메뉴 건너뛰기




Volumn 9, Issue 5, 2012, Pages 589-599

Applying epigenetics to alzheimer's disease via the latent early-life associated regulation (LEARn) model

Author keywords

Alzheimer; Envirome; Environment; Epigenetics; Epigenome; Heavy metal toxicity; Lead toxicity; Methylation; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; APOLIPOPROTEIN E3; CLUSTERIN; COMPLEMENT COMPONENT C1R; DNA BASE; GUANINE; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PRESENILIN 1; PRESENILIN 2;

EID: 84861123503     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/156720512800617955     Document Type: Review
Times cited : (55)

References (154)
  • 1
    • 79952730699 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • Thies W, Bleiler L. Alzheimer's disease facts and figures. Alzheimers Dement 7: 208-244 (2011).
    • (2011) Alzheimers Dement , vol.7 , pp. 208-244
    • Thies, W.1    Bleiler, L.2
  • 2
    • 79953854897 scopus 로고    scopus 로고
    • Alzheimer's disease: The challenge of the second century
    • 77sr71
    • Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Sci Transl Med 3: 77sr71 (2011).
    • (2011) Sci Transl Med , vol.3
    • Holtzman, D.M.1    Morris, J.C.2    Goate, A.M.3
  • 3
    • 72249106014 scopus 로고    scopus 로고
    • Balneotherapy, prevention of cognitive decline and care the Alzheimer patient and his family: Outcome of a multidisciplinary workgroup
    • Secher M, Soto M, Gillette S, Andrieu S, Villars H, Vellas B, et al. Balneotherapy, prevention of cognitive decline and care the Alzheimer patient and his family: outcome of a multidisciplinary workgroup. J Nutr Health Aging 13: 797-806 (2009).
    • (2009) J Nutr Health Aging , vol.13 , pp. 797-806
    • Secher, M.1    Soto, M.2    Gillette, S.3    Andrieu, S.4    Villars, H.5    Vellas, B.6
  • 4
    • 33644984720 scopus 로고    scopus 로고
    • Alzheimer's disease and the psychosocial burden for caregivers
    • Gruffydd E, Randle J. Alzheimer's disease and the psychosocial burden for caregivers. Community Pract 79:15-18 (2006).
    • (2006) Community Pract , vol.79 , pp. 15-18
    • Gruffydd, E.1    Randle, J.2
  • 5
    • 79951575493 scopus 로고    scopus 로고
    • Depression and Alzheimer's disease: Is stress the initiating factor in a common neuropathological cascade?
    • Aznar S, Knudsen GM. Depression and Alzheimer's disease: is stress the initiating factor in a common neuropathological cascade? J Alzheimers Dis 23:177-193 (2011).
    • (2011) J Alzheimers Dis , vol.23 , pp. 177-193
    • Aznar, S.1    Knudsen, G.M.2
  • 9
    • 67651180986 scopus 로고    scopus 로고
    • The amyloid hypothesis for Alzheimer's disease: A critical reappraisal
    • Hardy J. The amyloid hypothesis for Alzheimer's disease: a critical reappraisal. J Neurochem 110: 1129-1134 (2009).
    • (2009) J Neurochem , vol.110 , pp. 1129-1134
    • Hardy, J.1
  • 10
    • 4344570364 scopus 로고    scopus 로고
    • Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection
    • Liao L, Cheng D, Wang J, Duong DM, Losik TG, Gearing M, et al. Proteomic characterization of postmortem amyloid plaques isolated by laser capture microdissection. J Biol Chem 279: 37061-37068 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 37061-37068
    • Liao, L.1    Cheng, D.2    Wang, J.3    Duong, D.M.4    Losik, T.G.5    Gearing, M.6
  • 11
    • 0036736218 scopus 로고    scopus 로고
    • Amyloid precursor protein, presenilins, and alpha-synuclein: Molecular pathogenesis and pharmacological applications in Alzheimer's disease
    • Suh YH, Checler F. Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev 54: 469-525 (2002).
    • (2002) Pharmacol Rev , vol.54 , pp. 469-525
    • Suh, Y.H.1    Checler, F.2
  • 12
    • 70349295278 scopus 로고    scopus 로고
    • Structure-neurotoxicity relationships of amyloid beta-protein oligomers
    • Ono K, Condron MM, Teplow DB. Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci USA 106: 14745-14750 (2009).
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14745-14750
    • Ono, K.1    Condron, M.M.2    Teplow, D.B.3
  • 13
    • 79952414387 scopus 로고    scopus 로고
    • Comparison of four neuropathological scales for Alzheimer's disease
    • Brunnstrom H, Englund E. Comparison of four neuropathological scales for Alzheimer's disease. Clin Neuropathol 30: 56-69 (2011).
    • (2011) Clin Neuropathol , vol.30 , pp. 56-69
    • Brunnstrom, H.1    Englund, E.2
  • 14
    • 79751480420 scopus 로고    scopus 로고
    • Oxidative balance in Alzheimer's disease: Relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-beta
    • Tayler H, Fraser T, Miners JS, Kehoe PG, Love S. Oxidative balance in Alzheimer's disease: relationship to APOE, Braak tangle stage, and the concentrations of soluble and insoluble amyloid-beta. J Alzheimers Dis 22: 1363-1373 (2010).
    • (2010) J Alzheimers Dis , vol.22 , pp. 1363-1373
    • Tayler, H.1    Fraser, T.2    Miners, J.S.3    Kehoe, P.G.4    Love, S.5
  • 15
    • 75149192348 scopus 로고    scopus 로고
    • Neuropathologic alterations in mild cognitive impairment: A review
    • Markesbery WR. Neuropathologic alterations in mild cognitive impairment: a review. J Alzheimers Dis 19: 221-228 (2010).
    • (2010) J Alzheimers Dis , vol.19 , pp. 221-228
    • Markesbery, W.R.1
  • 16
    • 77954001458 scopus 로고    scopus 로고
    • Functional, global and cognitive decline correlates to accumulation of Alzheimer's pathology in MCI and AD
    • Sabbagh MN, Cooper K, DeLange J, Stoehr JD, Thind K, Lahti T, et al. Functional, global and cognitive decline correlates to accumulation of Alzheimer's pathology in MCI and AD. Curr Alzheimer Res 7: 280-286 (2010).
    • (2010) Curr Alzheimer Res , vol.7 , pp. 280-286
    • Sabbagh, M.N.1    Cooper, K.2    de Lange, J.3    Stoehr, J.D.4    Thind, K.5    Lahti, T.6
  • 17
    • 76849101075 scopus 로고    scopus 로고
    • Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders
    • Profenno LA, Porsteinsson AP, Faraone SV. Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders. Biol Psychiatry 67: 505-512 (2010).
    • (2010) Biol Psychiatry , vol.67 , pp. 505-512
    • Profenno, L.A.1    Porsteinsson, A.P.2    Faraone, S.V.3
  • 19
    • 78650122129 scopus 로고    scopus 로고
    • Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease
    • Frisardi V, Solfrizzi V, Seripa D, Capurso C, Santamato A, Sancarlo D, et al. Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease. Ageing Res Rev 9: 399-417 (2010).
    • (2010) Ageing Res Rev , vol.9 , pp. 399-417
    • Frisardi, V.1    Solfrizzi, V.2    Seripa, D.3    Capurso, C.4    Santamato, A.5    Sancarlo, D.6
  • 20
    • 78651294089 scopus 로고    scopus 로고
    • Linking cardiometabolic disorders to sporadic Alzheimer's disease: A perspective on potential mechanisms and mediators
    • Bhat NR. Linking cardiometabolic disorders to sporadic Alzheimer's disease: a perspective on potential mechanisms and mediators. J Neurochem 115: 551-562 (2010).
    • (2010) J Neurochem , vol.115 , pp. 551-562
    • Bhat, N.R.1
  • 21
    • 0026745610 scopus 로고
    • Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production
    • Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, et al. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature 360: 672-674 (1992).
    • (1992) Nature , vol.360 , pp. 672-674
    • Citron, M.1    Oltersdorf, T.2    Haass, C.3    McConlogue, L.4    Hung, A.Y.5    Seubert, P.6
  • 22
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870 (1996).
    • (1996) Nat Med , vol.2 , pp. 864-870
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3    Song, X.4    Citron, M.5    Suzuki, N.6
  • 23
    • 33644855143 scopus 로고    scopus 로고
    • Apolipoprotein E and Alzheimer disease
    • Huang Y. Apolipoprotein E and Alzheimer disease. Neurology 66: S79-85 (2006).
    • (2006) Neurology , vol.66
    • Huang, Y.1
  • 24
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families
    • Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 261: 921-923 (1993).
    • (1993) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3    Schmechel, D.E.4    Gaskell, P.C.5    Small, G.W.6
  • 25
    • 33750977825 scopus 로고    scopus 로고
    • Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics
    • Olarte L, Schupf N, Lee JH, Tang MX, Santana V, Williamson J, et al. Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics. Arch Neurol 63:1586-1590 (2006).
    • (2006) Arch Neurol , vol.63 , pp. 1586-1590
    • Olarte, L.1    Schupf, N.2    Lee, J.H.3    Tang, M.X.4    Santana, V.5    Williamson, J.6
  • 26
    • 16944362050 scopus 로고    scopus 로고
    • E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles
    • Lendon CL, Martinez A, Behrens IM, Kosik KS, Madrigal L, Norton J, et al. E280A PS-1 mutation causes Alzheimer's disease but age of onset is not modified by ApoE alleles. Human mutation 10: 186-195 (1997).
    • (1997) Human Mutation , vol.10 , pp. 186-195
    • Lendon, C.L.1    Martinez, A.2    Behrens, I.M.3    Kosik, K.S.4    Madrigal, L.5    Norton, J.6
  • 29
    • 1842507631 scopus 로고    scopus 로고
    • Alzheimer's disease: One disorder, too many genes?
    • Bertram L, Tanzi RE. Alzheimer's disease: one disorder, too many genes? Hum Mol Genet 13 Spec No 1: R135-141 (2004).
    • (2004) Hum Mol Genet , vol.13 , Issue.1
    • Bertram, L.1    Tanzi, R.E.2
  • 30
    • 77955036445 scopus 로고    scopus 로고
    • Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
    • Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, et al. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet 19: 3295-3301 (2010).
    • (2010) Hum Mol Genet , vol.19 , pp. 3295-3301
    • Corneveaux, J.J.1    Myers, A.J.2    Allen, A.N.3    Pruzin, J.J.4    Ramirez, M.5    Engel, A.6
  • 31
    • 79953032765 scopus 로고    scopus 로고
    • Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations
    • Lambert JC, Zelenika D, Hiltunen M, Chouraki V, Combarros O, Bullido MJ, et al. Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations. Neurobiol Aging 32: 756 e711-755 (2011).
    • (2011) Neurobiol Aging , vol.32 , Issue.756
    • Lambert, J.C.1    Zelenika, D.2    Hiltunen, M.3    Chouraki, V.4    Combarros, O.5    Bullido, M.J.6
  • 32
    • 79952592605 scopus 로고    scopus 로고
    • Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals
    • Lee JH, Cheng R, Barral S, Reitz C, Medrano M, Lantigua R, et al. Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals. Arch Neurol 68: 320-328 (2011).
    • (2011) Arch Neurol , vol.68 , pp. 320-328
    • Lee, J.H.1    Cheng, R.2    Barral, S.3    Reitz, C.4    Medrano, M.5    Lantigua, R.6
  • 33
    • 35248846473 scopus 로고    scopus 로고
    • Important Differences between Human and Mouse APOE Gene Promoters: Implications in Alzheimer's Disease
    • Ge Y-W, Maloney B, Alley GM, Lahiri DK. Important Differences between Human and Mouse APOE Gene Promoters: Implications in Alzheimer's Disease. J Neurochem 103: 1237-1257 (2007).
    • (2007) J Neurochem , vol.103 , pp. 1237-1257
    • Ge, Y.-W.1    Maloney, B.2    Alley, G.M.3    Lahiri, D.K.4
  • 34
    • 4444229063 scopus 로고    scopus 로고
    • APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals
    • Tycko B, Lee JH, Ciappa A, Saxena A, Li CM, Feng L, et al. APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals. Arch Neurol 61: 1434-1439 (2004).
    • (2004) Arch Neurol , vol.61 , pp. 1434-1439
    • Tycko, B.1    Lee, J.H.2    Ciappa, A.3    Saxena, A.4    Li, C.M.5    Feng, L.6
  • 35
    • 37549040895 scopus 로고    scopus 로고
    • Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease
    • Lv H, Jia L, Jia J. Promoter polymorphisms which modulate APP expression may increase susceptibility to Alzheimer's disease. Neurobiol Aging 29: 194-202 (2008).
    • (2008) Neurobiol Aging , vol.29 , pp. 194-202
    • Lv, H.1    Jia, L.2    Jia, J.3
  • 36
    • 26944436685 scopus 로고    scopus 로고
    • Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease
    • Lahiri DK, Wavrant De-Vrieze F, Ge Y-W, Maloney B, Hardy J. Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease. Neurobiol Aging 26: 1329-1341 (2005).
    • (2005) Neurobiol Aging , vol.26 , pp. 1329-1341
    • Lahiri, D.K.1    Wavrant De-Vrieze, F.2    Ge, Y.-W.3    Maloney, B.4    Hardy, J.5
  • 37
    • 73949124937 scopus 로고    scopus 로고
    • Promoter polymorphisms which modulate BACE1 expression are associated with sporadic Alzheimer's disease
    • Wang S, Jia J. Promoter polymorphisms which modulate BACE1 expression are associated with sporadic Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet 153B: 159-166 (2010).
    • (2010) Am J Med Genet B Neuropsychiatr Genet , vol.153 B , pp. 159-166
    • Wang, S.1    Jia, J.2
  • 38
    • 58249087544 scopus 로고    scopus 로고
    • The +347 C promoter allele up-regulates MAPT expression and is associated with Alzheimer's disease among the Chinese Han
    • Sun W, Jia J. The +347 C promoter allele up-regulates MAPT expression and is associated with Alzheimer's disease among the Chinese Han. Neuroscience letters 450: 340-343 (2009).
    • (2009) Neuroscience Letters , vol.450 , pp. 340-343
    • Sun, W.1    Jia, J.2
  • 39
    • 58149170562 scopus 로고    scopus 로고
    • Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease
    • Zuo X, Jia J. Promoter polymorphisms which modulate insulin degrading enzyme expression may increase susceptibility to Alzheimer's disease. Brain Res 1249: 1-8 (2009).
