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Volumn 5, Issue 3, 2012, Pages 293-309

Strategies to decrease ongoing oxidant burden in chronic obstructive pulmonary disease

Author keywords

antioxidants; COPD; glutathione; Nrf2; oxidants; redox; thiol; tobacco smoke

Indexed keywords

2 OXO 4 THIAZOLIDINECARBOXYLIC ACID; 2,2' DITHIODIPYRIDINE; 21 AMINOSTEROID; 3 CHLOROTYROSINE; ACETYLCYSTEINE; CARBOCISTEINE; CHALCONE; CIGARETTE SMOKE; DIETHYLSTILBESTROL; DISUFENTON SODIUM; EBSELEN; ERDOSTEINE; FUDOSTEINE; HYDROGEN PEROXIDE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LACTOFERRIN; LIPOCALIN; LYSINE DERIVATIVE; MYELOPEROXIDASE; NITRIC OXIDE SYNTHASE; NORPHENAZONE; PEROXYNITRITE; SEMIQUINONE; SULFORAPHANE; SUPEROXIDE DISMUTASE; THIONEINE; THIOREDOXIN; TIRILAZAD; UNINDEXED DRUG; XANTHINE OXIDASE;

EID: 84861421537     PISSN: 17512433     EISSN: 17512441     Source Type: Journal    
DOI: 10.1586/ecp.12.16     Document Type: Review
Times cited : (25)

References (190)
  • 1
    • 34548267728 scopus 로고    scopus 로고
    • International variation in the prevalence of COPD the BOLD study: A population-based prevalence study
    • Buist AS, McBurnie MA, Vollmer WM et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 370(9589), 741-750 (2007
    • (2007) Lancet , vol.370 , Issue.9589 , pp. 741-750
    • Buist, A.S.1    McBurnie, M.A.2    Vollmer, W.M.3
  • 2
    • 77954691090 scopus 로고    scopus 로고
    • Risk of COPD from exposure to biomass smoke: A meta-analysis
    • Hu G, Zhou Y, Tian J et al. Risk of COPD from exposure to biomass smoke: a meta-analysis. Chest 138(1), 20-31 (2010
    • (2010) Chest , vol.138 , Issue.1 , pp. 20-31
    • Hu, G.1    Zhou, Y.2    Tian, J.3
  • 3
    • 78650210969 scopus 로고    scopus 로고
    • Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease
    • Pillai SG, Kong X, Edwards LD et al. Loci identified by genome-wide association studies influence different disease-related phenotypes in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 182(12), 1498-1505 (2010
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , Issue.12 , pp. 1498-1505
    • Pillai, S.G.1    Kong, X.2    Edwards, L.D.3
  • 4
    • 77957719327 scopus 로고    scopus 로고
    • An official American thoracic society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease
    • Eisner MD, Anthonisen N, Coultas D et al. An official American thoracic society public policy statement: novel risk factors and the global burden of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 182(5), 693-718 (2010
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , Issue.5 , pp. 693-718
    • Eisner, M.D.1    Anthonisen, N.2    Coultas, D.3
  • 5
    • 3142517968 scopus 로고    scopus 로고
    • Association between chronic obstructive pulmonary disease and systemic inflammation: A systematic review and a meta-analysis
    • Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 59(7), 574-580 (2004
    • (2004) Thorax , vol.59 , Issue.7 , pp. 574-580
    • Gan, W.Q.1    Man, S.F.2    Senthilselvan, A.3    Sin, D.D.4
  • 6
    • 74849118542 scopus 로고    scopus 로고
    • Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: Is there a connection
    • Wouters EF, Reynaert NL, Dentener MA, Vernooy JH. Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection? Proc. Am. Thorac. Soc. 6(8), 638-647 (2009
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , Issue.8 , pp. 638-647
    • Wouters, E.F.1    Reynaert, N.L.2    Dentener, M.A.3    Vernooy, J.H.4
  • 7
    • 33750620057 scopus 로고    scopus 로고
    • Oxidative stress and redox regulation of lung inflammation in COPD
    • Rahman I, Adcock IM. Oxidative stress and redox regulation of lung inflammation in COPD. Eur. Respir. J. 28(1), 219-242 (2006
    • (2006) Eur. Respir. J. , vol.28 , Issue.1 , pp. 219-242
    • Rahman, I.1    Adcock, I.M.2
  • 8
    • 34548660457 scopus 로고    scopus 로고
    • Global strategy for the diagnosis management and prevention of chronic obstructive pulmonary disease: GOLD executive summary
    • Rabe KF, Hurd S, Anzueto A et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 176(6), 532-555 (2007
    • (2007) Am. J. Respir. Crit. Care Med. , vol.176 , Issue.6 , pp. 532-555
    • Rabe, K.F.1    Hurd, S.2    Anzueto, A.3
  • 9
    • 66149093072 scopus 로고    scopus 로고
    • The pathology of chronic obstructive pulmonary disease
    • Hogg JC, Timens W. The pathology of chronic obstructive pulmonary disease. Annu. Rev. Pathol. 4, 435-459 (2009
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 435-459
    • Hogg, J.C.1    Timens, W.2
  • 10
    • 80052706801 scopus 로고    scopus 로고
    • New insights into the immunology of chronic obstructive pulmonary disease
    • Brusselle GG, Joos GF, Bracke KR. New insights into the immunology of chronic obstructive pulmonary disease. Lancet 378(9795), 1015-1026 (2011
    • (2011) Lancet , vol.378 , Issue.9795 , pp. 1015-1026
    • Brusselle, G.G.1    Joos, G.F.2    Bracke, K.R.3
  • 11
    • 80052691591 scopus 로고    scopus 로고
    • The future of chronic obstructive pulmonary disease treatment- difficulties of and barriers to drug development
    • Martinez FJ, Donohue JF, Rennard SI. The future of chronic obstructive pulmonary disease treatment-difficulties of and barriers to drug development. Lancet 378(9795), 1027-1037 (2011
    • (2011) Lancet , vol.378 , Issue.9795 , pp. 1027-1037
    • Martinez, F.J.1    Donohue, J.F.2    Rennard, S.I.3
  • 12
    • 69149102202 scopus 로고    scopus 로고
    • Chronic obstructive pulmonary disease in nonsmokers
    • Salvi SS, Barnes PJ. Chronic obstructive pulmonary disease in nonsmokers. Lancet 374(9691), 733-743 (2009
    • (2009) Lancet , vol.374 , Issue.9691 , pp. 733-743
    • Salvi, S.S.1    Barnes, P.J.2
  • 14
    • 38449105137 scopus 로고    scopus 로고
    • Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: A pooled analysis
    • Gamble E, Grootendorst DC, Hattotuwa K et al. Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis. Eur. Respir. J. 30(3), 467-471 (2007
    • (2007) Eur. Respir. J. , vol.30 , Issue.3 , pp. 467-471
    • Gamble, E.1    Grootendorst, D.C.2    Hattotuwa, K.3
  • 16
    • 77949446867 scopus 로고    scopus 로고
    • Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: A research study
    • Louhelainen N, Stark H, Mazur W, Rytila P, Djukanovic R, Kinnula VL. Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study. BMC Pulm. Med. 10, 13 (2010
    • (2010) BMC Pulm. Med. , vol.10 , pp. 13
    • Louhelainen, N.1    Stark, H.2    Mazur, W.3    Rytila, P.4    Djukanovic, R.5    Kinnula, V.L.6
  • 17
    • 84860880317 scopus 로고    scopus 로고
    • SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
    • 10.1016/j. ypmed.2011.11.014 Epub ahead of print
    • Rahman I, Kinnula VL, Gorbunova V, Yao H. SIRT1 as a therapeutic target in inflammaging of the pulmonary disease. Prev. Med. doi:10.1016/j. ypmed.2011.11.014 (2011) (Epub ahead of print
    • (2011) Prev. Med.
    • Rahman, I.1    Kinnula, V.L.2    Gorbunova, V.3    Yao, H.4
  • 18
    • 33645065567 scopus 로고    scopus 로고
    • Matrix metalloproteinases in destructive pulmonary pathology
    • Elkington PT, Friedland JS. Matrix metalloproteinases in destructive pulmonary pathology. Thorax 61(3), 259-266 (2006
    • (2006) Thorax , vol.61 , Issue.3 , pp. 259-266
    • Elkington, P.T.1    Friedland, J.S.2
  • 19
    • 70349129549 scopus 로고    scopus 로고
    • Accelerated lung aging: A novel pathogenic mechanism of chronic obstructive pulmonary disease COPD
    • MacNee W. Accelerated lung aging: a novel pathogenic mechanism of chronic obstructive pulmonary disease (COPD). Biochem. Soc. Trans. 37(Pt 4), 819-823 (2009
    • (2009) Biochem. Soc. Trans. , vol.37 , Issue.PART 4 , pp. 819-823
    • Mac Nee, W.1
  • 20
    • 79957900741 scopus 로고    scopus 로고
    • Current concepts on oxidative carbonyl stress inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease
    • Yao H, Rahman I. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol. Appl. Pharmacol. 254(2), 72-85 (2011
    • (2011) Toxicol. Appl. Pharmacol. , vol.254 , Issue.2 , pp. 72-85
    • Yao, H.1    Rahman, I.2
  • 21
    • 37549027570 scopus 로고    scopus 로고
    • Transforming growth factor-b activation in the lung: Focus on fibrosis andreactive oxygen species
    • Koli K, Myllarniemi M, Keski-Oja J, Kinnula VL. Transforming growth factor-b activation in the lung: focus on fibrosis andreactive oxygen species. Antioxid. Redox. Signal 10(2), 333-342 (2008
    • (2008) Antioxid. Redox. Signal , vol.10 , Issue.2 , pp. 333-342
    • Koli, K.1    Myllarniemi, M.2    Keski-Oja, J.3    Kinnula, V.L.4
  • 23
    • 0030820791 scopus 로고    scopus 로고
    • Exhaled and nasal nitric oxide measurements: Recommendations
    • The European Respiratory Society Task Force
    • Kharitonov S, Alving K, Barnes PJ. Exhaled and nasal nitric oxide measurements: recommendations. The European Respiratory Society Task Force. Eur. Respir. J. 10(7), 1683-1693 (1997
    • (1997) Eur. Respir. J. , vol.10 , Issue.7 , pp. 1683-1693
    • Kharitonov, S.1    Alving, K.2    Barnes, P.J.3
  • 24
    • 4544235002 scopus 로고    scopus 로고
    • Noninvasive biomarkers of oxidative stress: Reproducibility and methodological issues
    • Rahman I, Biswas SK. Noninvasive biomarkers of oxidative stress: reproducibility and methodological issues. Redox. Rep. 9(3), 125-143 (2004
    • (2004) Redox. Rep. , vol.9 , Issue.3 , pp. 125-143
    • Rahman, I.1    Biswas, S.K.2
  • 25
    • 60249095715 scopus 로고    scopus 로고
    • Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: Current and future perspectives
    • Louhelainen N, Myllarniemi M, Rahman I, Kinnula VL. Airway biomarkers of the oxidant burden in asthma and chronic obstructive pulmonary disease: current and future perspectives. Int. J. Chron. Obstruct. Pulmon. Dis. 3(4), 585-603 (2008
    • (2008) Int. J. Chron. Obstruct. Pulmon. Dis. , vol.3 , Issue.4 , pp. 585-603
    • Louhelainen, N.1    Myllarniemi, M.2    Rahman, I.3    Kinnula, V.L.4
  • 26
    • 34548277025 scopus 로고    scopus 로고
    • From COPD to chronic systemic inflammatory syndrome
    • Fabbri LM, Rabe KF. From COPD to chronic systemic inflammatory syndrome? Lancet 370(9589), 797-799 (2007
    • (2007) Lancet , vol.370 , Issue.9589 , pp. 797-799
    • Fabbri, L.M.1    Rabe, K.F.2
  • 27
    • 0022272160 scopus 로고
    • Free-radical chemistry of cigarette smoke and its toxicological implications
    • Church DF, Pryor WA. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 64, 111-126 (1985
    • (1985) Environ. Health Perspect. , vol.64 , pp. 111-126
    • Church, D.F.1    Pryor, W.A.2
  • 28
    • 0027247805 scopus 로고
    • Oxidants in cigarette smoke radicals hydrogen peroxide peroxynitrate and peroxynitrite
    • Pryor WA, Stone K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann. NY Acad. Sci. 686, 12-27 (1993
    • (1993) Ann. NY Acad. Sci. , vol.686 , pp. 12-27
    • Pryor, W.A.1    Stone, K.2
  • 29
    • 0142075872 scopus 로고    scopus 로고
    • Neutrophil chemokines in severe exacerbations of chronic obstructive pulmonary disease: Fatal chemoattraction
    • Saetta M, Baraldo S, Zuin R. Neutrophil chemokines in severe exacerbations of chronic obstructive pulmonary disease: fatal chemoattraction? Am. J. Respir. Crit. Care Med. 168(8), 911-913 (2003
    • (2003) Am. J. Respir. Crit. Care Med. , vol.168 , Issue.8 , pp. 911-913
    • Saetta, M.1    Baraldo, S.2    Zuin, R.3
  • 30
    • 0029051473 scopus 로고
    • Generation and disposal of reactive oxygen metabolites in the lung
    • Kinnula VL, Crapo JD, Raivio KO. Generation and disposal of reactive oxygen metabolites in the lung. Lab. Invest. 73(1), 3-19 (1995
    • (1995) Lab. Invest. , vol.73 , Issue.1 , pp. 3-19
    • Kinnula, V.L.1    Crapo, J.D.2    Raivio, K.O.3
  • 31
    • 80052664252 scopus 로고    scopus 로고
    • Alternatively activated macrophages and airway disease
    • Byers DE, Holtzman MJ. Alternatively activated macrophages and airway disease. Chest 140(3), 768-774 (2011
    • (2011) Chest , vol.140 , Issue.3 , pp. 768-774
    • Byers, D.E.1    Holtzman, M.J.2
  • 32
    • 0033711405 scopus 로고    scopus 로고
    • Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease
    • Papi A, Romagnoli M, Baraldo S et al. Partial reversibility of airflow limitation and increased exhaled NO and sputum eosinophilia in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 162(5), 1773-1777 (2000
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , Issue.5 , pp. 1773-1777
    • Papi, A.1    Romagnoli, M.2    Baraldo, S.3
  • 33
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg JC, Chu F, Utokaparch S et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350(26), 2645-2653 (2004
    • (2004) N. Engl. J. Med. , vol.350 , Issue.26 , pp. 2645-2653
    • Hogg, J.C.1    Chu, F.2    Utokaparch, S.3
  • 34
    • 80053428842 scopus 로고    scopus 로고
    • Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease
    • Kirkham PA, Caramori G, Casolari P et al. Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 184(7), 796-802 (2011
    • (2011) Am. J. Respir. Crit. Care Med. , vol.184 , Issue.7 , pp. 796-802
    • Kirkham, P.A.1    Caramori, G.2    Casolari, P.3
  • 35
    • 68049084752 scopus 로고    scopus 로고
    • The overlap syndrome of asthma and COPD: What are its features and how important is it
    • Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it? Thorax 64(8), 728-735 (2009
    • (2009) Thorax , vol.64 , Issue.8 , pp. 728-735
    • Gibson, P.G.1    Simpson, J.L.2
  • 37
    • 0035153325 scopus 로고    scopus 로고
    • Relationship between airway inflammation and the frequency of exacerbations in patients with smoking-related COPD
    • Gompertz S, Bayley DL, Hill SL, Stockley RA. Relationship between airway inflammation and the frequency of exacerbations in patients with smoking-related COPD. Thorax 56(1), 36-41 (2001
    • (2001) Thorax , vol.56 , Issue.1 , pp. 36-41
    • Gompertz, S.1    Bayley, D.L.2    Hill, S.L.3    Stockley, R.A.4
  • 38
    • 0035137558 scopus 로고    scopus 로고
    • Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease
    • Aaron SD, Angel JB, Lunau M et al. Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 163(2), 349-355 (2001
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , Issue.2 , pp. 349-355
    • Aaron, S.D.1    Angel, J.B.2    Lunau, M.3
  • 39
    • 33846238535 scopus 로고    scopus 로고
    • 8-isoprostane as a marker of oxidative stress in nonsymptomatic cigarette smokers and COPD
    • Kinnula VL, Ilumets H, Myllarniemi M, Sovijarvi A, Rytila P. 8-isoprostane as a marker of oxidative stress in nonsymptomatic cigarette smokers and COPD. Eur. Respir. J. 29(1), 51-55 (2007
    • (2007) Eur. Respir. J. , vol.29 , Issue.1 , pp. 51-55
    • Kinnula, V.L.1    Ilumets, H.2    Myllarniemi, M.3    Sovijarvi, A.4    Rytila, P.5
  • 40
    • 0033833221 scopus 로고    scopus 로고
    • Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers
    • 3 Pt 1
    • Montuschi P, Collins JV, Ciabattoni G et al. Exhaled 8-isoprostane as an in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am. J. Respir. Crit. Care Med. 162(3 Pt 1), 1175-1177 (2000
    • (2000) Am. J. Respir. Crit. Care Med. , vol.162 , pp. 1175-1177
    • Montuschi, P.1    Collins, J.V.2    Ciabattoni, G.3
  • 41
    • 0037102347 scopus 로고    scopus 로고
    • 4-hydroxy-2-nonenal a specific lipid peroxidation product is elevated in lungs of patients with chronic obstructive pulmonary disease
    • Rahman I, van Schadewijk AA, Crowther AJ et al. 4-hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 166(4), 490-495 (2002
    • (2002) Am. J. Respir. Crit. Care Med. , vol.166 , Issue.4 , pp. 490-495
    • Rahman, I.1    Van Schadewijk, A.A.2    Crowther, A.J.3
  • 42
    • 33746585705 scopus 로고    scopus 로고
    • Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD
    • Rytila P, Rehn T, Ilumets H et al. Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD. Respir. Res. 7, 69 (2006
    • (2006) Respir. Res. , vol.7 , pp. 69
    • Rytila, P.1    Rehn, T.2    Ilumets, H.3
  • 43
    • 0038545583 scopus 로고    scopus 로고
    • Superoxide dismutases in the lung and human lung diseases
    • Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am. J. Respir. Crit. Care Med. 167(12), 1600-1619 (2003
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , Issue.12 , pp. 1600-1619
    • Kinnula, V.L.1    Crapo, J.D.2
  • 44
    • 65049090071 scopus 로고    scopus 로고
    • Environmental toxicity redox signaling and lung inflammation: The role of glutathione
    • Biswas SK, Rahman I. Environmental toxicity, redox signaling and lung inflammation: the role of glutathione. Mol. Aspects Med. 30(1-2), 60-76 (2009
    • (2009) Mol. Aspects Med. , vol.30 , Issue.1-2 , pp. 60-76
    • Biswas, S.K.1    Rahman, I.2
  • 45
    • 0023263523 scopus 로고
    • Normal alveolar epithelial lining fluid contains high levels of glutathione
    • Cantin AM, North SL, Hubbard RC, Crystal RG. Normal alveolar epithelial lining fluid contains high levels of glutathione. J. Appl. Physiol. 63(1), 152-157 (1987
    • (1987) J. Appl. Physiol. , vol.63 , Issue.1 , pp. 152-157
    • Cantin, A.M.1    North, S.L.2    Hubbard, R.C.3    Crystal, R.G.4
  • 46
    • 0029848789 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase: A regulator of nitric oxide bioavailability
    • Oury TD, Day BJ, Crapo JD. Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability. Lab. Invest. 75(5), 617-636 (1996
    • (1996) Lab. Invest. , vol.75 , Issue.5 , pp. 617-636
    • Oury, T.D.1    Day, B.J.2    Crapo, J.D.3
  • 47
    • 0031820982 scopus 로고    scopus 로고
    • Manganese superoxide dismutase but not CuZn superoxide dismutase is highly expressed in the granulomas of pulmonary sarcoidosis and extrinsic allergic alveolitis
    • Lakari E, Paakko P, Kinnula VL. Manganese superoxide dismutase, but not CuZn superoxide dismutase, is highly expressed in the granulomas of pulmonary sarcoidosis and extrinsic allergic alveolitis. Am. J. Respir. Crit. Care Med. 158(2), 589-596 (1998
    • (1998) Am. J. Respir. Crit. Care Med. , vol.158 , Issue.2 , pp. 589-596
    • Lakari, E.1    Paakko, P.2    Kinnula, V.L.3
  • 48
    • 0343415706 scopus 로고    scopus 로고
    • Manganese superoxide dismutase and catalase are coordinately expressed in the alveolar region in chronic interstitial pneumonias and granulomatous diseases of the lung
    • 2 Pt 1
    • Lakari E, Paakko P, Pietarinen-Runtti P, Kinnula VL. Manganese superoxide dismutase and catalase are coordinately expressed in the alveolar region in chronic interstitial pneumonias and granulomatous diseases of the lung. Am. J. Respir. Crit. Care Med. 161(2 Pt 1), 615-621 (2000
    • (2000) Am. J. Respir. Crit. Care Med. , vol.161 , pp. 615-621
    • Lakari, E.1    Paakko, P.2    Pietarinen-Runtti, P.3    Kinnula, V.L.4
  • 49
    • 0028245094 scopus 로고
    • Immunocytochemical localization of extracellular superoxide dismutase in human lung
    • Oury TD, Chang LY, Marklund SL, Day BJ, Crapo JD. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab. Invest. 70(6), 889-898 (1994
    • (1994) Lab. Invest. , vol.70 , Issue.6 , pp. 889-898
    • Oury, T.D.1    Chang, L.Y.2    Marklund, S.L.3    Day, B.J.4    Crapo, J.D.5
  • 50
    • 0024202127 scopus 로고
    • Induction of manganous superoxide dismutase by tumor necrosis factor: Possible protective mechanism
    • Wong GH, Goeddel DV. Induction of manganous superoxide dismutase by tumor necrosis factor: possible protective mechanism. Science 242(4880), 941-944 (1988
    • (1988) Science , vol.242 , Issue.4880 , pp. 941-944
    • Wong, G.H.1    Goeddel, D.V.2
  • 51
    • 0031964168 scopus 로고    scopus 로고
    • Antioxidant gene expression in rat lung after exposure to cigarette smoke
    • Gilks CB, Price K, Wright JL, Churg A. Antioxidant gene expression in rat lung after exposure to cigarette smoke. Am. J. Pathol. 152(1), 269-278 (1998
    • (1998) Am. J. Pathol. , vol.152 , Issue.1 , pp. 269-278
    • Gilks, C.B.1    Price, K.2    Wright, J.L.3    Churg, A.4
  • 52
    • 0032501998 scopus 로고    scopus 로고
    • Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues
    • MacMillan-Crow LA, Crow JP, Thompson JA. Peroxynitrite-mediated inactivation of manganese superoxide dismutase involves nitration and oxidation of critical tyrosine residues. Biochemistry 37(6), 1613-1622 (1998
    • (1998) Biochemistry , vol.37 , Issue.6 , pp. 1613-1622
    • MacMillan-Crow, L.A.1    Crow, J.P.2    Thompson, J.A.3
  • 53
    • 20044378676 scopus 로고    scopus 로고
    • Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity
    • Comhair SA, Xu W, Ghosh S et al. Superoxide dismutase inactivation in pathophysiology of asthmatic airway remodeling and reactivity. Am. J. Pathol. 166(3), 663-674 (2005
    • (2005) Am. J. Pathol. , vol.166 , Issue.3 , pp. 663-674
    • Comhair, S.A.1    Xu, W.2    Ghosh, S.3
  • 54
    • 0028827252 scopus 로고
    • Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
    • Li Y, Huang TT, Carlson EJ et al. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11(4), 376-381 (1995
    • (1995) Nat. Genet. , vol.11 , Issue.4 , pp. 376-381
    • Li, Y.1    Huang, T.T.2    Carlson, E.J.3
  • 55
    • 33644839261 scopus 로고    scopus 로고
    • Superoxide dismutase expression attenuates cigarette smoke-or elastase-generated emphysema in mice
    • Foronjy RF, Mirochnitchenko O, Propokenko O et al. Superoxide dismutase expression attenuates cigarette smoke-or elastase-generated emphysema in mice. Am. J. Respir. Crit. Care Med. 173(6), 623-631 (2006
    • (2006) Am. J. Respir. Crit. Care Med. , vol.173 , Issue.6 , pp. 623-631
    • Foronjy, R.F.1    Mirochnitchenko, O.2    Propokenko, O.3
  • 56
    • 0030682170 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase is upregulated with inducible nitric oxide synthase after NF-kB activation
    • 5 Pt 1
    • Brady TC, Chang LY, Day BJ, Crapo JD. Extracellular superoxide dismutase is upregulated with inducible nitric oxide synthase after NF-kB activation. Am. J. Physiol. 273(5 Pt 1), L1002-L1006 (1997
    • (1997) Am. J. Physiol. , vol.273
    • Brady, T.C.1    Chang, L.Y.2    Day, B.J.3    Crapo, J.D.4
  • 57
    • 0029064709 scopus 로고
    • Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia
    • USA
    • Carlsson LM, Jonsson J, Edlund T, Marklund SL. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc. Natl Acad. Sci. USA 92(14), 6264-6268 (1995
    • (1995) Proc. Natl Acad. Sci. , vol.92 , Issue.14 , pp. 6264-6268
    • Carlsson, L.M.1    Jonsson, J.2    Edlund, T.3    Marklund, S.L.4
  • 58
    • 77957273815 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM
    • USA
    • Yao H, Arunachalam G, Hwang JW et al. Extracellular superoxide dismutase protects against pulmonary emphysema by attenuating oxidative fragmentation of ECM. Proc. Natl Acad. Sci. USA 107(35), 15571-15576 (2010
    • (2010) Proc. Natl Acad. Sci. , vol.107 , Issue.35 , pp. 15571-15576
    • Yao, H.1    Arunachalam, G.2    Hwang, J.W.3
  • 59
    • 53149108208 scopus 로고    scopus 로고
    • Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: A potential mechanism underlying adult respiratory distress syndrome
    • Gongora MC, Lob HE, Landmesser U et al. Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome. Am. J. Pathol. 173(4), 915-926 (2008
    • (2008) Am. J. Pathol. , vol.173 , Issue.4 , pp. 915-926
    • Gongora, M.C.1    Lob, H.E.2    Landmesser, U.3
  • 60
    • 0032954805 scopus 로고    scopus 로고
    • Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia
    • Folz RJ, Abushamaa AM, Suliman HB. Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. J. Clin. Invest. 103(7), 1055-1066 (1999
    • (1999) J. Clin. Invest. , vol.103 , Issue.7 , pp. 1055-1066
    • Folz, R.J.1    Abushamaa, A.M.2    Suliman, H.B.3
  • 62
    • 0025296866 scopus 로고
    • Inhibition of lung injury inflammation and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis
    • 5 Pt 1
    • Mossman BT, Marsh JP, Sesko A et al. Inhibition of lung injury, inflammation, and interstitial pulmonary fibrosis by polyethylene glycol-conjugated catalase in a rapid inhalation model of asbestosis. Am. Rev. Respir. Dis. 141(5 Pt 1), 1266-1271 (1990
    • (1990) Am. Rev. Respir. Dis. , vol.141 , pp. 1266-1271
    • Mossman, B.T.1    Marsh, J.P.2    Sesko, A.3
  • 64
    • 0035161960 scopus 로고    scopus 로고
    • Extracellular glutathione peroxidase induction in asthmatic lungs: Evidence for redox regulation of expression in human airway epithelial cells
    • Comhair SA, Bhathena PR, Farver C, Thunnissen FB, Erzurum SC. Extracellular glutathione peroxidase induction in asthmatic lungs: evidence for redox regulation of expression in human airway epithelial cells. FASEB J. 15(1), 70-78 (2001
    • (2001) FASEB J. , vol.15 , Issue.1 , pp. 70-78
    • Comhair, S.A.1    Bhathena, P.R.2    Farver, C.3    Thunnissen, F.B.4    Erzurum, S.C.5
  • 66
    • 63349097906 scopus 로고    scopus 로고
    • Glutathione-S-transferases in lung and sputum specimens effects of smoking and COPD severity
    • Harju T, Mazur W, Merikallio H, Soini Y, Kinnula VL. Glutathione-S- transferases in lung and sputum specimens, effects of smoking and COPD severity. Respir. Res. 9, 80 (2008
    • (2008) Respir. Res. , vol.9 , pp. 80
    • Harju, T.1    Mazur, W.2    Merikallio, H.3    Soini, Y.4    Kinnula, V.L.5
  • 67
    • 67649962996 scopus 로고    scopus 로고
    • In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization
    • Aesif SW, Anathy V, Havermans M et al. In situ analysis of protein S-glutathionylation in lung tissue using glutaredoxin-1-catalyzed cysteine derivatization. Am. J. Pathol. 175(1), 36-45 (2009
    • (2009) Am. J. Pathol. , vol.175 , Issue.1 , pp. 36-45
    • Aesif, S.W.1    Anathy, V.2    Havermans, M.3
  • 68
    • 80051792530 scopus 로고    scopus 로고
    • Activation of the glutaredoxin-1 gene by nuclear factor-kB enhances signaling
    • Aesif SW, Kuipers I, van der Velden J et al. Activation of the glutaredoxin-1 gene by nuclear factor-kB enhances signaling. Free Radic. Biol. Med. 51(6), 1249-1257 (2011
    • (2011) Free Radic. Biol. Med. , vol.51 , Issue.6 , pp. 1249-1257
    • Aesif, S.W.1    Kuipers, I.2    Van Der Velden, J.3
  • 69
    • 3843142866 scopus 로고    scopus 로고
    • Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-b in vitro and in interstitial lung diseases in vivo
    • Peltoniemi M, Kaarteenaho-Wiik R, Saily M et al. Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-b in vitro and in interstitial lung diseases in vivo. Hum. Pathol. 35(8), 1000-1007 (2004
    • (2004) Hum. Pathol. , vol.35 , Issue.8 , pp. 1000-1007
    • Peltoniemi, M.1    Kaarteenaho-Wiik, R.2    Saily, M.3
  • 70
    • 80555157641 scopus 로고    scopus 로고
    • Cigarette smoke targets glutaredoxin 1 increasing S-glutathionylation and epithelial cell death
    • Kuipers I, Guala AS, Aesif SW et al. Cigarette smoke targets glutaredoxin 1, increasing S-glutathionylation and epithelial cell death. Am. J. Respir. Cell. Mol. Biol. 45(5), 931-937 (2011
    • (2011) Am. J. Respir. Cell. Mol. Biol. , vol.45 , Issue.5 , pp. 931-937
    • Kuipers, I.1    Guala, A.S.2    Aesif, S.W.3
  • 71
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47, 89-116 (2007
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 72
    • 22344438250 scopus 로고    scopus 로고
    • Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
    • Rangasamy T, Guo J, Mitzner WA et al. Disruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice. J. Exp. Med. 202(1), 47-59 (2005
    • (2005) J. Exp. Med. , vol.202 , Issue.1 , pp. 47-59
    • Rangasamy, T.1    Guo, J.2    Mitzner, W.A.3
  • 73
    • 58549105575 scopus 로고    scopus 로고
    • Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice
    • USA
    • Sussan TE, Rangasamy T, Blake DJ et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proc. Natl Acad. Sci. USA 106(1), 250-255 (2009
    • (2009) Proc. Natl Acad. Sci. , vol.106 , Issue.1 , pp. 250-255
    • Sussan, T.E.1    Rangasamy, T.2    Blake, D.J.3
  • 74
    • 84867350387 scopus 로고    scopus 로고
    • Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents
    • Giudice A, Arra C, Turco MC. Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents. Methods Mol. Biol. 647, 37-74 (2010
    • (2010) Methods Mol. Biol. , vol.647 , pp. 37-74
    • Giudice, A.1    Arra, C.2    Turco, M.C.3
  • 75
    • 33750613613 scopus 로고    scopus 로고
    • Glutathione peroxidase 2 the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2
    • Singh A, Rangasamy T, Thimmulappa RK et al. Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2. Am. J. Respir. Cell. Mol. Biol. 35(6), 639-650 (2006
    • (2006) Am. J. Respir. Cell. Mol. Biol. , vol.35 , Issue.6 , pp. 639-650
    • Singh, A.1    Rangasamy, T.2    Thimmulappa, R.K.3
  • 76
    • 15244356847 scopus 로고    scopus 로고
    • Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice
    • Rangasamy T, Cho CY, Thimmulappa RK et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J. Clin. Invest. 114(9), 1248-1259 (2004
    • (2004) J. Clin. Invest. , vol.114 , Issue.9 , pp. 1248-1259
    • Rangasamy, T.1    Cho, C.Y.2    Thimmulappa, R.K.3
  • 77
    • 29244473882 scopus 로고    scopus 로고
    • Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema
    • Iizuka T, Ishii Y, Itoh K et al. Nrf2-deficient mice are highly susceptible to cigarette smoke-induced emphysema. Genes Cells 10(12), 1113-1125 (2005
    • (2005) Genes Cells , vol.10 , Issue.12 , pp. 1113-1125
    • Iizuka, T.1    Ishii, Y.2    Itoh, K.3
  • 78
    • 0034534165 scopus 로고    scopus 로고
    • Antioxidant function of thioredoxin and glutaredoxin systems
    • Holmgren A. Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid. Redox Signal 2(4), 811-820 (2000
    • (2000) Antioxid. Redox Signal , vol.2 , Issue.4 , pp. 811-820
    • Holmgren, A.1
  • 79
    • 0242558977 scopus 로고    scopus 로고
    • Expression of the thioredoxin system in interstitial lung disease
    • Tiitto L, Kaarteenaho-Wiik R, Sormunen R et al. Expression of the thioredoxin system in interstitial lung disease. J. Pathol. 201(3), 363-370 (2003
    • (2003) J. Pathol. , vol.201 , Issue.3 , pp. 363-370
    • Tiitto, L.1    Kaarteenaho-Wiik, R.2    Sormunen, R.3
  • 80
    • 0034901958 scopus 로고    scopus 로고
    • Widespread expression of thioredoxin and thioredoxin reductase in non-small-cell lung carcinoma
    • Soini Y, Kahlos K, Napankangas U et al. Widespread expression of thioredoxin and thioredoxin reductase in non-small-cell lung carcinoma. Clin. Cancer Res. 7(6), 1750-1757 (2001
    • (2001) Clin. Cancer Res. , vol.7 , Issue.6 , pp. 1750-1757
    • Soini, Y.1    Kahlos, K.2    Napankangas, U.3
  • 81
    • 19444381651 scopus 로고    scopus 로고
    • Direct association of hepatopoietin with thioredoxin constitutes a redox signal transduction in activation of AP-1 NF-kB
    • Li Y, Liu W, Xing G, Tian C, Zhu Y, He F. Direct association of hepatopoietin with thioredoxin constitutes a redox signal transduction in activation of AP-1/NF-kB. Cell Signal 17(8), 985-996 (2005
    • (2005) Cell Signal , vol.17 , Issue.8 , pp. 985-996
    • Li, Y.1    Liu, W.2    Xing, G.3    Tian, C.4    Zhu, Y.5    He, F.6
  • 82
    • 42449089433 scopus 로고    scopus 로고
    • Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice
    • Sato A, Hoshino Y, Hara T et al. Thioredoxin-1 ameliorates cigarette smoke-induced lung inflammation and emphysema in mice. J. Pharmacol. Exp. Ther. 325(2), 380-388 (2008
    • (2008) J. Pharmacol. Exp. Ther. , vol.325 , Issue.2 , pp. 380-388
    • Sato, A.1    Hoshino, Y.2    Hara, T.3
  • 85
    • 0344009504 scopus 로고    scopus 로고
    • 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene
    • Mo Y, Feinstein SI, Manevich Y et al. 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. FEBS Lett. 555(2), 192-198 (2003)
    • (2003) FEBS Lett. , vol.555 , Issue.2 , pp. 192-198
    • Mo, Y.1    Feinstein, S.I.2    Manevich, Y.3
  • 86
    • 0036165792 scopus 로고    scopus 로고
    • Cell-specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis
    • Kinnula VL, Lehtonen S, Kaarteenaho-Wiik R et al. Cell-specific expression of peroxiredoxins in human lung and pulmonary sarcoidosis. Thorax 57(2), 157-164 (2002
    • (2002) Thorax , vol.57 , Issue.2 , pp. 157-164
    • Kinnula, V.L.1    Lehtonen, S.2    Kaarteenaho-Wiik, R.3
  • 87
    • 3843146451 scopus 로고    scopus 로고
    • Peroxiredoxins a novel protein family in lung cancer
    • Lehtonen ST, Svensk AM, Soini Y et al. Peroxiredoxins, a novel protein family in lung cancer. Int. J. Cancer 111(4), 514-521 (2004
    • (2004) Int. J. Cancer , vol.111 , Issue.4 , pp. 514-521
    • Lehtonen, S.T.1    Svensk, A.M.2    Soini, Y.3
  • 88
    • 0036190624 scopus 로고    scopus 로고
    • Overexpression of peroxiredoxins I II III V and VI in malignant mesothelioma
    • Kinnula VL, Lehtonen S, Sormunen R et al. Overexpression of peroxiredoxins I, II, III, V and VI in malignant mesothelioma. J. Pathol. 196(3), 316-323 (2002
    • (2002) J. Pathol. , vol.196 , Issue.3 , pp. 316-323
    • Kinnula, V.L.1    Lehtonen, S.2    Sormunen, R.3
  • 89
    • 0042568938 scopus 로고    scopus 로고
    • Essential role for the peroxiredoxin prdx1 in erythrocyte antioxidant defence and tumour suppression
    • Neumann CA, Krause DS, Carman CV et al. Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424(6948), 561-565 (2003
    • (2003) Nature , vol.424 , Issue.6948 , pp. 561-565
    • Neumann, C.A.1    Krause, D.S.2    Carman, C.V.3
  • 90
    • 77958005314 scopus 로고    scopus 로고
    • Peroxiredoxin-6 differentially regulates acute and chronic cigarette smoke-mediated lung inflammatory response and injury
    • Sundar IK, Chung S, Hwang JW et al. Peroxiredoxin-6 differentially regulates acute and chronic cigarette smoke-mediated lung inflammatory response and injury. Exp. Lung Res. 36(8), 451-462 (2010
    • (2010) Exp. Lung Res. , vol.36 , Issue.8 , pp. 451-462
    • Sundar, I.K.1    Chung, S.2    Hwang, J.W.3
  • 91
    • 79951643450 scopus 로고    scopus 로고
    • Multiple functions of peroxiredoxins: Peroxidases sensors and regulators of the intracellular messenger HO and protein chaperones
    • Rhee SG, Woo HA. Multiple functions of peroxiredoxins: peroxidases, sensors and regulators of the intracellular messenger HO, and protein chaperones. Antioxid. Redox Signal 15(3), 781-794 (2011
    • (2011) Antioxid. Redox Signal , vol.15 , Issue.3 , pp. 781-794
    • Rhee, S.G.1    Woo, H.A.2
  • 92
    • 69949115433 scopus 로고    scopus 로고
    • Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin
    • Park JW, Mieyal JJ, Rhee SG, Chock PB. Deglutathionylation of 2-Cys peroxiredoxin is specifically catalyzed by sulfiredoxin. J. Biol. Chem. 284(35), 23364-23374 (2009
    • (2009) J. Biol. Chem. , vol.284 , Issue.35 , pp. 23364-23374
    • Park, J.W.1    Mieyal, J.J.2    Rhee, S.G.3    Chock, P.B.4
  • 93
    • 10944237769 scopus 로고    scopus 로고
    • Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine
    • Chang TS, Jeong W, Woo HA, Lee SM, Park S, Rhee SG. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J. Biol. Chem. 279(49), 50994-51001 (2004
    • (2004) J. Biol. Chem. , vol.279 , Issue.49 , pp. 50994-51001
    • Chang, T.S.1    Jeong, W.2    Woo, H.A.3    Lee, S.M.4    Park, S.5    Rhee, S.G.6
  • 94
    • 84855263802 scopus 로고    scopus 로고
    • Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2
    • Baek JY, Han SH, Sung SH et al. Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2. J. Biol. Chem. 287(1), 81-89 (2012
    • (2012) J. Biol. Chem. , vol.287 , Issue.1 , pp. 81-89
    • Baek, J.Y.1    Han, S.H.2    Sung, S.H.3
  • 95
    • 77955960441 scopus 로고    scopus 로고
    • Cell-specific elevation of Nrf2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia
    • Mazur W, Lindholm P, Vuorinen K, Myllarniemi M, Salmenkivi K, Kinnula VL. Cell-specific elevation of Nrf2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. APMIS 118(9), 703-712 (2010
    • (2010) APMIS , vol.118 , Issue.9 , pp. 703-712
    • Mazur, W.1    Lindholm, P.2    Vuorinen, K.3    Myllarniemi, M.4    Salmenkivi, K.5    Kinnula, V.L.6
  • 96
    • 58149099624 scopus 로고    scopus 로고
    • Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs
    • Singh A, Ling G, Suhasini AN et al. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic. Biol. Med. 46(3), 376-386 (2009
    • (2009) Free Radic. Biol. Med. , vol.46 , Issue.3 , pp. 376-386
    • Singh, A.1    Ling, G.2    Suhasini, A.N.3
  • 97
    • 0042831342 scopus 로고    scopus 로고
    • Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers
    • 3 Pt 1
    • Hackett NR, Heguy A, Harvey BG et al. Variability of antioxidant-related gene expression in the airway epithelium of cigarette smokers. Am. J. Respir. Cell. Mol. Biol. 29(3 Pt 1), 331-343 (2003
    • (2003) Am. J. Respir. Cell. Mol. Biol. , vol.29 , pp. 331-343
    • Hackett, N.R.1    Heguy, A.2    Harvey, B.G.3
  • 98
    • 33947326921 scopus 로고    scopus 로고
    • Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease
    • Pierrou S, Broberg P, O'Donnell RA et al. Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 175(6), 577-586 (2007
    • (2007) Am. J. Respir. Crit. Care Med. , vol.175 , Issue.6 , pp. 577-586
    • Pierrou, S.1    Broberg, P.2    Odonnell, R.A.3
  • 99
    • 8644237366 scopus 로고    scopus 로고
    • Manganese superoxide dismutase is increased in the airways of smokers lungs
    • Harju T, Kaarteenaho-Wiik R, Sirvio R et al. Manganese superoxide dismutase is increased in the airways of smokers' lungs. Eur. Respir. J. 24(5), 765-771 (2004
    • (2004) Eur. Respir. J. , vol.24 , Issue.5 , pp. 765-771
    • Harju, T.1    Kaarteenaho-Wiik, R.2    Sirvio, R.3
  • 100
    • 79959982278 scopus 로고    scopus 로고
    • Smoking and COPD increase sputum levels of extracellular superoxide dismutase
    • Regan EA, Mazur W, Meoni E et al. Smoking and COPD increase sputum levels of extracellular superoxide dismutase. Free Radic. Biol. Med. 51(3), 726-732 (2011
    • (2011) Free Radic. Biol. Med. , vol.51 , Issue.3 , pp. 726-732
    • Regan, E.A.1    Mazur, W.2    Meoni, E.3
  • 101
    • 53649099660 scopus 로고    scopus 로고
    • Altered nrf2 keap1-bach1 equilibrium in pulmonary emphysema
    • Goven D, Boutten A, Lecon-Malas V et al. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Thorax 63(10), 916-924 (2008
    • (2008) Thorax , vol.63 , Issue.10 , pp. 916-924
    • Goven, D.1    Boutten, A.2    Lecon-Malas, V.3
  • 102
    • 51849129227 scopus 로고    scopus 로고
    • Decline in Nrf2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator DJ-1
    • Malhotra D, Thimmulappa R, Navas-Acien A et al. Decline in Nrf2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am. J. Respir. Crit. Care Med. 178(6), 592-604 (2008
    • (2008) Am. J. Respir. Crit. Care Med. , vol.178 , Issue.6 , pp. 592-604
    • Malhotra, D.1    Thimmulappa, R.2    Navas-Acien, A.3
  • 103
    • 57349151482 scopus 로고    scopus 로고
    • Downregulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease
    • Suzuki M, Betsuyaku T, Ito Y et al. Downregulated NF-E2-related factor 2 in pulmonary macrophages of aged smokers and patients with chronic obstructive pulmonary disease. Am. J. Respir. Cell. Mol. Biol. 39(6), 673-682 (2008
    • (2008) Am. J. Respir. Cell. Mol. Biol. , vol.39 , Issue.6 , pp. 673-682
    • Suzuki, M.1    Betsuyaku, T.2    Ito, Y.3
  • 104
    • 77951642473 scopus 로고    scopus 로고
    • Deletion of keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation
    • Blake DJ, Singh A, Kombairaju P et al. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Am. J. Respir. Cell. Mol. Biol. 42(5), 524-536 (2010
    • (2010) Am. J. Respir. Cell. Mol. Biol. , vol.42 , Issue.5 , pp. 524-536
    • Blake, D.J.1    Singh, A.2    Kombairaju, P.3
  • 105
    • 13244271908 scopus 로고    scopus 로고
    • The regulation and role of extracellular glutathione peroxidase
    • Comhair SA, Erzurum SC. The regulation and role of extracellular glutathione peroxidase. Antioxid. Redox Signal 7(1-2), 72-79 (2005
    • (2005) Antioxid. Redox Signal , vol.7 , Issue.1-2 , pp. 72-79
    • Comhair, S.A.1    Erzurum, S.C.2
  • 106
    • 0032993093 scopus 로고    scopus 로고
    • Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease
    • Comhair SA, Lewis MJ, Bhathena PR et al. Increased glutathione and glutathione peroxidase in lungs of individuals with chronic beryllium disease. Am. J. Respir. Crit. Care Med. 159(6), 1824-1829 (1999
    • (1999) Am. J. Respir. Crit. Care Med. , vol.159 , Issue.6 , pp. 1824-1829
    • Comhair, S.A.1    Lewis, M.J.2    Bhathena, P.R.3
  • 108
    • 0034653809 scopus 로고    scopus 로고
    • Localization of g-glutamylcysteine synthetase messenger RNA expression in lungs of smokers and patients with chronic obstructive pulmonary disease
    • Rahman I, van Schadewijk AA, Hiemstra PS et al. Localization of g-glutamylcysteine synthetase messenger RNA expression in lungs of smokers and patients with chronic obstructive pulmonary disease. Free Radic. Biol. Med. 28(6), 920-925 (2000
    • (2000) Free Radic. Biol. Med. , vol.28 , Issue.6 , pp. 920-925
    • Rahman, I.1    Van Schadewijk, A.A.2    Hiemstra, P.S.3
  • 110
    • 0037214170 scopus 로고    scopus 로고
    • Expression of antioxidant enzymes in bronchial metaplastic and dysplastic epithelium
    • Soini Y, Kaarteenaho-Wiik R, Paakko P, Kinnula V. Expression of antioxidant enzymes in bronchial metaplastic and dysplastic epithelium. Lung Cancer 39(1), 15-22 (2003
    • (2003) Lung Cancer , vol.39 , Issue.1 , pp. 15-22
    • Soini, Y.1    Kaarteenaho-Wiik, R.2    Paakko, P.3    Kinnula, V.4
  • 111
    • 34848830448 scopus 로고    scopus 로고
    • Glutathione S-transferase w in the lung and sputum supernatants of COPD patients
    • Harju TH, Peltoniemi MJ, Rytila PH et al. Glutathione S-transferase w in the lung and sputum supernatants of COPD patients. Respir. Res. 8, 48 (2007
    • (2007) Respir. Res. , vol.8 , pp. 48
    • Harju, T.H.1    Peltoniemi, M.J.2    Rytila, P.H.3
  • 112
    • 33750627460 scopus 로고    scopus 로고
    • Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease
    • Peltoniemi MJ, Rytila PH, Harju TH et al. Modulation of glutaredoxin in the lung and sputum of cigarette smokers and chronic obstructive pulmonary disease. Respir. Res. 7, 133 (2006
    • (2006) Respir. Res. , vol.7 , pp. 133
    • Peltoniemi, M.J.1    Rytila, P.H.2    Harju, T.H.3
  • 113
    • 0035888752 scopus 로고    scopus 로고
    • Increased expression of heme oxygenase HO-1 in alveolar spaces and HO-2 in alveolar walls of smokers
    • 8 Pt 1
    • Maestrelli P, El Messlemani AH, De Fina O et al. Increased expression of heme oxygenase (HO)-1 in alveolar spaces and HO-2 in alveolar walls of smokers. Am. J. Respir. Crit. Care Med. 164(8 Pt 1), 1508-1513 (2001
    • (2001) Am. J. Respir. Crit. Care Med. , vol.164 , pp. 1508-1513
    • Maestrelli, P.1    El Messlemani, A.H.2    De Fina, O.3
  • 114
    • 0037975679 scopus 로고    scopus 로고
    • Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients
    • Maestrelli P, Paska C, Saetta M et al. Decreased haem oxygenase-1 and increased inducible nitric oxide synthase in the lung of severe COPD patients. Eur. Respir. J. 21(6), 971-976 (2003
    • (2003) Eur. Respir. J. , vol.21 , Issue.6 , pp. 971-976
    • Maestrelli, P.1    Paska, C.2    Saetta, M.3
  • 115
    • 38949083243 scopus 로고    scopus 로고
    • Does the oxidative stress in chronic obstructive pulmonary disease cause thioredoxin peroxiredoxin oxidation
    • Lehtonen ST, Ohlmeier S, Kaarteenaho-Wiik R et al. Does the oxidative stress in chronic obstructive pulmonary disease cause thioredoxin/peroxiredoxin oxidation? Antioxid. Redox Signal. 10(4), 813-819 (2008
    • (2008) Antioxid. Redox Signal. , vol.10 , Issue.4 , pp. 813-819
    • Lehtonen, S.T.1    Ohlmeier, S.2    Kaarteenaho-Wiik, R.3
  • 116
    • 60249084174 scopus 로고    scopus 로고
    • Proteomic analysis in lung tissue of smokers and COPD patients
    • Lee EJ, In KH, Kim JH et al. Proteomic analysis in lung tissue of smokers and COPD patients. Chest 135(2), 344-352 (2009
    • (2009) Chest , vol.135 , Issue.2 , pp. 344-352
    • Lee, E.J.1    In, K.H.2    Kim, J.H.3
  • 117
    • 80555124930 scopus 로고    scopus 로고
    • Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients
    • Malhotra D, Thimmulappa RK, Mercado N et al. Denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients. J. Clin. Invest. 121(11), 4289-4302 (2011
    • (2011) J. Clin. Invest. , vol.121 , Issue.11 , pp. 4289-4302
    • Malhotra, D.1    Thimmulappa, R.K.2    Mercado, N.3
  • 118
    • 85027928310 scopus 로고    scopus 로고
    • Statin use in COPD patients is associated with a reduction in mortality: A national cohort study
    • Lawes CM, Thornley S, Young R et al. Statin use in COPD patients is associated with a reduction in mortality: a national cohort study. Prim. Care Respir. J. 21(1), 35-40 (2012
    • (2012) Prim. Care Respir. J. , vol.21 , Issue.1 , pp. 35-40
    • Lawes, C.M.1    Thornley, S.2    Young, R.3
  • 119
    • 80054899432 scopus 로고    scopus 로고
    • Statin use and hospitalization in patients with chronic obstructive pulmonary disease: A nationwide population-based cohort study in taiwan
    • Huang CC, Chan WL, Chen YC et al. Statin use and hospitalization in patients with chronic obstructive pulmonary disease: a nationwide population-based cohort study in Taiwan. Clin. Ther. 33(10), 1365-1370 (2011
    • (2011) Clin. Ther. , vol.33 , Issue.10 , pp. 1365-1370
    • Huang, C.C.1    Chan, W.L.2    Chen, Y.C.3
  • 120
    • 36049019384 scopus 로고    scopus 로고
    • Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease
    • Makita H, Nasuhara Y, Nagai K et al. Characterisation of phenotypes based on severity of emphysema in chronic obstructive pulmonary disease. Thorax 62(11), 932-937 (2007
    • (2007) Thorax , vol.62 , Issue.11 , pp. 932-937
    • Makita, H.1    Nasuhara, Y.2    Nagai, K.3
