Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

Nature

Volumn 424, Issue 6948, 2003, Pages 561-565

  Neumann, Carola A ^a   Krause, Daniela S ^a   Carman, Christopher V ^a   Das, Shampa ^a   Dubey, Devendra P ^a   Abraham, Jennifer L ^a   Bronson, Roderick T ^c   Fujiwara, Yuko ^b   Orkin, Stuart H ^b   Van Etten, Richard A ^a,d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c TUFTS UNIVERSITY   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; DRUG PRODUCTS; ENZYMES; HEMOGLOBIN; METABOLISM;

LYMPHOMAS;

TUMORS;

ANTIOXIDANT; PEROXIREDOXIN; PROTEIN; PROTEIN PRDX1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 8 HYDROXYGUANOSINE; 8-HYDROXYGUANOSINE; DRUG DERIVATIVE; GUANOSINE; HEMOGLOBIN; PEROXIDASE;

AGING; ANTIOXIDANT; CANCER; DEFENSE MECHANISM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; ERYTHROCYTE; FIBROBLAST; HEINZ BODY; HEMOLYTIC ANEMIA; HETEROZYGOTE; KILLER CELL; MOUSE; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; AGING; ANIMAL; CELL CYCLE; GENE DELETION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; LONGEVITY; LYMPHOMA; METABOLISM; NATURAL KILLER CELL; NEOPLASM; OXIDATIVE STRESS; PATHOLOGY; SARCOMA; SURVIVAL; TUMOR SUPPRESSOR GENE;

ANIMALIA;

AGING; ANEMIA, HEMOLYTIC; ANIMALS; ANTIOXIDANTS; CELL CYCLE; CELL SURVIVAL; DNA DAMAGE; ERYTHROCYTES; GENE DELETION; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; GUANOSINE; HEMOGLOBINS; KILLER CELLS, NATURAL; LONGEVITY; LYMPHOMA; MICE; NEOPLASMS; OXIDATIVE STRESS; PEROXIDASES; REACTIVE OXYGEN SPECIES; SARCOMA; SURVIVAL ANALYSIS;

EID: 0042568938     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature01819     Document Type: Article

References (31)

