메뉴 건너뛰기




Volumn 91, Issue 3, 1997, Pages 159-168

Nacystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defence in vitro

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACETYLCYSTEINE DERIVATIVE; AMBROXOL; ANTIOXIDANT; BUTHIONINE SULFOXIMINE; GLUTATHIONE; HYDROGEN PEROXIDE; LYSINE DERIVATIVE; NACYSTELYN; OXYGEN RADICAL; UNCLASSIFIED DRUG;

EID: 0030902329     PISSN: 09546111     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0954-6111(97)90052-4     Document Type: Article
Times cited : (124)

References (48)
  • 1
    • 0002926180 scopus 로고
    • Oxidants: Types, sources, and mechanisms of injury
    • Crystal RG, West JB, eds. New York: Raven Press
    • Schraufstätter IU, Cochrane CG. Oxidants: types, sources, and mechanisms of injury. In: Crystal RG, West JB, eds. The Lung, Scientific Foundations. New York: Raven Press, 1991; 1803-1810.
    • (1991) The Lung, Scientific Foundations , pp. 1803-1810
    • Schraufstätter, I.U.1    Cochrane, C.G.2
  • 2
    • 4244087065 scopus 로고
    • Reactive oxygen species in living systems: Source, biochemistry, and role in human disease
    • Halliwell B. Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 1991; 91: 3C-14S-3C-22S.
    • (1991) Am J Med , vol.91
    • Halliwell, B.1
  • 3
    • 0023263236 scopus 로고
    • Oxidant mediated epithelial cell injury in pulmonary fibrosis
    • Cantin AM, North GA, Fells RC et al. Oxidant mediated epithelial cell injury in pulmonary fibrosis. J Clin Invest 1987; 79: 1665-1673.
    • (1987) J Clin Invest , vol.79 , pp. 1665-1673
    • Cantin, A.M.1    North, G.A.2    Fells, R.C.3
  • 4
    • 0028230612 scopus 로고
    • The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis
    • Meyer A, Buhl R, Magnussen H. The effect of oral N-acetylcysteine on lung glutathione levels in idiopathic pulmonary fibrosis. Eur Respir J 1994; 7: 431-436.
    • (1994) Eur Respir J , vol.7 , pp. 431-436
    • Meyer, A.1    Buhl, R.2    Magnussen, H.3
  • 5
    • 0002030147 scopus 로고
    • The oxidative stress placed on the lung by cigarette smoke
    • Crystal RG, West JB, eds. New York: Raven Press
    • Church DF, Pryor WA. The oxidative stress placed on the lung by cigarette smoke. In: Crystal RG, West JB, eds. The Lung Scientific Foundation. New York: Raven Press, 1991; 1975-1979.
    • (1991) The Lung Scientific Foundation , pp. 1975-1979
    • Church, D.F.1    Pryor, W.A.2
  • 6
    • 3042744558 scopus 로고
    • Cellular injury by oxidants
    • Cochrane CG. Cellular injury by oxidants. Am J Med 1991; 91: 3C-23S-3C-30S.
    • (1991) Am J Med , vol.91
    • Cochrane, C.G.1
  • 7
    • 0002040944 scopus 로고
    • Antioxidants in the lung
    • Crystal RG, West JB, eds. New York: Raven Press
    • Heffner JE, Repine JE. Antioxidants in the lung. In: Crystal RG, West JB, eds. The Lung Scientific Foundation. New York: Raven Press, 1991; 1811-1820.
    • (1991) The Lung Scientific Foundation , pp. 1811-1820
    • Heffner, J.E.1    Repine, J.E.2
  • 8
    • 0024571519 scopus 로고
    • Free radical effects on lung metabolism
    • Jenkinson SG. Free radical effects on lung metabolism. Clin Chest Med 1989; 10: 37-47.
    • (1989) Clin Chest Med , vol.10 , pp. 37-47
    • Jenkinson, S.G.1
  • 9
    • 0025886739 scopus 로고
    • Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis
    • Borok Z, Buhl R, Grimes GJ et al. Effect of glutathione aerosol on oxidant-antioxidant imbalance in idiopathic pulmonary fibrosis. Lancet 1991; 338: 215-216.
    • (1991) Lancet , vol.338 , pp. 215-216
    • Borok, Z.1    Buhl, R.2    Grimes, G.J.3
  • 10
    • 0027227895 scopus 로고
    • Augmentation of respiratory epithelial lining fluid anti-oxidant screen by aerosolization of recombinant human Cu++/Zn++ Superoxide dismutase
    • Gillissen A, Roum JH, Hoyt RF et al. Augmentation of respiratory epithelial lining fluid anti-oxidant screen by aerosolization of recombinant human Cu++/Zn++ Superoxide dismutase. Chest 1993; 104: 811-815.
    • (1993) Chest , vol.104 , pp. 811-815
    • Gillissen, A.1    Roum, J.H.2    Hoyt, R.F.3
  • 11
    • 0024380927 scopus 로고
    • The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage
    • Prescott LF, Donovan JW, Jarvie DR et al. The disposition and kinetics of intravenous N-acetylcysteine in patients with paracetamol overdosage. Eur J Clin Pharmacol 1989; 37: 501-506.
    • (1989) Eur J Clin Pharmacol , vol.37 , pp. 501-506
    • Prescott, L.F.1    Donovan, J.W.2    Jarvie, D.R.3
  • 12
    • 0023130486 scopus 로고
    • The role of acetylcysteine in clinical toxicology
    • Flanagan RJ. The role of acetylcysteine in clinical toxicology. Med Toxicol 1987; 2: 93-104.
    • (1987) Med Toxicol , vol.2 , pp. 93-104
    • Flanagan, R.J.1
  • 13
    • 0025282179 scopus 로고
    • Augmentation of reduced glutathione levels in the epithelial lining fluid of the lower respiratory tract by direct aerosol administration of glutathione
    • Buhl R, Vogelmeier C, Crittenden M et al. Augmentation of reduced glutathione levels in the epithelial lining fluid of the lower respiratory tract by direct aerosol administration of glutathione. Proc Nat Acad Sci 1990; 87: 4063-4067.
    • (1990) Proc Nat Acad Sci , vol.87 , pp. 4063-4067
    • Buhl, R.1    Vogelmeier, C.2    Crittenden, M.3
  • 14
    • 0020537304 scopus 로고
    • Selective modification of lutathione metabolism
    • Meister A. Selective modification of lutathione metabolism. Science 1983; 220: 472-477.
    • (1983) Science , vol.220 , pp. 472-477
    • Meister, A.1
  • 15
    • 0024264526 scopus 로고
    • Glutathione metabolism and its selective modification
    • Meister A. Glutathione metabolism and its selective modification. J Biol Chem 1988; 262: 17205-17208.
    • (1988) J Biol Chem , vol.262 , pp. 17205-17208
    • Meister, A.1
  • 16
    • 0024546827 scopus 로고
    • Modulation of endothelial GSH concentrations effect of exogenous GSH and GSH monoethylester
    • Tsan M-F, White JE, Rosan CL. Modulation of endothelial GSH concentrations effect of exogenous GSH and GSH monoethylester. J Appl Physiol 1989; 66: 1029-1034.
    • (1989) J Appl Physiol , vol.66 , pp. 1029-1034
    • Tsan, M.-F.1    White, J.E.2    Rosan, C.L.3
  • 17
    • 0025221318 scopus 로고
    • Distribution studies of liposome-encapsulated glutathione administered to the lung
    • Jurima-Romet M, Barber RF, Demeester J et al. Distribution studies of liposome-encapsulated glutathione administered to the lung. Int J Pharmaceutics 1990; 63: 227-235.
    • (1990) Int J Pharmaceutics , vol.63 , pp. 227-235
    • Jurima-Romet, M.1    Barber, R.F.2    Demeester, J.3
  • 18
    • 0028361231 scopus 로고
    • Effect of N-acetylcysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue
    • Bridgeman MME, Marsden M, Selby C et al. Effect of N-acetylcysteine on the concentrations of thiols in plasma, bronchoalveolar lavage fluid, and lung tissue. Thorax 1994; 49: 670-675.
    • (1994) Thorax , vol.49 , pp. 670-675
    • Bridgeman, M.M.E.1    Marsden, M.2    Selby, C.3
  • 19
    • 0027184036 scopus 로고
    • Recombinant secretory leukoprotease inhibitor augments glutathione levels in respiratory epithelial lining fluid
    • Gillissen A, Birrer P, Buhl R et al. Recombinant secretory leukoprotease inhibitor augments glutathione levels in respiratory epithelial lining fluid. J Appl Physiol 1993; 75: 825-832.
    • (1993) J Appl Physiol , vol.75 , pp. 825-832
    • Gillissen, A.1    Birrer, P.2    Buhl, R.3
  • 20
    • 0025875051 scopus 로고
    • The metabolism of N-acetylcysteine by human endothelial cells
    • Cotgreave I, Moldéus P, Schuppe I. The metabolism of N-acetylcysteine by human endothelial cells. Biochem Pharmacol 1991; 42: 13-16.
    • (1991) Biochem Pharmacol , vol.42 , pp. 13-16
    • Cotgreave, I.1    Moldéus, P.2    Schuppe, I.3
  • 21
    • 4244116464 scopus 로고
    • Do SH-group carrying reducing agents affect the protease-antiprotease balance in bronchial secretions ?
    • App EM, Hochstrasser K, Tomkiewicz RP et al. Do SH-group carrying reducing agents affect the protease-antiprotease balance in bronchial secretions ? Eur Respir J 1993; 6: 438s.
    • (1993) Eur Respir J , vol.6
    • App, E.M.1    Hochstrasser, K.2    Tomkiewicz, R.P.3
  • 22
    • 4243942078 scopus 로고
    • Thio-group carrying mucolytic agents inactivate proteases such as human neutrophil elastase (HNE) in vitro
    • App EM, Tomkiewicz RP, Hochstrasser K et al. Thio-group carrying mucolytic agents inactivate proteases such as human neutrophil elastase (HNE) in vitro. Am Rev Respir Dis 1993; 4: A673.
    • (1993) Am Rev Respir Dis , vol.4
    • App, E.M.1    Tomkiewicz, R.P.2    Hochstrasser, K.3
  • 23
    • 0027406436 scopus 로고
    • Lung desposition of a Nacystelyn metered dose inhaler formulation
    • Hardy JG, Everard ML, Coffiner M et al. Lung desposition of a Nacystelyn metered dose inhaler formulation. J Aerosol Med 1993; 6: 37-44.
    • (1993) J Aerosol Med , vol.6 , pp. 37-44
    • Hardy, J.G.1    Everard, M.L.2    Coffiner, M.3
  • 24
    • 0013188810 scopus 로고
    • Determination of the mode of action of a novel mucolytic agent, nacystelyn
    • Marriott C, Ingham S, Coffiner M et al. Determination of the mode of action of a novel mucolytic agent, nacystelyn. Eur Respir J 1993; 6: 438s.
    • (1993) Eur Respir J , vol.6
    • Marriott, C.1    Ingham, S.2    Coffiner, M.3
  • 25
    • 0026600457 scopus 로고
    • Intratracheal N-acetylcysteine use in infants with chronic lung disease
    • Bibi H, Seifert B, Oullette M et al. Intratracheal N-acetylcysteine use in infants with chronic lung disease. Acta Paediatr 1992; 81: 335-339.
    • (1992) Acta Paediatr , vol.81 , pp. 335-339
    • Bibi, H.1    Seifert, B.2    Oullette, M.3
  • 27
    • 0014481378 scopus 로고
    • Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione
    • Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal Biochem 1969; 27: 502-522.
