New insights into the immunology of chronic obstructive pulmonary disease

The Lancet

Volumn 378, Issue 9795, 2011, Pages 1015-1026

  Brusselle, Guy G ^a   Joos, Guy F ^a   Bracke, Ken R ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTINUCLEAR ANTIBODY; B CELL ACTIVATING FACTOR; BRONCHODILATING AGENT; CELL RECEPTOR; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; CIGARETTE SMOKE; CORTICOSTEROID; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HIGH MOBILITY GROUP B1 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 10; INTERLEUKIN 8; MACROLIDE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MICRORNA; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3B; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PATTERN RECOGNITION RECEPTOR; RIG I LIKE RECEPTOR; ROFLUMILAST; TOCILIZUMAB; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG; URIC ACID;

ADAPTIVE IMMUNITY; APOPTOSIS; ARTICLE; ASTHMA; AUTOIMMUNITY; AUTOPHAGY; BRONCHIECTASIS; BRONCHIOLITIS OBLITERANS; BRONCHOPNEUMONIA; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CHRONIC BRONCHITIS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CIGARETTE SMOKING; CORTICOSTEROID THERAPY; CYSTIC FIBROSIS; DAMAGE ASSOCIATED MOLECULAR PATTERN; DISEASE COURSE; DISEASE EXACERBATION; EMPHYSEMA; EXTRACELLULAR MATRIX; GENETIC REGULATION; GENETIC SUSCEPTIBILITY; HAEMOPHILUS INFLUENZAE; HELPER CELL; HUMAN; HYPOXIA; IMMUNE RESPONSE; INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE; INNATE IMMUNITY; INTERFERON PRODUCTION; LANGERHANS CELL; LOW DRUG DOSE; LUNG ALVEOLUS CELL; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; LYMPHOID TISSUE; MAST CELL; MOLECULAR RECOGNITION; MONOCYTE; MYELOID DENDRITIC CELL; NATURAL KILLER CELL; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATHOGENESIS; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOMONAS AERUGINOSA; REGULATORY T LYMPHOCYTE; RHINOVIRUS INFECTION; SMOKING CESSATION; STREPTOCOCCUS PNEUMONIAE;

EID: 80052706801     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(11)60988-4     Document Type: Review

References (103)