  • 121
    • 0033898870 scopus 로고    scopus 로고
    • The effect of oral N-acetylcysteine in chronic bronchitis: A quantitative systematic review
    • Stey C, Steurer J, Bachmann S, Medici TC, Tramer MR. The effect of oral N-acetylcysteine in chronic bronchitis: a quantitative systematic review. Eur. Respir. J. 16(2), 253-262 (2000
    • (2000) Eur. Respir. J. , vol.16 , Issue.2 , pp. 253-262
    • Stey, C.1    Steurer, J.2    Bachmann, S.3    Medici, T.C.4    Tramer, M.R.5
  • 122
    • 0034961209 scopus 로고    scopus 로고
    • BRONCUS trial committee
    • The Bronchitis Randomized on NAC Cost-Utility Study BRONCUS: hypothesis and design
    • Decramer M, Dekhuijzen PN, Troosters T et al. The Bronchitis Randomized on NAC Cost-Utility Study (BRONCUS): hypothesis and design. BRONCUS trial committee. Eur. Respir. J. 17(3), 329-336 (2001
    • (2001) Eur. Respir. J. , vol.17 , Issue.3 , pp. 329-336
    • Decramer, M.1    Dekhuijzen, P.N.2    Troosters, T.3
  • 123
    • 20944433417 scopus 로고    scopus 로고
    • Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease
    • Bronchitis Randomized on NAC Cost-Utility Study BRONCUS: a randomised placebo-controlled trial
    • Decramer M, Rutten-van Molken M, Dekhuijzen PN et al. Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet 365(9470), 1552-1560 (2005
    • (2005) Lancet , vol.365 , Issue.9470 , pp. 1552-1560
    • Decramer, M.1    Rutten-Van Molken, M.2    Dekhuijzen, P.N.3
  • 124
    • 0035954121 scopus 로고    scopus 로고
    • Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: Systematic review
    • Poole PJ, Black PN. Oral mucolytic drugs for exacerbations of chronic obstructive pulmonary disease: systematic review. BMJ 322(7297), 1271-1274 (2001
    • (2001) BMJ , vol.322 , Issue.7297 , pp. 1271-1274
    • Poole, P.J.1    Black, P.N.2
  • 125
    • 0242363130 scopus 로고    scopus 로고
    • Preventing exacerbations of chronic bronchitis and COPD: Therapeutic potential of mucolytic agents
    • Poole PJ, Black PN. Preventing exacerbations of chronic bronchitis and COPD: therapeutic potential of mucolytic agents. Am. J. Respir. Med. 2(5), 367-370 (2003
    • (2003) Am. J. Respir. Med. , vol.2 , Issue.5 , pp. 367-370
    • Poole, P.J.1    Black, P.N.2
  • 126
    • 0034023927 scopus 로고    scopus 로고
    • Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: A meta-analysis of published double-blind placebo-controlled clinical trials
    • Grandjean EM, Berthet P, Ruffmann R, Leuenberger P. Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin. Ther. 22(2), 209-221 (2000
    • (2000) Clin. Ther. , vol.22 , Issue.2 , pp. 209-221
    • Grandjean, E.M.1    Berthet, P.2    Ruffmann, R.3    Leuenberger, P.4
  • 127
    • 13144274594 scopus 로고    scopus 로고
    • Randomised controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease ISRCTN21676344
    • Black PN, Morgan-Day A, McMillan TE, Poole PJ, Young RP. Randomised, controlled trial of N-acetylcysteine for treatment of acute exacerbations of chronic obstructive pulmonary disease [ISRCTN21676344]. BMC Pulm. Med. 4, 13 (2004
    • (2004) BMC Pulm. Med. , vol.4 , pp. 13
    • Black, P.N.1    Morgan-Day, A.2    McMillan, T.E.3    Poole, P.J.4    Young, R.P.5
  • 128
    • 20844451178 scopus 로고    scopus 로고
    • The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: The EQUALIFE study
    • Moretti M, Bottrighi P, Dallari R et al. The effect of long-term treatment with erdosteine on chronic obstructive pulmonary disease: the EQUALIFE study. Drugs Exp. Clin. Res. 30(4), 143-152 (2004
    • (2004) Drugs Exp. Clin. Res. , vol.30 , Issue.4 , pp. 143-152
    • Moretti, M.1    Bottrighi, P.2    Dallari, R.3
  • 129
    • 44849100529 scopus 로고    scopus 로고
    • Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease PEACE study: A randomised placebo-controlled study
    • Zheng JP, Kang J, Huang SG et al. Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE study): a randomised placebo-controlled study. Lancet 371(9629), 2013-2018 (2008
    • (2008) Lancet , vol.371 , Issue.9629 , pp. 2013-2018
    • Zheng, J.P.1    Kang, J.2    Huang, S.G.3
  • 130
    • 0030902329 scopus 로고    scopus 로고
    • Nacystelyn, a novel lysine salt of N-acetylcysteine to augment cellular antioxidant defence in vitro
    • Gillissen A, Jaworska M, Orth M et al. Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro. Respir. Med. 91(3), 159-168 (1997
    • (1997) Respir. Med. , vol.91 , Issue.3 , pp. 159-168
    • Gillissen, A.1    Jaworska, M.2    Orth, M.3
  • 131
    • 85016625765 scopus 로고    scopus 로고
    • Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease
    • Moretti M. Pharmacology and clinical efficacy of erdosteine in chronic obstructive pulmonary disease. Expert Rev. Respir. Med. 1(3), 307-316 (2007
    • (2007) Expert Rev. Respir. Med. , vol.1 , Issue.3 , pp. 307-316
    • Moretti, M.1
  • 132
    • 65549110824 scopus 로고    scopus 로고
    • Erdosteine: Its relevance in COPD treatment
    • Moretti M. Erdosteine: its relevance in COPD treatment. Expert Opin. Drug Metab. Toxicol. 5(3), 333-343 (2009
    • (2009) Expert Opin. Drug Metab. Toxicol. , vol.5 , Issue.3 , pp. 333-343
    • Moretti, M.1
  • 133
    • 75749085711 scopus 로고    scopus 로고
    • The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: A meta-analysis of individual patient data
    • Cazzola M, Floriani I, Page CP. The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data. Pulm. Pharmacol. Ther. 23(2), 135-144 (2010
    • (2010) Pulm. Pharmacol. Ther. , vol.23 , Issue.2 , pp. 135-144
    • Cazzola, M.1    Floriani, I.2    Page, C.P.3
  • 134
    • 0025615316 scopus 로고
    • Long-lasting effects on rheology and clearance of bronchial mucus after short-term administration of high doses of carbocysteine-lysine to patients with chronic bronchitis
    • Braga PC, Allegra L, Rampoldi C, Ornaghi A, Beghi G. Long-lasting effects on rheology and clearance of bronchial mucus after short-term administration of high doses of carbocysteine-lysine to patients with chronic bronchitis. Respiration 57(6), 353-358 (1990
    • (1990) Respiration , vol.57 , Issue.6 , pp. 353-358
    • Braga, P.C.1    Allegra, L.2    Rampoldi, C.3    Ornaghi, A.4    Beghi, G.5
  • 135
    • 0038023151 scopus 로고    scopus 로고
    • S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells
    • Cakan G, Turkoz M, Turan T, Ahmed K, Nagatake T. S-carboxymethylcysteine inhibits the attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells. Microb. Pathog. 34(6), 261-265 (2003
    • (2003) Microb. Pathog. , vol.34 , Issue.6 , pp. 261-265
    • Cakan, G.1    Turkoz, M.2    Turan, T.3    Ahmed, K.4    Nagatake, T.5
  • 136
    • 35748947732 scopus 로고    scopus 로고
    • Carbocisteine improves quality of life in patients with chronic obstructive pulmonary disease
    • Tatsumi K, Fukuchi Y. Carbocisteine improves quality of life in patients with chronic obstructive pulmonary disease. J. Am. Geriatr. Soc. 55(11), 1884-1886 (2007
    • (2007) J. Am. Geriatr. Soc. , vol.55 , Issue.11 , pp. 1884-1886
    • Tatsumi, K.1    Fukuchi, Y.2
  • 137
    • 0016263725 scopus 로고
    • An assessment of S-carboxymethylcysteine in the treatment of chronic bronchitis
    • Aylward M. An assessment of S-carboxymethylcysteine in the treatment of chronic bronchitis. Curr. Med. Res. Opin. 2(7), 387-394 (1974
    • (1974) Curr. Med. Res. Opin. , vol.2 , Issue.7 , pp. 387-394
    • Aylward, M.1
  • 138
    • 0017171687 scopus 로고
    • S-carboxymethylcysteine in the fluidification of sputum and treatment of chronic airway obstruction
    • Edwards GF, Steel AE, Scott JK, Jordan JW. S-carboxymethylcysteine in the fluidification of sputum and treatment of chronic airway obstruction. Chest 70(4), 506-513 (1976
    • (1976) Chest , vol.70 , Issue.4 , pp. 506-513
    • Edwards, G.F.1    Steel, A.E.2    Scott, J.K.3    Jordan, J.W.4
  • 139
    • 0020451480 scopus 로고
    • Double-blind study of carbocysteine against placebo in chronic bronchitis mucoregulation in respiratory tract disorders
    • Miskoviti G, Szule P, Mescaros K. Double-blind study of carbocysteine against placebo in chronic bronchitis; mucoregulation in respiratory tract disorders. Proc. R. Soc. Med. 5, 1-3 (1982
    • (1982) Proc. R. Soc. Med. , vol.5 , pp. 1-3
    • Miskoviti, G.1    Szule, P.2    Mescaros, K.3
  • 140
    • 0029947365 scopus 로고    scopus 로고
    • Prevention of acute exacerbations of chronic obstructive bronchitis with carbocysteine lysine salt monohydrate: A multicenter double-blind placebo-controlled trial
    • Allegra L, Cordaro CI, Grassi C. Prevention of acute exacerbations of chronic obstructive bronchitis with carbocysteine lysine salt monohydrate: a multicenter, double-blind, placebo-controlled trial. Respiration 63(3), 174-180 (1996
    • (1996) Respiration , vol.63 , Issue.3 , pp. 174-180
    • Allegra, L.1    Cordaro, C.I.2    Grassi, C.3
  • 141
    • 0022298166 scopus 로고
    • Long-term oral carbocisteine therapy in patients with chronic bronchitis a double blind trial with placebo control
    • Grillage M, Barnard-Jones K. Long-term oral carbocisteine therapy in patients with chronic bronchitis. A double blind trial with placebo control. Br. J. Clin. Pract. 39(10), 395-398 (1985
    • (1985) Br. J. Clin. Pract. , vol.39 , Issue.10 , pp. 395-398
    • Grillage, M.1    Barnard-Jones, K.2
  • 142
    • 33645091653 scopus 로고    scopus 로고
    • Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease
    • Yasuda H, Yamaya M, Sasaki T et al. Carbocisteine reduces frequency of common colds and exacerbations in patients with chronic obstructive pulmonary disease. J. Am. Geriatr. Soc. 54(2), 378-380 (2006
    • (2006) J. Am. Geriatr. Soc. , vol.54 , Issue.2 , pp. 378-380