    • (2009) Brain Res , vol.1249 , pp. 1-8
    • Zuo, X.1    Jia, J.2
  • 40
    • 0034439422 scopus 로고    scopus 로고
    • Epidemiology of dementia in Nigeria: Results from the Indianapolis-Ibadan study
    • Ogunniyi A, Baiyewu O, Gureje O, Hall KS, Unverzagt F, Siu SH, et al. Epidemiology of dementia in Nigeria: results from the Indianapolis-Ibadan study. Eur J Neurol 7: 485-490 (2000).
    • (2000) Eur J Neurol , vol.7 , pp. 485-490
    • Ogunniyi, A.1    Baiyewu, O.2    Gureje, O.3    Hall, K.S.4    Unverzagt, F.5    Siu, S.H.6
  • 42
    • 51649092529 scopus 로고    scopus 로고
    • Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases?
    • Miller DB, O'Callaghan JP. Do early-life insults contribute to the late-life development of Parkinson and Alzheimer diseases? Metabolism: clinical and experimental 57 Suppl 2: S44-49 (2008).
    • (2008) Metabolism: Clinical and Experimental , vol.57 , Issue.SUPPL. 2
    • Miller, D.B.1    O'Callaghan, J.P.2
  • 43
    • 33646236916 scopus 로고    scopus 로고
    • Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain
    • Bolin CM, Basha R, Cox D, Zawia NH, Maloney B, Lahiri DK, et al. Exposure to lead and the developmental origin of oxidative DNA damage in the aging brain. FASEB J 20: 788-790 (2006).
    • (2006) FASEB J , vol.20 , pp. 788-790
    • Bolin, C.M.1    Basha, R.2    Cox, D.3    Zawia, N.H.4    Maloney, B.5    Lahiri, D.K.6
  • 44
    • 2442586535 scopus 로고    scopus 로고
    • Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene
    • Bellingham SA, Lahiri DK, Maloney B, La Fontaine S, Multhaup G, Camakaris J. Copper depletion down-regulates expression of the Alzheimer's disease amyloid-beta precursor protein gene. J Biol Chem 279: 20378-20386 (2004).
    • (2004) J Biol Chem , vol.279 , pp. 20378-20386
    • Bellingham, S.A.1    Lahiri, D.K.2    Maloney, B.3    la Fontaine, S.4    Multhaup, G.5    Camakaris, J.6
  • 45
    • 3442888291 scopus 로고    scopus 로고
    • Metal and inflammatory targets for Alzheimer's disease
    • Rogers JT, Lahiri DK. Metal and inflammatory targets for Alzheimer's disease. Curr Drug Targets 5: 535-551 (2004).
    • (2004) Curr Drug Targets , vol.5 , pp. 535-551
    • Rogers, J.T.1    Lahiri, D.K.2
  • 46
    • 3442878151 scopus 로고    scopus 로고
    • Cholesterol and Alzheimer's disease: Clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors
    • Sambamurti K, Granholm AC, Kindy MS, Bhat NR, Greig NH, Lahiri DK, et al. Cholesterol and Alzheimer's disease: clinical and experimental models suggest interactions of different genetic, dietary and environmental risk factors. Curr Drug Targets 5: 517-528 (2004).
    • (2004) Curr Drug Targets , vol.5 , pp. 517-528
    • Sambamurti, K.1    Granholm, A.C.2    Kindy, M.S.3    Bhat, N.R.4    Greig, N.H.5    Lahiri, D.K.6
  • 47
    • 0036967251 scopus 로고    scopus 로고
    • Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain
    • Sparks DL, Lochhead J, Horstman D, Wagoner T, Martin T. Water quality has a pronounced effect on cholesterol-induced accumulation of Alzheimer amyloid beta (Abeta) in rabbit brain. J Alzheimers Dis 4: 523-529 (2002).
    • (2002) J Alzheimers Dis , vol.4 , pp. 523-529
    • Sparks, D.L.1    Lochhead, J.2    Horstman, D.3    Wagoner, T.4    Martin, T.5
  • 48
    • 0035853155 scopus 로고    scopus 로고
    • Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members
    • Friedland RP, Fritsch T, Smyth KA, Koss E, Lerner AJ, Chen CH, et al. Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proc Natl Acad Sci USA 98: 3440-3445 (2001).
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3440-3445
    • Friedland, R.P.1    Fritsch, T.2    Smyth, K.A.3    Koss, E.4    Lerner, A.J.5    Chen, C.H.6
  • 50
    • 77649339701 scopus 로고    scopus 로고
    • The LEARn (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps
    • Lahiri DK, Maloney B. The LEARn (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps. Exp Gerontol 45: 291-296 (2010).
    • (2010) Exp Gerontol , vol.45 , pp. 291-296
    • Lahiri, D.K.1    Maloney, B.2
  • 51
    • 12844273354 scopus 로고    scopus 로고
    • The fetal basis of amyloidogenesis: Exposure to lead and latent overexpression of amyloid precursor protein and betaamyloid in the aging brain
    • Basha MR, Wei W, Bakheet SA, Benitez N, Siddiqi HK, Ge YW, et al. The fetal basis of amyloidogenesis: exposure to lead and latent overexpression of amyloid precursor protein and betaamyloid in the aging brain. J Neurosci 25: 823-829 (2005).
    • (2005) J Neurosci , vol.25 , pp. 823-829
    • Basha, M.R.1    Wei, W.2    Bakheet, S.A.3    Benitez, N.4    Siddiqi, H.K.5    Ge, Y.W.6
  • 52
    • 70350432817 scopus 로고    scopus 로고
    • The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases
    • Lahiri DK, Maloney B, Zawia NH. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Mol Psychiatry 14: 992-1003 (2009).
    • (2009) Mol Psychiatry , vol.14 , pp. 992-1003
    • Lahiri, D.K.1    Maloney, B.2    Zawia, N.H.3
  • 53
    • 0030900626 scopus 로고    scopus 로고
    • DNA methylation and the association between genetic and epigenetic changes: Relation to carcinogenesis
    • Wachsman JT. DNA methylation and the association between genetic and epigenetic changes: relation to carcinogenesis. Mutat Res 375: 1-8 (1997).
    • (1997) Mutat Res , vol.375 , pp. 1-8
    • Wachsman, J.T.1
  • 54
    • 78651280460 scopus 로고    scopus 로고
    • Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine
    • Song CX, Szulwach KE, Fu Y, Dai Q, Yi C, Li X, et al. Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine. Nat Biotechnol 29: 68-72 (2011).
    • (2011) Nat Biotechnol , vol.29 , pp. 68-72
    • Song, C.X.1    Szulwach, K.E.2    Fu, Y.3    Dai, Q.4    Yi, C.5    Li, X.6
  • 55
    • 0033178246 scopus 로고    scopus 로고
    • Effect of oxidative DNA damage in promoter elements on transcription factor binding
    • Ghosh R, Mitchell DL. Effect of oxidative DNA damage in promoter elements on transcription factor binding. Nucleic Acids Res 27: 3213-3218 (1999).
