A new triterpenoid from Panax ginseng exhibits cytotoxicity through p53 and the caspase signaling pathway in the HepG2 cell line

Archives of Pharmacal Research

Volumn 31, Issue 3, 2008, Pages 323-329

  Huang, Jian ^a   Tang, Xiao Hui ^a   Ikejima, Takashi ^a   Sun, Xiu Jia ^b   Wang, Xiao Bo ^c   Xi, Rong Gang ^c   Wu, Li Jun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b QIQIHAR UNIVERSITY   (China)

^c 210th Hospital of People Liberation Army   (China)

Author keywords

Caspase; Cell cycle; Cytotoxicity; HepG2; p53; Panax ginseng; Triterpenoid

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE; PROTEIN P53; TP53 PROTEIN, HUMAN; TRITERPENE;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; ENZYMOLOGY; FLOW CYTOMETRY; GINSENG; HUMAN; IC 50; ISOLATION AND PURIFICATION; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; NICK END LABELING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; PLANT LEAF; SIGNAL TRANSDUCTION; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HUMANS; IN SITU NICK-END LABELING; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PANAX; PLANT LEAVES; SIGNAL TRANSDUCTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 46249091398     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1159-8     Document Type: Article

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