    • Yasuda, H.1    Yamaya, M.2    Sasaki, T.3
  • 143
    • 33750482082 scopus 로고    scopus 로고
    • Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells
    • Yasuda H, Yamaya M, Sasaki T et al. Carbocisteine inhibits rhinovirus infection in human tracheal epithelial cells. Eur. Respir. J. 28(1), 51-58 (2006
    • (2006) Eur. Respir. J. , vol.28 , Issue.1 , pp. 51-58
    • Yasuda, H.1    Yamaya, M.2    Sasaki, T.3
  • 144
    • 58849084547 scopus 로고    scopus 로고
    • Effect of fudosteine on mucin production
    • Rhee CK, Kang CM, You MB et al. Effect of fudosteine on mucin production. Eur. Respir. J. 32(5), 1195-1202 (2008
    • (2008) Eur. Respir. J. , vol.32 , Issue.5 , pp. 1195-1202
    • Rhee, C.K.1    Kang, C.M.2    You, M.B.3
  • 145
    • 11844288305 scopus 로고    scopus 로고
    • Inhibition of endotoxin-and antigen-induced airway inflammation by fudosteine, a mucoactive agent
    • Komatsu H, Yamaguchi S, Komorita N et al. Inhibition of endotoxin-and antigen-induced airway inflammation by fudosteine, a mucoactive agent. Pulm. Pharmacol. Ther. 18(2), 121-127 (2005
    • (2005) Pulm. Pharmacol. Ther. , vol.18 , Issue.2 , pp. 121-127
    • Komatsu, H.1    Yamaguchi, S.2    Komorita, N.3
  • 146
    • 11844306459 scopus 로고    scopus 로고
    • Phase III clinical study of SS320A double-blind trial in comparison with placebo
    • Nagaoka S, Takishima T, Nagano H et al. Phase III clinical study of SS320A. Double-blind trial in comparison with placebo. J. Clin. Ther. Med. 18(1), 109-140 (2002
    • (2002) J. Clin. Ther. Med. , vol.18 , Issue.1 , pp. 109-140
    • Nagaoka, S.1    Takishima, T.2    Nagano, H.3
  • 147
    • 0032962228 scopus 로고    scopus 로고
    • N-isobutyrylcysteine a donor of systemic thiols does not reduce the exacerbation rate in chronic bronchitis
    • Ekberg-Jansson A, Larson M, MacNee W et al. N-isobutyrylcysteine, a donor of systemic thiols, does not reduce the exacerbation rate in chronic bronchitis. Eur. Respir. J. 13(4), 829-834 (1999
    • (1999) Eur. Respir. J. , vol.13 , Issue.4 , pp. 829-834
    • Ekberg-Jansson, A.1    Larson, M.2    MacNee, W.3
  • 148
    • 0037008393 scopus 로고    scopus 로고
    • Ergothioneine treatment protects neurons against N-methyl-d-aspartate excitotoxicity in anin vivo rat retinal model
    • Moncaster JA, Walsh DT, Gentleman SM, Jen LS, Aruoma OI. Ergothioneine treatment protects neurons against N-methyl-d-aspartate excitotoxicity in anin vivo rat retinal model. Neurosci. Lett. 328(1), 55-59 (2002
    • (2002) Neurosci. Lett. , vol.328 , Issue.1 , pp. 55-59
    • Moncaster, J.A.1    Walsh, D.T.2    Gentleman, S.M.3    Jen, L.S.4    Aruoma, O.I.5
  • 149
    • 0037106099 scopus 로고    scopus 로고
    • Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    • Thimmulappa RK, Mai KH, Srisuma S, Kensler TW, Yamamoto M, Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62(18), 5196-5203 (2002
    • (2002) Cancer Res. , vol.62 , Issue.18 , pp. 5196-5203
    • Thimmulappa, R.K.1    Mai, K.H.2    Srisuma, S.3    Kensler, T.W.4    Yamamoto, M.5    Biswal, S.6
  • 150
    • 0037424262 scopus 로고    scopus 로고
    • Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival
    • Kwak MK, Wakabayashi N, Itoh K, Motohashi H, Yamamoto M, Kensler TW. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. J. Biol. Chem. 278(10), 8135-8145 (2003
    • (2003) J. Biol. Chem. , vol.278 , Issue.10 , pp. 8135-8145
    • Kwak, M.K.1    Wakabayashi, N.2    Itoh, K.3    Motohashi, H.4    Yamamoto, M.5    Kensler, T.W.6
  • 151
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of nrf2 and the antioxidant-responsive element
    • Balogun E, Hoque M, Gong P et al. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem. J. 371(Pt 3), 887-895 (2003
    • (2003) Biochem. J. , vol.371 , Issue.PART 3 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3
  • 152
    • 20144367578 scopus 로고    scopus 로고
    • Chalcones: An update on cytotoxic and chemoprotective properties
    • Go ML, Wu X, Liu XL. Chalcones: an update on cytotoxic and chemoprotective properties. Curr. Med. Chem. 12(4), 481-499 (2005
    • (2005) Curr. Med. Chem. , vol.12 , Issue.4 , pp. 481-499
    • Go, M.L.1    Wu, X.2    Liu, X.L.3
  • 153
    • 34248211743 scopus 로고    scopus 로고
    • Synthetic 2́ 5́-dimethoxychalcones as G 2 M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages
    • Wei BL, Teng CH, Wang JP, Won SJ, Lin CN. Synthetic 2́,5́- dimethoxychalcones as G(2)/M arrest-mediated apoptosis-inducing agents and inhibitors of nitric oxide production in rat macrophages. Eur. J. Med. Chem. 42(5), 660-668 (2007
    • (2007) Eur. J. Med. Chem. , vol.42 , Issue.5 , pp. 660-668
    • Wei, B.L.1    Teng, C.H.2    Wang, J.P.3    Won, S.J.4    Lin, C.N.5
  • 154
    • 29244443231 scopus 로고    scopus 로고
    • Blockade of nuclear factor-kB signaling pathway and anti-inflammatory activity of cardamomin a chalcone analog from alpinia conchigera
    • Lee JH, Jung HS, Giang PM et al. Blockade of nuclear factor-kB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera. J. Pharmacol. Exp. Ther. 316(1), 271-278 (2006
    • (2006) J. Pharmacol. Exp. Ther. , vol.316 , Issue.1 , pp. 271-278
    • Lee, J.H.1    Jung, H.S.2    Giang, P.M.3
  • 155
    • 79959429766 scopus 로고    scopus 로고
    • Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells
    • Kumar V, Kumar S, Hassan M et al. Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells. J. Med. Chem. 54(12), 4147-4159 (2011
    • (2011) J. Med. Chem. , vol.54 , Issue.12 , pp. 4147-4159
    • Kumar, V.1    Kumar, S.2    Hassan, M.3
  • 156
    • 58849096654 scopus 로고    scopus 로고
    • Effects of edaravone a free-radical scavenger on bleomycin-induced lung injury in mice
    • Tajima S, Bando M, Ishii Y et al. Effects of edaravone, a free-radical scavenger, on bleomycin-induced lung injury in mice. Eur. Respir. J. 32(5), 1337-1343 (2008
    • (2008) Eur. Respir. J. , vol.32 , Issue.5 , pp. 1337-1343
    • Tajima, S.1    Bando, M.2    Ishii, Y.3
  • 157
    • 80053510027 scopus 로고    scopus 로고
    • Beyond neurological disease: New targets for edaravone review
    • Kikuchi K, Uchikado H, Miyagi N et al. Beyond neurological disease: new targets for edaravone (review). Int. J. Mol. Med. 28(6), 899-906 (2011
    • (2011) Int. J. Mol. Med. , vol.28 , Issue.6 , pp. 899-906
    • Kikuchi, K.1    Uchikado, H.2    Miyagi, N.3
  • 158
    • 75149193424 scopus 로고    scopus 로고
    • Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: Focus on reactivity selectivity and reaction mechanisms
    • Aldini G, Vistoli G, Regazzoni L, Benfatto MC, Bettinelli I, Carini M. Edaravone inhibits protein carbonylation by a direct carbonyl-scavenging mechanism: focus on reactivity, selectivity, and reaction mechanisms. Antioxid. Redox Signal. 12(3), 381-392 (2010
    • (2010) Antioxid. Redox Signal. , vol.12 , Issue.3 , pp. 381-392
    • Aldini, G.1    Vistoli, G.2    Regazzoni, L.3    Benfatto, M.C.4    Bettinelli, I.5    Carini, M.6
  • 159
    • 11344260687 scopus 로고    scopus 로고
    • Edaravone protects against lung injury induced by intestinal ischemia reperfusion in rat
    • Ito K, Ozasa H, Horikawa S. Edaravone protects against lung injury induced by intestinal ischemia/reperfusion in rat. Free Radic. Biol. Med. 38(3), 369-374 (2005
    • (2005) Free Radic. Biol. Med. , vol.38 , Issue.3 , pp. 369-374
    • Ito, K.1    Ozasa, H.2    Horikawa, S.3
  • 160
    • 35649008900 scopus 로고    scopus 로고
    • Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls
    • Aldini G, Dalle-Donne I, Facino RM, Milzani A, Carini M. Intervention strategies to inhibit protein carbonylation by lipoxidation-derived reactive carbonyls. Med. Res. Rev. 27(6), 817-868 (2007
    • (2007) Med. Res. Rev. , vol.27 , Issue.6 , pp. 817-868
    • Aldini, G.1    Dalle-Donne, I.2    Facino, R.M.3    Milzani, A.4    Carini, M.5
  • 161
    • 33750318889 scopus 로고    scopus 로고
    • Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunction
    • Aldini G, Dalle-Donne I, Colombo R, Maffei Facino R, Milzani A, Carini M. Lipoxidation-derived reactive carbonyl species as potential drug targets in preventing protein carbonylation and related cellular dysfunction. Chem. Med. Chem. 1(10), 1045-1058 (2006
    • (2006) Chem. Med. Chem. , vol.1 , Issue.10 , pp. 1045-1058
    • Aldini, G.1    Dalle-Donne, I.2    Colombo, R.3    Maffei Facino, R.4    Milzani, A.5    Carini, M.6
  • 164
    • 0030014151 scopus 로고    scopus 로고
    • Lazaroid U-74389F attenuates phorbol ester-induced lung injury in rabbits
    • Miniati M, Cocci F, Monti S et al. Lazaroid U-74389F attenuates phorbol ester-induced lung injury in rabbits. Eur. Respir. J. 9(4), 758-764 (1996
    • (1996) Eur. Respir. J. , vol.9 , Issue.4 , pp. 758-764
    • Miniati, M.1    Cocci, F.2    Monti, S.3
  • 165
    • 0038465920 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade
    • Tuder RM, Zhen L, Cho CY et al. Oxidative stress and apoptosis interact and cause emphysema due to vascular endothelial growth factor receptor blockade. Am. J. Respir. Cell. Mol. Biol. 29(1), 88-97 (2003
    • (2003) Am. J. Respir. Cell. Mol. Biol. , vol.29 , Issue.1 , pp. 88-97
    • Tuder, R.M.1    Zhen, L.2    Cho, C.Y.3
  • 166
    • 4644313337 scopus 로고    scopus 로고
    • The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: Role of the lectin-like oxidized low-density lipoprotein receptor-1
    • Muscoli C, Sacco I, Alecce W et al. The protective effect of superoxide dismutase mimetic M40401 on balloon injury-related neointima formation: role of the lectin-like oxidized low-density lipoprotein receptor-1. J. Pharmacol. Exp. Ther. 311(1), 44-50 (2004
    • (2004) J. Pharmacol. Exp. Ther. , vol.311 , Issue.1 , pp. 44-50
    • Muscoli, C.1    Sacco, I.2    Alecce, W.3