    • (1999) Nucleic Acids Res , vol.27 , pp. 3213-3218
    • Ghosh, R.1    Mitchell, D.L.2
  • 56
    • 0034508137 scopus 로고    scopus 로고
    • Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription
    • Kuo MH, vom Baur E, Struhl K, Allis CD. Gcn4 activator targets Gcn5 histone acetyltransferase to specific promoters independently of transcription. Mol Cell 6: 1309-1320 (2000).
    • (2000) Mol Cell , vol.6 , pp. 1309-1320
    • Kuo, M.H.1    vom Baur, E.2    Struhl, K.3    Allis, C.D.4
  • 57
    • 0242348752 scopus 로고    scopus 로고
    • Histone lysine methylation: A signature for chromatin function
    • Sims RJ, 3rd, Nishioka K, Reinberg D. Histone lysine methylation: a signature for chromatin function. Trends Genet 19: 629-639 (2003).
    • (2003) Trends Genet , vol.19 , pp. 629-639
    • Sims III, R.J.1    Nishioka, K.2    Reinberg, D.3
  • 58
    • 77249099223 scopus 로고    scopus 로고
    • CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression
    • Zelko IN, Mueller MR, Folz RJ. CpG methylation attenuates Sp1 and Sp3 binding to the human extracellular superoxide dismutase promoter and regulates its cell-specific expression. Free Radic Biol Med 48: 895-904 (2010).
    • (2010) Free Radic Biol Med , vol.48 , pp. 895-904
    • Zelko, I.N.1    Mueller, M.R.2    Folz, R.J.3
  • 59
    • 40749117651 scopus 로고    scopus 로고
    • The environment, epigenetics and amyloidogenesis
    • Wu J, Basha MR, Zawia NH. The environment, epigenetics and amyloidogenesis. J Mol Neurosci 34: 1-7 (2008).
    • (2008) J Mol Neurosci , vol.34 , pp. 1-7
    • Wu, J.1    Basha, M.R.2    Zawia, N.H.3
  • 60
    • 0035312289 scopus 로고    scopus 로고
    • The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
    • Feng Q, Zhang Y. The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. Genes Dev 15: 827-832 (2001).
    • (2001) Genes Dev , vol.15 , pp. 827-832
    • Feng, Q.1    Zhang, Y.2
  • 61
    • 48449090298 scopus 로고    scopus 로고
    • Epigenetic biomarkers for human cancer: The time is now
    • Mulero-Navarro S, Esteller M. Epigenetic biomarkers for human cancer: the time is now. Crit Rev Oncol Hematol 68: 1-11 (2008).
    • (2008) Crit Rev Oncol Hematol , vol.68 , pp. 1-11
    • Mulero-Navarro, S.1    Esteller, M.2
  • 62
    • 10644237168 scopus 로고    scopus 로고
    • Sadenosylmethionine/ homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
    • Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. Sadenosylmethionine/ homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 28: 195-204 (2005).
    • (2005) Mol Cell Neurosci , vol.28 , pp. 195-204
    • Fuso, A.1    Seminara, L.2    Cavallaro, R.A.3    D'Anselmi, F.4    Scarpa, S.5
  • 64
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One 4: e6617 (2009).
    • (2009) PLoS One , vol.4
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 66
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop KA, Phillips ES, Jackson AA, Hanson MA, Burdge GC. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135: 1382-1386 (2005).
    • (2005) J Nutr , vol.135 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 68
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer's disease
    • Wang SC, Oelze B, Schumacher A. Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One 3: e2698 (2008).
    • (2008) PLoS One , vol.3
    • Wang, S.C.1    Oelze, B.2    Schumacher, A.3
  • 71
    • 0037960155 scopus 로고    scopus 로고
    • Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation
    • Takiguchi M, Achanzar WE, Qu W, Li G, Waalkes MP. Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation. Exp Cell Res 286: 355-365 (2003).
    • (2003) Exp Cell Res , vol.286 , pp. 355-365
    • Takiguchi, M.1    Achanzar, W.E.2    Qu, W.3    Li, G.4    Waalkes, M.P.5
  • 72
    • 77649225956 scopus 로고    scopus 로고
    • Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans
    • Kim KY, Kim DS, Lee SK, Lee IK, Kang JH, Chang YS, et al. Association of low-dose exposure to persistent organic pollutants with global DNA hypomethylation in healthy Koreans. Environmental health perspectives 118: 370-374 (2010).
    • (2010) Environmental Health Perspectives , vol.118 , pp. 370-374
    • Kim, K.Y.1    Kim, D.S.2    Lee, S.K.3    Lee, I.K.4    Kang, J.H.5    Chang, Y.S.6
  • 73
    • 73149096067 scopus 로고    scopus 로고
    • Effects of mixtures of polychlorinated biphenyls, methylmercury, and organochlorine pesticides on hepatic DNA methylation in prepubertal female Sprague-Dawley rats
    • Desaulniers D, Xiao GH, Lian H, Feng YL, Zhu J, Nakai J, et al. Effects of mixtures of polychlorinated biphenyls, methylmercury, and organochlorine pesticides on hepatic DNA methylation in prepubertal female Sprague-Dawley rats. Int J Toxicol 28: 294-307 (2009).
    • (2009) Int J Toxicol , vol.28 , pp. 294-307
    • Desaulniers, D.1    Xiao, G.H.2    Lian, H.3    Feng, Y.L.4    Zhu, J.5    Nakai, J.6
  • 74
    • 70350432817 scopus 로고    scopus 로고
    • The LEARn model: An epigenetic explanation for idiopathic neurobiological diseases
    • Lahiri DK, Maloney B, Zawia NH. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Mol Psychiatry 14: 992-1003 (2009).
    • (2009) Mol Psychiatry , vol.14 , pp. 992-1003
    • Lahiri, D.K.1    Maloney, B.2    Zawia, N.H.3
  • 75
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 8: 253-262 (2007).
    • (2007) Nat Rev Genet , vol.8 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 77
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain
    • Guo JU, Su Y, Zhong C, Ming GL, Song H. Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain. Cell 145: 423-434 (2011).
    • (2011) Cell , vol.145 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 79
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S, Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 324: 929-930 (2009).
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 80
    • 39849103298 scopus 로고    scopus 로고
    • Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: Relationship between kinetics and distribution of alkali-labile lesions
    • Lee YA, Durandin A, Dedon PC, Geacintov NE, Shafirovich V. Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesions. J Phys Chem B 112: 1834-1844 (2008).
    • (2008) J Phys Chem B , vol.112 , pp. 1834-1844
    • Lee, Y.A.1    Durandin, A.2    Dedon, P.C.3    Geacintov, N.E.4    Shafirovich, V.5
  • 81
    • 0027968491 scopus 로고
    • The DNAbinding efficiency of Sp1 is affected by redox changes
    • Ammendola R, Mesuraca M, Russo T, Cimino F. The DNAbinding efficiency of Sp1 is affected by redox changes. Eur J Biochem 225: 483-489 (1994).
    • (1994) Eur J Biochem , vol.225 , pp. 483-489
    • Ammendola, R.1    Mesuraca, M.2    Russo, T.3    Cimino, F.4
  • 82
    • 4043112183 scopus 로고    scopus 로고
    • Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2)
    • Valinluck V, Tsai HH, Rogstad DK, Burdzy A, Bird A, Sowers LC. Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucleic Acids Res 32: 4100-4108 (2004).
