, I., Delvaux, A., Octave, J.N., 1993. Activation of protein kinase C increases the extracellular release of the transmembrane amyloid protein precursor of Alzheimer's disease. Biochim. Biophys. Acta 1181, 214-218.
15. Fuchs, E., Raghavan, S., 2002. Getting under the skin of epidermal morphogenesis. Nat. Rev. Genet. 3, 199-209.
16. Grose, R., Werner, S., 2002. An aPPArently protective mechanism for keratinocytes in wounded skin. Trends Mol. Med. 8, 149-151.
17. Guo, Q., Robinson, N., Mattson, M.P., 1998. Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis. J. Biol. Chem. 273, 12341-12351.
18. Hoffmann, J., Twiesselmann, C., Kummer, M. P., Romagnoli, P., Herzog, V., 2000. A possible role for the Alzheimer amyloid precursor protein in the regulation of epidermal basal cell proliferation. Eur. J. Cell Biol. 79. 905-914.
19. Holbrook, K. A., 1994. Ultrastructure of epidermis, in: Watt, F. M. Leigh, I. M. (Eds.), The Keratinocytes Handbook. Cambridge University Press, Cambridge, pp. 3-39.
20. Jamora, C., Fuchs, E., 2002. Intercellular adhesion, signalling and the cytoskeleton. Nat. Cell Biol. 4. E101-108.
21. Jin, L. W., Ninomiya, H., Roch, J. M., Schubert, D., Masliah, E., Otero, D. A., Saitoh, T., 1994. Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension. J. Neurosci. 14, 5461-5470.
22. Jones, J. C., Goidman, A. E., Yang, H. Y., Goidman, R. D., 1985. The organizational fate of intermediate filament networks in two epithelial cell types during mitosis. J. Cell Biol. 100, 93-102.
23. Kalinin, A. E., Kajava, A. V., Steinert, P. M., 2002. Epithelial barrier function: assembly and structural features of the cornified cell envelope. Bioessays 24, 789-800.
24. Kane, L. P., Shapiro, V. S., Stokoe, D., Weiss, A., 1999. Induction of NF-kappaB by the Akt/PKB kinase. Curr. Biol. 9, 601-604.
25. Kirfel, G., Borm, B., Rigort, A., Herzog, V., 2002. The secretory beta-amyloid precursor protein is a motogen for human epidermal keratinocytes. Eur. J. Cell Biol. 81, 664-676.
26. Kirfel, G., Rigort, A., Borm, B., Herzog, V., 2004. Cell migration: rear detachment and the formation of migration tracks. Eur. J. Cell Biol. 83, 717-724.
27. Kummer, C., Wehner, S., Quast, T., Werner, S., Herzog, V., 2002. Expression and potential function of beta-amyloid precursorproteins during cutaneous wound repair. Exp. Cell Res. 280, 222-232.
28. Lindl, T., 2002. Zell- und Gewebekultur. Spektrum Akademischer Verlag, Heidelberg-Berlin.
29. Madison, K. C., 2003. Barrier function of the skin: "la raison d'etre" of the epidermis. J. Invest. Dermatol. 121, 231-241.
30. Mattson, M. P., 1997. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Physiol. Rev. 77, 1081-1132.
31. Milward, E. A., Papadopoulos, R., Fuller, S. J., Moir, R. D., Small, D., Beyreuther, K., Masters, C. E., 1992. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth. Neuron 9, 129-137.
32. Munz, B., Hubner, G., Tretter, Y., Alzheimer, C., Werner, S., 1999. A novel role of activin in inflammation and repair. J. Endocrinol. 161, 187-193.
33. Nanney, L. B., Sundberg, J. P., King, L. E., 1996. Increased epidermal growth factor receptor in fsn/fsn mice. J. Invest. Dermatol. 106, 1169-1174.
34. Narindrasorasak, S., Lowery, D. E., Altman, R. A., Gonzalez-DeWhitt, P. A., Greenberg, B.D., Kisilevsky, R., 1992. Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins. Lab. Invest. 67, 643-652.
35. Perez, R. G., Zheng, H., Van der Ploeg, L. H., Koo, E. H., 1997. The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity. J. Neurosci. 47, 9407-9414.
