Functional, global and cognitive decline correlates to accumulation of alzheimer's pathology in MCI and AD

Current Alzheimer Research

Volumn 7, Issue 4, 2010, Pages 280-286

  Sabbagh, M N ^a   Cooper, K ^b   Delange, J ^b   Stoehr, J D ^b   Thind, K ^a   Lahti, T ^a   Reisberg, B ^c   Sue, L ^a   Vedders, L ^a   Fleming, S R ^b   Beach, T G ^a  

^a SUN HEALTH RESEARCH INSTITUTE   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Cognition; Neuropathology; Plaques; Staging; Tangles

Indexed keywords

AGED; ALZHEIMER DISEASE; AMNESIA; ARTICLE; AUTOPSY; BRAAK STAGING; ENTORHINAL CORTEX; FEMALE; FUNCTIONAL ASSESSMENT; FUNCTIONAL ASSESSMENT STAGING; GLOBAL DETERIORATION SCALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; PARIETAL LOBE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RATING SCALE; SENILE PLAQUE; TEMPORAL CORTEX;

AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBRAL CORTEX; COGNITION DISORDERS; COHORT STUDIES; DISABILITY EVALUATION; DISEASE PROGRESSION; ENTORHINAL CORTEX; FEMALE; HIPPOCAMPUS; HUMANS; LONGITUDINAL STUDIES; MALE; NEUROFIBRILLARY TANGLES; NEUROPSYCHOLOGICAL TESTS; PLAQUE, AMYLOID; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX;

EID: 77954001458     PISSN: 15672050     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720510791162340     Document Type: Article

References (45)

