The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro

Journal of Biological Chemistry

Volumn 274, Issue 3, 1999, Pages 1257-1266

  Rakemann, Tim ^a   Niehof, Monika ^a   Kubicka, Stefan ^a   Fischer, Martina ^a   Manns, Michael P ^a   Rose John, Stefan ^b   Trautwein, Christian ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Medizinische Hochschule Hannover ^*

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 6; STAT3 PROTEIN;

ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

ANIMALS; ANTIGENS, CD; BIOLOGICAL TRANSPORT; CELL LINE; CELL NUCLEUS; CYTOKINE RECEPTOR GP130; DNA; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HAPTOGLOBINS; HUMANS; INTERLEUKIN-6; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C3H; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-6; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; STAT3 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TYROSINE;

EID: 0033556164     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.3.1257     Document Type: Article

References (42)

1. Hirano, T. (1994) in The Cytokine Handbook (Thompson, A., ed) pp. 145-168, Academic Press, London
2. Mackiewicz, A., Koj, A., and Sehgal, P. B. (1995) Ann. N. Y. Acad. Sci. 762, 1-52
3. Lutticken, C., Wegenka, U. M., Yuan, J., Buschmann, J., Schindler, C., Ziemiecki, A., Harpur, A. G., Wilks, A. F., Yasukawa, K., Taga, T., Kishimoto, T., Barbieri, G., Pellegrini, S., Sendtner, M., Heinrich, P. C., and Horn, F. (1994) Science 263, 89-92
4. Stahl, N., Boulton, T. G., Farruggella, T. J., Ip, N. Y., Davis, S., Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Barbieri, G., Pellegrini, S., Ihle, J. N., and Yancopoulos, G. D. (1994) Science 263, 92-95
5. Darnell, J. E., Kerr, I. M., and Stark, G. R. (1994) Science 264, 1415-1421
6. Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fuijtani, Y., Yamaguchi, T., Nakajima, K., and Hirano, T. (1996) Immunity 6, 449-460
7. Sasse, J., Hemmann, U., Schwartz, C., Schniertshauser, U., Heesel, B., Landgraf, C., Schneider-Mergener, J., Heinrich, P. C., and Horn, F. (1997) Mol. Cell. Biol. 17, 1-10
8. Ihle, J. N. (1996) Cell 84, 331-334
9. Trautwein, C., Böker, K., and Manns, M. P. (1994) Gut 35, 1163-1166
10. Wegenka, U. M., Lütticken, C., Buschmann, J., Yuan, J., Lottspeich, F., Müller-Esterl, W., Schindler, C., Roeb, E., Heinrich, P. C., and Horn, F. (1994) Mol. Cell. Biol. 14, 3186-3196
11. Cressmann, D. E., Diamond R. H., and Taub, R. (1995) Hepatology 21, 1443-1449
12. Trautwein, C., Rakemann, T., Niehof, M., Rose-John, S., and Manns, M. P. (1996) Gastroenterology 110, 1854-1862
13. Cressmann, D. E., Greenbaum, L. E., DeAnglis, R. A., Ciliberto, G., Furth, E. E., Poli, V., and Taub, R. (1996) Science 274, 1379-1383
14. Yamada, Y., Kirillova, I., Peschon, J. J., and Fausto, N. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 1441-1446
15. Taga, T., Hibi, M., Hirato, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., and Kishimoto, T. (1989) Cell 58, 573-581
16. Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., and Kishimoto, T. (1990) Cell 63, 1149-1157