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 28
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxylradical, superoxide, and hypochlorus acid
    • Aruoma OI, Halliwell B, Hoey BM et al The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxylradical, superoxide, and hypochlorus acid. Free Rad Biol Med 1989; 6: 593-597.
    • (1989) Free Rad Biol Med , vol.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3
  • 30
    • 0025979799 scopus 로고
    • The effects of sulfasalazine metabolites on hemoglobin-catalyzed lipid peroxidation
    • Yamada T, Volkmer C, Grisham MB. The effects of sulfasalazine metabolites on hemoglobin-catalyzed lipid peroxidation. Free Rad Biol Med 1991; 10: 41-49.
    • (1991) Free Rad Biol Med , vol.10 , pp. 41-49
    • Yamada, T.1    Volkmer, C.2    Grisham, M.B.3
  • 31
    • 0028337106 scopus 로고
    • Eine einfache Reinigungsmethode für granulo- und monozytäre Zellen am Beispiel der Glutathionbestimmung in Serum und Zellen bei Patienten mit einer COPD
    • Gillissen A, Jaworska M, Schärling B et al. Eine einfache Reinigungsmethode für granulo- und monozytäre Zellen am Beispiel der Glutathionbestimmung in Serum und Zellen bei Patienten mit einer COPD. Atemw-Lungenkrkh 1994; 20: 308-309.
    • (1994) Atemw-Lungenkrkh , vol.20 , pp. 308-309
    • Gillissen, A.1    Jaworska, M.2    Schärling, B.3
  • 32
    • 0025953529 scopus 로고
    • Passive smoking by humans sensitizes circulating neutrophils
    • Anderson R, Theron AJ, Richards GA et al. Passive smoking by humans sensitizes circulating neutrophils. Am Rev Respir Dis 1991; 144: 570-574.
    • (1991) Am Rev Respir Dis , vol.144 , pp. 570-574
    • Anderson, R.1    Theron, A.J.2    Richards, G.A.3
  • 33
    • 0028097891 scopus 로고
    • Current smoking of elderly men reduces antioxidants in alveolar macrophages
    • Kondo T, Tagami S, Yoshioka A et al. Current smoking of elderly men reduces antioxidants in alveolar macrophages. Am J Respir Crit Care Med 1994; 149: 178-182.
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 178-182
    • Kondo, T.1    Tagami, S.2    Yoshioka, A.3
  • 34
    • 0019140628 scopus 로고
    • A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture
    • Pick E, Keisari Y. A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture. J Immunol Meth 1980; 38: 161-170.
    • (1980) J Immunol Meth , vol.38 , pp. 161-170
    • Pick, E.1    Keisari, Y.2
  • 35
    • 0025457975 scopus 로고
    • Extracellular glutathione suppresses human lung fibroblasts proliferation
    • Cantin AM, Larivée P, Begin RO. Extracellular glutathione suppresses human lung fibroblasts proliferation. Am J Respir Cell Mol Biol 1990; 3: 79-85.
    • (1990) Am J Respir Cell Mol Biol , vol.3 , pp. 79-85
    • Cantin, A.M.1    Larivée, P.2    Begin, R.O.3
  • 36
    • 0024578662 scopus 로고
    • Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract of patients with idiopathic pulmonary fibrosis
    • Cantin A, Hubbard RC, Crystal RG. Glutathione deficiency in the epithelial lining fluid of the lower respiratory tract of patients with idiopathic pulmonary fibrosis. Am Rev Respir Dis 1989; 139: 370-372.
    • (1989) Am Rev Respir Dis , vol.139 , pp. 370-372
    • Cantin, A.1    Hubbard, R.C.2    Crystal, R.G.3
  • 37
    • 0028126051 scopus 로고
    • N-acetylcysteine enhances recovery from acute lung injury in man
    • Suter PM, Domenighetti G, Schaller M-D et al. N-acetylcysteine enhances recovery from acute lung injury in man. Chest 1994; 105: 190-194.
