Characterization of the neurotrophic interaction between nerve growth factor and secreted α-amyloid precursor protein

Journal of Neuroscience Research

Volumn 63, Issue 5, 2001, Pages 410-420

  Luo, Jin Jun ^a   Wallace, Matthew S ^a,b   Hawver, David B ^a   Kusiak, John W ^a   Wallace, William C ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b Georgetown Day School   (United States)

Author keywords

Amyloid precursor protein; Cortical neurons; Insulin signaling pathway; Neurotrophic activity; NGF; PC12 cells

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; OLIVARY NUCLEUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BASAL NUCLEUS OF MEYNERT; CATTLE; CELL DIFFERENTIATION; CEREBRAL CORTEX; COLORING AGENTS; CULTURE MEDIA; DRUG SYNERGISM; ENDOPEPTIDASES; FETAL BLOOD; FLUORESCENT DYES; GROWTH SUBSTANCES; HORSES; HUMANS; INSULIN; NERVE GROWTH FACTOR; NEURITES; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; ORGANIC CHEMICALS; PC12 CELLS; PHENOTYPE; PHOSPHOPROTEINS; RATS; SIGNAL TRANSDUCTION;

EID: 0035282739     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4547(20010301)63:5<410::AID-JNR1036>3.0.CO;2-B     Document Type: Article

References (40)

1. Amyloid precursor protein modulates the interaction of nerve growth factor with p75 receptor and potentiates its activation of trkA phosphorylation
2. Down regulation of amyloid precursor protein inhibits neurite outgrowth in vitro
3. Trophic effect of β-amyloid precursor protein on cerebral cortical neurons in culture
4. Bcl-2 affects survival but not neuronal differentiation of PC12 cells
5. Age and damage induced changes in amyloid protein precursor immunohistochemistry in the rat brain
6. Beta amyloid precursor protein mediates neuronal cell-cell and cell surface adhesion
7. Cleavage of amyloid β peptide during constitutive processing of its precursor
8. Secreted β-amyloid precursor protein stimulates mitogen activated protein kinase and enhances tau phosphorylation
9. Nerve growth factor prevents the death and stimulates neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium
10. Pharmacological modulation of Alzheimer's β-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
11. Increased expression of β-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage
12. Expression of APP in the early stage of brain damage
13. Heat shock proteins protect against stress related phosphorylation of tau in neuronal PC12 cells that have acquired thermotolerance
14. Amyloid β-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth
15. Role of amyloid precursor protein (APP): Study with antisense transfection of human neuroblatoma cells
16. Death of PC12 cells and hippocampal neurons induced by adenoviral mediated FAD human amyloid precursor protein gene expression
17. Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein
18. Evidence for excitoprotective and intraneuronal calcium regulating roles for secreted forms of the β-amyloid precursor protein
19. The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth
20. Secreted forms of amyloid β/A4 precursor protein (APP) binds to two distinct APP binding sites on rat B103 neuron like cells through two different domains but only one site is involved in neurotropic activity
21. Rapid appearance of beta-amyloid precursor protein immunoreactivity in damaged axons and reactive glial cells in rat brain following needle stab injury
22. The β-amyloid precursor protein of Alzheimer's disease enhances neuronal viability and modulates neuronal polarity
23. Muscle weakness in β-amyloid precursor protein deficient knockout mice is associated with altered motor neuron numbers and myofiber composition
24. Immunohistochemical characterization of alterations in the distibution of amyloid precursor proteins and β amyloid peptide after experimental brain injury in the rat
25. From differentiation to proliferation: The secretory amyloid precursor protein as a local mediator of growth in thyroid epithelial cells
26. Nerve and epidemial growth factors induce the release of the Alzheimer amyloid precursor from PC12 cultures
27. Cell surface β-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
28. Multiple agents rescue PC12 cells from serum-free cell death by translation- and transcription-independent mechanisms
29. Secreted form of amyloid β protein is involved in the growth regulation of fibroblasts
30. The promoter of Alzheimer's disease amyloid A4 precursor gene
31. The expression of amyloid beta protein precursor protects nerve cells from β-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix
32. Beta-amyloid precursor protein is differentially expressed in axotomized sensory and motor systems
33. Reactive microglia/macrophages phagocytose amyloid precursor protein produced by neurons following neural damage
34. Expression of β-amyloid precursor protein in reactive astrocytes following neuronal damage
35. Amyloid precursor protein in the cerebral cortex is rapidly and persistently induced by loss of subcortical innervation
36. Chronic elevation of secreted amyloid precursor protein in subcortically lesioned rats and its exacerbation in aged rats
37. Amyloid precursor protein potentiates the neurotrophic activity of NGF
38. Amyloid precursor protein requires the insulin signaling pathway for neurotrophic activity
39. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
40. b-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity