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Volumn 13, Issue 2, 2011, Pages 149-157

Metabolic syndrome: From the genetics to the pathophysiology

Author keywords

Adolescents; Arterial blood pressure; Cardiometabolic syndrome; Cholesterol; CLOCK; Diabetes; DNA methylation; Dyslipidemia; Epigenetics; Epistasis; Gene; Genetics; Glucose; Hypertension; Insulin; Insulin resistance; miRNAs; Newborns; Obesity; SLC6A4; SLC7A1; Small for gestational age; Systems biology; Triglycerides; Variants

Indexed keywords

CYCLOOXYGENASE 2; FARNESOID X RECEPTOR; MICRORNA; PREGNANE X RECEPTOR; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR CLOCK;

EID: 79955974521     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-010-0164-9     Document Type: Review
Times cited : (74)

References (37)
  • 1
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Despres JP, Lemieux I: Abdominal obesity and metabolic syndrome. Nature 2006, 444:881-887.
    • (2006) Nature , vol.444 , pp. 881-887
    • Despres, J.P.1    Lemieux, I.2
  • 2
    • 34247193564 scopus 로고    scopus 로고
    • Metabolic syndrome: Is it a syndrome? Does it matter?
    • Kahn R: Metabolic syndrome: is it a syndrome? Does it matter? Circulation 2007, 115:1806-1810.
    • (2007) Circulation , vol.115 , pp. 1806-1810
    • Kahn, R.1
  • 3
    • 0031851293 scopus 로고    scopus 로고
    • Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation
    • Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998, 15:539-553.
    • (1998) Diabet Med , vol.15 , pp. 539-553
    • Alberti, K.G.1    Zimmet, P.Z.2
  • 4
    • 0035897696 scopus 로고    scopus 로고
    • Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)
    • Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001, 285:2486-2497.
    • (2001) JAMA , vol.285 , pp. 2486-2497
  • 5
    • 25144459980 scopus 로고    scopus 로고
    • The metabolic syndrome - A new worldwide definition
    • DOI 10.1016/S0140-6736(05)67402-8, PII S0140673605674028
    • Alberti KG, Zimmet P, Shaw J: The metabolic syndrome - a new worldwide definition. Lancet 2005, 366:1059-1062. (Pubitemid 41338752)
    • (2005) Lancet , vol.366 , Issue.9491 , pp. 1059-1062
    • Alberti, K.G.M.M.1    Zimmet, P.2    Shaw, J.3
  • 6
    • 59049085845 scopus 로고    scopus 로고
    • Genetics of the cardiometabolic syndrome: New insights and therapeutic implications
    • Sookoian S, Pirola CJ: Genetics of the cardiometabolic syndrome: new insights and therapeutic implications. Ther Adv Cardiovasc Dis 2007, 1:37-47.
    • (2007) Ther Adv Cardiovasc Dis , vol.1 , pp. 37-47
    • Sookoian, S.1    Pirola, C.J.2
  • 7
    • 72449197565 scopus 로고    scopus 로고
    • Novel functions for small RNA molecules
    • Zhang C: Novel functions for small RNA molecules. Curr Opin Mol Ther 2009, 11:641-651.
    • (2009) Curr Opin Mol Ther , vol.11 , pp. 641-651
    • Zhang, C.1
  • 8
    • 34249700597 scopus 로고    scopus 로고
    • Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: Let's call the whole thing off
    • Weaver IC: Epigenetic programming by maternal behavior and pharmacological intervention. Nature versus nurture: let's call the whole thing off. Epigenetics 2007, 2:22-28.
    • (2007) Epigenetics , vol.2 , pp. 22-28
    • Weaver, I.C.1
  • 9
    • 67849130563 scopus 로고    scopus 로고
    • ToppGene Suite for gene list enrichment analysis and candidate gene prioritization
    • This article demonstrates the bioinformatic tool for gene list functional enrichment, candidate gene prioritization, and identification and prioritization of novel disease candidate genes in the interactome
    • Chen J, Bardes EE, Aronow BJ, et al.: ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res 2009, 37:W305-W311. This article demonstrates the bioinformatic tool for gene list functional enrichment, candidate gene prioritization, and identification and prioritization of novel disease candidate genes in the interactome.
    • (2009) Nucleic Acids Res , vol.37
    • Chen, J.1    Bardes, E.E.2    Aronow, B.J.3
  • 10
    • 67249147301 scopus 로고    scopus 로고
    • Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes
    • Sookoian S, Gianotti TF, Schuman M, et al.: Gene prioritization based on biological plausibility over genome wide association studies renders new loci associated with type 2 diabetes. Genet Med 2009, 11:338-343.
    • (2009) Genet Med , vol.11 , pp. 338-343
    • Sookoian, S.1    Gianotti, T.F.2    Schuman, M.3
  • 11
    • 71649108660 scopus 로고    scopus 로고
    • Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: A meta-analysis in 49,577 individuals
