Peroxynitrite decomposition catalyst FeTMPyP provides partial protection against intestinal ischemia and reperfusion injury in infant rats

Pediatric Research

Volumn 62, Issue 1, 2007, Pages 43-48

  Stefanutti, Giorgio ^a   Pierro, Agostino ^a   Smith, Virpi V ^a   Klein, Nigel J ^a   Eaton, Simon ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5,10,15,20 TETRAKIS(N METHYL 4' PYRIDYL)PORPHYRINATO IRON; FREE RADICAL; GLUTATHIONE; INTERCELLULAR ADHESION MOLECULE 1; MALONALDEHYDE; MYELOPEROXIDASE; NITRATE; NITRIC OXIDE; NITRITE; PADGEM PROTEIN; PEROXYNITRITE; PORPHYRIN DERIVATIVE; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYST; CONTROLLED STUDY; ILEUM; INTESTINE ISCHEMIA; LIPID PEROXIDATION; LUNG; LUNG INJURY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REPERFUSION INJURY;

ANIMALS; ANIMALS, SUCKLING; ENDOTHELIAL CELLS; GLUTATHIONE; INTERCELLULAR ADHESION MOLECULE-1; INTESTINES; ISCHEMIA; MALONDIALDEHYDE; METALLOPORPHYRINS; NITRATES; NITRITES; P-SELECTIN; PEROXIDASE; PEROXYNITROUS ACID; RANDOM ALLOCATION; RATS; REPERFUSION INJURY; VASCULAR CELL ADHESION MOLECULE-1;

EID: 34250857454     PISSN: 00313998     EISSN: None     Source Type: Journal    
DOI: 10.1203/PDR.0b013e31806790c0     Document Type: Article

References (39)