    • (2004) Nucleic Acids Res , vol.32 , pp. 4100-4108
    • Valinluck, V.1    Tsai, H.H.2    Rogstad, D.K.3    Burdzy, A.4    Bird, A.5    Sowers, L.C.6
  • 83
    • 70349140909 scopus 로고    scopus 로고
    • Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice
    • Dosunmu R, Wu J, Adwan L, Maloney B, Basha MR, McPherson CA, et al. Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice. J Alzheimers Dis 18: 211-230 (2009).
    • (2009) J Alzheimers Dis , vol.18 , pp. 211-230
    • Dosunmu, R.1    Wu, J.2    Adwan, L.3    Maloney, B.4    Basha, M.R.5    McPherson, C.A.6
  • 84
    • 20944444583 scopus 로고    scopus 로고
    • Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes
    • Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, et al. Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes. FASEB J 19: 739-749 (2005).
    • (2005) FASEB J , vol.19 , pp. 739-749
    • Sun, X.1    Wang, Y.2    Qing, H.3    Christensen, M.A.4    Liu, Y.5    Zhou, W.6
  • 85
    • 77649119442 scopus 로고    scopus 로고
    • Genotoxic fungicide methyl thiophanate as an oxidative stressor inducing 8-oxo-7,8-dihydro-2'-deoxyguanosine adducts in DNA and mutagenesis
    • Saquib Q, Al-Khedhairy AA, Singh BR, Arif JM, Musarrat J. Genotoxic fungicide methyl thiophanate as an oxidative stressor inducing 8-oxo-7,8-dihydro-2'-deoxyguanosine adducts in DNA and mutagenesis. J Environ Sci Health B 45: 40-45 (2010).
    • (2010) J Environ Sci Health B , vol.45 , pp. 40-45
    • Saquib, Q.1    Al-Khedhairy, A.A.2    Singh, B.R.3    Arif, J.M.4    Musarrat, J.5
  • 86
    • 0029610549 scopus 로고
    • vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides
    • Bagchi D, Bagchi M, Hassoun EA, Stohs SJ. In vitro and in vivo generation of reactive oxygen species, DNA damage and lactate dehydrogenase leakage by selected pesticides. Toxicology 104: 129-140 (1995).
    • (1995) Toxicology , vol.104 , pp. 129-140
    • Bagchi, D.1    Bagchi, M.2    Hassoun, E.A.3    Stohs, S.J.4
  • 88
    • 28244481785 scopus 로고    scopus 로고
    • Oxidative stress-induced DNA damage by particulate air pollution
    • Risom L, Moller P, Loft S. Oxidative stress-induced DNA damage by particulate air pollution. Mutat Res 592: 119-137 (2005).
    • (2005) Mutat Res , vol.592 , pp. 119-137
    • Risom, L.1    Moller, P.2    Loft, S.3
  • 89
    • 0035226686 scopus 로고    scopus 로고
    • Effect of varying dietary fat levels on rat growth and oxidative DNA damage
    • Djuric Z, Lewis SM, Lu MH, Mayhugh M, Tang N, Hart RW. Effect of varying dietary fat levels on rat growth and oxidative DNA damage. Nutr Cancer 39: 214-219 (2001).
    • (2001) Nutr Cancer , vol.39 , pp. 214-219
    • Djuric, Z.1    Lewis, S.M.2    Lu, M.H.3    Mayhugh, M.4    Tang, N.5    Hart, R.W.6
  • 91
    • 33746638798 scopus 로고    scopus 로고
    • Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake
    • Thompson HJ, Heimendinger J, Diker A, O'Neill C, Haegele A, Meinecke B, et al. Dietary botanical diversity affects the reduction of oxidative biomarkers in women due to high vegetable and fruit intake. J Nutr 136: 2207-2212 (2006).
    • (2006) J Nutr , vol.136 , pp. 2207-2212
    • Thompson, H.J.1    Heimendinger, J.2    Diker, A.3    O'Neill, C.4    Haegele, A.5    Meinecke, B.6
  • 92
    • 65249086293 scopus 로고    scopus 로고
    • Comparison of lifelong and late life exercise on oxidative stress in the cerebellum
    • Cui L, Hofer T, Rani A, Leeuwenburgh C, Foster TC. Comparison of lifelong and late life exercise on oxidative stress in the cerebellum. Neurobiol Aging 30: 903-909 (2009).
    • (2009) Neurobiol Aging , vol.30 , pp. 903-909
    • Cui, L.1    Hofer, T.2    Rani, A.3    Leeuwenburgh, C.4    Foster, T.C.5
  • 93
    • 49749144430 scopus 로고    scopus 로고
    • Blood oxidative stress biomarkers: Influence of sex, exercise training status, and dietary intake
    • Bloomer RJ, Fisher-Wellman KH. Blood oxidative stress biomarkers: influence of sex, exercise training status, and dietary intake. Gend Med 5: 218-228 (2008).
    • (2008) Gend Med , vol.5 , pp. 218-228
    • Bloomer, R.J.1    Fisher-Wellman, K.H.2
  • 94
    • 4344680938 scopus 로고    scopus 로고
    • Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase
    • Pinlaor S, Ma N, Hiraku Y, Yongvanit P, Semba R, Oikawa S, et al. Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase. Carcinogenesis 25:1535-1542 (2004).
    • (2004) Carcinogenesis , vol.25 , pp. 1535-1542
    • Pinlaor, S.1    Ma, N.2    Hiraku, Y.3    Yongvanit, P.4    Semba, R.5    Oikawa, S.6
  • 96
    • 0034625125 scopus 로고    scopus 로고
    • Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halidedependent formation of hydroxyl radical
    • Shen Z, Wu W, Hazen SL. Activated leukocytes oxidatively damage DNA, RNA, and the nucleotide pool through halidedependent formation of hydroxyl radical. Biochemistry 39: 5474-5482 (2000).
    • (2000) Biochemistry , vol.39 , pp. 5474-5482
    • Shen, Z.1    Wu, W.2    Hazen, S.L.3
  • 98
    • 0037111170 scopus 로고    scopus 로고
    • Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients
    • Cecchi C, Fiorillo C, Sorbi S, Latorraca S, Nacmias B, Bagnoli S, et al. Oxidative stress and reduced antioxidant defenses in peripheral cells from familial Alzheimer's patients. Free Radic Biol Med 33: 1372-1379 (2002).
    • (2002) Free Radic Biol Med , vol.33 , pp. 1372-1379
    • Cecchi, C.1    Fiorillo, C.2    Sorbi, S.3    Latorraca, S.4    Nacmias, B.5    Bagnoli, S.6
  • 99
    • 0036905921 scopus 로고    scopus 로고
    • Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer's disease brain. A review
    • Butterfield DA. Amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity: implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res 36: 1307-1313 (2002).
    • (2002) Free Radic Res , vol.36 , pp. 1307-1313
    • Butterfield, D.A.1
  • 100
    • 79951805276 scopus 로고    scopus 로고
    • Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion
    • Kikuchi Y, Yasuhara T, Agari T, Kondo A, Kuramoto S, Kameda M, et al. Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion. J Cell Physiol 226: 1390-1398 (2010).
    • (2010) J Cell Physiol , vol.226 , pp. 1390-1398
    • Kikuchi, Y.1    Yasuhara, T.2    Agari, T.3    Kondo, A.4    Kuramoto, S.5    Kameda, M.6
  • 101
    • 77956992830 scopus 로고    scopus 로고
    • Epigenetic reprogramming of host genes in viral and microbial pathogenesis
    • Paschos K, Allday MJ. Epigenetic reprogramming of host genes in viral and microbial pathogenesis. Trends Microbiol 18: 439-447 (2010).
    • (2010) Trends Microbiol , vol.18 , pp. 439-447
    • Paschos, K.1    Allday, M.J.2
  • 102
    • 0037240878 scopus 로고    scopus 로고
    • The NuRD complex: Linking histone modification to nucleosome remodeling
    • Feng Q, Zhang Y. The NuRD complex: linking histone modification to nucleosome remodeling. Curr Top Microbiol Immunol 274: 269-290 (2003).
    • (2003) Curr Top Microbiol Immunol , vol.274 , pp. 269-290
    • Feng, Q.1    Zhang, Y.2
  • 103
    • 80051644174 scopus 로고    scopus 로고
    • Histone Deacetylase Inhibitors Reverse CpG Methylation by Regulating DNMT1 through ERK Signaling
    • Sarkar S, Abujamra AL, Loew JE, Forman LW, Perrine SP, Faller DV. Histone Deacetylase Inhibitors Reverse CpG Methylation by Regulating DNMT1 through ERK Signaling. Anticancer Res 31: 2723-2732 (2011).
    • (2011) Anticancer Res , vol.31 , pp. 2723-2732
    • Sarkar, S.1    Abujamra, A.L.2    Loew, J.E.3    Forman, L.W.4    Perrine, S.P.5    Faller, D.V.6
  • 105
    • 9144234107 scopus 로고    scopus 로고
    • Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein
    • Kim HS, Kim EM, Kim NJ, Chang KA, Choi Y, Ahn KW, et al. Inhibition of histone deacetylation enhances the neurotoxicity induced by the C-terminal fragments of amyloid precursor protein. J Neurosci Res 75:117-124 (2004).
    • (2004) J Neurosci Res , vol.75 , pp. 117-124
    • Kim, H.S.1    Kim, E.M.2    Kim, N.J.3    Chang, K.A.4    Choi, Y.5    Ahn, K.W.6
  • 106
  • 107
    • 76749091005 scopus 로고    scopus 로고
    • Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    • Kilgore M, Miller CA, Fass DM, Hennig KM, Haggarty SJ, Sweatt JD, et al. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 35: 870-880 (2010).
    • (2010) Neuropsychopharmacology , vol.35 , pp. 870-880
    • Kilgore, M.1    Miller, C.A.2    Fass, D.M.3    Hennig, K.M.4    Haggarty, S.J.5    Sweatt, J.D.6
  • 108
    • 67649379393 scopus 로고    scopus 로고
    • Histone acetyltransferase inhibitors and preclinical studies
    • Manzo F, Tambaro FP, Mai A, Altucci L. Histone acetyltransferase inhibitors and preclinical studies. Expert Opin Ther Pat 19: 761-774 (2009).
    • (2009) Expert Opin Ther Pat , vol.19 , pp. 761-774
    • Manzo, F.1    Tambaro, F.P.2    Mai, A.3    Altucci, L.4
  • 110
    • 41149090082 scopus 로고    scopus 로고
    • DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    • Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One 2: e895 (2007).
    • (2007) PLoS One , vol.2
    • Siegmund, K.D.1    Connor, C.M.2    Campan, M.3    Long, T.I.4    Weisenberger, D.J.5    Biniszkiewicz, D.6
  • 111
    • 78249271058 scopus 로고    scopus 로고
    • Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
    • Osorio FG, Varela I, Lara E, Puente XS, Espada J, Santoro R, et al. Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease. Aging Cell 9: 947-957 (2010).
    • (2010) Aging Cell , vol.9 , pp. 947-957
    • Osorio, F.G.1    Varela, I.2    Lara, E.3    Puente, X.S.4    Espada, J.5    Santoro, R.6
  • 112
    • 0000847978 scopus 로고    scopus 로고
    • Gene-expression profile of the ageing brain in mice
    • Lee CK, Weindruch R, Prolla TA. Gene-expression profile of the ageing brain in mice. Nat Genet 25: 294-297 (2000).
    • (2000) Nat Genet , vol.25 , pp. 294-297
    • Lee, C.K.1    Weindruch, R.2    Prolla, T.A.3
  • 113
    • 63549135460 scopus 로고    scopus 로고
    • Meta-analysis of agerelated gene expression profiles identifies common signatures of aging
    • de Magalhaes JP, Curado J, Church GM. Meta-analysis of agerelated gene expression profiles identifies common signatures of aging. Bioinformatics 25: 875-881 (2009).
    • (2009) Bioinformatics , vol.25 , pp. 875-881
    • de Magalhaes, J.P.1    Curado, J.2    Church, G.M.3
  • 114
    • 77952519089 scopus 로고    scopus 로고
    • DNA methylation as a universal biomarker
    • Levenson VV. DNA methylation as a universal biomarker. Expert Rev Mol Diagn 10: 481-488 (2010).
    • (2010) Expert Rev Mol Diagn , vol.10 , pp. 481-488
    • Levenson, V.V.1
  • 115
    • 33751179713 scopus 로고    scopus 로고
    • Genes are not our destiny: The somatic epitype bridges between the genotype and the phenotype
    • doi:10.1038/nrn2022-c1
    • Lahiri DK, Maloney B. Genes are not our destiny: the somatic epitype bridges between the genotype and the phenotype. Nat Rev Neurosci 7: doi:10.1038/nrn2022-c1: (2006).
    • (2006) Nat Rev Neurosci , vol.7
    • Lahiri, D.K.1    Maloney, B.2
  • 116
    • 38149024924 scopus 로고    scopus 로고
    • Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): Evidence for a developmental origin and environmental link for AD
    • Wu J, Basha MR, Brock B, Cox DP, Cardozo-Pelaez F, McPherson CA, et al. Alzheimer's disease (AD)-like pathology in aged monkeys after infantile exposure to environmental metal lead (Pb): evidence for a developmental origin and environmental link for AD. J Neurosci 28: 3-9 (2008).
    • (2008) J Neurosci , vol.28 , pp. 3-9
    • Wu, J.1    Basha, M.R.2    Brock, B.3    Cox, D.P.4    Cardozo-Pelaez, F.5    McPherson, C.A.6
  • 118
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • Barrachina M, Ferrer I. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J Neuropathol Exp Neurol 68: 880-891 (2009).
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 119
    • 0031714732 scopus 로고    scopus 로고
    • The relationships between age, sex, and the incidence of dementia and Alzheimer disease: A meta-analysis
    • Gao S, Hendrie HC, Hall KS, Hui S. The relationships between age, sex, and the incidence of dementia and Alzheimer disease: a meta-analysis. Arch Gen Psychiatry 55: 809-815 (1998).