    • Sookoian S, Gemma C, Pirola CJ: Influence of hepatocyte nuclear factor 4α (HNF4α) gene variants on the risk of type 2 diabetes: a meta-analysis in 49,577 individuals. Mol Genet Metab 2010, 99:80-89.
    • (2010) Mol Genet Metab , vol.99 , pp. 80-89
    • Sookoian, S.1    Gemma, C.2    Pirola, C.J.3
  • 12
    • 77952469210 scopus 로고    scopus 로고
    • Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension
    • Sookoian S, Gianotti TF, Gemma C, et al.: Role of genetic variation in insulin-like growth factor 1 receptor on insulin resistance and arterial hypertension. J Hypertens 2010, 28:1194-1202.
    • (2010) J Hypertens , vol.28 , pp. 1194-1202
    • Sookoian, S.1    Gianotti, T.F.2    Gemma, C.3
  • 13
    • 67249117049 scopus 로고    scopus 로고
    • Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
    • Hindorff LA, Sethupathy P, Junkins HA, et al.: Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A 2009, 106:9362-9367.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9362-9367
    • Hindorff, L.A.1    Sethupathy, P.2    Junkins, H.A.3
  • 15
    • 39449137183 scopus 로고    scopus 로고
    • Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adults
    • DOI 10.1038/oby.2007.64, PII OBY200764
    • Sookoian S, Gianotti TF, Gemma C, et al.: Contribution of the functional 5-HTTLPR variant of the SLC6A4 gene to obesity risk in male adults. Obesity (Silver Spring) 2008, 16:488-491. (Pubitemid 351271937)
    • (2008) Obesity , vol.16 , Issue.2 , pp. 488-491
    • Sookoian, S.1    Gianotti, T.F.2    Gemma, C.3    Burgueo, A.4    Pirola, C.J.5
  • 16
    • 77955152755 scopus 로고    scopus 로고
    • Nuclear receptors linking circadian rhythms and cardiometabolic control
    • Duez H, Staels B: Nuclear receptors linking circadian rhythms and cardiometabolic control. Arterioscler Thromb Vasc Biol 2010, 30:1529-1534.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , pp. 1529-1534
    • Duez, H.1    Staels, B.2
  • 18
    • 34548480183 scopus 로고    scopus 로고
    • Common genetic variation in CLOCK transcription factor are associated with nonalcoholic fatty liver disease
    • Sookoian S, Castano G, Gemma C, et al.: Common genetic variations in CLOCK transcription factor are associated with nonalcoholic fatty liver disease. World J Gastroenterol 2007, 13:4242-4248. (Pubitemid 47377164)
    • (2007) World Journal of Gastroenterology , vol.13 , Issue.31 , pp. 4242-4248
    • Sookoian, S.1    Castano, G.2    Gemma, C.3    Gianotti, T.F.4    Pirola, C.J.5
  • 19
    • 74049138315 scopus 로고    scopus 로고
    • Cumulative effects and predictive value of common obesity-susceptibility variants identified by genomewide association studies
    • Li S, Zhao JH, Luan J, et al.: Cumulative effects and predictive value of common obesity-susceptibility variants identified by genomewide association studies. Am J Clin Nutr 2010, 91:184-190.
    • (2010) Am J Clin Nutr , vol.91 , pp. 184-190
    • Li, S.1    Zhao, J.H.2    Luan, J.3
  • 23
    • 34547415510 scopus 로고    scopus 로고
    • Genetic epistasis in the VLDL catabolic pathway is associated with deleterious variations on triglyceridemia in obese subjects
    • DOI 10.1038/sj.ijo.0803586, PII 0803586
    • Brisson D, St-Pierre J, Santure M, et al.: Genetic epistasis in the VLDL catabolic pathway is associated with deleterious variations on triglyceridemia in obese subjects. Int J Obes (Lond) 2007, 31:1325-1333. (Pubitemid 47172622)
    • (2007) International Journal of Obesity , vol.31 , Issue.8 , pp. 1325-1333
    • Brisson, D.1    St-Pierre, J.2    Santure, M.3    Hudson, T.J.4    Despres, J.P.5    Vohl, M.C.6    Gaudet, D.7
  • 24
    • 77954978940 scopus 로고    scopus 로고
    • Gene-gene interaction between serotonin transporter (SLC6A4) and CLOCK modulates the risk of metabolic syndrome in rotating shiftworkers
    • Sookoian S, Gianotti TF, Burgueño A, Pirola CJ: Gene-gene interaction between serotonin transporter (SLC6A4) and CLOCK modulates the risk of metabolic syndrome in rotating shiftworkers. Chronobiol Int 2010, 27:1202-1218.
    • (2010) Chronobiol Int , vol.27 , pp. 1202-1218
    • Sookoian, S.1    Gianotti, T.F.2    Burgueño, A.3    Pirola, C.J.4
  • 25
    • 41149172495 scopus 로고    scopus 로고
    • Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion
    • Ling C, Del Guerra S, Lupi R, et al.: Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion. Diabetologia 2008, 51:615-622.
    • (2008) Diabetologia , vol.51 , pp. 615-622
    • Ling, C.1    Del Guerra, S.2    Lupi, R.3
  • 26
    • 67349133607 scopus 로고    scopus 로고
    • Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns
    • Silver Spring
    • Gemma C, Sookoian S, Alvarinas J, et al.: Maternal pregestational BMI is associated with methylation of the PPARGC1A promoter in newborns. Obesity (Silver Spring) 2009, 17:1032-1039.
    • (2009) Obesity , vol.17 , pp. 1032-1039
    • Gemma, C.1    Sookoian, S.2    Alvarinas, J.3
  • 27
    • 77950627693 scopus 로고    scopus 로고
    • Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents
    • Gemma C, Sookoian S, Dieuzeide G, et al.: Methylation of TFAM gene promoter in peripheral white blood cells is associated with insulin resistance in adolescents. Mol Genet Metab 2010, 100:83-87.
    • (2010) Mol Genet Metab , vol.100 , pp. 83-87
    • Gemma, C.1    Sookoian, S.2    Dieuzeide, G.3
  • 29
  • 30
    • 73249133400 scopus 로고    scopus 로고
    • Epigenetics: A molecular link between environmental factors and type 2 diabetes
    • Ling C, Groop L: Epigenetics: a molecular link between environmental factors and type 2 diabetes. Diabetes 2009, 58:2718-2725.
    • (2009) Diabetes , vol.58 , pp. 2718-2725
    • Ling, C.1    Groop, L.2
  • 31
    • 34547727263 scopus 로고    scopus 로고
    • Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: A mechanism for functional single-nucleotide polymorphisms related to phenotypes
    • DOI 10.1086/519979
    • Sethupathy P, Borel C, Gagnebin M, et al.: Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3′ untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes. Am J Hum Genet 2007, 81:405-413. (Pubitemid 47236088)
    • (2007) American Journal of Human Genetics , vol.81 , Issue.2 , pp. 405-413
    • Sethupathy, P.1    Borel, C.2    Gagnebin, M.3    Grant, G.R.4    Deutsch, S.5    Elton, T.S.6    Hatzigeorgiou, A.G.7    Antonarakis, S.E.8
  • 32
    • 16844374196 scopus 로고    scopus 로고
    • A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension
    • DOI 10.1111/j.1572-0241.2005.41168.x
    • Sookoian S, Castano G, Garcia SI, et al.: A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension. Am J Gastroenterol 2005, 100:636-642. (Pubitemid 40487564)
    • (2005) American Journal of Gastroenterology , vol.100 , Issue.3 , pp. 636-642
    • Sookoian, S.1    Castano, G.2    Garcia, S.I.3    Viudez, P.4    Gonzalez, C.5    Pirola, C.J.6
  • 33
    • 61649092260 scopus 로고    scopus 로고
    • Mechanistic insights into the link between a polymorphism of the 3?UTR of the SLC7A1 gene and hypertension
    • Yang Z, Kaye DM: Mechanistic insights into the link between a polymorphism of the 3?UTR of the SLC7A1 gene and hypertension. Hum Mutat 2009, 30:328-333.
    • (2009) Hum Mutat , vol.30 , pp. 328-333
    • Yang, Z.1    Kaye, D.M.2
  • 34
    • 33947712377 scopus 로고    scopus 로고
    • Identification of a novel polymorphism in the 3′UTR of the L-arginine transporter gene SLC7A1: Contribution to hypertension and endothelial dysfunction
    • DOI 10.1161/CIRCULATIONAHA.106.665836
    • Yang Z, Venardos K, Jones E, et al.: Identification of a novel polymorphism in the 3′UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. Circulation 2007, 115:1269-1274. (Pubitemid 46594771)
    • (2007) Circulation , vol.115 , Issue.10 , pp. 1269-1274
    • Yang, Z.1    Venardos, K.2    Jones, E.3    Morris, B.J.4    Chin-Dusting, J.5    Kaye, D.M.6
  • 35
    • 77953787211 scopus 로고    scopus 로고
    • MiR-33 contributes to the regulation of cholesterol homeostasis
    • The authors demonstrated that miR-33 appears to regulate both HDL biogenesis in the liver and cellular cholesterol efflux
    • Rayner KJ, Suarez Y, Davalos A, et al.: MiR-33 contributes to the regulation of cholesterol homeostasis. Science 2010, 328:1570-1573. The authors demonstrated that miR-33 appears to regulate both HDL biogenesis in the liver and cellular cholesterol efflux.
    • (2010) Science , vol.328 , pp. 1570-1573
    • Rayner, K.J.1    Suarez, Y.2    Davalos, A.3
  • 36
    • 77951092180 scopus 로고    scopus 로고
    • Targeting of mRNAs by multiple miRNAs: The next step
    • Peter ME: Targeting of mRNAs by multiple miRNAs: the next step. Oncogene 2010, 29:2161-2164.
    • (2010) Oncogene , vol.29 , pp. 2161-2164
    • Peter, M.E.1
  • 37
    • 77954269901 scopus 로고    scopus 로고
    • The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function
    • Warde-Farley D, Donaldson SL, Comes O, et al: The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 2010:W214-220.
    • (2010) Nucleic Acids Res
    • Warde-Farley, D.1    Donaldson, S.L.2    Comes, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.