1. Schoenberg MH, Beger HG 1993 Reperfusion injury after intestinal ischemia. Crit Care Med 21:1376-1386
2. Eaton S, Hall N, Rees CM, Pierro A 2004 Necrotizing enterocolitis: pathogenesis, medical management and surgery. Br J Intensive Care 14:101-105
3. Clark LA. 2000 Malrotation. In: Ashcraft KW (ed) Pediatric Surgery. W.B. Saunders, Philadelphia, PA, pp 425-434.
4. Fallat ME. 2000 Intussusception. In: Ashcraft KW (ed) Pediatric Surgery. W.B. Saunders, Philadelphia, PA, pp 518-526.
5. Fink MP 1993 Adequacy of Gut Oxygenation in Endotoxemia and Sepsis. Crit Care Med 21:S4-S8
6. Moore FA 1999 The role of the gastrointestinal tract in postinjury multiple organ failure. Am J Surg 178:449-453
7. Sonntag J, Wagner MH, Waldschmidt J, Wit J, Obladen M 1998 Multisystem organ failure and capillary leak syndrome in severe necrotizing enterocolitis of very low birth weight infants. J Pediatr Surg 33:481-484
8. Cuzzocrea S, Misko TP, Costantino G, Mazzon E, Micali A, Caputi AP, MacArthur H, Salvemini D 2000 Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion. FASEB J 14:1061-1072
9. Chung DH, Ethridge RT, Kim S, Owens-Stovall S, Hernandez A, Kelly DR, Evers BM 2001 Molecular mechanisms contributing to necrotizing enterocolitis. Ann Surg 233:835-842
10. Sisley AC, Desai T, Harig JM, Gewertz BL 1994 Neutrophil depletion attenuates human intestinal reperfusion injury. J Surg Res 57:192-196
11. Hernandez LA, Grisham MB, Twohig B, Arfors KE, Harlan JM, Granger DN 1987 Role of neutrophils in ischemia-reperfusion-induced microvascular injury. Am J Physiol 253:H699-H703
12. Pierro A, Eaton S 2004 Intestinal ischemia reperfusion injury and multisystem organ failure. Semin Pediatr Surg 13:11-17
13. Stefanutti G, Lister P, Smith VV, Peters MJ, Klein NJ, Pierro A, Eaton S 2005 P-Selectin expression, neutrophil infiltration and histological injury in neonates with necrotizing enterocolitis. J Pediatr Surg 40:942-948
14. Zhang M, Austen WG Jr, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD Jr, Carroll MC 2004 Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci USA 101:3886-3891
15. Chen Y, Lui VC, Rooijen NV, Tam PK 2004 Depletion of intestinal resident macrophages prevents ischaemia reperfusion injury in gut. Gut 53:1772-1780
16. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D 2001 Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 53:135-159
17. Szabo C, Ohshima H 1997 DNA damage induced by peroxynitrite: Subsequent biological effects. Nitric Oxide 1:373-385
18. Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M, Freeman BA 1994 Nitric oxide regulation of superoxide and peroxynitrite- dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem 269:26066-26075
19. Fukumoto K, Pierro A, Zammit VA, Spitz L, Eaton S 2004 Tyrosine nitration of carnitine palmitoyl transferase I during endotoxaemia in suckling rats. Biochim Biophys Acta 1683:1-6
20. Castro L, Rodriguez M, Radi R 1994 Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide. J Biol Chem 269:29409-29415
21. Salvemini D, Riley DP, Lennon PJ, Wang ZQ, Currie MG, MacArthur H, Misko TP 1999 Protective effects of a superoxide dismutase mimetic and peroxynitrite decomposition catalysts in endotoxin-induced intestinal damage. Br J Pharmacol 127:685-692
22. Thiyagarajan M, Kaul CL, Sharma SS 2004 Neuroprotective efficacy and therapeutic time window of peroxynitrite decomposition catalysts in focal cerebral ischemia in rats. Br J Pharmacol 142:899-911
23. Kang JL, Lee HS, Pack IS, Leonard S, Castranova V 2001 Iron tetrakis (n-methyl-4′-pyridyl) porphyrinato (FeTMPyP) is a potent scavenging antioxidant and an inhibitor of stimulant-induced NF-kappaB activation of raw 264.7 macrophages. J Toxicol Environ Health A 64:291-310
24. Stefanutti G, Vejchapipat P, Williams SR, Pierro A, Eaton S 2004 Heart energy metabolism after intestinal ischaemia and reperfusion. J Pediatr Surg 39:179-183
25. Bertin R, Demarco F, Mouroux I, Portet R 1993 Postnatal-development of nonshivering thermogenesis in rats - effects of rearing temperature. J Dev Physiol 19:9-15
26. Chiu CJ, McArdle AH, Brown R, Scott HJ, Gurd FN 1970 Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 101:478-483
27. Vinardi S, Pierro A, Parkinson EJ, Vejchapipat P, Stefanutti G, Spitz L, Eaton S 2003 Hypothermia throughout intestinal ischaemia-reperfusion injury attenuates lung neutrophil infiltration. J Pediatr Surg 38:88-91
28. Stefanutti G, Pierro A, Vinardi S, Spitz L, Eaton S 2005 Moderate hypothermia protects against systemic oxidative stress in intestinal ischaemia and reperfusion injury. Shock 24:159-164
29. Horie Y, Wolf R, Miyasaka M, Anderson DC, Granger DN 1996 Leukocyte adhesion and hepatic microvascular responses to intestinal ischemia/reperfusion in rats. Gastroenterology 111:666-673
30. Naito Y, Takagi T, Ichikawa H, Tomatsuri N, Kuroda M, Isozaki Y, Katada K, Uchiyama K, Kokura S, Yoshida N, Okanoue T, Yoshikawa T 2004 A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats. Nitric Oxide 10:170-177
31. Di Napoli M, Papa F 2005 M-40403 metaphore pharmaceuticals. IDrugs 8:67-76
32. Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Aston K, Riley DP, Salvemini D 2001 Protective effects of a new stable, highly active SOD mimetic, M40401 in splanchnic artery occlusion and reperfusion. Br J Pharmacol 132:19-29
33. Gibson DD, Brackett DJ, Squires RA, Balla AK, Lerner MR, Mccay PB, Pennington LR 1993 Evidence that the large loss of glutathione observed in ischemia reperfusion of the small-intestine is not due to oxidation to glutathione disulfide. Free Radic Biol Med 14:427-433
34. Srivastava SK, Beutler E 1969 The transport of oxidized glutathione from human erythrocytes. J Biol Chem 244:9-16
35. Schrammel A, Gorren AC, Schmidt K, Pfeiffer S, Mayer B 2003 S-nitrosation of glutathione by nitric oxide, peroxynitrite, and -NO/O2-. Free Radic Biol Med 34:1078-1088
36. Ghezzi P 2005 Regulation of protein function by glutathionylation. Free Radic Res 39:573-580
37. Williams JP, Pechet TT, Weiser MR, Reid R, Kobzik L, Moore FD Jr, Carroll MC, Hechtman HB 1999 Intestinal reperfusion injury is mediated by IgM and complement. J Appl Physiol 86:938-942
38. Zhu L, Gunn C, Beckman JS 1992 Bactericidal activity of peroxynitrite. Arch Biochem Biophys 298:452-457
39. Ferdinandy P 2006 Peroxynitrite: just an oxidative/nitrosative stressor or a physiological regulator as well? Br J Pharmacol 148:1-3