Localization of γ-glutamylcysteine synthetase messenger rna expression in lungs of smokers and patients with chronic obstructive pulmonary disease

Free Radical Biology and Medicine

Volumn 28, Issue 6, 2000, Pages 920-925

  Rahman, Irfan ^a   Van Schadewuk, Annemarie A M ^b,c   Hiemstra, Peter S ^b   Stolk, Jan ^b   Van Krieken, J Han J M ^c   Macnee, William ^a   De Boer, Willem I ^b,c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Department of Pulmonology And ^*  (Netherlands)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Glutamylcysteine synthetase; COPD; Free radical; Glutathione; Lungs; mRNA; Smokers

Indexed keywords

CD68 ANTIGEN; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; EPITHELIUM; FEMALE; FORCED EXPIRATORY VOLUME; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LUNG ALVEOLUS EPITHELIUM; MACROPHAGE; MALE; PRIORITY JOURNAL; SMOKING;

AGED; ANTIOXIDANTS; BRONCHI; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; IN SITU HYBRIDIZATION; LUNG; LUNG DISEASES, OBSTRUCTIVE; MALE; MIDDLE AGED; PULMONARY ALVEOLI; RNA, MESSENGER; SMOKING;

EID: 0034653809     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(00)00179-9     Document Type: Article

References (39)