1. AD Lopez, CD Mathers, M Ezzati, DT Jamison, CJ Murray Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data Lancet 367 2006 1747 1757
2. R Pauwels, K Rabe Burden and clinical features of chronic obstructive pulmonary disease (COPD) Lancet 364 2004 613 620
3. SS Salvi, PJ Barnes Chronic obstructive pulmonary disease in non-smokers Lancet 374 2009 733 743
4. NJ Sinden, RA Stockley Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence Thorax 65 2010 930 936
5. EF Wouters, NL Reynaert, MA Dentener, JH Vernooy Systemic and local inflammation in asthma and chronic obstructive pulmonary disease: is there a connection? Proc Am Thorac Soc 6 2009 638 647
6. EF Wouters, KH Groenewegen, MA Dentener, JH Vernooy Systemic inflammation in chronic obstructive pulmonary disease: the role of exacerbations Proc Am Thorac Soc 4 2007 626 634
7. JC Hogg, W Timens The pathology of chronic obstructive pulmonary disease Annu Rev Pathol 4 2009 435 459
8. CBES Laurell The electrophoretic alpha-1 globulin pattern of serum in alpha-1 antitrypsin deficiency Scand J Clin Lab Invest 15 1963 132 140
9. I Rahman, IM Adcock Oxidative stress and redox regulation of lung inflammation in COPD Eur Respir J 28 2006 219 242
10. T Tsuji, K Aoshiba, A Nagai Cigarette smoke induces senescence in alveolar epithelial cells Am J Respir Cell Mol Biol 31 2004 643 649
11. MG Cosio, M Saetta, A Agusti Immunologic aspects of chronic obstructive pulmonary disease N Engl J Med 360 2009 2445 2454
12. IK Demedts, T Demoor, KR Bracke, GF Joos, GG Brusselle Role of apoptosis in the pathogenesis of COPD and pulmonary emphysema Respir Res 7 2006 53
13. RW Vandivier, PM Henson, IS Douglas Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease Chest 129 2006 1673 1682
14. B Opitz, V van Laak, J Eitel, N Suttorp Innate immune recognition in infectious and noninfectious diseases of the lung Am J Respir Crit Care Med 181 2010 1294 1309
15. N Ferhani, S Letuve, A Kozhich et al. Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease Am J Respir Crit Care Med 181 2010 917 927
16. M Lommatzsch, S Cicko, T Muller et al. Extracellular adenosine triphosphate and chronic obstructive pulmonary disease Am J Respir Crit Care Med 181 2010 928 934
17. A Churg, S Zhou, X Wang, R Wang, JL Wright The role of interleukin-1beta in murine cigarette smoke-induced emphysema and small airway remodeling Am J Respir Cell Mol Biol 40 2009 482 490
18. S Cicko, M Lucattelli, T Muller et al. Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema J Immunol 185 2010 688 697
19. ZH Chen, HP Kim, FC Sciurba et al. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease PLoS One 3 2008 e3316
20. ZH Chen, HC Lam, Y Jin et al. Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema Proc Natl Acad Sci USA 107 2010 18880 18885
21. KF Chung, IM Adcock Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction Eur Respir J 31 2008 1334 1356
22. IK Demedts, A Morel-Montero, S Lebecque et al. Elevated MMP-12 protein levels in induced sputum from patients with COPD Thorax 61 2006 196 201
23. M Saetta, A Di Stefano, G Turato et al. CD8+ T-lymphocytes in peripheral airways of smokers with chronic obstructive pulmonary disease Am J Respir Crit Care Med 157 1998 822 886
24. RA Urbanowicz, JR Lamb, I Todd, JM Corne, LC Fairclough Enhanced effector function of cytotoxic cells in the induced sputum of COPD patients Respir Res 11 2010 76
25. JV Fahy, BF Dickey Airway mucus function and dysfunction N Engl J Med 363 2010 2233 2247
26. SD Shapiro Transgenic and gene-targeted mice as models for chronic obstructive pulmonary disease Eur Respir J 29 2007 375 378
27. A Guerassimov, Y Hoshino, Y Takubo et al. The development of emphysema in cigarette smoke-exposed mice is strain dependent Am J Respir Crit Care Med 170 2004 974 980
28. AI D'Hulst, T Maes, KR Bracke et al. Cigarette smoke-induced pulmonary emphysema in scid-mice. Is the acquired immune system required? Respir Res 6 2005 147
29. FM Botelho, GJ Gaschler, S Kianpour et al. Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice Am J Respir Cell Mol Biol 42 2010 394 403
30. CK Andersson, M Mori, L Bjermer, CG Lofdahl, JS Erjefalt Alterations in lung mast cell populations in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 181 2010 206 217
31. E Vivier, DH Raulet, A Moretta et al. Innate or adaptive immunity? The example of natural killer cells Science 331 2011 44 49
32. MA Degli-Esposti, MJ Smyth Close encounters of different kinds: dendritic cells and NK cells take centre stage Nat Rev Immunol 5 2005 112 124
33. BN Lambrecht, H Hammad The role of dendritic and epithelial cells as master regulators of allergic airway inflammation Lancet 376 2010 835 843
34. M Lommatzsch, K Bratke, T Knappe et al. Acute effects of tobacco smoke on human airway dendritic cells in vivo Eur Respir J 35 2010 1130 1136
35. CM Freeman, FJ Martinez, MK Han et al. Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease Am J Respir Crit Care Med 180 2009 1179 1188
36. IK Demedts, KR Bracke, G Van Pottelberge et al. Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 175 2007 998 1005
37. WR Heath, FR Carbone Dendritic cell subsets in primary and secondary T cell responses at body surfaces Nat Immunol 10 2009 1237 1244
38. M Saetta, M Mariani, P Panina-Bordignon et al. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease Am J Respir Crit Care Med 165 2002 1404 1409
39. S Grumelli, DB Corry, LZ Song et al. An immune basis for lung parenchymal destruction in chronic obstructive pulmonary disease and emphysema PLoS Med 1 2004 e8
40. A Di Stefano, G Caramori, I Gnemmi et al. T helper type 17-related cytokine expression is increased in the bronchial mucosa of stable chronic obstructive pulmonary disease patients Clin Exp Immunol 157 2009 316 324
41. H Imaoka, T Hoshino, S Takei et al. Interleukin-18 production and pulmonary function in COPD Eur Respir J 31 2008 287 297
42. P Miossec, T Korn, VK Kuchroo Interleukin-17 and type 17 helper T cells N Engl J Med 361 2009 888 898
43. Q Tang, JA Bluestone The Foxp3+ regulatory T cell: a jack of all trades, master of regulation Nat Immunol 9 2008 239 244
44. SH Lee, S Goswami, A Grudo et al. Antielastin autoimmunity in tobacco smoking-induced emphysema Nat Med 13 2007 567 569
45. B Barcelo, J Pons, JM Ferrer, J Sauleda, A Fuster, AG Agusti Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking Eur Respir J 31 2008 555 562
46. LJ Smyth, C Starkey, J Vestbo, D Singh CD4-regulatory cells in COPD patients Chest 132 2007 156 163
47. J Plumb, LJ Smyth, HR Adams, J Vestbo, A Bentley, SD Singh Increased T-regulatory cells within lymphocyte follicles in moderate COPD Eur Respir J 34 2009 89 94
48. FR D'Alessio, K Tsushima, NR Aggarwal et al. CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury J Clin Invest 119 2009 2898 2913
49. JC Hogg, F Chu, S Utokaparch et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease N Engl J Med 350 2004 2645 2653
50. BW van der Strate, DS Postma, CA Brandsma et al. Cigarette smoke-induced emphysema: A role for the B cell? Am J Respir Crit Care Med 173 2006 751 758
51. GG Brusselle, T Demoor, KR Bracke, CA Brandsma, W Timens Lymphoid follicles in (very) severe COPD: beneficial or harmful? Eur Respir J 34 2009 219 230
52. TD Randall Bronchus-associated lymphoid tissue (BALT) structure and function Adv Immunol 107 2010 187 241
53. GR Van Pottelberge, KR Bracke, S Van den Broeck et al. Plasmacytoid dendritic cells in pulmonary lymphoid follicles of patients with COPD Eur Respir J 36 2010 781 791
54. F Polverino, S Baraldo, E Bazzan et al. A novel insight into adaptive immunity in chronic obstructive pulmonary disease: B cell activating factor belonging to the tumor necrosis factor family Am J Respir Crit Care Med 182 2010 1011 1019
55. SN Mueller, KA Hosiawa-Meagher, BT Konieczny et al. Regulation of homeostatic chemokine expression and cell trafficking during immune responses Science 317 2007 670 674
56. J Rangel-Moreno, DM Carragher, M de la Luz Garcia-Hernandez et al. The development of inducible bronchus-associated lymphoid tissue depends on IL-17 Nat Immunol 12 2011 639 646
57. S Sethi, TF Murphy Infection in the pathogenesis and course of chronic obstructive pulmonary disease N Engl J Med 359 2008 2355 2365
58. S Sethi, J Maloney, L Grove, C Wrona, CS Berenson Airway inflammation and bronchial bacterial colonization in chronic obstructive pulmonary disease Am J Respir Crit Care Med 173 2006 991 998
59. JR Hurst, Vestbo Jr, A Anzueto et al. Susceptibilty to exacerbation in chronic obstructive pulmonary disease N Engl J Med 363 2010 1128 1138
60. M Hilty, C Burke, H Pedro et al. Disordered microbial communities in asthmatic airways PLoS One 5 2010 e8578
61. CS Berenson, MA Garlipp, LJ Grove, J Maloney, S Sethi Impaired phagocytosis of nontypeable Haemophilus influenzae by human alveolar macrophages in chronic obstructive pulmonary disease J Infect Dis 194 2006 1375 1384
62. AE Taylor, TK Finney-Hayward, JK Quint et al. Defective macrophage phagocytosis of bacteria in COPD Eur Respir J 35 2010 1039 1047
63. A Rosell, E Monso, N Soler et al. Microbiologic determinants of exacerbation in chronic obstructive pulmonary disease Arch Intern Med 165 2005 891 897
64. MA Sanjuan, CP Dillon, SW Tait et al. Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis Nature 450 2007 1253 1257
65. B Levine, N Mizushima, HW Virgin Autophagy in immunity and inflammation Nature 469 2011 323 335
66. S Sethi, N Evans, BJ Grant, TF Murphy New strains of bacteria and exacerbations of chronic obstructive pulmonary disease N Engl J Med 347 2002 465 471
67. T Seemungal, R Harper-Owen, A Bhowmik et al. Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease Am J Respir Crit Care Med 164 2001 1618 1623
68. M Singh, SH Lee, P Porter et al. Human rhinovirus proteinase 2A induces TH1 and TH2 immunity in patients with chronic obstructive pulmonary disease J Allergy Clin Immunol 125 2010 1369-78e2
69. P Mallia, SD Message, V Gielen et al. Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation Am J Respir Crit Care Med 183 2011 734 742
70. A Papi, CM Bellettato, F Braccioni et al. Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations Am J Respir Crit Care Med 173 2006 1114 1121
