Dehydrocostuslactone, a medicinal plant-derived sesquiterpene lactone, induces apoptosis coupled to endoplasmic reticulum stress in liver cancer cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 2, 2009, Pages 808-819

  Hsu, Ya Ling ^a   Wu, Ling Yu ^a   Kuo, Po Lin ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS INDUCING FACTOR; CALCIUM; CASPASE 4; DEHYDROCOSTUS LACTONE; ENDONUCLEASE G; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN IRE1; PROTEIN KINASE R; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; X BOX BINDING PROTEIN 1; ANTINEOPLASTIC AGENT; CASPASE; LACTONE; SESQUITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CARCINOMA CELL; CELL PROLIFERATION; CELL STIMULATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOSOL; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA SPLICING; TUMOR VOLUME; UPREGULATION; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; ENDOPLASMIC RETICULUM; IMMUNOBLOTTING; LIVER TUMOR; METABOLISM; NUDE MOUSE; OXIDATIVE STRESS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAUSSUREA; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CALCIUM; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; ENDOPLASMIC RETICULUM; HUMANS; IMMUNOBLOTTING; LACTONES; LIVER NEOPLASMS; MICE; MICE, NUDE; OXIDATIVE STRESS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SAUSSUREA; SESQUITERPENES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 65649118121     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.108.148395     Document Type: Article

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