17. Fischer, M., Goldschmitt, J., Peschel, C., Brakenhoff, J. P. G., Kallen, K.J., Wollmer, A., Grötzinger, J., and Rose-John, S. (1997) Nat. Biotechnol. 15, 142-145
18. Van Dam, M., Müllberg, J., Schooltink, H., Stoyan, T., Brakenhoff, J., Heinrich, P. C., and Rose-John, S. (1993) J. Biol. Chem. 268, 15285-15290
19. Trautwein, C., Rakemann, T., Pietrangelo, A., Plumpe, J., Montosi, G., and Manns, M. P. (1996) J. Biol. Chem. 271, 22262-22270
20. Hocke, G. M., Barry, D., and Fey, G. H. (1992) Mol. Cell. Biol. 12, 2282-2294
21. Niehof, M., Manns, M. P., and Trautwein, C. (1997) Mol. Cell. Biol. 17, 3600-3613
22. Trautwein, C., Caelles, C., van der Geer, P., Hunter, T., Karin, M., and Chojkier, M. (1993) Nature 364, 544-547
23. Campos, S. P., Wang, Y., and Baumann, H. (1996) J. Biol. Chem. 271, 24418-24424
24. Ceresa, B. P., and Pessin, J. E. (1996) J. Biol. Chem. 271, 12121-12124
25. Zhong, Z., Wen, Z., and Darnell, J. E. (1994) Science 264, 95-98
26. Heinrich, P. C., Castell, J. V., and Andus, T. (1990) Biochem. J. 265, 621-636
27. Akira, S., and Kishimoto, T. (1992) Immunol. Rev. 127, 25-50
28. Somers, W., Stahl, M., and Seehra, J. S. (1997) EMBO J. 16, 989-997
29. Ward, L. D., Hammacher, A., Howlett, G. J., Matthews, J. M., Fabri, L., Moritz, R. L., Nice, E. C., Weinstock, J., and Simpson, R. J. (1996) J. Biol. Chem. 271, 20138-20144
30. Nesbitt, J. E., and Fuller, G. M. (1992) J. Biol. Chem. 267, 5739-5742
31. Zohlnhöfer, D., Graeve, L., Rose-John, S., Schooltink, H., Dittrich, E., and Heinrich, P. C. (1992) FEBS Lett. 306, 219-222
32. Dittrich, E., Rose-John, S., Gerhartz, C., Müllberg, J., Stoyan, T., Yasukawa, K., Heinrich, P. C., and Graeve, L. (1994) J. Biol. Chem. 269, 19014-19020
33. Dittrich, E., Haft, C. R., Muys, L., Heinrich, P. C., and Graeve, L. (1996) J. Biol. Chem. 271, 5487-5494
34. Graeve, L., Korolenko, T. A., Hemmann, U., Weiergräber, O., Dittrich, E., and Heinrich, P. C. (1996) FEBS Lett. 399, 131-134
35. Peters, M., Jacobs, S., Ehlers, M., Vollmer, P., Müllberg, J., Wolf, E., Brem, G., Meyer zum Büschenfelde, K.-H., and Rose-John, S. (1996) J. Exp. Med. 183, 1399-1406
36. Peters, M., Schirmacher, P., Goldschmitt, J., Odenthal, M., Peschel, C., Fattori, E., Ciliberto, G., Dienes, H.-P., Meyer zum Büschenfelde, K.-H., and Rose-John, S. (1997) J. Exp. Med. 159, 1474-1481
37. Rose-John, S., and Heinrich, P. C. (1994) Biochem. J. 300, 281-290
38. Baumann, H., Wang, Y., Morella, K. K., Lai, C.-F., Dams, H., Hilton, D. J., Hawley, R. G., and Mackiewicz. (1996) J. Immunol 157, 284-290
39. Weiergräber, O., Hemmann, U., Küster, A., Müller-Newen, G., Schneider, J., Rose-John, S., Kurschat, P., Brakenhoff, J. P., Hart, M., Stabel, S., and Heinrich, P. C. (1995) Eur. J. Biochem. 234, 661-669
40. Tajima, S., Tsuji, K., Ebihara, Y., Sui, X., Tanaka, R., Muraoka, K., Yoshida, M., Yamada, K., Yasukawa, K., Taga, T., Kishimoto, T., and Nakahata, T. (1996) J. Exp. Med. 184, 1357-1364
41. Minami, M., Inoue, M., Takeda, K., Matsumoto, M., Kishimoto, T., and Akira, S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3963-3966
42. Mizuhara, H., O'Neill, E., Seki, N., Ogawa, T., Kusunoki, C., Otsuka, K., Satoh, S., Niwa, M., Senoh, H., and Fujiwara, H. (1994) J. Exp. Med. 179, 1529-1537