1. Blessed G, Tomlinson BE, Roth M. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatr 114: 797-811 (1968).
2. Crystal H, Dickenson D, Fuld P, Masur D, Scott R, Mehler M, et al. Clinico-pathological studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 38: 1682-7 (1988).
3. Arriagada PV, Growden JH, Hedley-Whyte ET, Hyman B. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42: 631-9 (1992).
4. Giannakopoulos P, Herrman FR, Busiere T, Bouras C, Kovari E, Perl DP, et al. Tangle and neuron numbers, but not amyloid loads, predict cognitive status in Alzheimer's disease. Neurology 60:1495-500 (2003).
5. Bierer LM, Hof PR, Purohit DP, Carlin L, Schmeidler J, Davis KL, et al. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease. Arch Neurol 52(1): 81-8 (1995).
6. von Gunten A, Kovari E, Bussere T, Rivara CB, Gold G, Bouras C, et al. Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease. Neurobiol Aging 27(2): 270-7 (2006).
7. Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, et al. Long-term effects of Abeta42 immunization in Alzheimer's disease: follow-up of a randomized, placebo-controlled phase I trial. Lancet 372(9634): 216-23 (2008).
8. Thal DR, Arendt T, Waldmann G, Holzer M, Zedlick D, Rub U, et al. Progression of neurofibrillary changes and PHF-tau in end-stage Alzheimer's disease is different from plaque and cortical microglial pathology. Neurobiol Aging 19(6): 517-25 (1998).
9. Kraemer HC, Taylor JL, Tinklenberg JR, Yesavage JA. The stages of Alzheimer's disease a reappraisal. Dement Geriatr Cogn Disord 9(6): 299-308 (1998).
10. Bobinski M, Wegiel J, Wisniewski HM, Tarnawski M, Reisberg B, Mlodzik B, et al. Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer Disease. Dementia 6: 205-10 (1995).
11. Bobinski M, Wegiel J, Tarnawski M, Bobinski M, Reisberg B, de Leon MJ, et al. Relationships between regional neuronal loss and neurofibrillary changes in the hippocampal formation and duration and severity of Alzheimer disease. J Neuropathol Exp Neurol 56(4): 414-20 (1997).
12. Braak H, Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol 82: 239-59 (1991).
13. Khachaturian ZS. Diagnosis of Alzheimer's disease. Arch Neurol 42: 1097-104 (1985).
14. Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, et al. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41(4): 479-86 (1991).
15. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34(7): 939-944 (1984).
16. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, et al. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology 47(5): 1113-24 (1996).
17. Roman GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, et al. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43(2): 250-60 (1993).
18. Emre M. Dementia associated with Parkinson's disease. Lancet Neurol 2(4): 229-37 (2003).
19. Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, et al. Consortium for Frontotemporal Lobar Degeneration. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol 114(1): 5-22 (2007).
20. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol 56(3): 303-8 (1999).
21. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th ed.), Washington DC: American Psychiatric Association. (1994)
22. Reisberg B, Franssen E, Bobinski M, Auer S, Monteiro I, Boksay I, et al. Overview of methodological issues for pharmacological trials in mild, moderate, and severe Alzheimer's disease. Int Psychogeriatr 8(2): 159-93 (1996).
23. Reisberg B, Sclan SG, Franssen E, Kluger A, Ferris S. Dementia staging in chronic care populations. Alzheimer Dis Assoc Dis 8(Supp1): s188-s205 (1994).
24. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry 139(9): 1136-9 (1982).
25. Cohen-Mansfield J, Reisberg B, Bonnema J, Berg L, Dastoor D, Pfeffer RI, et al. Staging methods for the assessment of dementia: perspectives. J Clin Psychiatry 57: 190-8 (1996).
26. Sclan SG, Reisberg B. Functional Assessment Staging (FAST) in Alzheimer's disease: reliability, validity, and ordinality. Int Psychogeriatr 4(Supp1): 55-69 (1992).
27. Folstein MF, Folstein S, McHugh PR. J. "Mini-Mental State" a practical method for grading the cognitive state of patients for the clinician. Psychiatr Res 12: 189-98 (1975).
28. Monteiro IM, Boksay I, Auer SR, Torossian C, Sinaiko E, Reisberg B. Reliability of routine clinical instruments for the assessment of Alzheimer's disease administered by telephone. J Geriatr Neurol 11: 18-24 (1998).
29. Cummings BJ, Cotman CW. Image analysis of beta-amyloid load in Alzheimer's disease and relation to dementia severity. Lancet 346: 1524-8 (1995).
30. Cummings BJ, Pike CJ, Shankle R, Cotman CW. Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's Disease. Neurbiol Aging 17(6): 921-33 (1996).
31. Naslund J, Haroutunian V, Mohs R, Davis KL, Davies KL, Greengard P, et al. Correlation between elevated levels of amyloid betapeptide in the brain and cognitive decline. JAMA 283(12): 1571-7 (2000).
32. Bussiere T, Friend PD, Sadeghi N, Wicinski B, Lin GI, Bouras C, et al. Stereologic assessment of the total cortical volume occupied by amyloid deposits an dits relationship with cognitive status in aging and Alzheimer's disease. Neouroscience 112(1): 75-91 (2002).
33. Price JL, Davis PB, Morris JC, White DL. The distribution of tangles, plaques, and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 12(4): 295-312 (1991).
34. McKee AC, Kosik KS, Kowall NW. Neuritic pathology and dementia in Alzheimer's disease. Ann Neurol 30: 156-65 (1991).
35. Haroutunian V, Purohit D, Perl D, Marin D, Khan K, Lantz M, et al. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease. Arch Neurol 56: 713-8 (1999).
36. Guizollet AL, Weintraub S, Mash DC, Mesulam MM. Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment. Arch Neurol 60(5): 729-36 (2003).
37. Bennett DA, Schneider JA, Wilson RW, Bienas JL, Arnold SE. Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function. Arch Neurol 61: 378-84 (2004).
38. Berg L, McKeel DW Fr., Miller FP, Storandt M, Rubin EH, Morris FC, et al. Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype. Arch Neurol 55(3): 326-35 (1998).
39. Gomez-Isla T, Price JL, McKeel Jr. DW, Morris JC, Growdon JH, Hyman BT. Profound loss of layer II entorhinal cotex neurons occurs in very mild Alzheimer's Disease. J Neurosci 16(14): 4491-500 (1996).
40. Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30: 572-580 (1991).
41. Ingelsson M, Fukumoto H, Newell KL, Growdon JH, Hedley- Whyte ET, Frosch MP, et al. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology 62(6): 925-31 (2004).
42. Peterson RC, Doody R, Kurtz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch Neurol 58: 1985-1992 (2001).
43. Tierney MC, Szalal JP, Snow WG, Fisher RH, Noves A, Nadon G, et al. Prediction of probably Alzheimer's disease in memoryimpaired patients: a prospective longitudinal study. Neurology 46: 661-5 (1996).
44. Morris JC. Mild cognitive impairment and preclinical Alzheimer's disease. Geriatrics (Suppl): 9-14 (2005).
45. Storandt M, Grant EA, Miller JP, Morris JC. Rates of progression in mild cognitive impairment and early Alzheimer's disease. Neurology 59(7): 1034-41 (2002).