Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia

APMIS

Volumn 118, Issue 9, 2010, Pages 703-712

  Mazur, Witold ^a   Lindholm, Pamela ^a   Vuorinen, Kirsi ^a   MyllÄrniemi, Marjukka ^a   Salmenkivi, Kaisa ^a   Kinnula, Vuokko L ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

antioxidant; fibrosis; IPF; NRF2; NSIP; Oxidant; sulfiredoxin 1

Indexed keywords

DJ 1 PROTEIN; KELCH LIKE ECH ASSOCIATED PROTEIN 1; OXIDOREDUCTASE; SULFIREDOXIN 1; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL LEVEL; CONTROLLED STUDY; FEMALE; FIBROSING ALVEOLITIS; GENE ACTIVATION; HUMAN; HUMAN TISSUE; INTERSTITIAL PNEUMONIA; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; MALE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WESTERN BLOTTING;

AGED; BIOLOGICAL MARKERS; FEMALE; HAMARTOMA; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; LUNG DISEASES; LUNG DISEASES, INTERSTITIAL; MALE; MIDDLE AGED; NF-E2-RELATED FACTOR 2; ONCOGENE PROTEINS; OXIDATIVE STRESS; OXIDOREDUCTASES ACTING ON SULFUR GROUP DONORS; PULMONARY FIBROSIS; VITAL CAPACITY;

EID: 77955960441     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2010.02646.x     Document Type: Article

References (34)