1. Deneke, S. M.; Fanburg, B. L. Regulation of cellular glutathione. Am. J. Physiol. 257:L163-L173; 1989.
2. Meister, A; Anderson, M. E. Glutathione. Annu. Rev. Biochem. 52:711-760; 1983.
3. Rahman, I.; MacNee, W. Lung glutathione and oxidative stress: implications in cigarette smoke-induced airway disease. Am. J. Physiol. 277:L1067-L1088; 1999.
4. Cross, C. E.; van der Vliet, A.; O'Neill, C. A.; Louie, S.; Halliwell, B. Oxidants, antioxidants, and respiratory tract lining fluids. Environ. Health Perspect. 102:185-191; 1994.
5. Lannan, S.; Donaldson, K.; Brown, D.; MacNee, W. Effects of cigarette smoke and its condensates on alveolar cell injury in vitro. Am. J. Physiol. 266:L92-L100; 1994.
6. Seelig, G.F.; Meister, A. γ-Glutamylcysteine synthetase. J. Biol. Chem. 259:3534-3538; 1984.
7. Seelig, G. F.; Simondsen, R. P.; Meister, A. Reversible dissociation of γ-glutamylcysteine synthetase into two subunits. J. Biol. Chem. 259:9345-9347;1984.
8. Huang, C. S.; Chang, L. S.; Anderson, M. E.; Meister, A. Catalytic and regulatory properties of the heavy subunit of rat kidney γ-glutamylcysteine synthetase. J. Biol. Chem. 268:19675-19680; 1993.
9. Shi, M. M.; Kugelman, A.; Takeo, I.; Tian, L.; Forman, H. J. Quinone-induced oxidative stress elevates glutathione and induces γ-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J. Biol. Chem. 269:26512-26517; 1994.
10. Galloway, D. C.; Blake, D. G.; Shepherd, A. G.; McLellan, L. I. Regulation of human γ-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells. Biochem. J. 328:99-104; 1997.
11. Rahman, I.; Smith, C. A. D.; Antonicelli, F.; MacNee, W. Characterisation of γ-glutamylcysteine-heavy subunit gene promoter: critical role for AP-1. FEBS Lett. 427:129-133; 1998.
12. Rahman, I.; Smith, C. A. D.; Lawson, M. F.; Harrison, D. J.; MacNee, W. Induction of γ-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells. FEBS Lett. 396:21-25; 1996.
13. Rahman, I.; Bel, A.; Mulier, B.; Lawson, M. F.; Harrison, D. J.; MacNee, W; Smith, C. A. D. Transcriptional regulation of γ-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells. Biochem. Biophys. Res. Commun. 229:832-837; 1996.
14. Rahman, I.; Bel, A.; Mulier, B.; Donaldson, K.; MacNee, W. Differential effects of oxidants and dexamethasone on γ-glutamylcysteine synthetase and γ-glutamyl transpeptidase in alveolar epithelial cells. Am. J. Physiol. 275:L80-L86; 1998.
15. Rahman, I.; Antonicelli, F.; MacNee, W. Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-α and dexamethasone in human alveolar epithelial cells. J. Biol. Chem. 274:5088-5096; 1999.
16. Morris, P. E.; Bernard, G. R. Significance of glutathione in lung disease and implications for therapy. Am. J. Med. Sci. 307:119-127; 1994.
17. [©17] Snider, G. Chronic obstructive pulmonary disease: risk factors, pathophysiology and pathogenesis. Annu. Rev. Med. 40:411-429; 1989.
18. Rahman, I.; MacNee, W. Role of oxidants/antioxidants in smoking-induced airways diseases. Free Radic. Biol. Med. 21:669-681; 1996.
19. Cantin, A.M.; North, S. L.; Hubbard, R. C.; Crystal, R G. Normal alveolar epithelial lining fluid contains high levels of glutathione. J. Appl. Physiol. 63:152-157; 1987.
20. Morrison, D.; Rahman, I.; Lannan, S.; MacNee, W. Epithelial permeability, inflammation, and oxidant stress in the airspaces of smokers. Am. J. Respir. Crit. Care Med. 159:473-479; 1999.
21. Skwarski, K.; Rahman, I.; Drost, E.; Morrison, D.; Skwarska, E.; Watchorn, T.; Mulier, B.; MacNee, W. Effect of acute cigarette smoking on oxidant/antioxidant imbalance in the airspaces of chronic smokers (abstract). Am. J. Respir. Crit. Care Med. 155:A197; 1997.
22. de Boer, W. I.; Schadewijk, A.; Sont, J. K.; Sharma, H. S.; Stolk, J.; Hiemstra, P. S.; Krieken, J. H. J. M. Transforming growth factor-β1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 158:1951-1957; 1998.
23. Arsalane, K.; Dubois, C. M.; Muanza, T.; Begin, R.; Boudreau, F.; Asselin, C.; Cantin, A. M. Transforming growth factor-β1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme γ-glutamylcysteine synthetase. Am. J. Respir. Cell. Mol. Biol. 17:599-607; 1997.
24. Grashoff, W. F. H.; Sont, J. K.; Sterk, P. J.; Hiemstra, P. S.; de Boer, W. I.; Stolk, J.; van Krieken, J. H. J. M. Chronic obstructive pulmonary disease: the role of bronchiolar mast cells and macrophages. Am. J. Pathol. 151:1785-1790; 1997.
25. Gipp, J. J.; Chang, C.; Mulcahy, R. T. Cloning and nucleotide sequence of a full-length cDNA for human liver γ-glutamylcysteine synthetase. Biochem. Biophys. Res. Commun. 185:29-35; 1992.
26. de Boer, W. I.; Schuller, A. G. P.; Vermey, M.; van der Kwast, T. H. Expression of growth factors and receptors during specific phases in regenerating urothelium after acute injury in vivo. Am. J. Pathol. 145:1199-1207; 1994.
27. Gipp, J.; Bailey, H. H.; Mulcahy, R. T. Cloning and sequencing of the cDNA for the light subunit of human liver γ-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues. Biochem. Biophys. Res. Commun. 206:584-589; 1995.
28. Cook, J. A.; Pass, H. I.; Iype, S. N.; Friedman, N.; DeGraff, W.; Russo, A.; Mitchell, J. B. Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue. Cancer Res. 51:4287-4294; 1991.
29. Blair S. L.; Heerdt, P.; Sachar, S.; Abolhada, A.; Hochwald, S.; Cheng, H.; Burt. M. Glutathione metabolism in patients with non-small cell lung cancers. Cancer Res. 57:152-155; 1997.
30. Freeman, B. A.; Mason, R. J.; Williams, M. C.; Crapo, J. D. Antioxidant enzyme activity in alveolar type II cells after exposure of rats to hyperoxia. Exp. Lung Res. 10:203-222; 1986.
31. Morales, A.; Garcia-Ruiz, C.; Miranda, M.; Mari, M.; Collell, A.; Ardite, E.; Fernandez-Checa, J. C. Tumour necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of γ-glutamylcysteine synthetase. J. Biol. Chem. 272:30371-30379; 1997.
32. Border, W. A.; Ruoslahti, E. Transforming growth factor-β1 in disease: the dark side of tissue repair. J. Clin. Invest. 90:1-7; 1992.
33. Corrin, B.; Butcher, D.; McAnulty, B. J.; Dubois, R. M.; Black, C. M.; Laurent, G. J.; Harrison, N. K. Immunohistochemical localization of transforming growth factor-β1 in the lungs of patients with systemic sclerosis, cryptogenic fibrosing alveolitis and other lung disorders. Histopathology 24:145-150; 1994.
34. Vignola, A.; Chanez, M. P.; Chiappara, G.; Merendino, A.; Pace, E.; Rizzo, A.; La Rocca, A. M.; Bellia, V.; Bonsignore, G.; Bousquet, J. Transforming growth factor-β1 expression in mucosal biopsies in asthma and chronic bronchitis. Am. J. Respir. Crit. Care Med. 156:591-599; 1997.
35. Das, S. K.; Fanburg, B. J. TGF-β1 produces a "prooxidant" effect on bovine pulmonary artery endothelial cells in culture. Am. J. Physiol. 262:L249-L254; 1991.
36. White, A. C.; Das, S. K.; Fanburg, B. L. Reduction of glutathione is associated with growth restriction and enlargement of bovine pulmonary artery endothelial cells produced by transforming growth factor-β1. Am. J. Respir. Cell. Mol. Biol. 6:364-368; 1992.
37. Das, S. K.; White, A. C.; Fanburg, B. L. Modulation of transforming growth factor-β1 antiproliferative effects on endothelial cells by cysteine, cystine and N-acetylcysteine. J. Clin. Invest. 90:1649-1656; 1992.
38. Keatings, V. M.; Collins, P.D.; Scott, D. N.; Barnes, P. J. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am. J. Respir. Crit. Care Med. 153:530-534; 1992.
39. Linden, M.; Rasmussen, J. B.; Piitulainen, E.; Tunek, A.; Larson, M.; Tegner, H.; Venge, P.; Laitinen, L. A.; Brattsand, R. Airway inflammation in smokers with non-obstructive and obstructive chronic bronchitis. Am. Rev. Respir. Dis. 148:1226-1232; 1993.