  • 167
    • 0036667559 scopus 로고    scopus 로고
    • Inhibition of airway inflammation and hyper-reactivity by an antioxidant mimetic
    • Chang LY, Crapo JD. Inhibition of airway inflammation and hyper-reactivity by an antioxidant mimetic. Free Radic. Biol. Med. 33(3), 379-386 (2002
    • (2002) Free Radic. Biol. Med. , vol.33 , Issue.3 , pp. 379-386
    • Chang, L.Y.1    Crapo, J.D.2
  • 169
    • 0037103792 scopus 로고    scopus 로고
    • Oxidation of nitric oxide by oxomanganese-salen complexes: A new mechanism for cellular protection by superoxide dismutase catalase mimetics
    • Sharpe MA, Ollosson R, Stewart VC, Clark JB. Oxidation of nitric oxide by oxomanganese-salen complexes: a new mechanism for cellular protection by superoxide dismutase/catalase mimetics. Biochem. J. 366(Pt 1), 97-107 (2002
    • (2002) Biochem. J. , vol.366 , Issue.PART 1 , pp. 97-107
    • Sharpe, M.A.1    Ollosson, R.2    Stewart, V.C.3    Clark, J.B.4
  • 170
    • 0029555770 scopus 로고
    • A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury in vitro
    • Day BJ, Shawen S, Liochev SI, Crapo JD. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury in vitro. J. Pharmacol. Exp. Ther. 275(3), 1227-1232 (1995
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , Issue.3 , pp. 1227-1232
    • Day, B.J.1    Shawen, S.2    Liochev, S.I.3    Crapo, J.D.4
  • 171
    • 0031573475 scopus 로고    scopus 로고
    • Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury
    • Day BJ, Fridovich I, Crapo JD. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch. Biochem. Biophys. 347(2), 256-262 (1997
    • (1997) Arch. Biochem. Biophys. , vol.347 , Issue.2 , pp. 256-262
    • Day, B.J.1    Fridovich, I.2    Crapo, J.D.3
  • 172
    • 0042848453 scopus 로고    scopus 로고
    • Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion
    • Ferrer-Sueta G, Vitturi D, Batinic-Haberle I et al. Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. J. Biol. Chem. 278(30), 27432-27438 (2003
    • (2003) J. Biol. Chem. , vol.278 , Issue.30 , pp. 27432-27438
    • Ferrer-Sueta, G.1    Vitturi, D.2    Batinic-Haberle, I.3
  • 173
    • 1642505511 scopus 로고    scopus 로고
    • Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: Implication for their use in targeting oxidation-reduction reactions in innate immunity
    • Tse HM, Milton MJ, Piganelli JD. Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity. Free Radic. Biol. Med. 36(2), 233-247 (2004
    • (2004) Free Radic. Biol. Med. , vol.36 , Issue.2 , pp. 233-247
    • Tse, H.M.1    Milton, M.J.2    Piganelli, J.D.3
  • 174
    • 2942713709 scopus 로고    scopus 로고
    • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase SOD mimetic properties protects lungs from radiation-induced injury
    • Vujaskovic Z, Batinic-Haberle I, Rabbani ZN et al. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic. Biol. Med. 33(6), 857-863 (2002
    • (2002) Free Radic. Biol. Med. , vol.33 , Issue.6 , pp. 857-863
    • Vujaskovic, Z.1    Batinic-Haberle, I.2    Rabbani, Z.N.3
  • 175
    • 0036061614 scopus 로고    scopus 로고
    • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone
    • Piganelli JD, Flores SC, Cruz C et al. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 51(2), 347-355 (2002
    • (2002) Diabetes , vol.51 , Issue.2 , pp. 347-355
    • Piganelli, J.D.1    Flores, S.C.2    Cruz, C.3
  • 176
    • 9444222523 scopus 로고    scopus 로고
    • Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress
    • Zhang HJ, Doctrow SR, Xu L et al. Redox modulation of the liver with chronic antioxidant enzyme mimetic treatment prevents age-related oxidative damage associated with environmental stress. FASEB J. 18(13), 1547-1549 (2004
    • (2004) FASEB J. , vol.18 , Issue.13 , pp. 1547-1549
    • Zhang, H.J.1    Doctrow, S.R.2    Xu, L.3
  • 177
    • 33646365882 scopus 로고    scopus 로고
    • Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging
    • Zhang HJ, Doctrow SR, Oberley LW, Kregel KC. Chronic antioxidant enzyme mimetic treatment differentially modulates hyperthermia-induced liver HSP70 expression with aging. J. Appl. Physiol. 100(4), 1385-1391 (2006
    • (2006) J. Appl. Physiol. , vol.100 , Issue.4 , pp. 1385-1391
    • Zhang, H.J.1    Doctrow, S.R.2    Oberley, L.W.3    Kregel, K.C.4
  • 178
    • 19944404781 scopus 로고    scopus 로고
    • NF-kB plays a major role during the systemic and local acute inflammatory response followingintestinal reperfusion injury
    • Souza DG, Vieira AT, Pinho V et al. NF-kB plays a major role during the systemic and local acute inflammatory response followingintestinal reperfusion injury. Br. J. Pharmacol. 145(2), 246-254 (2005
    • (2005) Br. J. Pharmacol. , vol.145 , Issue.2 , pp. 246-254
    • Souza, D.G.1    Vieira, A.T.2    Pinho, V.3
  • 179
    • 0037417802 scopus 로고    scopus 로고
    • Chemogenomic identification of Ref-1 AP-1 as a therapeutic target for asthma
    • USA
    • Nguyen C, Teo JL, Matsuda A et al. Chemogenomic identification of Ref-1/ AP-1 as a therapeutic target for asthma. Proc. Natl Acad. Sci. USA 100(3), 1169-1173 (2003
    • (2003) Proc. Natl Acad. Sci. , vol.100 , Issue.3 , pp. 1169-1173
    • Nguyen, C.1    Teo, J.L.2    Matsuda, A.3
  • 180
    • 79955472293 scopus 로고    scopus 로고
    • Alleviation of oxidative stress by potent and selective thioredoxin-mimetic peptides
    • Bachnoff N, Trus M, Atlas D. Alleviation of oxidative stress by potent and selective thioredoxin-mimetic peptides. Free Radic. Biol. Med. 50(10), 1355-1367 (2011
    • (2011) Free Radic. Biol. Med. , vol.50 , Issue.10 , pp. 1355-1367
    • Bachnoff, N.1    Trus, M.2    Atlas, D.3
  • 181
    • 34250857454 scopus 로고    scopus 로고
    • Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats
    • Stefanutti G, Pierro A, Smith VV, Klein NJ, Eaton S. Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats. Pediatr. Res. 62(1), 43-48 (2007
    • (2007) Pediatr. Res. , vol.62 , Issue.1 , pp. 43-48
    • Stefanutti, G.1    Pierro, A.2    Smith, V.V.3    Klein, N.J.4    Eaton, S.5
  • 182
    • 0037448784 scopus 로고    scopus 로고
    • Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction
    • Pacher P, Liaudet L, Bai P et al. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction. Circulation 107(6), 896-904 (2003
    • (2003) Circulation , vol.107 , Issue.6 , pp. 896-904
    • Pacher, P.1    Liaudet, L.2    Bai, P.3
  • 183
    • 2342613645 scopus 로고    scopus 로고
    • Potential therapeutic effect of antioxidant therapy in shock and inflammation
    • Cuzzocrea S, Thiemermann C, Salvemini D. Potential therapeutic effect of antioxidant therapy in shock and inflammation. Curr. Med. Chem. 11(9), 1147-1162 (2004
    • (2004) Curr. Med. Chem. , vol.11 , Issue.9 , pp. 1147-1162
    • Cuzzocrea, S.1    Thiemermann, C.2    Salvemini, D.3
  • 184
    • 16244368485 scopus 로고    scopus 로고
    • Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species
    • Shi H, Timmins G, Monske M et al. Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species. Arch. Biochem. Biophys. 437(1), 59-68 (2005
    • (2005) Arch. Biochem. Biophys. , vol.437 , Issue.1 , pp. 59-68
    • Shi, H.1    Timmins, G.2    Monske, M.3
  • 185
    • 65649112534 scopus 로고    scopus 로고
    • Nitration of distinct tyrosine residues causes inactivation of histone deacetylase-2
    • Osoata GO, Yamamura S, Ito M et al. Nitration of distinct tyrosine residues causes inactivation of histone deacetylase-2. Biochem. Biophys. Res. Commun. 384(3), 366-371 (2009
    • (2009) Biochem. Biophys. Res. Commun. , vol.384 , Issue.3 , pp. 366-371
    • Osoata, G.O.1    Yamamura, S.2    Ito, M.3
  • 186
    • 52149108919 scopus 로고    scopus 로고
    • S-nitrosylation of histone deacetylase-2 induces chromatin remodelling in neurons
    • Nott A, Watson PM, Robinson JD, Crepaldi L, Riccio A. S-nitrosylation of histone deacetylase-2 induces chromatin remodelling in neurons. Nature 455(7211), 411-415 (2008
    • (2008) Nature , vol.455 , Issue.7211 , pp. 411-415
    • Nott, A.1    Watson, P.M.2    Robinson, J.D.3    Crepaldi, L.4    Riccio, A.5
  • 187
    • 80052424406 scopus 로고    scopus 로고
    • l-NAME and l-arginine differentially ameliorate cigarette smoke-induced emphysema in mice
    • Valenca SS, Rueff-Barroso CR, Pimenta WA et al. l-NAME and l-arginine differentially ameliorate cigarette smoke-induced emphysema in mice. Pulm. Pharmacol. Ther. 24(5), 587-594 (2011
    • (2011) Pulm. Pharmacol. Ther. , vol.24 , Issue.5 , pp. 587-594
    • Valenca, S.S.1    Rueff-Barroso, C.R.2    Pimenta, W.A.3
  • 188
    • 80054696408 scopus 로고    scopus 로고
    • Inducible NOS inhibition reverses tobacco smoke-induced emphysema and pulmonary hypertension in mice
    • Seimetz M, Parajuli N, Pichl A et al. Inducible NOS inhibition reverses tobacco smoke-induced emphysema and pulmonary hypertension in mice. Cell 147(2), 293-305 (2011
    • (2011) Cell , vol.147 , Issue.2 , pp. 293-305
    • Seimetz, M.1    Parajuli, N.2    Pichl, A.3
  • 189
    • 1342328149 scopus 로고    scopus 로고
    • Superoxide dismutases in malignant cells and human tumors
    • Kinnula VL, Crapo JD. Superoxide dismutases in malignant cells and human tumors. Free Radic. Biol. Med. 36(6), 718-744 (2004
    • (2004) Free Radic. Biol. Med. , vol.36 , Issue.6 , pp. 718-744
    • Kinnula, V.L.1    Crapo, J.D.2
  • 190
    • 3042689052 scopus 로고    scopus 로고
    • Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung
    • Kinnula VL, Paakko P, Soini Y. Antioxidant enzymes and redox regulating thiol proteins in malignancies of human lung. FEBS Lett. 569(1-3), 1-6 (2004)
    • (2004) FEBS Lett. , vol.569 , Issue.1-3 , pp. 1-6
    • Kinnula, V.L.1    Paakko, P.2    Soini, Y.3


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