    • (1998) Arch Gen Psychiatry , vol.55 , pp. 809-815
    • Gao, S.1    Hendrie, H.C.2    Hall, K.S.3    Hui, S.4
  • 120
  • 121
    • 0036212338 scopus 로고    scopus 로고
    • Olfactory neural cells: An untapped diagnostic and therapeutic resource. The 2000 Ogura Lecture
    • Perry C, Mackay-Sim A, Feron F, McGrath J. Olfactory neural cells: an untapped diagnostic and therapeutic resource. The 2000 Ogura Lecture. Laryngoscope 112: 603-607 (2002).
    • (2002) Laryngoscope , vol.112 , pp. 603-607
    • Perry, C.1    Mackay-Sim, A.2    Feron, F.3    McGrath, J.4
  • 122
    • 78651455002 scopus 로고    scopus 로고
    • An integrated approach to genome studies
    • Lahiri DK. An integrated approach to genome studies. Science 331: 147 (2011).
    • (2011) Science , vol.331 , pp. 147
    • Lahiri, D.K.1
  • 123
    • 33846956780 scopus 로고    scopus 로고
    • Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress
    • Chan A, Shea TB. Supplementation with apple juice attenuates presenilin-1 overexpression during dietary and genetically-induced oxidative stress. J Alzheimers Dis 10: 353-358 (2006).
    • (2006) J Alzheimers Dis , vol.10 , pp. 353-358
    • Chan, A.1    Shea, T.B.2
  • 124
    • 1642337794 scopus 로고    scopus 로고
    • Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice
    • Rogers EJ, Milhalik S, Orthiz D, Shea TB. Apple juice prevents oxidative stress and impaired cognitive performance caused by genetic and dietary deficiencies in mice. J Nutr Health Aging 8: 92-97 (2004).
    • (2004) J Nutr Health Aging , vol.8 , pp. 92-97
    • Rogers, E.J.1    Milhalik, S.2    Orthiz, D.3    Shea, T.B.4
  • 125
    • 79951576248 scopus 로고    scopus 로고
    • Disease specificity and pathologic progression of tau pathology in brainstem nuclei of Alzheimer's disease and progressive supranuclear palsy
    • Dugger BN, Tu M, Murray ME, Dickson DW. Disease specificity and pathologic progression of tau pathology in brainstem nuclei of Alzheimer's disease and progressive supranuclear palsy. Neuroscience letters 491: 122-126 (2011).
    • (2011) Neuroscience Letters , vol.491 , pp. 122-126
    • Dugger, B.N.1    Tu, M.2    Murray, M.E.3    Dickson, D.W.4
  • 126
    • 33845535334 scopus 로고    scopus 로고
    • Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging
    • Sabbagh MN, Shah F, Reid RT, Sue L, Connor DJ, Peterson LK, et al. Pathologic and nicotinic receptor binding differences between mild cognitive impairment, Alzheimer disease, and normal aging. Arch Neurol 63: 1771-1776 (2006).
    • (2006) Arch Neurol , vol.63 , pp. 1771-1776
    • Sabbagh, M.N.1    Shah, F.2    Reid, R.T.3    Sue, L.4    Connor, D.J.5    Peterson, L.K.6
  • 127
    • 0034754471 scopus 로고    scopus 로고
    • Melatonin protects SHSY5Y neuroblastoma cells from cobaltinduced oxidative stress, neurotoxicity and increased beta-amyloid secretion
    • Olivieri G, Hess C, Savaskan E, Ly C, Meier F, Baysang G, et al. Melatonin protects SHSY5Y neuroblastoma cells from cobaltinduced oxidative stress, neurotoxicity and increased beta-amyloid secretion. Journal of Pineal Research 31: 320-325 (2001).
    • (2001) Journal of Pineal Research , vol.31 , pp. 320-325
    • Olivieri, G.1    Hess, C.2    Savaskan, E.3    Ly, C.4    Meier, F.5    Baysang, G.6
  • 128
    • 79952039402 scopus 로고    scopus 로고
    • Docosahexaenoic acid: Brain accretion and roles in neuroprotection after brain hypoxia and ischemia
    • Mayurasakorn K, Williams JJ, Ten VS, Deckelbaum RJ. Docosahexaenoic acid: brain accretion and roles in neuroprotection after brain hypoxia and ischemia. Curr Opin Clin Nutr Metab Care 14: 158-167 (2011).
    • (2011) Curr Opin Clin Nutr Metab Care , vol.14 , pp. 158-167
    • Mayurasakorn, K.1    Williams, J.J.2    Ten, V.S.3    Deckelbaum, R.J.4
  • 129
    • 80054875266 scopus 로고    scopus 로고
    • Modulation of Nrf2/ARE pathway by food polyphenols: A nutritional neuroprotective strategy for cognitive and neurodegenerative disorders
    • Scapagnini G, Vasto S, Abraham NG, Caruso C, Zella D, Fabio G. Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders. Mol Neurobiol 44: 192-201 (2011).
    • (2011) Mol Neurobiol , vol.44 , pp. 192-201
    • Scapagnini, G.1    Vasto, S.2    Abraham, N.G.3    Caruso, C.4    Zella, D.5    Fabio, G.6
  • 130
    • 84655164303 scopus 로고    scopus 로고
    • Neuroinflammation: Modulation by flavonoids and mechanisms of action
    • Spencer JP, Vafeiadou K, Williams RJ, Vauzour D. Neuroinflammation: Modulation by flavonoids and mechanisms of action. Mol Aspects Med 33(1): 83-97 (2011).
    • (2011) Mol Aspects Med , vol.33 , Issue.1 , pp. 83-97
    • Spencer, J.P.1    Vafeiadou, K.2    Williams, R.J.3    Vauzour, D.4
  • 132
    • 80051993184 scopus 로고    scopus 로고
    • The beneficial effects of physical activity on impaired adult neurogenesis and cognitive performance
    • Lafenetre P, Leske O, Wahle P, Heumann R. The beneficial effects of physical activity on impaired adult neurogenesis and cognitive performance. Front Neurosci 5: 51 (2011).
    • (2011) Front Neurosci , vol.5 , pp. 51
    • Lafenetre, P.1    Leske, O.2    Wahle, P.3    Heumann, R.4
  • 133
    • 79955675256 scopus 로고    scopus 로고
    • Diet induced epigenetic changes and their implications for health
    • McKay JA, Mathers JC. Diet induced epigenetic changes and their implications for health. Acta Physiol (Oxf) 202: 103-118 (2011).
    • (2011) Acta Physiol (Oxf) , vol.202 , pp. 103-118
    • McKay, J.A.1    Mathers, J.C.2
  • 137
    • 79955974521 scopus 로고    scopus 로고
    • Metabolic syndrome: From the genetics to the pathophysiology
    • Sookoian S, Pirola CJ. Metabolic syndrome: from the genetics to the pathophysiology. Curr Hypertens Rep 13: 149-157 (2011).
    • (2011) Curr Hypertens Rep , vol.13 , pp. 149-157
    • Sookoian, S.1    Pirola, C.J.2
  • 138
    • 82455164292 scopus 로고    scopus 로고
    • Metabolic Syndrome Is Also a Risk Factor for Primary Liver Cancer in Patients Younger than 65 Years of Age?
    • doi: 10.1002/hep.24643
    • Montella M, Polesel J, Talamini R, Crispo A, Giudice A, Izzo F, et al. Metabolic Syndrome Is Also a Risk Factor for Primary Liver Cancer in Patients Younger than 65 Years of Age? Hepatology 54(6): 2277-8. doi: 10.1002/hep.24643. (2011).