1. Finkel, T. Oxygen radicals and signaling. Curr. Opin. Cell Biol 10, 248-253 (1998).
2. Finkel, T. & Holbrook, N. J. Oxidants, oxidative stress and the biology of ageing. Nature 408, 239-246 (2000).
3. Chae, H. Z. et al. Cloning and sequencing of thiol-specific antioxidant from mammalian brain: alkyl hydroperoxide reductase and thiol-specific antioxidant define a large family of antioxidant enzymes. Proc Natl. Acad. Sci. 91, 7017-7021 (1994).
4. Prosperi, M. T., Ferbus, D., Karczinski, I. & Goubin, G. A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins. J. Biol. Chem. 268, 11050-11056 (1993).
5. Ishii, T. et al. Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein. J. Biol Chem. 268, 18633-18636 (1993).
6. Prosperi, M. T., Apiou, F., Dutrillaux, B. & Goubin, G. Organization and chromosomal assignment of two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed pseudogene. Genomics 19, 236-241 (1994).
7. Lyu, M. S. et al. Genetic mapping of six mouse peroxiredoxin genes and fourteen peroxiredoxin related sequences. Mammal. Genome 10, 1017-1019 (1999).
8. Prosperi, M.-T., Ferbus, D., Rouillard, D. & Goubin, G. The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress. FEBS Lett. 423, 39-44 (1998).
9. Kang, S. W. et al. Mammalian peroxiredoxin isoforms can reduce hydrogen peroxide in response to growth factors and tumor necrosis factor-α. J. Biol. Chem. 273, 6297-6302 (1998).
10. Shau, H., Gupta, R. K. & Golub, S. H. Identification of a natural killer enhancing factor (NKEF) from human erythroid cells. Cell. Immunol. 147, 1-11 (1993).
11. Iwahara, S. et al. Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. Biochemistry 34, 13398-13406 (1995).
12. Wen, S.-T. & Van Etten, R. A. The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity. Genes. Dev. 11, 2456-2467 (1997).
13. Chang, T.-S. et al. Regulation of peroxiredoxin 1 activity by Cdc2-mediated phosphorylation. J. Biol. Chem. 277, 25370-25376 (2002).
14. Shau, H. et al. Endogenous natural killer enhancing factor-B increases cellular resistance to oxidative stress. Free Radic. Biol. Med. 22, 497-507 (1997).
15. Chung, Y. M., Yoo, Y. D., Park, J. K., Kiim, Y.-T. & Kim, H. J. Increased expression of peroxiredoxin II confers resistance to cisplatin. Anticancer Res. 21, 1129-1134 (2001).
16. Struthers, L., Patel, R., Clark, J. & Thomas, S. Direct detection of 8-oxodeoxyguanosine and 8-oxoguanine by avidin and its analogues. Anal. Biochem. 255, 20-31 (1998).
17. Cerewenka, A. & Lanier, L. L. Natural killer cells, viruses and cancer. Nature Rev. Immunol 1, 41-49. (2001).
18. Takei, F., Brennan, J. & Mager, D. L. The Ly49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155, 67-77 (1997).
19. Sauri, H., Ashjian, P. H., Kim, A. T. & Shau, H. Recombinant natural killer enhancing factor augments natural killer cytotoxicity. J. Leuk. Biol. 59, 925-931 (1996).
20. Butterfield, L. H., Merino, A., Golub, S. H. & Shau, H. From cytoprotection to tumor suppression: the multifactorial role of peroxiredoxins. Antioxid. Redox Signal. 1, 385-402 (1999).
21. Johnson, R. M., Goyette, G., Ravindranath, Y. & Ho, Y.-S. Red cells from glutathione peroxidase-1-deficient mice have nearly normal defenses against exogenous peroxides. Blood 96, 1985-1988 (2000).
22. Friedman, J. S. et al. Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant. J. Exp. Med. 193, 925-934 (2001).
23. Henderson, C. J. et al. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases. Proc. Natl Acad. Sci. USA 95, 5275-5280 (1998).
24. Ramos-Gomez, M. et al. Sensitivity to carcinogenesis in increased and chemoprotective efficacy of enzyme inducers is lost in Nrf2 transcription factor-deficient mice. Proc. Natl Acad. Sci. USA 98, 2941-2943 (2001).
25. Noh, D.-Y. et al. Overexpression of peroxiredoxin in human breast cancer. Anticancer Res. 21, 2085-2090 (2001).
26. Mu, Z. M., Yin, X. Y. & Prochownik, E. V. Pag, a putative tumor suppressor, interacts with the Myc box II domain of c-Myc and selectively alters its biological function and target gene expression. J. Biol. Chem. 277, 43175-43184 (2002).
27. Westphal, C. H. & Leder, P. Transposon-generated "knock-out" and 'knock-in' gene-targeting constructs for use in mice. Curr. Biol. 7, 530-533 (1997).
28. Hoffmann-Fezer, G. et al. Biotin labeling as an alternative nonradioactive approach to determination of red cell survival. Ann. Hematol. 67, 81-87 (1993).
29. Frank, J., Biesalski, H. K., Dominici, S. & Pompella, A. The visualization of oxidant stress in tissues and isolated cells. Histol. Histopathol. 15, 173-184 (2000).
30. Dubey, D. P. et al. The MHC influences NK and NKT cell functions associated with immune abnormalities and life span. Mech. Aging Dev. 113, 117-134 (2000).
31. Lee, T.-H. et al. Peroxiredoxin 11 is essential for sustaining life span of erythrocytes in mice. Blood 101, 5033-5038 (2003).