In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-γ, and TNF-α

Journal of Immunology

Volumn 157, Issue 2, 1996, Pages 798-805

  Gazzinelli, Ricardo T ^a,d   Wysocka, Maria ^b   Hieny, Sara ^a   Scharton Kersten, Tanya ^a   Cheever, Allen ^a   Kühn, Ralf ^c   Müller, Werner ^c   Trinchieri, Giorgio ^b   Sher, Alan ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b WISTAR INSTITUTE   (United States)

^c UNIVERSITY OF COLOGNE   (Germany)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; MONOKINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; HOST PARASITE INTERACTION; IMMUNE RESPONSE; LETHALITY; LIVER NECROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ACUTE DISEASE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0029959459     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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