    • (2011) Hepatology , vol.54 , Issue.6 , pp. 2277-2278
    • Montella, M.1    Polesel, J.2    Talamini, R.3    Crispo, A.4    Giudice, A.5    Izzo, F.6
  • 139
    • 80052664767 scopus 로고    scopus 로고
    • Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: Implication for the understanding of metabolic syndrome
    • Jousse C, Parry L, Lambert-Langlais S, Maurin AC, Averous J, Bruhat A, et al. Perinatal undernutrition affects the methylation and expression of the leptin gene in adults: implication for the understanding of metabolic syndrome. FASEB J 25: 3271-3278 (2011).
    • (2011) FASEB J , vol.25 , pp. 3271-3278
    • Jousse, C.1    Parry, L.2    Lambert-Langlais, S.3    Maurin, A.C.4    Averous, J.5    Bruhat, A.6
  • 140
    • 79959824776 scopus 로고    scopus 로고
    • Epigenetic codes of PPARgamma in metabolic disease
    • Sugii S, Evans RM. Epigenetic codes of PPARgamma in metabolic disease. FEBS Lett 585: 2121-2128 (2011).
    • (2011) FEBS Lett , vol.585 , pp. 2121-2128
    • Sugii, S.1    Evans, R.M.2
  • 141
    • 82355190897 scopus 로고    scopus 로고
    • The early programming of metabolic health: Is epigenetic setting the missing link?
    • Sebert S, Sharkey D, Budge H, Symonds ME. The early programming of metabolic health: is epigenetic setting the missing link? Am J Clin Nutr 94(6 Suppl):1953S-1958S. (2011).
    • (2011) Am J Clin Nutr , vol.94 , Issue.6 SUPPL.
    • Sebert, S.1    Sharkey, D.2    Budge, H.3    Symonds, M.E.4
  • 142
    • 79955102501 scopus 로고    scopus 로고
    • Maternal exposure to the holocaust and health complaints in offspring
    • Flory JD, Bierer LM, Yehuda R. Maternal exposure to the holocaust and health complaints in offspring. Dis Markers 30: 133-139 (2011).
    • (2011) Dis Markers , vol.30 , pp. 133-139
    • Flory, J.D.1    Bierer, L.M.2    Yehuda, R.3
  • 143
    • 79954533286 scopus 로고    scopus 로고
    • Epigenetic priming of the metabolic syndrome
    • Bruce KD, Cagampang FR. Epigenetic priming of the metabolic syndrome. Toxicol Mech Methods 21: 353-361 (2011).
    • (2011) Toxicol Mech Methods , vol.21 , pp. 353-361
    • Bruce, K.D.1    Cagampang, F.R.2
  • 144
  • 145
    • 78649832440 scopus 로고    scopus 로고
    • Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition
    • Pentinat T, Ramon-Krauel M, Cebria J, Diaz R, Jimenez-Chillaron JC. Transgenerational inheritance of glucose intolerance in a mouse model of neonatal overnutrition. Endocrinology 151: 5617-5623 (2010).
    • (2010) Endocrinology , vol.151 , pp. 5617-5623
    • Pentinat, T.1    Ramon-Krauel, M.2    Cebria, J.3    Diaz, R.4    Jimenez-Chillaron, J.C.5
  • 146
    • 77954264029 scopus 로고    scopus 로고
    • Idiopathic environmental intolerances (IEI): From molecular epidemiology to molecular medicine
    • De Luca C, Scordo G, Cesareo E, Raskovic D, Genovesi G, Korkina L. Idiopathic environmental intolerances (IEI): from molecular epidemiology to molecular medicine. Indian J Exp Biol 48: 625-635 (2010).
    • (2010) Indian J Exp Biol , vol.48 , pp. 625-635
    • de Luca, C.1    Scordo, G.2    Cesareo, E.3    Raskovic, D.4    Genovesi, G.5    Korkina, L.6
  • 147
    • 77955921659 scopus 로고    scopus 로고
    • A high-fat diet impairs neurogenesis: Involvement of lipid peroxidation and brain-derived neurotrophic factor
    • Park HR, Park M, Choi J, Park KY, Chung HY, Lee J. A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor. Neuroscience letters 482: 235-239 (2010).
    • (2010) Neuroscience Letters , vol.482 , pp. 235-239
    • Park, H.R.1    Park, M.2    Choi, J.3    Park, K.Y.4    Chung, H.Y.5    Lee, J.6
  • 148
    • 4444285924 scopus 로고    scopus 로고
    • Alteration of polyunsaturated fatty acid status and metabolism in health and disease
    • Zamaria N. Alteration of polyunsaturated fatty acid status and metabolism in health and disease. Reprod Nutr Dev 44: 273-282 (2004).
    • (2004) Reprod Nutr Dev , vol.44 , pp. 273-282
    • Zamaria, N.1
  • 150
    • 34548715144 scopus 로고    scopus 로고
    • Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    • Dolinoy DC, Huang D and Jirtle RL. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A 104: 13056-13061 (2007).
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13056-13061
    • Dolinoy, D.C.1    Huang, D.2    Jirtle, R.L.3
  • 151
    • 33644911218 scopus 로고    scopus 로고
    • Cholesterol, APOE genotype, and Alzheimer disease: An epidemiologic study of Nigerian Yoruba
    • Hall K, Murrell J, Ogunniyi A, Deeg M, Baiyewu O, Gao S, et al. Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba. Neurology 66: 223-227 (2006).
    • (2006) Neurology , vol.66 , pp. 223-227
    • Hall, K.1    Murrell, J.2    Ogunniyi, A.3    Deeg, M.4    Baiyewu, O.5    Gao, S.6
  • 152
    • 33846983823 scopus 로고    scopus 로고
    • How and when environmental agents and dietary factors affect the course of Alzheimer's disease: The "LEARn" model (Latent Early-Life Associated Regulation) may explain the triggering of AD
    • Lahiri DK, Maloney B., Basha M.R, Ge YW, Zawia NH. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (Latent Early-Life Associated Regulation) may explain the triggering of AD. Curr Alzheimer Res 4:219-228 (2007).
    • (2007) Curr Alzheimer Res , vol.4 , pp. 219-228
    • Lahiri, D.K.1    Maloney, B.2    Basha, M.R.3    Ge, Y.W.4    Zawia, N.H.5
  • 153
    • 56049100240 scopus 로고    scopus 로고
    • Early-life events may trigger biochemical pathways for Alzheimer's disease: The "LEARn" model
    • Lahiri DK, Zawia NH, Greig NH, Sambamurti K, Maloney B. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Biogerontology 9:375-379 (2008).
    • (2008) Biogerontology , vol.9 , pp. 375-379
    • Lahiri, D.K.1    Zawia, N.H.2    Greig, N.H.3    Sambamurti, K.4    Maloney, B.5
  • 154
    • 84861145892 scopus 로고    scopus 로고
    • Epigenetics: A paradigm shift in understanding Alzheimer's Disease
    • [Epub ahead of print]
    • Zawia NH, Lahiri DK. Epigenetics: A paradigm shift in understanding Alzheimer's Disease. Curr Alzheimer Res [Epub ahead of print] (2012).
    • (2012) Curr Alzheimer Res
    • Zawia, N.H.1    Lahiri, D.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.