Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD

Thorax

Volumn 56, Issue 1, 2001, Pages 36-41

  Gompertz, S ^a   Bayley, D L ^a   Hill, S L ^a   Stockley, R A ^a  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

Chronic obstructive pulmonary disease; Inflammation; Secretory leukoprotease inhibitor(SLPI)

Indexed keywords

C REACTIVE PROTEIN; ELASTASE; INTERLEUKIN 8; LEUKOTRIENE B4; MYELOPEROXIDASE; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ADULT; AGED; ARTICLE; BRONCHIECTASIS; BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; FEMALE; HUMAN; INFLAMMATION; LUNG FUNCTION; MALE; PRIORITY JOURNAL; SMOKING;

AGED; BIOLOGICAL MARKERS; BRONCHIECTASIS; BRONCHITIS; C-REACTIVE PROTEIN; FEMALE; FORCED EXPIRATORY VOLUME; HUMANS; LUNG DISEASES, OBSTRUCTIVE; LUNG VOLUME MEASUREMENTS; MALE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; SECRETORY LEUKOCYTE PEPTIDASE INHIBITOR; SMOKING; SPUTUM; VITAL CAPACITY;

EID: 0035153325     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thorax.56.1.36     Document Type: Article

References (30)

1. Determinants of health related quality of life in patients with chronic obstructive pulmonary disease
2. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease
3. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease
4. The role of infection in COPD
5. Nebulizer vs spacer for bronchodilator delivery in patients hospitalized for acute exacerbations of COPD
6. Controlled trial of oral prednisone in outpatients with acute COPD exacerbation
7. Multicentre randomised placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease
8. Relationship of sputum inflammatory changes to symptoms and lung function changes in COPD exacerbations
9. 1 in smokers are associated with increased levels of neutrophils
10. Airway inflammation in COPD assessed by sputum levels of interleukin-8
11. Airways inflammation in chronic bronchitis: The effects of smoking and α-1antitrypsin deficiency
12. Increases in CD4+ T lymphocytes, macrophages, neutrophils and interleukin 8 positive cells in the airways of patients with bronchiectasis
13. Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitis
14. Inhaled corticosteroids reduce neutrophilic bronchial inflammation in patients with chronic obstructive pulmonary disease
15. Effect of fluticasone propionate on sputum of patients with chronic bronchitis and emphysema
16. Changes in bronchial inflammation during acute exacerbations of chronic bronchitis
17. Relationship of sputum colour to nature and outpatient management of acute exacerbations of COPD
18. Physiological and radiological characterisation of patients diagnosed with chronic obstructive pulmonary disease in primary care
19. BTS guidelines for the management of chronic obstructive pulmonary disease
20. Simple method for quantifying viable bacterial numbers in sputum
21. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis
22. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: The ISOLDE trial
23. Sputum induction to assess airway inflammation: Is it an inflammatory stimulus?
24. The influence of antibiotics and other factors on reconsultation for acute lower respiratory tract illness in primary care
25. Cellular mechanisms in the pathogenesis of COPD
26. Secretory leukoprotease inhibitor: A native antimicrobial protein presenting a new therapeutic option?
27. Regulation of secretory leukocyte protease inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes
28. Corticosteroids increase secretory leukocyte protease inhibitor transcript levels in airway epithelial cells
29. Alpha1-antitrypsin and leukocyte elastase in infected and non-infected sputum
30. Inflammation: Role of the neutrophil and the eosinophil