    • (1994) Chest , vol.105 , pp. 190-194
    • Suter, P.M.1    Domenighetti, G.2    Schaller, M.-D.3
  • 39
    • 0029093174 scopus 로고
    • Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals
    • Meyer A, Buhl R, Kampf S et al. Intravenous N-acetylcysteine and lung glutathione of patients with pulmonary fibrosis and normals. Am J Respir Crit Care Med 1995; 152: 1055-1060.
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 1055-1060
    • Meyer, A.1    Buhl, R.2    Kampf, S.3
  • 40
    • 0026741271 scopus 로고
    • Glutathione depletion in HIV-infected patients: Role of cysteine deficiency and effect of oral N-acetylcysteine
    • de Quay B, Malinverni R, Lauterburg BH. Glutathione depletion in HIV-infected patients: role of cysteine deficiency and effect of oral N-acetylcysteine. AIDS 1992; 6: 815-819.
    • (1992) AIDS , vol.6 , pp. 815-819
    • De Quay, B.1    Malinverni, R.2    Lauterburg, B.H.3
  • 41
    • 0026343403 scopus 로고
    • Glutathione deficiency produced by inhibition of its synthesis, and its reversal: Applications in research and therapy
    • Meister A. Glutathione deficiency produced by inhibition of its synthesis, and its reversal: applications in research and therapy. Pharmacol Ther 1991; 51: 155-194.
    • (1991) Pharmacol Ther , vol.51 , pp. 155-194
    • Meister, A.1
  • 42
    • 0023732216 scopus 로고
    • Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: Correlation to effects on cellular variables
    • Eklund A, Eriksson O, Hakansson L et al. Oral N-acetylcysteine reduces selected humoral markers of inflammatory cell activity in BAL fluid from healthy smokers: correlation to effects on cellular variables. Eur Respir J 1988; 1: 832-838.
    • (1988) Eur Respir J , vol.1 , pp. 832-838
    • Eklund, A.1    Eriksson, O.2    Hakansson, L.3
  • 43
    • 0028052960 scopus 로고
    • Identification of N-acetylcysteine as a new substrate for rat liver microsomal glutathione transferase
    • Weinander R, Anderson C, Morgenstern R. Identification of N-acetylcysteine as a new substrate for rat liver microsomal glutathione transferase. J Biol Chem 1994; 269: 71-76.
    • (1994) J Biol Chem , vol.269 , pp. 71-76
    • Weinander, R.1    Anderson, C.2    Morgenstern, R.3
  • 44
    • 12644289777 scopus 로고    scopus 로고
    • Monographie Lysin-Monohydrat
    • Frankfurt/Eschborn: Govi Verlag GmbH
    • Deutscher Apotheker Verlag. Monographie Lysin-Monohydrat. In: German Pharmacopoeia. Frankfurt/Eschborn: Govi Verlag GmbH, 1996.
    • (1996) German Pharmacopoeia
  • 45
    • 0026914862 scopus 로고
    • Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine
    • Phelps DT, Deneke SM, Daley DL et al. Elevation of glutathione levels in bovine pulmonary artery endothelial cells by N-acetylcysteine. Am J Respir Cell Mol Biol 1992; 7: 293-299.
    • (1992) Am J Respir Cell Mol Biol , vol.7 , pp. 293-299
    • Phelps, D.T.1    Deneke, S.M.2    Daley, D.L.3
  • 46
    • 0023179937 scopus 로고
    • Gastrointestinal metabolism of N-acetyl cysteine in the rat, including an assay for sulfite in biological systems
    • Cotgreave IA, Berggren M, Jones TW et al. Gastrointestinal metabolism of N-acetyl cysteine in the rat, including an assay for sulfite in biological systems. Biopharm Drug Dispos 1987; 8: 377-386.
    • (1987) Biopharm Drug Dispos , vol.8 , pp. 377-386
    • Cotgreave, I.A.1    Berggren, M.2    Jones, T.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.