36. Pietrzik, C. U., Hoffmann, J., Stober, K., Chen, C. Y., Bauer, C., Otero, D. A., Roch, J. M., Herzog, V., 1998. From differentiation to proliferation: the secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells. Proc. Natl. Acad. Sci. USA 95, 1770-1775.
37. Rappolee, D. A., Mark, D., Banda, M. J., Werb, Z., 1988. Wound macrophages express TGF-alpha and other growth factors in vivo: analysis by mRNA phenotyping. Science 241, 708-712.
38. Ray, P., Devaux, Y., Stolz, D. B., Yarlagadda, M., Watkins, S. C., Lu, Y., Chen, L., Yang, X. F., Ray, A., 2003. Inducible expression of keratinocyte growth factor (KGF) in mice inhibits lung epithelial cell death induced by hyperoxia. Proc. Natl. Acad. Sci. USA 100, 6098-6103.
39. Rheinwald, J. G., Green, H., 1975. Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6, 331-343.
40. Rossjohn, J., Cappai, R., Feil, S. C., Henry, A., McKinstry, W. J., Galatis, D., Hesse, L., Multhaup, G., Beyreuther, K., Masters, C. L., et al., 1999. Crystal structure of the N-terminal, growth factor-like domain of Alzheimer amyloid precursor protein. Nat. Struct. Biol. 6, 327-331.
41. Saitoh, T., Sundsmo, M., Roch, J. M., Kimura, N., Cole, G., Schubert, D., Oltersdorf, T., Schenk, D. B., 1989. Secreted form of amyloid beta protein precursor is involved in the growth regulation of fibroblasts. Cell 58, 615-622.
42. Schubert, D., Behl, C., 1993. The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix. Brain Res. 629, 275-82.
43. Schubert, D., LaCorbiere, M., Saitoh, T., Cole, G., 1989. Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate. Proc. Natl. Acad. Sci. USA 86, 2066-2069.
44. Shin, I., Bakin, A. V., Rodeck, U., Brunet, A., Arteaga, C. L., 2001. Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol. Biol. Cell 12, 3328-3339.
45. Shipley, G. D., Pittelkow, M. R., 1987. Control of growth and differentiation in vitro of human keratinocytes cultured in serum-free medium. Arch. Dermatol. 123, 1541a-1544a.
46. Siemes, C., Quast, T., Klein, E., Bieber, T., Hooper, N. M., Herzog, V., 2004. Normalized proliferation of normal and psoriatic keratinocytes by suppression of alpha-secretase. J. Invest. Dermatol. 123, 556-563.
47. Skerrow, C. J., 1978. Intercellular adhesion and its role in epidermal differentiation. Invest. Cell Pathol. 1, 23-37.
48. Skovronsky, D. M., Moore, D. B., Milla, M. E., Doms, R. W., Lee, V. M., 2000. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-Golgi network. J. Biol. Chem. 275, 2568-2575.
49. Sonnenberg, A., Gehlsen, K. R., Aumailley, M., Timpl, R., 1991. Isolation of alpha 6 beta 1 integrins from platelets and adherent cells by affinity chromatography on mouse laminin fragment E8 and human laminin pepsin fragment. Exp. Cell Res. 197, 234-244.
50. -+ dependent protein kinase. Biochem. Biophys. Res. Commun. 135, 397-402.
51. Teraki, Y., Shiohara, T., 1999. Apoptosis and the skin. Eur. J. Dermatol. 9, 413-425; quiz 426.
52. Watt, F. M., 2002. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 21, 3919-3926.
53. Watt, F. M., Kubler, M. D., Hotchin, N. A., Nicholson, L. J., Adams, J. C., 1993. Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions. J. Cell Sci. 106, 175-182.
54. Werner, S., 1998. Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev. 9, 153-165.
55. Werner, S., Grose, R., 2003. Regulation of wound healing by growth factors and cytokines. Physiol. Rev. 83, 835-870.
56. Werner, S., Peters, K. G., Lonaaker, M.T., Fuller-Pace, F., Banda, M. J., Williams, L. T., 1992. Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc. Natl. Acad. Sci. USA 89, 6896-6900.