1. American Thoracic SocietyEuropean Respiratory Society: international multidisciplinary consensus classification of the idiopathic interstitial pneumonias. Am J Respir Crit Care Med 2002 165 : 277 304.
2. Barbas-Filho JV, Ferreira MA, Sesso A, Kairalla RA, Carvalho CR, Capelozzi VL. Evidence of type II pneumocyte apoptosis in the pathogenesis of idiopathic pulmonary fibrosis (IFP)usual interstitial pneumonia (UIP). J Clin Pathol 2001 54 : 132 8.
3. Selman M, Pardo A. Idiopathic pulmonary fibrosis: an epithelialfibroblastic cross-talk disorder. Respir Res 2002 3 : 3.
4. Waghray M, Cui Z, Horowitz JC, Subramanian IM, Martinez FJ, Toews GB, et al. Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts. FASEB J 2005 19 : 854 6.
5. Kharitonov SA, Barnes PJ. Exhaled markers of pulmonary disease. Am J Respir Crit Care Med 2001 163 : 1693 722.
6. Kinnula VL, Fattman CL, Tan RJ, Oury TD. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am J Respir Crit Care Med 2005 172 : 417 22.
7. Koli K, Myllarniemi M, Keski-Oja J, Kinnula VL. Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 2008 10 : 333 42.
8. Lakari E, Soini Y, Säily M, Koistinen P, Pääkkö P, Kinnula VL. Inducible nitric oxide synthase, but not xanthine oxidase, is highly expressed in interstitial pneumonias and granulomatous diseases of human lung. Am J Clin Pathol 2002 117 : 132 42.
9. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000 279 : L1005 28.
10. Bringardner BD, Baran CP, Eubank TD, Marsh CB. The role of inflammation in the pathogenesis of idiopathic pulmonary fibrosis. Antioxid Redox Signal 2008 10 : 287 301.
11. Bellocq A, Azoulay E, Marullo S, Flahault A, Fouqueray B, Philippe C, et al. Reactive oxygen and nitrogen intermediates increase transforming growth factor-beta1 release from human epithelial alveolar cells through two different mechanisms. Am J Respir Cell Mol Biol 1999 21 : 128 36.
12. Cantin AM, North SL, Hubbard RC, Crystal RG. Normal alveolar epithelial lining fluid contains high levels of glutathione. J Appl Physiol 1987 63 : 152 7.
13. Kinnula VL, Crapo JD, Raivio KO. Generation and disposal of reactive oxygen metabolites in the lung. Lab Invest 1995 73 : 3 19.
14. Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med 2003 167 : 1600 19.
15. Kuwano K, Nakashima N, Inoshima I, Hagimoto N, Fujita M, Yoshimi M, et al. Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias. Eur Respir J 2003 21 : 232 40.
16. Rottoli P, Magi B, Cianti R, Bargagli E, Vagaggini C, Nikiforakis N, et al. Carbonylated proteins in bronchoalveolar lavage of patients with sarcoidosis, pulmonary fibrosis associated with systemic sclerosis and idiopathic pulmonary fibrosis. Proteomics 2005 5 : 2612 8.
17. Cantin AM, Hubbard RC, Crystal RG. Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract in idiopathic pulmonary fibrosis. Am Rev Respir Dis 1989 139 : 370 2.
18. Markart P, Luboeinski T, Korfei M, Schmidt R, Wygrecka M, Mahavadi P, et al. Alveolar oxidative stress is associated with elevated levels of nonenzymatic low-molecular-weight antioxidants in patients with different forms of chronic fibrosing interstitial lung diseases. Antioxid Redox Signal 2009 11 : 227 40.
19. Kinnula VL, Hodgson UA, Lakari EK, Tan RJ, Sormunen RT, Soini YM, et al. Extracellular superoxide dismutase has a highly specific localization in idiopathic pulmonary fibrosisusual interstitial pneumonia. Histopathology 2006 49 : 66 74.
20. Lakari E, Pääkkö P, Pietarinen-Runtti P, Kinnula VL. Manganese superoxide dismutase and catalase are coordinately expressed in the alveolar region in chronic interstitial pneumonias and granulomatous diseases of the lung. Am J Respir Crit Care Med 2000 161 : 615 21.
21. Lakari E, Pylkäs P, Pietarinen-Runtti P, Pääkkö P, Soini Y, Kinnula VL. Expression and regulation of hemeoxygenase 1 in healthy human lung and interstitial lung disorders. Hum Pathol 2001 32 : 1257 63.
22. Peltoniemi M, Kaarteenaho-Wiik R, Säily M, Sormunen R, Päkkö P, Holmgren A, et al. Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. Hum Pathol 2004 35 : 1000 7.
23. Tiitto L, Kaarteenaho-Wiik R, Sormunen R, Holmgren A, Pääkkö P, Soini Y, et al. Expression of the thioredoxin system in interstitial lung disease. J Pathol 2003 201 : 363 70.
24. Tiitto LH, Peltoniemi MJ, Kaarteenaho-Wiik RL, Soini YM, Pääkkö PK, Sormunen RT, et al. Cell-specific regulation of gamma-glutamylcysteine synthetase in human interstitial lung diseases. Hum Pathol 2004 35 : 832 9.
25. Vuorinen K, Ohlmeier S, Leppäranta O, Salmenkivi K, Myllarniemi M, Kinnula VL. Peroxiredoxin II expression and its association with oxidative stress and cell proliferation in human idiopathic pulmonary fibrosis. J Histochem Cytochem 2008 56 : 951 9.
26. Walters DM, Cho HY, Kleeberger SR. Oxidative stress and antioxidants in the pathogenesis of pulmonary fibrosis: a potential role for Nrf2. Antioxid Redox Signal 2008 10 : 321 32.
27. Woo HA, Kang SW, Kim HK, Yang KS, Chae HZ, Rhee SG. Reversible oxidation of the active site cysteine of peroxiredoxins to cysteine sulfinic acid. Immunoblot detection with antibodies specific for the hyperoxidized cysteine-containing sequence. J Biol Chem 2003 278 : 47361 4.
28. Singh A, Ling G, Suhasini AN, Zhang P, Yamamoto M, Navas-Acien A, et al. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med 2009 46 : 376 86.
29. Cho HY, Reddy SP, Yamamoto M, Kleeberger SR. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004 18 : 1258 60.
30. Lehtonen ST, Markkanen PM, Peltoniemi M, Kang SW, Kinnula VL. Variable overoxidation of peroxiredoxins in human lung cells in severe oxidative stress. Am J Physiol Lung Cell Mol Physiol 2005 288 : L997 1001.
31. Myllärniemi M, Vuorinen K, Pulkkinen V, Kankaanranta H, Aine T, Salmenkivi K, et al. Gremlin localization and expression levels partially differentiate idiopathic interstitial pneumonia severity and subtype. J Pathol 2008 214 : 456 63.
32. Rangasamy T, Cho CY, Thimmulappa RK, Zhen L, Srisuma SS, Kensler TW, et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004 114 : 1248 59.
33. Malhotra D, Thimmulappa R, Navas-Acien A, Sandford A, Elliott M, Singh A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med 2008 178 : 592 604.
34. Pietarinen-Runtti P, Lakari E, Raivio KO, Kinnula VL. Expression of antioxidant enzymes in human inflammatory cells. Am J Physiol Cell Physiol 2000 278 : C118 25.