71. TF Murphy, AL Brauer, BJB Grant, S Sethi Moraxella catarrhalis in chronic obstructive pulmonary disease: burden of disease and immune response Am J Respir Crit Care Med 172 2005 195 199
72. CA Feghali-Bostwick, AS Gadgil, LE Otterbein et al. Autoantibodies in patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 177 2008 156 163
73. B Nunez, J Sauleda, JM Anto et al. Anti-tissue antibodies are related to lung function in chronic obstructive pulmonary disease Am J Respir Crit Care Med 183 2011 1025 1031
74. CM Greene, TB Low, SJ O'Neill, NG McElvaney Anti-proline-glycine-proline or antielastin autoantibodies are not evident in chronic inflammatory lung disease Am J Respir Crit Care Med 181 2010 31 35
75. AM Wood, P de Pablo, CD Buckley, A Ahmad, RA Stockley Smoke exposure as a determinant of autoantibody titre in {alpha}1-antitrypsin deficiency and COPD Eur Respir J 37 2011 32 38
76. HP Bonarius, CA Brandsma, HA Kerstjens et al. Antinuclear autoantibodies are more prevalent in COPD in association with low body mass index but not with smoking history Thorax 66 2010 101 107
77. E Gamble, DC Grootendorst, K Hattotuwa et al. Airway mucosal inflammation in COPD is similar in smokers and ex-smokers: a pooled analysis Eur Respir J 30 2007 467 471
78. L Sorokin The impact of the extracellular matrix on inflammation Nat Rev Immunol 10 2010 712 723
79. NM Weathington, AH van Houwelingen, BD Noerager et al. A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation Nat Med 12 2006 317 323
80. TR Richens, DJ Linderman, SA Horstmann et al. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA Am J Respir Crit Care Med 179 2009 1011 1021
81. HK Eltzschig, P Carmeliet Hypoxia and inflammation N Engl J Med 364 2011 656 665
82. GR Van Pottelberge, P Mestdagh, KR Bracke et al. MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease Am J Respir Crit Care Med 183 2011 898 906
83. J Takamizawa, H Konishi, K Yanagisawa et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival Cancer Res 64 2004 3753 3756
84. N Mercado, R Thimmulappa, CM Thomas et al. Decreased histone deacetylase 2 impairs Nrf2 activation by oxidative stress Biochem Biophys Res Commun 406 2011 292 298
85. K Ito, M Ito, WM Elliott et al. Decreased Histone Deacetylase Activity in Chronic Obstructive Pulmonary Disease N Engl J Med 352 2005 1967 1976
86. IM Adcock, L Tsaprouni, P Bhavsar, K Ito Epigenetic regulation of airway inflammation Curr Opin Immunol 19 2007 694 700
87. C Fletcher, R Peto The natural history of chronic airflow obstruction BMJ 1 1977 1645 1648
88. R Kohansal, P Martinez-Camblor, A Agusti, AS Buist, DM Mannino, JB Soriano The natural history of chronic airflow obstruction revisited: an analysis of the Framingham offspring cohort Am J Respir Crit Care Med 180 2009 3 10
89. LI Kunz, TS Lapperre, JB Snoeck-Stroband et al. Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD Respir Res 12 2011 34
90. TS Lapperre, JB Snoeck-Stroband, MM Gosman et al. Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial Ann Intern Med 151 2009 517 527
91. KL Hattotuwa, MJ Gizycki, TW Ansari, PK Jeffery, NC Barnes The effects of inhaled fluticasone on airway inflammation in chronic obstructive pulmonary disease: a double-blind, placebo-controlled biopsy study Am J Respir Crit Care Med 165 2002 1592 1596
92. NC Barnes, YS Qiu, ID Pavord et al. Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease Am J Respir Crit Care Med 173 2006 736 743
93. IM Adcock, PJ Barnes Molecular mechanisms of corticosteroid resistance Chest 134 2008 394 401
94. PJ Barnes Immunology of asthma and chronic obstructive pulmonary disease Nat Rev Immunol 8 2008 183 192
95. BM Vanaudenaerde, SE Verleden, R Vos et al. Innate and Adaptive Interleukin-17-producing Lymphocytes in Chronic Inflammatory Lung Disorders Am J Respir Crit Care Med 183 2011 977 986
96. DC Grootendorst, SA Gauw, RM Verhoosel et al. Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD Thorax 62 2007 1081 1087
97. KF Rabe, S Hurd, A Anzeuto et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary Am J Respir Crit Care Med 176 2007 532 555
98. PM Calverley, KF Rabe, UM Goehring for the M2-124 and M2-125 study groups Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials Lancet 374 2009 685 694
99. TA Seemungal, TM Wilkinson, JR Hurst, WR Perera, RJ Sapsford, JA Wedzicha Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations Am J Respir Crit Care Med 178 2008 1139 1147
100. S Hodge, G Hodge, H Jersmann et al. Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease Am J Respir Crit Care Med 178 2008 139 148
101. SI Rennard, C Fogarty, S Kelsen et al. The safety and efficacy of infliximab in moderate to severe chronic obstructive pulmonary disease Am J Respir Crit Care Med 175 2007 926 934
102. BG Cosio, L Tsaprouni, K Ito, E Jazrawi, IM Adcock, PJ Barnes Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages J Exp Med 200 2004 689 695
103. PA Ford, AL Durham, RE Russell, F Gordon, IM Adcock, PJ Barnes Treatment effects of low-dose theophylline combined with an inhaled corticosteroid in COPD Chest 137 2010 1338 1344